Selected Publications
2012 Miné-Hattab, J. and Rothstein, R. Increased chromosome mobility facilitates homology search during recombination. Nature Cell Biol., 14: 510–517, 2012.
2012 Thorpe, P.H., Dittmar, J.C. and Rothstein, R. ScreenTroll: A searchable database to compare genome-wide yeast screens. Database, doi:10.1093/database/bas022, 2012.
2012 García-Rodríguez, N., del Carmen Díaz de la Loza, M., Andreson, B., Monje-Casas, F., Rothstein, R. and Wellinger, R.E. Impaired Manganese Metabolism Causes Mitotic Misregulation. J. Biol. Chem., doi: 10.1074/jbc.M112.358309, 2012.
2011 Bernstein, K.A., Reid, R.J.D., Sunjevaric, I., Demuth, K., Burgess, R.C. and Rothstein, R. The Shu complex, which contains Rad51 paralogues, promotes DNA repair through inhibition of the Srs2 anti-recombinase. Molec. Biol. Cell 22: 1599-1607, 2011.
2011 León Ortiz AM, Reid RJ, Dittmar JC, Rothstein R, Nicolas A. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. DNA Repair (Amst). 10: 506-17, 2011.
2011 Eckert-Boulet, N., Rothstein, R. and Lisby, M. Cell biology of homologous recombination in yeast. Methods Mol Biol. 745: 523-36, 2011.
2011 Thorpe, P.H., Alvaro, D.A., Lisby, M. and Rothstein, R. Bringing Rad52 foci into focus. J. Cell Biol. 194: 665-667, 2011.
2011 Reid RJ, González-Barrera S, Sunjevaric I, Alvaro D, Ciccone S, Wagner M, Rothstein R. Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage. Genome Res., 3:477-86, 2011.
2011 Chang M, Dittmar JC, Rothstein R. Long telomeres are preferentially extended during recombination-mediated telomere maintenance. Nat Struct Mol Biol., 4:451-456, 2011.
2010 Bernstein KA, Gangloff S, Rothstein R. The RecQ DNA helicases in DNA repair. Annu Rev Genet., 44:393-417, 2010.
2010 Dittmar JC, Reid RJ, Rothstein R. ScreenMill: a freely available software suite for growth measurement, analysis and visualization of high-throughput screen data. BMC Bioinformatics, 11:353, 2010.
2010 Andreson BL, Gupta A, Georgieva BP, Rothstein R. The ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damage. Nucleic Acids Res. 38(19):6490-501. 2010.
2010 Barlow, J.H. and Rothstein, R. Timing is everything: cell cycle control of Rad52. Cell Division, 5: 7, 2010.
2009 Mortensen, U.H., Lisby, M. and Rothstein, R. Rad52. Current Biol, 19(16): R676-7, 2009.
2009 Chang, M., Luke, B., Kraft, C., Li, Z., Peter, M., Lingner, J. and Rothstein, R. Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics, 183(3): 779-91, 2009.
2009 Burgess, R.C., Lisby, M., Altmannova, V., Krejci, L., Sung, P. and Rothstein, R. Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo. J Cell Biol, 185(6): 969-81, 2009.
2009 Lisby, M. and Rothstein, R. Choreography of recombination proteins during the DNA damage response. DNA Repair, 8(9): 1068-76, 2009.
2009 Bernstein, K.A. and Rothstein, R. At loose ends: resecting a double-strand break. Cell, 137(5): 807-10, 2009.
2009 Thorpe, P.H., Bruno, J. and Rothstein, R. Kinetochore asymmetry defines a single yeast lineage. PNAS, 106(16): 6673-8, 2009.
2009 Barlow, J.H. and Rothstein, R. Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase. EMBO J, 28: 1121-30, 2009.
2009 Bernstein, K.A., Shor, E., Sunjevaric, I., Fumasoni, M., Burgess, R.C., Foiani, M., Branzei, D. and Rothstein, R. Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J, 28: 915-25, 2009.
2008 Thorpe, P.H., Bruno, J. and Rothstein, R. Modeling stem cell asymmetry in yeast. Cold Spring Harb Symp Quant Biol, 73: 81-8, 2008.
2008 Reid, R.J., Sunjevaric, I., Voth, W.P., Ciccone, S., Du, W., Olsen, A.E., Stillman, D.J. and Rothstein, R. Chromosome-scale genetic mapping using a set of 16 conditionally stable Saccharomyces cerevisiae chromosomes. Genetics, 180: 1799-808, 2008.
2008 Weinstein, J. and Rothstein, R. The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1. DNA Repair, 7(4): 558-71, 2008.
2008 Barlow, J.H., Lisby, M. and Rothstein, R. Differential regulation of the cellular response to DNA double-strand breaks in G1. Molecular Cell, 30(1): 73-85, 2008.
2008 Plate, I., Albertsen, L., Lisby, M., Hallwyl, S.C.L., Feng, Q., Seong, C., Rothstein, R., Sung, P. and Mortensen, U.H. Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae. DNA Repair 7: 57-66, 2008.
2008 Kanaar, R. Wyman, C. and Rothstein, R. Quality control in DNA break metabolism: in the 'end', it's a good thing. EMBO J 27: 581-588, 2008.
2007 Aguilera, A. and Rothstein, R. In: Topics in Current Genetics - Molecular Genetics of Recombination, Springer-Verlag, Berlin, 2007
2007 Alvaro D., Lisby M. and Rothstein R. Genome-Wide Analysis of Rad52 Foci Reveals Diverse Mechanisms Impacting Recombination. PLoS Genet 3(12): e228, 2007.
2007 Torres-Rosell, J., Sunjevaric, I., De Piccoli, G., Sacher, M., Eckert-Boulet, N., Reid, R., Jentsch, S., Rothstein, R., Aragón, L., Lisby, M. The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nat Cell Biol. 9 (8): 923-31, 2007
2007 Burgess, R.C., Rahman, S., Lisby, M., Rothstein, R. and Zhao, X. The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. Mol Cell Biol. 27 (17): 6153-62, 2007
2007 Thorpe, P.H., González-Barrera, S. and Rothstein, R. More is not always better: the genetic constraints of polyploidy. Trends in Genetics, 23(6): 263-266, 2007
2007 Lisby, M. and Rothstein, R. The cell biology of mitotic recombination in Saccharomyces cerevisiae. In: Topics in Current Genetics - Molecular Genetics of Recombination (A. Aguilera and R. Rothstein, eds.), Springer-Verlag, Berlin, pp. 317-333, 2007
2007 Feng, Q., Düring L., Antúnez de Mayolo, A., Lettier G., Lisby M., Erdeniz N., Mortensen H.U., Rothstein, R. Rad52 and Rad59 exhibit both overlapping and distinct functions. DNA Repair, 6(1): 27-37, 2007
2006 Lettier G., Feng, Q., Antúnez de Mayolo, A., Erdeniz, N., Reid, R.J.D., Lisby, M., Mortensen, H.M. and Rothstein, R. The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae. PLoS Genet, 2(11): e194, 2006.
2006 Alvaro D., Sunjevaric I., Reid R., Lisby M., and Rothstein R. Systematic Hybrid LOH: a new method to reduce false positives and negatives during screening of yeast gene deletion libraries. Yeast, 23: 1097-1106, 2006
2006 Wagner, M., Price, G. and Rothstein, R. The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae. Genetics, 174: 555-73, 2006.
2006 Antúnez de Mayolo, A., Lisby, M., Erdeniz, N., Thybo, T., Mortensen, U.H., and Rothstein, R. Multiple start codons and phosphorylation result in discrete Rad52 protein species. Nucleic Acids Res, 34: 2587-97, 2006.
2006 Thorpe, P.H., Marrero, V.A., Savitsky, M.H., Sunjevaric, I., Freeman, T.C., Rothstein, R. Cells expressing murine RAD52 splice variants favor sister chromatid repair. Molec. Cell. Biol, 26: 3752-63, 2006.
2005 Shor, E., Weinstein, J. and Rothstein, R A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: Four genes involved in error-free DNA repair. Genetics 169: 1275-1289, 2005.
2004 Lisby, M. and Rothstein, R. DNA repair: keeping it together. Current Biol. 14: R994-R996, 2004.
2004 Lisby, M., Barlow, J.H., Burgess, R.C. and Rothstein, R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118: 699-713, 2004.
2004 Reid, R.J.D and Rothstein, R. Stay close to your sister. Molecular Cell 14: 418-420,2004.
2004 Lisby, M. and Rothstein, R. DNA damage checkpoint and repair centers. Current Opinion in Cell Biology 16:328-334, 2004.
2003 Lisby, M., Antúnez de Mayolo, A., Mortensen, U.H., and Rothstein, R. Cell Cycle regulated centers of DNA double-strand break repair. Cell Cycle, 2: 479-483, 2003.
2003 Lisby, M., Mortensen, U.H. and Rothstein, R. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre. Nature Cell Biol. 5: 572-577, 2003.
2003 Chabes, A., Georgieva, B., Domkin, V., Zhao, X., Rothstein, R. and Thelander, L. Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell, 112: 391-401, 2003.
2002 Shor, E., Gangloff, S., Wagner, M., Weinstein, J., Price, G., and Rothstein, R. Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae. Genetics, 162:647-662, 2002.
2002 Mortensen, U.H., Erdeniz, N., Feng, Q. and Rothstein, R. A molecular genetic dissection of the evolutionarily conserved N-terminus of yeast Rad52. Genetics, 161: 549-562, 2002.
2002 Zhao, X. and Rothstein, R. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. Proc. Natl. Acad. Sci. USA 99: 3746-3751, 2002.
2002 Reid, R.J.D., Sunjevaric, I.Keddache, M. and Rothstein, R. Efficient PCR-based gene disruption in Saccharomyces strains using intergenic primers. Yeast 19: 319-328, 2002.
2001 Lisby, M., Rothstein, R. and Mortensen, U.H. Rad52 forms DNA repair and recombination centers during S phase. Proc. Natl. Acad. Sci. USA 98: 8276-8282, 2001.
1998 Zhao, X., Muller, E.G.D. and Rothstein, R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Molecular Cell 2: 329-340, 1998.
1997 Zou, H. and Rothstein, R. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 90: 87-96, 1997
1996 Mortensen, U.H., Bendixen, C., Sunjevaric, I. and Rothstein, R. DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. USA 93: 10729-10734, 1996.

Publications Archive
2010 Barlow, J.H. and Rothstein, R. Timing is everything: cell cycle control of Rad52. Cell Division, 5: 7, 2010.
2009 Shi, I., Hallwyl, S.C., Seong, C., Mortensen, U., Rothstein, R. and Sung, P. Role of the Rad52 amino-terminal DNA binding activity in DNA strand capture in homologous recombination. J Biol Chem, 284(48): 33275-38, 2009.
2009 Moore, D.M., Karlin, J., González-Barrera, S., Mardiros, A., Lisby, M., Doughty, A., Gilley, J., Rothstein, R., Friedberg, E.C. and Fischhaber, P.L. Rad10 exhibits lesion-dependent genetic requirements for recruitment to DNA double-strand breaks in Saccharomyces cerevisiae. Nucleic Acids Res, 37(19): 6429-38, 2009.
2009 Mortensen, U.H., Lisby, M. and Rothstein, R. Rad52. Current Biol, 19(16): R676-7, 2009.
2009 Chang, M., Luke, B., Kraft, C., Li, Z., Peter, M., Lingner, J. and Rothstein, R. Telomerase is essential to alleviate pif1-induced replication stress at telomeres. Genetics, 183(3): 779-91, 2009.
2009 Burgess, R.C., Lisby, M., Altmannova, V., Krejci, L., Sung, P. and Rothstein, R. Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo. J Cell Biol, 185(6): 969-81, 2009.
2009 Bernstein, K.A. and Rothstein, R. At loose ends: resecting a double-strand break. Cell, 137(5): 807-10, 2009.
2009 Lisby, M. and Rothstein, R. Choreography of recombination proteins during the DNA damage response. DNA Repair, 8(9): 1068-76, 2009.
2009 Thorpe, P.H., Bruno, J. and Rothstein, R. Kinetochore asymmetry defines a single yeast lineage. Proc. Natl. Acad. Sci. USA, 106(16): 6673-8, 2009.
2009 Barlow, J.H. and Rothstein, R. Rad52 recruitment is DNA replication independent and regulated by Cdc28 and the Mec1 kinase. EMBO J, 28: 1121-30, 2009.
2009 Bernstein, K.A., Shor, E., Sunjevaric, I., Fumasoni, M., Burgess, R.C., Foiani, M., Branzei, D. and Rothstein, R. Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J, 28: 915-25, 2009.
2009 Matulova, P., Marini, V., Burgess, R.C., Sisakova, A., Kwon, Y., Rothstein, R., Sung, P. and Krejci, L. Cooperativity of Mus81.Mms4 with Rad54 in the resolution of recombination and replication intermediates. DNA Repair, 7(4): 558-71, 2009.
2008 Thorpe, P.H., Bruno, J. and Rothstein, R. Modeling stem cell asymmetry in yeast. Cold Spring Harb Symp Quant Biol, 73: 81-8, 2008.
2008 Reid, R.J., Sunjevaric, I., Voth, W.P., Ciccone, S., Du, W., Olsen, A.E., Stillman, D.J. and Rothstein, R. Chromosome-scale genetic mapping using a set of 16 conditionally stable Saccharomyces cerevisiae chromosomes. Genetics, 180: 1799-808, 2008.
2008 Weinstein, J. and Rothstein, R. The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1. DNA Repair, 7(4): 558-71, 2008.
2008 Barlow, J.H., Lisby, M. and Rothstein, R. Differential regulation of the cellular response to DNA double-strand breaks in G1. Molecular Cell, 30(1): 73-85, 2008.
2008 Plate, I., Albertsen, L., Lisby, M., Hallwyl, S.C.L., Feng, Q., Seong, C., Rothstein, R., Sung, P. and Mortensen, U.H. Rad52 multimerization is important for its nuclear localization in Saccharomyces cerevisiae. DNA Repair 7: 57-66, 2008.
2008 Kanaar, R. Wyman, C. and Rothstein, R. Quality control in DNA break metabolism: in the 'end', it's a good thing. EMBO J 27: 581-588, 2008.
2007 Aguilera, A. and Rothstein, R. In: Topics in Current Genetics - Molecular Genetics of Recombination, Springer-Verlag, Berlin, 2007
2007 Alvaro D., Lisby M. and Rothstein R. Genome-Wide Analysis of Rad52 Foci Reveals Diverse Mechanisms Impacting Recombination. PLoS Genet 3(12): e228, 2007.
2007 Torres-Rosell, J., Sunjevaric, I., De Piccoli, G., Sacher, M., Eckert-Boulet, N., Reid, R., Jentsch, S., Rothstein, R., Aragón, L., Lisby, M. The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus. Nat Cell Biol. 9 (8): 923-31, 2007
2007 Burgess, R.C., Rahman, S., Lisby, M., Rothstein, R. and Zhao, X. The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination. Mol Cell Biol. 27 (17): 6153-62, 2007
2007 Thorpe, P.H., González-Barrera, S. and Rothstein, R. More is not always better: the genetic constraints of polyploidy. Trends in Genetics, 23(6): 263-266, 2007
2007 Lisby, M. and Rothstein, R. The cell biology of mitotic recombination in Saccharomyces cerevisiae. In: Topics in Current Genetics - Molecular Genetics of Recombination (A. Aguilera and R. Rothstein, eds.), Springer-Verlag, Berlin, pp. 317-333, 2007
2007 Feng, Q., Düring L., Antúnez de Mayolo, A., Lettier G., Lisby M., Erdeniz N., Mortensen H.U., Rothstein, R. Rad52 and Rad59 exhibit both overlapping and distinct functions. DNA Repair, 6(1): 27-37, 2007
2007 O'Neil, J., Tchinda, J., Gutierrez, A., Moreau, L., Maser, R.S., Wong, K.K., Li, W., McKenna, K., Liu, X.S., Feng, B., Neuberg, D., Silverman, L., DeAngelo, D.J., Kutok, J.L., Rothstein, R., DePinho, R.A., Chin, L., Lee, C. and Look, A.T. Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Medicine, 204(13): 3059-66, 2007
2006 Lettier G., Feng, Q., Antúnez de Mayolo, A., Erdeniz, N., Reid, R.J.D., Lisby, M., Mortensen, H.M. and Rothstein, R. The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae. PLoS Genetics, 2(11):e194, 2006.
2006 Alvaro D., Sunjevaric I., Reid R., Lisby M., and Rothstein R. Systematic Hybrid LOH: a new method to reduce false positives and negatives during screening of yeast gene deletion libraries. Yeast, 23: 1097-1106, 2006
2006 Wagner, M., Price, G. and Rothstein, R. The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae. Genetics, 174: 555-73, 2006.
2006 Cagney G, Alvaro D., Reid J.D.R., Thorpe H.P., Rothstein R.and Krogan J.N. Functional genomics of the yeast DNA-damage response. Genome Biology, 7:233, 2006.
2006 Antúnez de Mayolo, A., Lisby, M., Erdeniz, N., Thybo, T., Mortensen, U.H., and Rothstein, R. Multiple start codons and phosphorylation result in discrete Rad52 protein species. Nucleic Acids Res, 34: 2587-97, 2006.
2006 Thorpe, P.H., Marrero, V.A., Savitsky, M.H., Sunjevaric, I., Freeman, T.C., Rothstein, R. Cells expressing murine RAD52 splice variants favor sister chromatid repair. Molec. Cell. Biol, 26: 3752-63, 2006.
2005 Lisby, M. and Rothstein, R. Localization of checkpoint and repair proteins in eukaryotes. Biochimie 87: 579-589, 2005.
2005 Chang, M., Bellaoui, M., Zhang, C., Desai, R., Morozov, P., Delgado-Cruzata, L., Rothstein, R., Freyer, G.A., Boone, C., Brown, G.W. RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J 24: 2024-2033, 2005.
2005 Shor, E., Weinstein, J. and Rothstein, R A genetic screen for top3 suppressors in Saccharomyces cerevisiae identifies SHU1, SHU2, PSY3 and CSM2: Four genes involved in error-free DNA repair. Genetics 169: 1275-1289, 2005.
2004 Rothstein, R. and Shor, E. Topoisomerases: The Type III-RecQ Helicase Systems. In: Encyclopedia of Biological Chemistry, Elsevier/Academic Press, Oxford, Vol.1, pp.812-816, 2004.
2004 Lisby, M. and Rothstein, R. DNA repair: keeping it together. Current Biol. 14: R994-R996, 2004.
2004 Lisby, M., Barlow, J.H., Burgess, R.C. and Rothstein, R. Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell 118: 699-713, 2004.
2004 Reid, R.J.D and Rothstein, R. Stay close to your sister. Molecular Cell 14: 418-420,2004.
2004 Lisby, M. and Rothstein, R. DNA damage checkpoint and repair centers. Current Opinion in Cell Biology 16: 328-334, 2004.
2004 Gupta, V., Peterson, C.B., Dice, L.T., Uchiki, T., Racca, J., Guo, J.T., Xu, Y., Hettich, R., Zhao, X., Rothstein, R. and Dealwis, C.G. Sml1p is a dimer in solution: characterization of denaturation and renaturation of recombinant Sml1p. Biochemistry 43: 8568-8578, 2004.
2003 Lisby, M., Antúnez de Mayolo, A., Mortensen, U.H., and Rothstein, R. Cell Cycle regulated centers of DNA double-strand break repair. Cell Cycle, 2: 479-483, 2003.
2003 Lisby, M., Mortensen, U.H. and Rothstein, R. Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre. Nature Cell Biol. 5: 572-577, 2003.
2003 Chabes, A., Georgieva, B., Domkin, V., Zhao, X., Rothstein, R. and Thelander, L. Survival of DNA damage in yeast directly depends on increased dNTP levels allowed by relaxed feedback inhibition of ribonucleotide reductase. Cell, 112: 391-401, 2003.
2002 Shor, E., Gangloff, S., Wagner, M., Weinstein, J., Price, G., and Rothstein, R. Mutations in homologous recombination genes rescue top3 slow growth in Saccharomyces cerevisiae. Genetics, 162:647-662, 2002.
2002 Mortensen, U.H., Erdeniz, N., Feng, Q. and Rothstein, R. A molecular genetic dissection of the evolutionarily conserved N-terminus of yeast Rad52. Genetics, 161: 549-562, 2002.
2002 Reid, R. Lisby, M. and Rothstein, R. Cloning-free genome alterations in Saccharomyces cerevisiae using adaptamer-mediated PCR. In: Methods in Enzymology, Vol. 350., G. R. Fink and C. Guthrie, Eds., Academic Press, New York, pp. 258-277, 2002.
2002 Krejci, L., Song, B., Bussen, W., Rothstein, R., Mortensen, U.H. and Sung, P. Interaction with Rad51 is indispensable for recombination mediator function of Rad52. J Biol Chem, 277(42): 40132-41.
2002 Georgieva, B. and Rothstein, R. kar-mediated plasmid transfer between yeast strains, an alternative to traditional transformation methods. In: Methods in Enzymology, Vol. 350., G. R. Fink and C. Guthrie, Eds., Academic Press, New York, pp. 278-289, 2002.
2002 Zhao, X. and Rothstein, R. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. Proc. Natl. Acad. Sci. USA 99: 3746-3751, 2002.
2002 Reid, R.J.D., Sunjevaric, I.Keddache, M. and Rothstein, R. Efficient PCR-based gene disruption in Saccharomyces strains using intergenic primers. Yeast 19: 319-328, 2002.
2001 Zhao, X., Chabes, A., Domkin, V., Thelander, L. and Rothstein, R. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J. 20: 3544-3553, 2001.
2001 Lisby, M., Rothstein, R. and Mortensen, U.H. Rad52 forms DNA repair and recombination centers during S phase. Proc. Natl. Acad. Sci. USA 98: 8276-8282, 2001.
2000 Rothstein, R., Michel, B. and Gangloff, S. Replication fork pausing and recombination or "gimme a break" Genes Dev.14-1: 1-10, 2000.
2000 Denamur, E., Lecointe, G., Darlu, P., Tenaillon, O., Acquaviva, C., Sayada, C., Sunjevaric, I., Rothstein, R., Elion, J., Taddei, F., Radman, M. and Matic, I. Evolutionary implications of the frequent horizontal transfer of mismatch repair genes. Cell 103: 711-721, 2000.
2000 Georgieva, B., Zhao, X. and Rothstein, R. Damage response and dNTP regulation: The interaction between ribonucleotide reductase and its inhibitor, Sml1. Cold Spring Harbor Symp. Quant. Biol. 65: 343-346, 2000.
2000 Zhao, X., Georgieva, B., Chabes, A., Domkin, V., Ippel, J.H., Schleucher, J., Wijmenga, S., Thelander, L and Rothstein, R. Mutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethality. Molec. Cell. Biol. 20: 9076-9083, 2000.
2000 Smith, J., Zou, H. and Rothstein, R. Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance. Biochimie 82: 71-78, 2000.
2000 Musumeci, O., Andreu, A.L., Shanske, S., Bresolin, N., Comi, G.P., Rothstein, R., Schon, E.A. and DiMauro, S..2000. Intragenic inversion of mtDNA: a new type of pathogenic mutation in a patient with mitochondrial myopathy. Am. J. Hum. Genet. 66: 1900-1904, 2000.
2000 Ebrahimi, F.A.W., Edmondson, J., Rothstein, R. and Chess, A. YAC transgene mediated olfactory receptor gene choice. Dev. Dyn. 217: 225-231, 2000.
2000 Erdeniz, N. and Rothstein, R. Rsp5, a ubiquitin protein ligase, is involved in degradation of the single-stranded DNA binding protein, Rfa1, in Saccharomyces cerevisiae. Molec. Cell. Biol. 20: 224-232, 2000.
2000 Gangloff, S., Rothstein, R. The shuffling of a mortal coil Nat. Genetics.22: 4-6, 1999.
1999 Franklin, A.E., McElver, J., Sunjevaric, I., Rothstein, R., Bowen, B. and Cande, W.Z. Three-dimensional microscopy of the Rad51 recombination protein during meiotic prophase. The Plant Cell 11: 809-824, 1999.
1999 Gangloff, S., de Massey, B., Arthur, L., Rothstein, R. and Fabre, F. The essential role of yeast topoisomerase III in meiosis depends on recombination. EMBO J. 18: 1701-1710, 1999.
1999 Smith, J. and Rothstein, R. An allele of RFA1 suppresses RAD52-dependent double-strand break repair in Saccharomyces cerevisiae. Genetics 151: 447-458, 1999.
1998 Zhao, X., Muller , E.G.D. and Rothstein, R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Molecular Cell 2: 329-340, 1998.
1998 Cayanis, E., Russo, J.J., Kalachikov, S., Ye, X., Park, S.H., Sunjevaric, I., de Fatima Bonaldo, Lawton, L., M., Venkatraj, V.S., Schon, E., Soares, M.B., Rothstein, R., Warburton, D., Edelman, I.S., Zhang, P., Efstratiadis, A. and Fischer, S.G. High-resolution YAC-cosmid-STS map of human chromosome 13. Genomics 47: 26-43, 1998.
1997 Hudson Jr., J.R., Dawson, E.P., Rushing, K.L., Jackson, C.H., Lockshon, D., Conover, D., Lanciault, C., Harris, J.R., Simmons, S.J., Rothstein, R. and Fields, S. The complete set of predicted genes from Saccharomyces cerevisiae in a readily usable form. Genome Res. 7: 1169-1173, 1997.
1997 Erdeniz, N., Mortensen, U.H. and Rothstein, R. Cloning-free PCR-based allele replacement methods. Genome Res. 7: 1174-1183, 1997.
1997 Zou, H. and Rothstein, R. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 90: 87-96, 1997
1996 Jiang, H., Xie, Y., Houston, P., Stemke-Hale, K., Mortensen, U.H., Rothstein, R. and Kodadek, T. Direct association between the yeast Rad51 and Rad54 recombination proteins. J. Biol. Chem. 271: 33181-33186, 1996.
1996 Mortensen, U.H., Bendixen, C., Sunjevaric, I. and Rothstein, R. DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. USA 93: 10729-10734, 1996.
1996 Yang, H., Bard, M., Bruner, D.A., Gleeson, A., Deckelbaum, R.J., Aljinovic, G., Pohl, T.M., Rothstein, R. and Sturley, S.L. Sterol esterification in yeast: a two gene process. Science 27: 1353-1356, 1996.
1996 Gangloff, S., Zou, H. and Rothstein, R. Gene conversion plays the major role in controlling the stability of large tandem repeats in yeast. EMBO J. 15: 1715-1725, 1996.
1996 Fischer, S.G., Cayanis, E., De Fatima Bonaldo, M., Bowcock, A.M., Deaven, L., Edelman, I.S., Gallardo, T., Kalachikov, S., Lawton, L., Lovett, M., Osborne-Lawrence, S., Rothstein, R., Russo, J.J., Soares, M.B., Sunjevaric, I., Venkatraj, V.S., Warburton, D., Zhang, P. and Efstratiadis, A. A high-resolution annotated physical map of the human chromosome 13q12-13 region containing the breast cancer susceptibility locus BRCA2. Proc. Natl. Acad. Sci. USA 93: 690-694, 1996.
1995 Gobin, S.J.P., Alcaïde-Loridan, C., Bono, M.-R., Ottone, C., Chumakov, I., Rothstein, R. and Fellous, M. Transfer of yeast artificial chromosomes into mammalian cells and comparative study of their integrity. Gene 163: 27-33, 1995.
1995 Emanuel, S.L., Cook, J.R., O'Rear, J., Rothstein, R. and Pestka, S. New vectors of manipulation and selection of functional yeast artificial chromosomes (YACs) containing human DNA inserts. Gene 155: 167-174, 1995.
1995 Smith, J. and Rothstein, R. A mutation in the gene encoding the Saccharomyces cerevisiae single-stranded DNA binding protein Rfa1 stimulates a RAD52-independent pathway for direct-repeat recombination. Molec. Cell. Biol. 15: 1632-1641, 1995.
1994 Gangloff, S., McDonald, J.P., Bendixen, C., Arthur, L. and Rothstein, R. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: a potential eukaryotic reverse gyrase. Molec. Cell. Biol. 14: 8391-8398, 1994.
1994 Bendixen, C., Sunjevaric, I., Bauchwitz, R. and Rothstein, R. Identification of a mouse homologue of the Saccharomyces cerevisiae recombination and repair gene, RAD52. Genomics 23: 300-303, 1994.
1994 Heard, E., Avner, P. and Rothstein, R. Creation of a deletion series of mouse YACs covering a 500 kb region around Xist. Nucleic Acids Res. 22: 1830-1837, 1994.
1994 Bendixen, C., Gangloff, S. and Rothstein, R. A yeast mating-selection scheme for detection of protein-protein interactions. Nucleic Acids Res. 22: 1778-1779, 1994.
1994 McDonald, J.P. and Rothstein, R. Unrepaired heteroduplex DNA in Saccharomyces cerevisiae is decreased in RAD1/RAD52-independent recombination. Genetics 137: 393-405, 1994.
1994 Fischer, S.G., Cayanis, E., Russo, J.J., Sunjevaric, I., Boukhgalter, B., Zhang, P., Yu, M.-T., Rothstein, R., Warburton, D., Edelman, I.S. and Efstratiadis, A. Assembly of ordered contigs of cosmids selected with YACs of human chromosome 13. Genomics 21: 525-537, 1994.
1994 Gangloff, S., Lieber, M.R. and Rothstein, R. Transcription, topoisomerases and recombination. Experientia 50: 261-269, 1994.
1994 Fasullo, M., Dave, P. and Rothstein, R. DNA-damaging agents stimulate the formation of directed reciprocal translocations in Saccharomyces cerevisiae. Mutation Res. 314: 121-133, 1994.
1992 Bailis, A.M., Arthur, L. and Rothstein, R. Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene. Molec. Cell. Biol. 12: 4988-4993, 1992.
1991 Thomas, B.J. and Rothstein, R. Sex, maps and imprinting. Cell 64: 1-3, 1991.
1990 Bailis, A.M. and Rothstein, R. A defect in mismatch repair in Saccharomyces cerevisiae stimulates ectopic recombination between homeologous genes by an excision repair dependent process. Genetics 126: 535-547, 1990.
1990 Pachnis, V., Pevny, L., Rothstein, R., and Costantini, F. Transfer of a yeast artificial chromosome carrying human DNA from Saccharomyces cerevisiae into mammalian cells. Proc. Natl. Acad. Sci. USA 87: 5109-5113, 1990.
1989 Thomas, B. and Rothstein, R. The genetic control of direct repeat recombination in Saccharomyces: The effect of rad52 and rad1 on recombination at GAL10, a transcriptionally regulated gene. Genetics 123: 725-738, 1989.
1989 Wallis, J.W., Chrebet, G., Brodsky, G., Rolfe, M. and Rothstein, R. A hyper-recombination mutation in Saccharomyces cerevisiae identifies a novel eukaryotic topoisomerase. Cell 58: 409-419, 1989.
1989 Thomas, B. and Rothstein, R. Elevated recombination rates in transcriptionally active DNA. Cell 56: 619-630, 1989.
1988 Thomas, D., Rothstein, R., Rosenberg, N. and Surdin-Kerjan, Y. SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: Physiology and regulation of both enzymes. Molec. Cell. Biol. 8: 5132-5139, 1988.
1988 Ronne, H. and Rothstein, R. Mitotic sectored colonies: evidence of heteroduplex DNA formation during direct repeat recombination. Proc. Natl. Acad. Sci. USA 85: 2696-2700, 1988.
1987 Rothstein, R., Helms, C. and Rosenberg, N. Concerted deletions and inversions are caused by mitotic recombination between delta sequences in Saccharomyces cerevisiae. Molec. Cell. Biol. 7: 1198-1207, 1987.
1984 Szostak, J.W. and Rothstein, R.J. Theory and practice of genetic engineering. In: Plant-Microbe Interactions: Molecular and Genetic Perspectives.T. Kosuge and E.W. Nester, Eds., Macmillan Publishing Co., New York, pp. 125-145, 1984.
1983 Szostak, J.W., Orr-Weaver, T.L., Rothstein, R.J. and Stahl, F.W. The double-strand-break model for genetic recombination. Cell 33: 25-35, 1983.
1981 Orr-Weaver, T., Szostak, J.W. and Rothstein, R.J. Yeast transformation: A model system for the study of recombination. Proc. Natl. Acad. Sci. USA 78: 6354-6358, 1981.
1981 Rothstein, R.J. and Wu, R. Modification of the bacteriophage M13mp2: Introduction of new restriction sites for cloning. Gene 15: 167-176, 1981.
1980 Rothstein, R.J. and Sherman, F. CYC7-2: An iso-2-cytochrome c mutation in yeast which is dependent upon the mating type for expression. Genetics 94: 891-898, 1980.
1980 Rothstein, R.J. and Sherman, F. Genes affecting the expression of cytochrome c in yeast: Genetic mapping and genetic interactions. Genetics 94: 871-889, 1980.
1979 Rothstein, R.J. Deletions of a tyrosine tRNA in Saccharomyces cerevisiae. Cell 17: 185-190, 1979.
1977 Rothstein, R.J. A genetic fine structure analysis of the suppressor 3 locus in Saccharomyces. Genetics 85: 55-64, 1977.
1977 Rothstein, R.J.Esposito, R.E. and Esposito, M.S. The effect of ochre suppression on meiosis and ascospore formation in Saccharomyces. Genetics 85: 35-54, 1977.