mat a												
Synced to SGD on Sat Jul  8 00:51:39 2017
Plate #	Row	Column	ORF	Gene	Alias	Description	GO Biological Process	GO Molecular Function	GO Cellular Component	record no.	strain	batch	
1	A	2	YAL068C	PAU8	seripauperin PAU8	Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions	meiotic cell cycle, sporulation, transcription from RNA polymerase II promoter	molecular_function	cellular_component	338	BY4741	01_1	
1	A	3	YAL067C	SEO1	putative permease SEO1	Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide	other	other	membrane	339	BY4741	01_1	
1	A	4	YAL066W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	340	BY4741	01_1	
1	A	5	YAL065C	-	-	Putative protein of unknown function; shows sequence similarity to FLO1 and other flocculins	biological_process	molecular_function	cellular_component	341	BY4741	01_1	
1	A	6	YAL062W	GDH3	glutamate dehydrogenase (NADP(+)) GDH3|FUN51	NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication	cellular amino acid metabolic process	oxidoreductase activity	nucleus, mitochondrion, cytoplasm	345	BY4741	01_1	
1	A	7	YAL061W	BDH2	putative dehydrogenase BDH2	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3	biological_process	oxidoreductase activity	nucleus, cytoplasm	346	BY4741	01_1	
1	A	8	YAL060W	BDH1	(R,R)-butanediol dehydrogenase|BDH	NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	other	oxidoreductase activity	cytoplasm	347	BY4741	01_1	
1	A	9	YAL059W	ECM1	-	Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm	ribosomal subunit export from nucleus, nuclear transport	molecular_function	nucleus, nucleolus	348	BY4741	01_1	
1	A	10	YAL058W	CNE1	calnexin|FUN48	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast	response to chemical, proteolysis involved in cellular protein catabolic process, protein folding	unfolded protein binding	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	349	BY4741	01_1	
1	A	11	YAL056W	GPB2	KRH1	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication	meiotic cell cycle, response to chemical, invasive growth in response to glucose limitation, sporulation, pseudohyphal growth, transcription from RNA polymerase II promoter, signaling	enzyme regulator activity, signal transducer activity	mitochondrion, membrane, cytoplasm, plasma membrane	351	BY4741	01_1	
1	A	12	YAL055W	PEX22	ubiquitin-protein transferase activating protein PEX22|YAF5	Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation	protein targeting, transmembrane transport, peroxisome organization, regulation of protein modification process, protein modification by small protein conjugation or removal, signaling	enzyme regulator activity	peroxisome, membrane, cytoplasm	352	BY4741	01_1	
1	B	1	YAL053W	FLC2	flavin adenine dinucleotide transporter FLC2|HUF2	Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication	transmembrane transport, ion transport, nucleobase-containing compound transport, lipid metabolic process, protein folding, cell wall organization or biogenesis, response to osmotic stress	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	354	BY4741	01_1	
1	B	2	YAL051W	OAF1	oleate-activated transcription factor OAF1|YAF1	Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; regulates chromatin silencing at telomeres; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication	response to chemical, lipid metabolic process, chromatin organization, transcription from RNA polymerase II promoter, monocarboxylic acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus	355	BY4741	01_1	
1	B	3	YAL049C	AIM2	protein AIM2	Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor	biological_process	molecular_function	cytoplasm	356	BY4741	01_1	
1	B	4	YAL048C	GEM1	ERMES complex Ca(2+)-binding regulatory GTPase GEM1|GON1	Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases	mitochondrion organization, regulation of organelle organization, organelle inheritance	GTPase activity, hydrolase activity, ion binding	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm	357	BY4741	01_1	
1	B	5	YAL046C	BOL3	AIM1	Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2)	protein maturation	molecular_function	mitochondrion, cytoplasm	359	BY4741	01_1	
1	B	6	YAL045C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A	biological_process	molecular_function	cellular_component	360	BY4741	01_1	
1	B	7	YAL044C	GCV3	glycine decarboxylase subunit H	H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF	cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	361	BY4741	01_1	
1	B	8	YAL042W	ERV46	FUN9	Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport	Golgi vesicle transport	molecular_function	membrane, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	363	BY4741	01_1	
1	B	9	YAL043C-a	membrane, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	membrane, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	membrane, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	-	-	-	364	BY4741	01_1	
1	B	10	YAL040C	CLN3	cyclin CLN3|WHI1|FUN10|DAF1	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1	vacuole organization, mitotic cell cycle, protein phosphorylation, organelle fusion, membrane fusion, regulation of protein modification process, regulation of cell cycle	enzyme regulator activity	nucleus	366	BY4741	01_1	
1	B	11	YAL039C	CYC3	holocytochrome c synthase CYC3|CCHL	Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant	protein complex biogenesis	lyase activity	mitochondrial envelope, mitochondrion, cytoplasm	367	BY4741	01_1	
1	B	12	YAL037W	-	-	Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	369	BY4741	01_1	
1	C	1	YAL036C	RBG1	GTP-binding protein RBG1|FUN11	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid	cytoplasmic translation, response to starvation	ion binding	ribosome, cytoplasm	370	BY4741	01_1	
1	C	2	YAL035W	FUN12	translation initiation factor eIF5B|eIF5B|yIF2	Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2	cytoplasmic translation, translational initiation, regulation of translation, rRNA processing, organelle assembly, ribosomal small subunit biogenesis, ribosome assembly	RNA binding, GTPase activity, hydrolase activity, ion binding, translation factor activity, RNA binding	ribosome, mitochondrion, cytoplasm	371	BY4741	01_1	
1	C	3	YAL034C	FUN19	-	Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	374	BY4741	01_1	
1	C	4	YAL031C	GIP4	protein phosphatase regulator GIP4|FUN21	Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate	regulation of protein modification process, protein dephosphorylation, chromosome segregation	enzyme binding, enzyme regulator activity	cytoplasm	377	BY4741	01_1	
1	C	5	YAL030W	SNC1	SNAP receptor SNC1	Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication	organelle fusion, vesicle organization, membrane fusion, Golgi vesicle transport, exocytosis, endocytosis	other	cytoplasmic vesicle, endomembrane system, cellular bud, membrane, site of polarized growth, Golgi apparatus, cytoplasm, plasma membrane	378	BY4741	01_1	
1	C	6	YAL029C	MYO4	myosin 4|SHE1|FUN22	Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication	organelle inheritance	cytoskeletal protein binding, hydrolase activity	cellular bud, site of polarized growth, cytoskeleton, mitochondrion, cytoplasm	379	BY4741	01_1	
1	C	7	YAL028W	FRT2	HPH2	Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication	response to osmotic stress	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	380	BY4741	01_1	
1	C	8	YAL027W	SAW1	DNA-binding protein SAW1	5'- and 3'-flap DNA binding protein; recruits Rad1p-Rad10p to single-strand annealing intermediates with 3' non-homologous tails for removal during double-strand break repair; complexes with Rad1p-Rad10p and stimulates its endonuclease activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	DNA repair, regulation of DNA metabolic process, cellular response to DNA damage stimulus	DNA binding	nucleus	381	BY4741	01_1	
1	C	9	YAL026C	DRS2	aminophospholipid-translocating P4-type ATPase DRS2|SWA3|FUN38	Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease	response to chemical, ribosome assembly, Golgi vesicle transport, lipid transport, conjugation, ion transport, organelle assembly, ribosomal small subunit biogenesis, endosomal transport, endocytosis	hydrolase activity, ATPase activity	Golgi apparatus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	382	BY4741	01_1	
1	C	10	YAL023C	PMT2	dolichyl-phosphate-mannose-protein mannosyltransferase PMT2|FUN25	Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication	response to chemical, proteolysis involved in cellular protein catabolic process, protein glycosylation, signaling	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	385	BY4741	01_1	
1	C	11	YAL022C	FUN26	nucleoside transmembrane transporter FUN26	High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside (NmR) levels between the cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter (ENT) family member	transmembrane transport, nucleobase-containing compound transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	386	BY4741	01_1	
1	C	12	YAL021C	CCR4	CCR4-NOT core exoribonuclease subunit CCR4|NUT21|FUN27	Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening	mitotic cell cycle, DNA replication, RNA catabolic process, regulation of DNA metabolic process, transcription from RNA polymerase II promoter, regulation of cell cycle, DNA-templated transcription, elongation	hydrolase activity, nuclease activity	nucleus, cytoplasm	387	BY4741	01_1	
1	D	1	YAL020C	ATS1	KTI13|FUN28	Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; forms a stable heterodimer with Kti11p	tRNA processing, cell budding, cytoskeleton organization, RNA modification	molecular_function	cytoplasm	388	BY4741	01_1	
1	D	2	YAL019W	FUN30	DNA-dependent ATPase FUN30	Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate	DNA repair, chromatin organization, cellular response to DNA damage stimulus, transcription from RNA polymerase II promoter	chromatin binding, hydrolase activity, DNA binding, ATPase activity	nucleus, chromosome, mitochondrion, cytoplasm	389	BY4741	01_1	
1	D	3	YAL018C	LDS1	-	Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds2p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	cell wall, membrane	390	BY4741	01_1	
1	D	4	YAL017W	PSK1	serine/threonine protein kinase PSK1|FUN31	PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication	carbohydrate metabolic process, protein phosphorylation, generation of precursor metabolites and energy	kinase activity, transferase activity	cytoplasm	391	BY4741	01_1	
1	D	5	YAL015C	NTG1	bifunctional N-glycosylase/AP lyase NTG1|ogg2|SCR1|FUN33	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication	DNA repair, response to chemical, DNA replication, mitochondrion organization, regulation of organelle organization, cellular response to DNA damage stimulus, response to oxidative stress, regulation of DNA metabolic process	hydrolase activity, hydrolase activity, acting on glycosyl bonds, lyase activity, nuclease activity	nucleus, mitochondrion, cytoplasm	393	BY4741	01_1	
1	D	6	YAL014C	SYN8	syntaxin|SLT2|UIP2	Endosomal SNARE related to mammalian syntaxin 8	other	other	cytoplasmic vesicle, endomembrane system, cytoplasm	394	BY4741	01_1	
1	D	7	YAL013W	DEP1	Rpd3L histone deacetylase complex subunit DEP1|FUN54	Component of the Rpd3L histone deacetylase complex; required for diauxic shift-induced histone H2B deposition onto rDNA genes; transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation	response to heat, carbohydrate metabolic process, chromatin organization, DNA replication, histone modification, lipid metabolic process, regulation of DNA metabolic process, transcription from RNA polymerase II promoter	molecular_function	nucleus, chromosome	395	BY4741	01_1	
1	D	8	YAL011W	SWC3	SWC1	Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae	chromatin organization	molecular_function	nucleus, chromosome, mitochondrion, cytoplasm	397	BY4741	01_1	
1	D	9	YAL010C	MDM10	FUN37	Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex is often co-localized with peroxisomes and concentrated areas of pyruvate dehydrogenase	protein targeting, mitochondrion organization, transmembrane transport, ion transport, protein complex biogenesis, lipid transport	molecular_function	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm	398	BY4741	01_1	
1	D	10	YAL009W	SPO7	Nem1-Spo7 phosphatase regulatory subunit SPO7	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation	protein dephosphorylation, lipid metabolic process, nucleus organization	phosphatase activity, hydrolase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	399	BY4741	01_1	
1	D	11	YAL008W	FUN14	MCP3	Integral mitochondrial outer membrane (MOM) protein; dosage suppressor of an MDM10 null that reduces ERMES-related phenotypes, such as alterations in mitochondrial morphology, protein complex assembly, and lipid profile; dosage suppressor of MDM12, MDM34, and MMM1 null mutant growth defects; novel mechanism of MOM import involving Tom70p, the TOM complex, and the TIM23 complex, requiring mitochondrial membrane potential and processing by the IMP complex for correct biogenesis	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	400	BY4741	01_1	
1	D	12	YAL007C	ERP2	-	Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication	Golgi vesicle transport	molecular_function	cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, cytoplasm	401	BY4741	01_1	
1	E	1	YAL004W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C	biological_process	molecular_function	cellular_component	402	BY4741	01_1	
1	E	2	YAL005C	SSA1	Hsp70 family ATPase SSA1|YG100	ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; required for ubiquitin-dependent degradation of short-lived proteins; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, cell wall; 98% identical to paralog Ssa2p with different functional specificity in propagation of yeast [URE3] prions, vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils	cytoplasmic translation, transmembrane transport, proteolysis involved in cellular protein catabolic process, protein targeting, mitochondrion organization, protein folding, protein modification by small protein conjugation or removal, nuclear transport	RNA binding, hydrolase activity, unfolded protein binding, ATPase activity	nucleus, vacuole, cell wall, plasma membrane, membrane, cytoplasm	403	BY4741	01_1	
1	E	3	YAL002W	VPS8	CORVET complex membrane-binding subunit VPS8|VPL8|VPT8|FUN15	Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif	protein targeting, endosomal transport	enzyme binding	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm	405	BY4741	01_1	
1	E	4	YAR002W	NUP60	FG-nucleoporin NUP60	FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; relocalizes to the cytosol in response to hypoxia; both NUP1 and NUP60 are homologous to human NUP153	response to heat, peptidyl-amino acid modification, chromatin organization, DNA repair, protein targeting, cellular response to DNA damage stimulus, nucleobase-containing compound transport, regulation of protein modification process, protein modification by small protein conjugation or removal, nuclear transport	ion binding, lipid binding, structural molecule activity	nucleus, endomembrane system, membrane, cytoplasm	407	BY4741	01_1	
1	E	5	YAR003W	SWD1	COMPASS subunit protein SWD1|SAF49|CPS50|FUN16	Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7	peptidyl-amino acid modification, telomere organization, protein alkylation, chromatin organization, histone modification	transferase activity, methyltransferase activity	nucleus	408	BY4741	01_1	
1	E	6	YAR014C	BUD14	protein phosphatase regulator BUD14	Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress	cell morphogenesis, cytoskeleton organization, regulation of organelle organization, cytokinesis, regulation of transport, protein complex biogenesis, regulation of cell cycle	enzyme regulator activity	nucleus, cellular bud, site of polarized growth, cytoplasm	413	BY4741	01_1	
1	E	7	YAR015W	ADE1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress	nucleobase-containing small molecule metabolic process	ligase activity	nucleus, cytoplasm	414	BY4741	01_1	
1	E	8	YAR018C	KIN3	serine/threonine protein kinase KIN3|NPK1|FUN52	Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol	protein phosphorylation, chromosome segregation	kinase activity, transferase activity	cellular_component	415	BY4741	01_1	
1	E	9	YAR020C	PAU7	seripauperin PAU7	Member of the seripauperin multigene family; active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme	biological_process	molecular_function	cellular_component	417	BY4741	01_1	
1	E	10	YAR023C	-	DUP240 family protein	Putative integral membrane protein; member of DUP240 gene family	biological_process	molecular_function	cellular_component	418	BY4741	01_1	
1	E	11	YAR027W	UIP3	DUP240 family protein UIP3	Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family	biological_process	molecular_function	nucleus, membrane, endomembrane system, vacuole, cytoplasm	419	BY4741	01_1	
1	E	12	YAR028W	-	DUP240 family protein	Putative integral membrane protein; member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	membrane, vacuole, cytoplasm	420	BY4741	01_1	
1	F	1	YAR029W	-	DUP240 family protein	Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	cytoplasm	421	BY4741	01_1	
1	F	2	YAR031W	PRM9	pheromone-regulated DUP240 family protein PRM9	Pheromone-regulated protein; contains 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family; PRM9 has a paralog, PRM8, that arose from a segmental duplication	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	422	BY4741	01_1	
1	F	3	YAR030C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9	biological_process	molecular_function	cellular_component	423	BY4741	01_1	
1	F	4	YAR035W	YAT1	carnitine O-acetyltransferase YAT1	Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated	other	transferase activity	mitochondrion, cytoplasm	425	BY4741	01_1	
1	F	5	YAR037W	mitochondrion, cytoplasm	mitochondrion, cytoplasm	mitochondrion, cytoplasm	-	-	-	426	BY4741	01_1	
1	F	6	YAR040C	-	-	-	-	-	-	427	BY4741	01_1	
1	F	7	YAR042W	SWH1	oxysterol-binding protein related protein SWH1|OSH1|YAR044W	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats and FFAT motif; interacts with ER anchor Scs2p at the nucleus-vacuole junction; regulated by sterol binding; SWH1 has a paralog, OSH2, that arose from the whole genome duplication	lipid transport, exocytosis, endocytosis	lipid binding, ion binding	nucleus, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, Golgi apparatus, cytoplasm	428	BY4741	01_1	
1	F	8	YAR043C	nucleus, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, Golgi apparatus, cytoplasm	nucleus, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, Golgi apparatus, cytoplasm	nucleus, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, Golgi apparatus, cytoplasm	-	-	-	429	BY4741	01_1	
1	F	9	YAR044W	-	-	-	-	-	-	430	BY4741	01_1	
1	F	10	YAR047C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	431	BY4741	01_1	
1	F	11	YLL001W	DNM1	dynamin-related GTPase DNM1	Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy	organelle fission, mitochondrion organization, peroxisome organization, protein complex biogenesis, organelle inheritance	GTPase activity, hydrolase activity	peroxisome, mitochondrion, membrane, mitochondrial envelope, cytoplasm	1489	BY4741	12_1	
1	F	12	YLL002W	RTT109	H3 histone acetyltransferase RTT109|KAT11|REM50|KIM2	Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p	peptidyl-amino acid modification, DNA repair, protein acylation, chromatin organization, cellular response to DNA damage stimulus, transposition, histone modification, regulation of DNA metabolic process, transcription from RNA polymerase II promoter	transferase activity	nucleus	1490	BY4741	12_1	
1	G	1	YLL005C	SPO75	-	Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	membrane	1493	BY4741	12_1	
1	G	2	YLL006W	MMM1	ERMES complex subunit MMM1|YME6	ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase	protein targeting, mitochondrion organization, transmembrane transport, ion transport, protein complex biogenesis, lipid transport	molecular_function	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm	1494	BY4741	12_1	
1	G	3	YLL009C	COX17	copper metallochaperone COX17	Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant	mitochondrion organization, ion transport, protein complex biogenesis	ion binding	mitochondrial envelope, mitochondrion, cytoplasm	1497	BY4741	12_1	
1	G	4	YLL010C	PSR1	phosphatase	Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR1 has a paralog, PSR2, that arose from the whole genome duplication	response to heat, response to osmotic stress	phosphatase activity, hydrolase activity	membrane, plasma membrane, cytoplasm	1498	BY4741	12_1	
1	G	5	YLL012W	YEH1	sterol esterase	Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication	lipid metabolic process	hydrolase activity	membrane	1500	BY4741	12_1	
1	G	6	YLL013C	PUF3	mRNA-binding protein PUF3	Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins	mitochondrion organization, generation of precursor metabolites and energy, cellular respiration, RNA catabolic process	RNA binding, mRNA binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1501	BY4741	12_1	
1	G	7	YLL014W	EMC6	-	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93	protein folding	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1502	BY4741	12_1	
1	G	8	YLL015W	BPT1	ATP-binding cassette bilirubin transporter BPT1	ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p	vacuole organization, ion transport, organelle fusion, membrane fusion	transmembrane transporter activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	1503	BY4741	12_1	
1	G	9	YLL016W	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	-	-	-	1504	BY4741	12_1	
1	G	10	YLL017W	-	-	-	-	-	-	1505	BY4741	12_1	
1	G	11	YLL019C	KNS1	serine/threonine protein kinase KNS1|L124	Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation	peptidyl-amino acid modification, protein phosphorylation, transcription from RNA polymerase III promoter	kinase activity, transferase activity	nucleus, cytoplasm	1507	BY4741	12_1	
1	G	12	YLL020C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1	biological_process	molecular_function	cellular_component	1508	BY4741	12_1	
1	H	1	YLL021W	SPA2	PPF1|PEA1|FUS6	Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication	mitotic cell cycle, response to chemical, cell morphogenesis, cell budding, cytoskeleton organization, regulation of organelle organization, cytokinesis, conjugation, pseudohyphal growth	enzyme binding, structural molecule activity	cell cortex, cellular bud, site of polarized growth, cytoplasm	1509	BY4741	12_1	
1	H	3	YLL023C	POM33	nucleoporin POM33	Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress	protein complex biogenesis, nucleus organization	structural molecule activity	nucleus, endomembrane system, ribosome, membrane, endoplasmic reticulum, cytoplasm	1511	BY4741	12_1	
1	H	4	YLL024C	SSA2	Hsp70 family chaperone SSA2|YG102	HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation	transmembrane transport, proteolysis involved in cellular protein catabolic process, protein targeting, nucleobase-containing compound transport, protein folding, nuclear transport	RNA binding, hydrolase activity, unfolded protein binding, ion binding, ATPase activity	vacuole, mitochondrion, cell wall, plasma membrane, membrane, cytoplasm	1512	BY4741	12_1	
1	H	5	YLL025W	PAU17	seripauperin PAU17	Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene	biological_process	molecular_function	vacuole, cytoplasm	1513	BY4741	12_1	
1	H	6	YLL026W	HSP104	chaperone ATPase HSP104	Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation	response to heat, carbohydrate metabolic process, response to chemical, response to oxidative stress, protein folding, oligosaccharide metabolic process	hydrolase activity, ion binding, unfolded protein binding, ATPase activity	nucleus, cytoplasm	1514	BY4741	12_1	
1	H	7	YLL028W	TPO1	-	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane	transmembrane transport, ion transport	transmembrane transporter activity	vacuole, cellular bud, membrane, cytoplasm, plasma membrane	1516	BY4741	12_1	
1	H	8	YLL029W	FRA1	RUP2	Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation	response to chemical, transcription from RNA polymerase II promoter	molecular_function	cytoplasm	1517	BY4741	12_1	
1	H	9	YLL032C	-	-	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene	biological_process	RNA binding, mRNA binding	ribosome, cytoplasm	1520	BY4741	12_1	
1	H	10	YLL033W	IRC19	RRG4|GON2	Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci	meiotic cell cycle, sporulation, DNA recombination	molecular_function	cellular_component	1521	BY4741	12_1	
1	H	11	YLL038C	ENT4	-	Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome	cytoskeleton organization, endocytosis	other	cell cortex, cytoskeleton, cytoplasm	1526	BY4741	12_1	
1	H	12	YLL039C	UBI4	ubiquitin|UB14|SCD2	Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress	meiotic cell cycle, sporulation, protein modification by small protein conjugation or removal	other	cytoplasm	1527	BY4741	12_1	
2	A	1	YLL040C	VPS13	membrane morphogenesis protein VPS13|VPT2|SOI1	Protein involved in prospore membrane morphogenesis; peripheral membrane protein that localizes to the prospore membrane and at numerous membrane contact sites; involved in sporulation, vacuolar protein sorting, prospore membrane formation during sporulation, and protein-Golgi retention; required for mitochondrial integrity; contains a PH-like domain; homologous to human CHAC and COH1 which are involved in Chorea-acanthocytosis and Cohen syndrome, respectively	meiotic cell cycle, protein targeting, sporulation, mitochondrion organization, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, mitochondrion, membrane, cytoplasm	1528	BY4741	12_1	
2	A	3	YLL041C	SDH2	succinate dehydrogenase iron-sulfur protein subunit SDH2|SDHB|ACN17	Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p	generation of precursor metabolites and energy, cellular respiration	oxidoreductase activity	vacuole, mitochondrion, membrane, mitochondrial envelope, cytoplasm	1529	BY4741	12_1	
2	A	4	YLL042C	ATG10	E2-like conjugating enzyme|APG10	Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy	protein targeting, mitochondrion organization	transferase activity	cellular_component	1530	BY4741	12_1	
2	A	5	YLL043W	FPS1	-	Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state	response to chemical, ion transport, conjugation, carbohydrate transport	transmembrane transporter activity	vacuole, membrane, cytoplasm, plasma membrane	1531	BY4741	12_1	
2	A	6	YLL045C	RPL8B	eL8|ribosomal 60S subunit protein L8B|L8e|rp6|YL5|L8B|L4B|SCL41|KRB1	Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1533	BY4741	12_1	
2	A	7	YLL046C	RNP1	-	Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication	other	RNA binding	cytoplasm	1534	BY4741	12_1	
2	A	8	YLL047W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1	biological_process	molecular_function	cellular_component	1535	BY4741	12_1	
2	A	9	YLL051C	FRE6	putative ferric-chelate reductase	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels	cellular ion homeostasis, ion transport	oxidoreductase activity	membrane, vacuole, cytoplasm	1539	BY4741	12_1	
2	A	10	YLL052C	AQY2	-	Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains	transmembrane transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	1540	BY4741	12_1	
2	A	11	YLL053C	-	-	Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin	biological_process	molecular_function	membrane	1541	BY4741	12_1	
2	A	12	YLL054C	-	-	Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	biological_process	nucleic acid binding transcription factor activity, DNA binding	cellular_component	1542	BY4741	12_1	
2	B	1	YLL055W	YCT1	-	High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene	ion transport, amino acid transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1543	BY4741	12_1	
2	B	2	YLL056C	-	-	Putative protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively	biological_process	molecular_function	cellular_component	1544	BY4741	12_1	
2	B	3	YLL057C	JLP1	sulfonate dioxygenase	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation	other	oxidoreductase activity	cellular_component	1545	BY4741	12_1	
2	B	4	YLL058W	-	cystathionine gamma-synthase	Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene	other	transferase activity	cellular_component	1546	BY4741	12_1	
2	B	5	YLL060C	GTT2	glutathione transferase GTT2	Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress	other	transferase activity	mitochondrion, cytoplasm	1548	BY4741	12_1	
2	B	6	YLL061W	MMP1	S-methylmethionine permease MMP1	High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p	other	transmembrane transporter activity	membrane, plasma membrane	1549	BY4741	12_1	
2	B	7	YLL062C	MHT1	S-adenosylmethionine-homocysteine S-methyltransferase MHT1	S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio	cellular amino acid metabolic process	transferase activity, methyltransferase activity	cytoplasm	1550	BY4741	12_1	
2	B	8	YLL063C	AYT1	acetyltransferase	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis	other	transferase activity	cellular_component	1551	BY4741	12_1	
2	B	9	YLR001C	-	-	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated	biological_process	molecular_function	membrane, vacuole, mitochondrion, cytoplasm	1556	BY4741	12_1	
2	B	10	YLR003C	CMS1	-	Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	1558	BY4741	12_1	
2	B	11	YLR004C	THI73	-	Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs	other	other	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1559	BY4741	12_1	
2	B	12	YLR011W	LOT6	flavin-dependent quinone reductase	FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions	response to chemical, protein targeting, regulation of transport, response to oxidative stress, nuclear transport	oxidoreductase activity, transcription factor binding	nucleus, cytoplasm	1566	BY4741	12_1	
2	C	1	YLR012C	-	-	Putative protein of unknown function; YLR012C is not an essential gene	biological_process	molecular_function	cellular_component	1567	BY4741	12_1	
2	C	2	YLR013W	GAT3	-	Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants	other	nucleic acid binding transcription factor activity, DNA binding	nucleus	1568	BY4741	12_1	
2	C	3	YLR014C	PPR1	-	Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p	nucleobase-containing small molecule metabolic process, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding, ion binding	nucleus	1569	BY4741	12_1	
2	C	4	YLR015W	BRE2	CPS60	Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L	peptidyl-amino acid modification, telomere organization, protein alkylation, chromatin organization, histone modification	transferase activity, methyltransferase activity	nucleus	1570	BY4741	12_1	
2	C	5	YLR016C	PML1	-	Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p	RNA splicing, mRNA processing, nucleobase-containing compound transport, nuclear transport	molecular_function	nucleus, cytoplasm	1571	BY4741	12_1	
2	C	6	YLR017W	MEU1	S-methyl-5-thioadenosine phosphorylase	Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression	cellular amino acid metabolic process	transferase activity, transferring glycosyl groups, RNA binding, transferase activity, mRNA binding	cytoplasm	1572	BY4741	12_1	
2	C	7	YLR018C	POM34	-	Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication	protein targeting, cytoskeleton organization, nuclear transport, nucleus organization	structural molecule activity	nucleus, endomembrane system, membrane	1573	BY4741	12_1	
2	C	8	YLR019W	PSR2	putative phosphatase	Plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR2 has a paralog, PSR1, that arose from the whole genome duplication	response to heat, response to osmotic stress	phosphatase activity, hydrolase activity	membrane, plasma membrane, cytoplasm	1574	BY4741	12_1	
2	C	9	YLR020C	YEH2	sterol esterase	Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication	lipid metabolic process, cell wall organization or biogenesis	hydrolase activity	membrane, plasma membrane	1575	BY4741	12_1	
2	C	10	YLR021W	IRC25	DMP2|PBA3|POC3	Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)	RNA catabolic process, protein complex biogenesis	molecular_function	other	1576	BY4741	12_1	
2	C	11	YLR023C	IZH3	-	Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity	cellular ion homeostasis	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1578	BY4741	12_1	
2	C	12	YLR024C	UBR2	putative ubiquitin-protein ligase UBR2	Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex	response to chemical, protein modification by small protein conjugation or removal, proteolysis involved in cellular protein catabolic process	transferase activity	cytoplasm	1579	BY4741	12_1	Incorrect	
2	D	1	YLR025W	SNF7	ESCRT-III subunit protein SNF7|VPL5|RNS4|VPS32|DID1	One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III	response to chemical, ion transport, vesicle organization, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, endosomal transport	other	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	1580	BY4741	12_1	
2	D	2	YLR027C	AAT2	aspartate transaminase AAT2|ASP5	Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells	monocarboxylic acid metabolic process, cellular amino acid metabolic process	transferase activity	peroxisome, cytoplasm	1582	BY4741	12_1	
2	D	3	YLR028C	ADE16	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16	Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine	meiotic cell cycle, sporulation, generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transferase activity, hydrolase activity	cytoplasm	1583	BY4741	12_1	
2	D	4	YLR042C	-	-	Cell wall protein of unknown function; localizes to the cytoplasm; deletion improves xylose fermentation in industrially engineered strains; YLR042C is not an essential gene	biological_process	molecular_function	cell wall, vacuole, cytoplasm	2653	BY4741	12_2	
2	D	5	YLR043C	TRX1	thioredoxin TRX1|LMA1	Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication	vacuole organization, response to chemical, organelle fusion, response to oxidative stress, Golgi vesicle transport, membrane fusion, organelle inheritance	oxidoreductase activity	nucleus, vacuole, mitochondrion, mitochondrial envelope, cytoplasm	2654	BY4741	12_2	
2	D	6	YLR044C	PDC1	indolepyruvate decarboxylase 1	Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, cellular amino acid metabolic process, nucleobase-containing small molecule metabolic process	lyase activity	nucleus, cytoplasm	2655	BY4741	12_2	
2	D	7	YLR046C	-	RLA1	Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication	biological_process	molecular_function	membrane, vacuole, cytoplasm	2657	BY4741	12_2	
2	D	8	YLR047C	FRE8	putative ferric-chelate reductase	Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p	cellular ion homeostasis	oxidoreductase activity	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	2658	BY4741	12_2	
2	D	9	YLR048W	RPS0B	uS2|ribosomal 40S subunit protein S0B|S2|S0B|YST2|NAB1B	Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2	cytoplasmic translation, rRNA processing, organelle assembly, nucleobase-containing compound transport, ribosomal small subunit biogenesis, ribosome assembly, nuclear transport	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	2659	BY4741	12_2	
2	D	10	YLR049C	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	2660	BY4741	12_2	
2	D	11	YLR053C	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	2664	BY4741	12_2	
2	D	12	YLR054C	OSW2	-	Protein of unknown function reputedly involved in spore wall assembly	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	membrane, cytoplasm	2665	BY4741	12_2	
2	E	1	YLR055C	SPT8	SAGA complex subunit SPT8	Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification, transcription from RNA polymerase II promoter	transcription factor activity, protein binding, transcription factor binding	nucleus	2666	BY4741	12_2	
2	E	2	YLR056W	ERG3	C-5 sterol desaturase|PSO6|SYR1	C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D	lipid metabolic process	oxidoreductase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2667	BY4741	12_2	
2	E	3	YLR057W	MNL2	putative mannosidase MNL2	Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene	response to chemical, proteolysis involved in cellular protein catabolic process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	2668	BY4741	12_2	
2	E	4	YLR058C	SHM2	glycine hydroxymethyltransferase SHM2|SHMT2	Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis	other	transferase activity	membrane, site of polarized growth, plasma membrane, cytoplasm	2669	BY4741	12_2	
2	E	5	YLR059C	REX2	YNT20	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease	rRNA processing, mitochondrion organization	nuclease activity, hydrolase activity	mitochondrion, cytoplasm	2670	BY4741	12_2	
2	E	6	YLR061W	RPL22A	eL22|ribosomal 60S subunit protein L22A|L22e|rp4|l1c|YL31|L22A	Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	2672	BY4741	12_2	
2	E	7	YLR062C	BUD28	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay	mitotic cell cycle, cytokinesis	molecular_function	cellular_component	2673	BY4741	12_2	
2	E	8	YLR063W	BMT6	25S rRNA (uracil2843-N3)-methyltransferase	Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene	rRNA processing, RNA modification	transferase activity, methyltransferase activity	cytoplasm	2674	BY4741	12_2	
2	E	9	YLR064W	PER33	-	Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus, membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2675	BY4741	12_2	
2	E	10	YLR065C	ENV10	SND2	Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control	protein maturation	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2676	BY4741	12_2	
2	E	11	YLR067C	PET309	-	Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs)	translational initiation, mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	RNA binding, mRNA binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	2678	BY4741	12_2	
2	E	12	YLR068W	FYV7	-	Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin	rRNA processing, ribosomal small subunit biogenesis	molecular_function	nucleus, nucleolus	2679	BY4741	12_2	
2	F	1	YLR069C	MEF1	-	Mitochondrial elongation factor involved in translational elongation	mitochondrial translation, mitochondrion organization, translational elongation	RNA binding, translation factor activity, RNA binding	mitochondrion, cytoplasm	2680	BY4741	12_2	
2	F	2	YLR070C	XYL2	D-xylulose reductase XYL2	Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect	carbohydrate metabolic process	oxidoreductase activity	cellular_component	2681	BY4741	12_2	
2	F	3	YLR072W	LAM6	LTC1	Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes	lipid transport	other	mitochondrion, cytoplasm	2683	BY4741	12_2	
2	F	4	YLR073C	RFU1	-	Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes	other	enzyme regulator activity	cytoplasmic vesicle, endomembrane system, cytoplasm	2684	BY4741	12_2	
2	F	5	YLR074C	BUD20	-	C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593	mitotic cell cycle, cytokinesis, ribosomal subunit export from nucleus, nuclear transport	other	nucleus, cytoplasm	2685	BY4741	12_2	
2	F	6	YLR077W	FMP25	BCA1	Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria	mitochondrion organization, protein complex biogenesis	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2688	BY4741	12_2	
2	F	7	YLR079W	SIC1	BYC1|cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1|SDB25	Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1	mitotic cell cycle, regulation of protein modification process, protein phosphorylation, regulation of cell cycle	enzyme regulator activity	nucleus, cytoplasm	2690	BY4741	12_2	
2	F	8	YLR080W	EMP46	-	Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication	Golgi vesicle transport	other	membrane, cytoplasmic vesicle, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	2691	BY4741	12_2	
2	F	9	YLR081W	GAL2	galactose permease GAL2	Galactose permease; required for utilization of galactose; also able to transport glucose	carbohydrate metabolic process, carbohydrate transport	transmembrane transporter activity	membrane, plasma membrane	2692	BY4741	12_2	
2	F	10	YLR082C	SRL2	-	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation	other	molecular_function	nucleus, cytoplasm	2693	BY4741	12_2	
2	F	11	YLR083C	EMP70	TMN1|p24a	Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication	invasive growth in response to glucose limitation, cellular ion homeostasis, endosomal transport, pseudohyphal growth	molecular_function	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	2694	BY4741	12_2	
2	F	12	YLR084C	RAX2	-	N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p	mitotic cell cycle, cytokinesis	molecular_function	endomembrane system, mitochondrion, cell wall, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm	2695	BY4741	12_2	
2	G	1	YLR085C	ARP6	-	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A	chromatin organization	chromatin binding	nucleus, chromosome, cytoplasm	2696	BY4741	12_2	
2	G	2	YLR087C	CSF1	-	Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein maturation, generation of precursor metabolites and energy	molecular_function	mitochondrion, cytoplasm	2698	BY4741	12_2	
2	G	3	YLR089C	ALT1	alanine transaminase ALT1	Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive	cellular amino acid metabolic process	transferase activity	mitochondrion, cytoplasm	2700	BY4741	12_2	
2	G	4	YLR090W	XDJ1	-	Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	protein targeting, mitochondrion organization, transmembrane transport, protein folding	enzyme regulator activity	nucleus, mitochondrion, membrane, mitochondrial envelope, cytoplasm	2701	BY4741	12_2	
2	G	5	YLR091W	GEP5	RRG5	Protein of unknown function; required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine	mitochondrion organization	molecular_function	mitochondrion, cytoplasm	2702	BY4741	12_2	
2	G	6	YLR092W	SUL2	sulfate permease	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates	ion transport	transmembrane transporter activity	membrane, plasma membrane	2703	BY4741	12_2	
2	G	7	YLR093C	NYV1	MAM2	v-SNARE component of the vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane	vacuole organization, organelle fusion, vesicle organization, membrane fusion	other	vacuole, membrane, cytoplasm	2704	BY4741	12_2	
2	G	8	YLR094C	GIS3	-	Protein of unknown function	signaling	molecular_function	nucleus, cytoplasm	2705	BY4741	12_2	
2	G	9	YLR095C	IOC2	-	Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p	chromatin organization	chromatin binding, DNA binding, ATPase activity, hydrolase activity	nucleus	2706	BY4741	12_2	
2	G	10	YLR096W	KIN2	serine/threonine protein kinase KIN2	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication	protein phosphorylation, exocytosis	kinase activity, transferase activity	membrane, plasma membrane	2707	BY4741	12_2	
2	G	11	YLR097C	HRT3	SCF ubiquitin ligase complex subunit HRT3	Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies	response to chemical, proteolysis involved in cellular protein catabolic process	protein binding, bridging, transferase activity	other	2708	BY4741	12_2	
2	G	12	YLR098C	CHA4	SIL3|SIL2	DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain	cellular amino acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus	2709	BY4741	12_2	
2	H	1	YLR099C	ICT1	lysophosphatidic acid acyltransferase ICT1	Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant	lipid metabolic process	transferase activity	cellular_component	2710	BY4741	12_2	
2	H	3	YLR102C	APC9	anaphase promoting complex subunit 9	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition	chromatin organization, protein modification by small protein conjugation or removal	transferase activity	nucleus	2713	BY4741	12_2	
2	H	4	YLR104W	LCL2	-	Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole	response to chemical, proteolysis involved in cellular protein catabolic process	molecular_function	vacuole, cytoplasm	2715	BY4741	12_2	
2	H	5	YLR107W	REX3	RNA exonuclease	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases	rRNA processing	nuclease activity, hydrolase activity	nucleus, cytoplasm	2718	BY4741	12_2	
2	H	6	YLR108C	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus	2719	BY4741	12_2	
2	H	7	YLR109W	AHP1	thioredoxin peroxidase AHP1|cTPxIII	Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	response to chemical, response to oxidative stress	oxidoreductase activity	membrane, plasma membrane, cytoplasm	2720	BY4741	12_2	
2	H	8	YLR111W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2722	BY4741	12_2	
2	H	9	YLR112W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2723	BY4741	12_2	
2	H	10	YLR113W	HOG1	mitogen-activated protein kinase HOG1|SSK3	Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress	response to heat, response to chemical, protein phosphorylation, DNA replication, regulation of DNA metabolic process, transcription from RNA polymerase II promoter, signaling, response to osmotic stress, regulation of cell cycle	chromatin binding, kinase activity, transferase activity, signal transducer activity	nucleus, cytoplasm	2724	BY4741	12_2	
2	H	11	YLR114C	AVL9	-	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress	Golgi vesicle transport	molecular_function	cellular bud, site of polarized growth, cytoplasm	2725	BY4741	12_2	
2	H	12	YLR118C	-	palmitoyl-(protein) hydrolase|APT1	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS	other	hydrolase activity	nucleus, cytoplasm	2729	BY4741	12_2	
3	A	1	YLR119W	SRN2	ESCRT-I subunit protein SRN2|VPL16|VPS37|SRN10	Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus	protein targeting, ion transport, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport	other	nucleus, cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	2730	BY4741	12_2	
3	A	2	YLR120C	YPS1	aspartyl protease|YAP3	Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor	protein maturation, conjugation, cell wall organization or biogenesis, signaling	peptidase activity, hydrolase activity	membrane, plasma membrane	2731	BY4741	12_2	
3	A	4	YLR121C	YPS3	aspartyl protease|YPS4	Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor	cell wall organization or biogenesis	peptidase activity, hydrolase activity	membrane, plasma membrane	2732	BY4741	12_2	
3	A	5	YLR122C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C	biological_process	molecular_function	cellular_component	2733	BY4741	12_2	
3	A	6	YLR123C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif	biological_process	molecular_function	cellular_component	2734	BY4741	12_2	
3	A	7	YLR124W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2735	BY4741	12_2	
3	A	8	YLR125W	-	-	Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene	biological_process	molecular_function	cellular_component	2736	BY4741	12_2	Incorrect	
3	A	9	YML089C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage	biological_process	molecular_function	cellular_component	481	BY4730	13_1	
3	A	10	YML088W	UFO1	SCF ubiquitin ligase complex subunit UFO1	F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation	response to chemical, cellular response to DNA damage stimulus, proteolysis involved in cellular protein catabolic process	protein binding, bridging, transferase activity	nucleus, cytoplasm	482	BY4730	13_1	
3	A	11	YML087C	AIM33	cytochrome-b5 reductase	Protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	483	BY4730	13_1	
3	A	12	YML086C	ALO1	D-arabinono-1,4-lactone oxidase	D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress	response to chemical, response to oxidative stress	oxidoreductase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	484	BY4730	13_1	
3	B	1	YML084W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	486	BY4730	13_1	
3	B	2	YML083C	-	-	Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions	biological_process	molecular_function	cellular_component	487	BY4730	13_1	
3	B	3	YML082W	-	putative cystathionine gamma-synthase	Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication	other	lyase activity	nucleus, cytoplasm	488	BY4730	13_1	
3	B	4	YML081W	TDA9	AAF1	Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication	monocarboxylic acid metabolic process	DNA binding	nucleus	489	BY4730	13_1	
3	B	5	YML080W	DUS1	tRNA dihydrouridine synthase	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17	tRNA processing, RNA modification	oxidoreductase activity	nucleus	490	BY4730	13_1	
3	B	6	YML079W	-	-	Non-essential protein of unknown function; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm	biological_process	molecular_function	nucleus, cytoplasm	491	BY4730	13_1	
3	B	7	YML078W	CPR3	peptidylprolyl isomerase CPR3|CYP3	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria	protein folding	isomerase activity	mitochondrion, cytoplasm	492	BY4730	13_1	
3	B	8	YML063W	RPS1B	eS1|ribosomal 40S subunit protein S1B|S1e|rp10B|S1B|RP10B|PLC2	Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	507	BY4741	13_1	
3	B	9	YML062C	MFT1	MFT52	Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance	nucleobase-containing compound transport, DNA recombination, nuclear transport, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	structural molecule activity	nucleus, chromosome	508	BY4741	13_1	
3	B	10	YML061C	PIF1	DNA helicase PIF1|TST1	DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; important for crossover recombination; translation from different start sites produces mitochondrial and nuclear forms; nuclear form is a catalytic inhibitor of telomerase; mitochondrial form involved in DNA repair and recombination; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells	DNA replication, DNA recombination, DNA repair, telomere organization, mitochondrion organization, regulation of organelle organization, cellular response to DNA damage stimulus, regulation of DNA metabolic process	hydrolase activity, enzyme regulator activity, DNA binding, helicase activity	nucleus, chromosome, mitochondrion, membrane, mitochondrial envelope, cytoplasm	509	BY4741	13_1	
3	B	11	YML060W	OGG1	8-oxoguanine glycosylase OGG1	Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance	DNA repair, telomere organization, cellular response to DNA damage stimulus	hydrolase activity, hydrolase activity, acting on glycosyl bonds, lyase activity, nuclease activity	nucleus, chromosome, mitochondrion, cytoplasm	510	BY4741	13_1	
3	B	12	YML059C	NTE1	lysophospholipase	Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes	lipid metabolic process	hydrolase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	511	BY4741	13_1	
3	C	1	YML058W	SML1	ribonucleotide reductase inhibiting protein SML1	Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication	mitochondrion organization, cellular response to DNA damage stimulus	enzyme regulator activity	nucleus, cytoplasm	512	BY4741	13_1	
3	C	2	YML057W	CMP2	calcineurin catalytic subunit A|CNA2	Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication	response to chemical, cellular ion homeostasis, conjugation, signaling	phosphatase activity, hydrolase activity	cytoplasm	513	BY4741	13_1	
3	C	3	YML058C-A	cytoplasm	cytoplasm	cytoplasm	-	-	-	514	BY4741	13_1	
3	C	4	YML056C	IMD4	IMP dehydrogenase IMD4	Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication	biological_process	RNA binding, mRNA binding, oxidoreductase activity	cytoplasm	515	BY4741	13_1	
3	C	5	YML055W	SPC2	signal peptidase complex subunit SPC2|SPY1	Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p	protein targeting, protein maturation	peptidase activity, hydrolase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	516	BY4741	13_1	
3	C	6	YML054C	CYB2	FCB2	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions	monocarboxylic acid metabolic process	oxidoreductase activity	nucleus, mitochondrial envelope, mitochondrion, cytoplasm	517	BY4741	13_1	
3	C	7	YML053C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene	biological_process	molecular_function	nucleus, cytoplasm	518	BY4741	13_1	
3	C	8	YML052W	SUR7	-	Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches)	meiotic cell cycle, sporulation, endocytosis	molecular_function	cell cortex, mitochondrion, membrane, cytoplasm, plasma membrane	519	BY4741	13_1	
3	C	9	YML051W	GAL80	transcription regulator GAL80	Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding	carbohydrate metabolic process, transcription from RNA polymerase II promoter	transcription factor binding, enzyme regulator activity	nucleus, cytoplasm	520	BY4741	13_1	
3	C	10	YML050W	AIM32	-	Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	cellular_component	521	BY4741	13_1	
3	C	11	YML048W	GSF2	ECM6	Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression	protein folding	unfolded protein binding	membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	523	BY4741	13_1	
3	C	12	YML048W-A	membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	-	-	-	524	BY4741	13_1	
3	D	1	YML037C	-	-	Putative protein of unknown function; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene	biological_process	molecular_function	cytoplasmic vesicle, cytoplasm	534	BY4741	13_2	
3	D	2	YML035C	AMD1	AMP deaminase|AMD3	AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools	nucleobase-containing small molecule metabolic process	hydrolase activity	cytoplasm	536	BY4741	13_2	
3	D	3	YML034W	SRC1	HEH1|YML033W	Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication	mitotic cell cycle, organelle fission, chromosome segregation	molecular_function	nucleus, endomembrane system, chromosome	537	BY4741	13_2	
3	D	4	YML035C-A	nucleus, endomembrane system, chromosome	nucleus, endomembrane system, chromosome	nucleus, endomembrane system, chromosome	-	-	-	538	BY4741	13_2	
3	D	5	YML033W	-	-	-	-	-	-	539	BY4741	13_2	
3	D	6	YML032C	RAD52	recombinase RAD52	Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination	meiotic cell cycle, DNA repair, telomere organization, organelle fission, cellular response to DNA damage stimulus, DNA recombination	other	nucleus, chromosome	540	BY4741	13_2	
3	D	7	YML030W	RCF1	AIM31	Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast	mitochondrion organization, protein complex biogenesis	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	543	BY4741	13_2	
3	D	8	YML029W	USA1	-	Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p	response to chemical, RNA splicing, proteolysis involved in cellular protein catabolic process, protein complex biogenesis, mRNA processing	structural molecule activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	544	BY4741	13_2	
3	D	9	YML028W	TSA1	thioredoxin peroxidase TSA1|cTPxI|TPX1|ZRG14	Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication	carbohydrate metabolic process, response to chemical, cellular response to DNA damage stimulus, response to oxidative stress, protein folding, regulation of cell cycle	enzyme regulator activity, oxidoreductase activity, unfolded protein binding	cytoplasm	545	BY4741	13_2	
3	D	10	YML026C	RPS18B	uS13|ribosomal 40S subunit protein S18B|S18B|S13	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation, rRNA processing, nucleobase-containing compound transport, ribosomal small subunit biogenesis, nuclear transport	structural constituent of ribosome, structural molecule activity	ribosome, mitochondrion, cytoplasm	547	BY4741	13_2	
3	D	11	YML024W	RPS17A	eS17|ribosomal 40S subunit protein S17A|S17e|rp51A|S17A|RPL51A|RP51A	Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication	cytoplasmic translation, organelle assembly, ribosomal small subunit biogenesis, ribosome assembly	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	549	BY4741	13_2	
3	D	12	YML020W	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	553	BY4741	13_2	
3	E	1	YML019W	OST6	dolichyl-diphosphooligosaccharide--protein glycotransferase	Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p	peptidyl-amino acid modification, protein complex biogenesis, protein glycosylation	molecular_function	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	554	BY4741	13_2	
3	E	2	YML018C	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication	biological_process	molecular_function	membrane, vacuole, cytoplasm	555	BY4741	13_2	
3	E	3	YML017W	PSP2	MRS15	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing	biological_process	RNA binding, mRNA binding	cytoplasm	556	BY4741	13_2	
3	E	4	YML016C	PPZ1	salt homeostasis regulator	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular ion homeostasis, protein dephosphorylation	phosphatase activity, hydrolase activity	nucleus, membrane, plasma membrane, cytoplasm	557	BY4741	13_2	
3	E	5	YML014W	TRM9	tRNA (carboxymethyluridine(34)-5-O)-methyltransferase|KTI1	tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses	response to chemical, regulation of translation, translational elongation, tRNA processing, RNA modification	transferase activity, methyltransferase activity	nucleus, cytoplasm	559	BY4741	13_2	
3	E	6	YML013W	UBX2	SEL1	Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis	response to chemical, proteolysis involved in cellular protein catabolic process	protein binding, bridging	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm, plasma membrane	560	BY4741	13_2	
3	E	7	YML013C-A	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm, plasma membrane	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm, plasma membrane	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm, plasma membrane	-	-	-	561	BY4741	13_2	
3	E	8	YML012W	ERV25	-	Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24,	Golgi vesicle transport	molecular_function	cytoplasmic vesicle, endomembrane system, vacuole, cytoplasm	562	BY4741	13_2	
3	E	9	YML011C	RAD33	-	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus	DNA repair, cellular response to DNA damage stimulus	molecular_function	nucleus	563	BY4741	13_2	
3	E	10	YML009c	nucleus	nucleus	nucleus	-	-	-	567	BY4741	13_2	
3	E	11	YML008C	ERG6	sterol 24-C-methyltransferase|VID1|SED6|LIS1|ISE1	Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane	lipid metabolic process	transferase activity, methyltransferase activity	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm	568	BY4741	13_2	
3	E	12	YML007W	YAP1	PDR4|DNA-binding transcription factor YAP1|SNQ3|PAR1	Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication	response to heat, response to chemical, response to oxidative stress, transcription from RNA polymerase II promoter, signaling	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	569	BY4741	13_2	
3	F	1	YML006C	GIS4	-	CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway	cellular ion homeostasis, signaling	molecular_function	membrane, plasma membrane	570	BY4741	13_2	
3	F	2	YML005W	TRM12	TYW2	S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family	tRNA processing, RNA modification	transferase activity, methyltransferase activity	cytoplasm	571	BY4741	13_2	
3	F	3	YML004C	GLO1	lactoylglutathione lyase GLO1	Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress	monocarboxylic acid metabolic process	lyase activity	nucleus, cytoplasm	572	BY4741	13_2	
3	F	4	YML003W	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	573	BY4741	13_2	
3	F	5	YML002W	-	-	Putative protein of unknown function; expression induced by heat and by calcium shortage	biological_process	molecular_function	cellular_component	574	BY4741	13_2	
3	F	6	YML001W	YPT7	Rab family GTPase YPT7|VAM4|AST4	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7	vacuole organization, protein targeting, regulation of organelle organization, organelle fusion, membrane fusion, organelle inheritance, endosomal transport, endocytosis	GTPase activity, hydrolase activity	endomembrane system, vacuole, mitochondrion, membrane, mitochondrial envelope, cytoplasm	575	BY4741	13_2	
3	F	7	YMR002W	MIX17	MIC17	Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress	generation of precursor metabolites and energy, cellular respiration	molecular_function	nucleus, mitochondrial envelope, mitochondrion, cytoplasm	577	BY4741	13_2	
3	F	8	YMR003W	AIM34	-	Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion, cytoplasm	578	BY4741	13_2	
3	F	9	YMR006C	PLB2	lysophospholipase	Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine	lipid metabolic process	hydrolase activity	cell wall, extracellular region	581	BY4741	13_2	
3	F	10	YMR007W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YMR007W is not an essential gene	biological_process	molecular_function	cellular_component	582	BY4741	13_2	
3	F	11	YMR008C	PLB1	lysophospholipase	Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication	lipid metabolic process	hydrolase activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	583	BY4741	13_2	
3	F	12	YMR009W	ADI1	acireductone dioxygenase (Ni2+-requiring)	Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant	cellular amino acid metabolic process	oxidoreductase activity	nucleus, cytoplasm	584	BY4741	13_2	
3	G	1	YMR010W	ANY1	-	Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	585	BY4741	13_2	
3	G	2	YMR011W	HXT2	hexose transporter HXT2	High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose	carbohydrate transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	586	BY4741	13_2	
3	G	3	YMR012W	CLU1	translation initiation factor 3 subunit CLU1|TIF31	Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough	cytoplasmic translation, translational initiation	RNA binding, translation factor activity, RNA binding, mRNA binding	cytoplasm	587	BY4741	13_2	
3	G	4	YMR014W	BUD22	-	Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern	rRNA processing, ribosomal small subunit biogenesis	molecular_function	nucleus, nucleolus	589	BY4741	13_2	
3	G	5	YMR015C	ERG5	C-22 sterol desaturase|CYP61	C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs	lipid metabolic process	oxidoreductase activity	endomembrane system, endoplasmic reticulum, cytoplasm	590	BY4741	13_2	
3	G	6	YMR016C	SOK2	-	Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication	pseudohyphal growth	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	591	BY4741	13_2	
3	G	7	YMR017W	SPO20	DBI9	Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog	meiotic cell cycle, sporulation	ion binding, lipid binding	nucleus, membrane, plasma membrane, cytoplasm	592	BY4741	13_2	
3	G	8	YMR018W	PEX9	-	Putative protein of unknown function with similarity to human PEX5Rp; transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene; PEX5Rp is also known as peroxin protein 5 related protein	biological_process	molecular_function	cellular_component	593	BY4741	13_2	
3	G	9	YMR019W	STB4	-	Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay;	biological_process	DNA binding	nucleus, mitochondrion, cytoplasm	594	BY4741	13_2	
3	G	10	YMR020W	FMS1	polyamine oxidase	Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis	cofactor metabolic process, vitamin metabolic process, monocarboxylic acid metabolic process	oxidoreductase activity	cytoplasm	595	BY4741	13_2	
3	G	11	YMR021C	MAC1	CUA1	Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS	cellular ion homeostasis, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	596	BY4741	13_2	
3	G	12	YMR022W	UBC7	E2 ubiquitin-conjugating protein UBC7|DER2|QRI8	Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly	response to chemical, chromatin organization, proteolysis involved in cellular protein catabolic process, cell wall organization or biogenesis	transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	597	BY4741	13_2	
3	H	1	YMR023C	MSS1	PET53	Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3	tRNA processing, mitochondrion organization, RNA modification	ion binding	membrane, mitochondrial envelope, mitochondrion, cytoplasm	598	BY4741	13_2	
3	H	3	YMR024W	MRPL3	mitochondrial 54S ribosomal protein YmL3|YmL3	Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	599	BY4741	13_2	
3	H	4	YMR025W	CSI1	-	Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome	response to chemical, protein modification by small protein conjugation or removal, conjugation, signaling	molecular_function	nucleus	600	BY4741	13_2	
3	H	5	YMR026C	PEX12	ubiquitin-protein ligase peroxin 12|PAS11	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder	protein targeting, protein modification by small protein conjugation or removal, transmembrane transport, peroxisome organization	transferase activity	peroxisome, membrane, cytoplasm	601	BY4741	13_2	
3	H	6	YMR027W	-	putative methyltransferase	A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA damage; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene	biological_process	phosphatase activity, hydrolase activity	nucleus, cytoplasm	602	BY4741	13_2	
3	H	7	YMR029C	FAR8	-	Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p	response to chemical, conjugation, signaling	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	604	BY4741	13_2	
3	H	8	YMR030W	RSF1	-	Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes	generation of precursor metabolites and energy, cellular respiration, transcription from RNA polymerase II promoter, signaling	molecular_function	nucleus, mitochondrion, cytoplasm	605	BY4741	13_2	
3	H	9	YMR031W-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C	biological_process	molecular_function	cellular_component	606	BY4741	13_2	
3	H	10	YMR031C	EIS1	-	Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication	other	molecular_function	membrane, mitochondrion, plasma membrane, cytoplasm	607	BY4741	13_2	
3	H	11	YMR032W	HOF1	formin-binding protein HOF1|CYK2	Protein that regulates actin cytoskeleton organization; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; localized to bud neck; phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; contains an SH3 domain; N terminus controls cell size and levels of actin cables, while C terminus controls actin cable organization via direct regulation of the formin Bnr1p	mitotic cell cycle, cytoskeleton organization, regulation of organelle organization, cytokinesis, cellular response to DNA damage stimulus	cytoskeletal protein binding	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	608	BY4741	13_2	
3	H	12	YMR034C	RCH1	-	Putative transporter; localizes to the plasma membrane in response to high levels of extracellular calcium; member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene	biological_process	other	membrane	610	BY4741	13_2	
4	A	1	YMR035W	IMP2	endopeptidase catalytic subunit	Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p	protein targeting, mitochondrion organization, protein maturation	peptidase activity, hydrolase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	611	BY4741	13_2	
4	A	2	YMR036C	MIH1	putative tyrosine protein phosphatase MIH1	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25	mitotic cell cycle, protein phosphorylation, regulation of protein modification process, regulation of cell cycle	phosphatase activity, hydrolase activity	nucleus, cytoplasm	612	BY4741	13_2	
4	A	3	YMR039C	SUB1	chromatin-binding transcription coactivator SUB1|TSP1	Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)	meiotic cell cycle, DNA repair, response to chemical, sporulation, transcription from RNA polymerase III promoter, cellular response to DNA damage stimulus, DNA-templated transcription, termination, DNA-templated transcription, initiation, transcription from RNA polymerase II promoter, response to osmotic stress, regulation of cell cycle, DNA-templated transcription, elongation	chromatin binding, transcription factor activity, protein binding	nucleus	615	BY4741	13_2	
4	A	5	YMR040W	YET2	-	Protein of unknown function that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog, YET1, that arose from the whole genome duplication	biological_process	molecular_function	membrane, endomembrane system, ribosome, endoplasmic reticulum, cytoplasm	616	BY4741	13_2	
4	A	6	YMR041C	ARA2	D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2	NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase	other	oxidoreductase activity	cellular_component	617	BY4741	13_2	
4	A	7	YMR042W	ARG80	ARGRI|ARGR1	Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p	transcription from RNA polymerase II promoter, cellular amino acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus	618	BY4741	13_2	
4	A	8	YMR044W	IOC4	-	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing	chromatin organization, chromosome segregation	DNA binding, ATPase activity, hydrolase activity	nucleus	620	BY4741	13_2	
4	A	9	YMR140W	SIP5	-	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress	response to starvation	molecular_function	cytoplasm	721	BY4741	13_4	
4	A	10	YMR141C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YMR141C is not an essential gene	biological_process	molecular_function	cellular_component	722	BY4741	13_4	
4	A	11	YMR143W	RPS16A	uS9|ribosomal 40S subunit protein S16A|S9|rp61R|S16A	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	724	BY4741	13_4	
4	A	12	YMR144W	FDO1	-	Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating type switching; localized to the nucleus; not an essential gene	other	molecular_function	nucleus	725	BY4741	13_4	
4	B	1	YMR145C	NDE1	NADH-ubiquinone reductase (H(+)-translocating) NDE1|NDH1	Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication	carbohydrate metabolic process, cofactor metabolic process, nucleobase-containing small molecule metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	726	BY4741	13_4	
4	B	2	YMR147W	-	-	Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery	biological_process	molecular_function	other	728	BY4741	13_4	
4	B	3	YMR148W	OSW5	-	Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion	biological_process	molecular_function	membrane	729	BY4741	13_4	
4	B	4	YMR151W	YIM2	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1	biological_process	molecular_function	cellular_component	731	BY4741	13_4	
4	B	5	YMR150C	IMP1	endopeptidase catalytic subunit IMP1|PET-TS2858	Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificty) and Som1p	protein targeting, mitochondrion organization, protein maturation	peptidase activity, hydrolase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	732	BY4741	13_4	
4	B	6	YMR152W	YIM1	-	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism, based on localization to lipid droplets; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	cellular response to DNA damage stimulus	molecular_function	endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	733	BY4741	13_4	
4	B	7	YMR153W	NUP53	FG-nucleoporin NUP53	FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication	peptidyl-amino acid modification, mitotic cell cycle, organelle fission, protein targeting, regulation of organelle organization, regulation of protein modification process, protein modification by small protein conjugation or removal, nuclear transport, nucleus organization, regulation of cell cycle	ion binding, lipid binding, DNA binding	nucleus, endomembrane system, membrane	734	BY4741	13_4	
4	B	8	YMR153C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of verified gene NUP53/YMR153W	biological_process	molecular_function	cellular_component	735	BY4741	13_4	
4	B	9	YMR155W	-	-	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen	biological_process	molecular_function	membrane, vacuole, cytoplasm	737	BY4741	13_4	
4	B	10	YMR156C	TPP1	polynucleotide 3'-phosphatase	DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase	DNA repair, cellular response to DNA damage stimulus	phosphatase activity, DNA binding, hydrolase activity	nucleus	738	BY4741	13_4	
4	B	11	YMR157C	AIM36	FMP39	Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	739	BY4741	13_4	
4	B	12	YMR158W-A	mitochondrion, cytoplasm	mitochondrion, cytoplasm	mitochondrion, cytoplasm	-	-	-	741	BY4741	13_4	
4	C	1	YMR159C	ATG16	APG15|APG16|CVT11|SAP18	Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	protein targeting, mitochondrion organization, protein lipidation	protein binding, bridging, transferase activity	nucleus, cytoplasm	742	BY4741	13_4	
4	C	2	YMR161W	HLJ1	type I HSP40 co-chaperone HLJ1	Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ	response to chemical, proteolysis involved in cellular protein catabolic process	enzyme regulator activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	744	BY4741	13_4	
4	C	3	YMR162C	DNF3	aminophospholipid-translocating P4-type ATPase DNF3	Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone	response to chemical, ion transport, lipid transport, conjugation	hydrolase activity, ATPase activity	cytoplasmic vesicle, endomembrane system, membrane, site of polarized growth, endoplasmic reticulum, Golgi apparatus, cytoplasm, plasma membrane	745	BY4741	13_4	
4	C	4	YMR163C	INP2	-	Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene	organelle inheritance, peroxisome organization	other	peroxisome, membrane, cytoplasm	746	BY4741	13_4	
4	C	5	YMR164C	MSS11	-	Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1	carbohydrate metabolic process, invasive growth in response to glucose limitation, pseudohyphal growth, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity	nucleus	747	BY4741	13_4	
4	C	6	YMR166C	MME1	-	Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers	transmembrane transport, ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	749	BY4741	13_4	
4	C	7	YMR167W	MLH1	mismatch repair ATPase MLH1|PMS2	Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer	meiotic cell cycle, DNA repair, organelle fission, cellular response to DNA damage stimulus, DNA recombination	hydrolase activity, DNA binding, ion binding, ATPase activity	nucleus, mitochondrion, cytoplasm	750	BY4741	13_4	
4	C	8	YMR169C	ALD3	aldehyde dehydrogenase (NAD(+)) ALD3	Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose	cellular amino acid metabolic process	oxidoreductase activity	cytoplasm	752	BY4741	13_4	
4	C	9	YMR170C	ALD2	aldehyde dehydrogenase (NAD(+)) ALD2	Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p	cellular amino acid metabolic process	oxidoreductase activity	cytoplasm	753	BY4741	13_4	
4	C	10	YMR172C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF HOT1/YMR172W	biological_process	molecular_function	cellular_component	756	BY4741	13_4	
4	C	11	YMR173W-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W	biological_process	molecular_function	membrane	758	BY4741	13_4	
4	C	12	YMR174C	PAI3	IA3	Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact	other	enzyme regulator activity	nucleus, cytoplasm	759	BY4741	13_4	
4	D	1	YMR175W	SIP18	-	Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication	response to chemical	ion binding, lipid binding	cytoplasm	760	BY4741	13_4	
4	D	2	YMR176W	ECM5	-	Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress	response to chemical, response to oxidative stress	molecular_function	nucleus, chromosome, cytoplasm	761	BY4741	13_4	
4	D	3	YMR177W	MMT1	MFT1	Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication	cellular ion homeostasis	molecular_function	membrane, mitochondrion, cytoplasm	762	BY4741	13_4	
4	D	4	YMR178W	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	763	BY4741	13_4	
4	D	5	YMR179W	SPT21	-	Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress	chromatin organization, transcription from RNA polymerase II promoter	molecular_function	nucleus	764	BY4741	13_4	
4	D	6	YMR180C	CTL1	polynucleotide 5'-phosphatase|CTH1	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication	biological_process	phosphatase activity, hydrolase activity	nucleus, cytoplasm	765	BY4741	13_4	
4	D	7	YMR182C	RGM1	-	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog, USV1, that arose from the whole genome duplication	transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, chromosome, cytoplasm	767	BY4741	13_4	
4	D	8	YMR183C	SSO2	syntaxin	Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication	meiotic cell cycle, sporulation, organelle fusion, vesicle organization, membrane fusion, Golgi vesicle transport	lipid binding, ion binding	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	768	BY4741	13_4	
4	D	9	YMR184W	ADD37	-	Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress	response to chemical, proteolysis involved in cellular protein catabolic process	molecular_function	cytoplasm	769	BY4741	13_4	
4	D	10	YMR186W	HSC82	Hsp90 family chaperone HSC82|HSP90	Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication	response to heat, telomere organization, protein complex biogenesis, protein folding	hydrolase activity, unfolded protein binding, ATPase activity	mitochondrion, membrane, cytoplasm, plasma membrane	771	BY4741	13_4	
4	D	11	YMR187C	-	-	Putative protein of unknown function; YMR187C is not an essential gene	biological_process	molecular_function	membrane	772	BY4741	13_4	
4	D	12	YMR188C	MRPS17	mitochondrial 37S ribosomal protein MRPS17	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	773	BY4741	13_4	
4	E	1	YMR189W	GCV2	glycine decarboxylase subunit P|GSD2	P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm	cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	774	BY4741	13_4	
4	E	2	YMR190C	SGS1	ATP-dependent DNA helicase SGS1	RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant	mitotic cell cycle, meiotic cell cycle, organelle fission, DNA replication, DNA recombination, DNA repair, telomere organization, regulation of organelle organization, cellular response to DNA damage stimulus, chromosome segregation, regulation of DNA metabolic process, regulation of cell cycle	hydrolase activity, helicase activity, ATPase activity	nucleus, chromosome, nucleolus	775	BY4741	13_4	
4	E	3	YMR191W	SPG5	-	Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources	protein complex biogenesis	other	cellular_component	776	BY4741	13_4	
4	E	4	YMR192W	GYL1	APP2	Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication	regulation of transport, Golgi vesicle transport, exocytosis	other	cytoplasmic vesicle, endomembrane system, mitochondrion, cellular bud, membrane, site of polarized growth, Golgi apparatus, cytoplasm, plasma membrane	777	BY4741	13_4	
4	E	5	YMR193W	MRPL24	mitochondrial 54S ribosomal protein YmL24/YmL14|YmL14|YmL24|MRPL14	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	778	BY4741	13_4	
4	E	6	YMR194W	RPL36A	eL36|ribosomal 60S subunit protein L36A|L36e|YL39|L39|L36A|RPL39B	Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication	cytoplasmic translation	RNA binding, structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	779	BY4741	13_4	
4	E	7	YMR193C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	780	BY4741	13_4	
4	E	8	YMR195W	ICY1	-	Protein of unknown function; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; ICY1 has a paralog, ICY2, that arose from the whole genome duplication	biological_process	molecular_function	membrane, vacuole, cytoplasm	781	BY4741	13_4	
4	E	9	YMR196W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene	biological_process	molecular_function	cytoplasm	782	BY4741	13_4	
4	E	10	YMR198W	CIK1	-	Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog, VIK1, that arose from the whole genome duplication	mitotic cell cycle, meiotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, organelle fusion, chromosome segregation, conjugation, regulation of cell cycle, nucleus organization	hydrolase activity, ATPase activity	nucleus, cytoskeleton, microtubule organizing center, cytoplasm	784	BY4741	13_4	
4	E	11	YMR199W	CLN1	cyclin CLN1	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1	regulation of protein modification process, protein phosphorylation, regulation of cell cycle	enzyme regulator activity	nucleus, cytoplasm	785	BY4741	13_4	
4	E	12	YMR201C	RAD14	-	Protein that recognizes and binds damaged DNA during NER; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein; NER stands for nucleotide excision repair	DNA repair, cellular response to DNA damage stimulus	DNA binding, ion binding	nucleus	787	BY4741	13_4	
4	F	1	YMR202W	ERG2	C-8 sterol isomerase ERG2|END11	C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP	lipid metabolic process	isomerase activity	endomembrane system, endoplasmic reticulum, cytoplasm	788	BY4741	13_4	
4	F	2	YMR204C	INP1	-	Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane	organelle inheritance, peroxisome organization	protein binding, bridging	peroxisome, membrane, cytoplasm	790	BY4741	13_4	
4	F	3	YMR205C	PFK2	6-phosphofructokinase subunit beta	Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes	generation of precursor metabolites and energy, monocarboxylic acid metabolic process, nucleobase-containing small molecule metabolic process, carbohydrate metabolic process, cofactor metabolic process, ion transport, protein complex biogenesis, cellular ion homeostasis	RNA binding, kinase activity, transferase activity, mRNA binding	vacuole, mitochondrion, membrane, cytoplasm	791	BY4741	13_4	
4	F	4	YMR206W	-	-	Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	792	BY4741	13_4	
4	F	5	YMR207C	HFA1	acetyl-CoA carboxylase HFA1	Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon	lipid metabolic process, monocarboxylic acid metabolic process	ligase activity	mitochondrion, cytoplasm	793	BY4741	13_4	
4	F	6	YMR210W	MGL2	putative carboxylic ester hydrolase	Monoacylglycerol lipase; palmitoyl monoacylglycerol is the preferred substrate; role in triacylglycerol catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif; has similarity to acyltransferases, Eeb1p and Eht1p, and human ABHD1	lipid metabolic process, monocarboxylic acid metabolic process	transferase activity, hydrolase activity	cellular_component	796	BY4741	13_4	
4	F	7	YMR214W	SCJ1	-	One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins	response to chemical, protein folding, proteolysis involved in cellular protein catabolic process	other	endomembrane system, endoplasmic reticulum, cytoplasm	800	BY4741	13_4	
4	F	8	YMR215W	GAS3	putative 1,3-beta-glucanosyltransferase	Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation	biological_process	transferase activity	cell wall, membrane, vacuole, plasma membrane, cytoplasm	801	BY4741	13_4	
4	F	9	YMR216C	SKY1	serine/threonine protein kinase SKY1	SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1	response to chemical, protein targeting, RNA splicing, protein phosphorylation, regulation of transport, cellular ion homeostasis, mRNA processing, nuclear transport	kinase activity, transferase activity	cytoplasm	802	BY4741	13_4	
4	F	10	YMR219W	ESC1	-	Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p	chromatin organization	molecular_function	nucleus, chromosome	805	BY4741	13_4	
4	F	11	YMR221C	FMP42	-	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy	biological_process	molecular_function	membrane, vacuole, mitochondrion, cytoplasm	807	BY4741	13_4	
4	F	12	YMR222C	FSH2	putative serine hydrolase	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cytoplasm	808	BY4741	13_4	
4	G	1	YMR223W	UBP8	ubiquitin-specific protease UBP8	Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of histone H2B	peptidyl-amino acid modification, RNA splicing, protein alkylation, chromatin organization, histone modification, protein modification by small protein conjugation or removal	peptidase activity, hydrolase activity, structural molecule activity	nucleus	809	BY4741	13_4	
4	G	2	YMR224C	MRE11	MRX complex nuclease subunit|NGS1|XRS4|RAD58	Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress	meiotic cell cycle, DNA repair, organelle fission, sporulation, cellular response to DNA damage stimulus, DNA recombination	kinase activity, transferase activity, hydrolase activity, DNA binding, structural molecule activity, nuclease activity	nucleus, mitochondrion, cytoplasm	810	BY4741	13_4	
4	G	3	YMR225C	MRPL44	mitochondrial 54S ribosomal protein YmL44|YmL44|YMR44	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	811	BY4741	13_4	
4	G	4	YMR226C	-	oxidoreductase|TMA29	NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments	biological_process	oxidoreductase activity	nucleus, membrane, ribosome, cytoplasm	812	BY4741	13_4	
4	G	5	YMR228W	MTF1	RNA polymerase specificity factor	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation	DNA-templated transcription, initiation	transcription factor activity, protein binding	mitochondrial envelope, mitochondrion, cytoplasm	814	BY4741	13_4	
4	G	6	YMR230W	RPS10B	eS10|ribosomal 40S subunit protein S10B|S10e|S10B	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia	cytoplasmic translation, nucleobase-containing compound transport, nuclear transport	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	816	BY4741	13_4	
4	G	7	YMR231W	PEP5	tethering complex subunit PEP5|VPT11|VPS11|VPL9|VAM1|END1	Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones	vacuole organization, chromatin organization, regulation of transport, organelle fusion, Golgi vesicle transport, regulation of organelle organization, vesicle organization, histone modification, protein complex biogenesis, membrane fusion, endosomal transport, protein modification by small protein conjugation or removal	ion binding, transferase activity, lipid binding	vacuole, cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	817	BY4741	13_5	
4	G	8	YMR232W	FUS2	-	Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p	response to chemical, cell morphogenesis, organelle fusion, conjugation, nucleus organization	molecular_function	nucleus, mitochondrion, site of polarized growth, cytoplasm	818	BY4741	13_5	
4	G	9	YMR233W	TRI1	-	Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, nucleolus, cytoplasm	819	BY4741	13_5	
4	G	10	YMR234W	RNH1	RNA-DNA hybrid ribonuclease	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I.	RNA catabolic process	nuclease activity, hydrolase activity	nucleus, cytoplasm	820	BY4741	13_5	
4	G	11	YMR237W	BCH1	exomer complex subunit	Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	carbohydrate metabolic process, Golgi vesicle transport, cell wall organization or biogenesis	enzyme binding	cytoplasmic vesicle, endomembrane system, ribosome, Golgi apparatus, cytoplasm	823	BY4741	13_5	
4	G	12	YMR238W	DFG5	putative mannan endo-1,6-alpha-mannosidase	Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p	cell budding, pseudohyphal growth, cell wall organization or biogenesis	molecular_function	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	824	BY4741	13_5	
4	H	1	YMR241W	YHM2	-	Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome	mitochondrion organization, ion transport	transmembrane transporter activity, DNA binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	827	BY4741	13_5	
4	H	3	YMR242C	RPL20A	eL20|ribosomal 60S subunit protein L20A|L20e|L20A|L18A|RPL18A2	Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	828	BY4741	13_5	
4	H	4	YMR243C	ZRC1	Zn(2+) transporter ZRC1|OSR1	Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication	cellular ion homeostasis	transmembrane transporter activity	membrane, vacuole, cytoplasm	829	BY4741	13_5	
4	H	5	YMR244W	-	-	Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole	biological_process	molecular_function	vacuole, cytoplasm	830	BY4741	13_5	
4	H	6	YMR245W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	831	BY4741	13_5	
4	H	7	YMR244C-A	COA6	-	Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress	mitochondrion organization, protein complex biogenesis, cellular ion homeostasis	molecular_function	nucleus, mitochondrion, mitochondrial envelope, cytoplasm	832	BY4741	13_5	
4	H	8	YMR246W	FAA4	long-chain fatty acid-CoA ligase FAA4	Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4	lipid transport, cofactor metabolic process, ion transport	ligase activity	membrane, plasma membrane, cytoplasm	833	BY4741	13_5	
4	H	9	YMR247C	RKR1	ubiquitin-protein ligase RKR1|LTN1	RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration	regulation of translation, chromatin organization, translational elongation, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal	transferase activity	nucleus, ribosome, cytoplasm	834	BY4741	13_5	
4	H	10	YMR250W	GAD1	glutamate decarboxylase GAD1	Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress	response to chemical, response to oxidative stress, cellular amino acid metabolic process	lyase activity	cytoplasm	835	BY4741	13_5	
4	H	11	YMR251W	GTO3	omega-class glutathione transferase	Omega class glutathione transferase; putative cytosolic localization	other	transferase activity	cytoplasm	836	BY4741	13_5	
4	H	12	YMR251W-A	HOR7	-	Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication	other	molecular_function	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	837	BY4741	13_5	
5	A	1	YMR252C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene	biological_process	molecular_function	mitochondrion, cytoplasm	838	BY4741	13_5	
5	A	2	YMR253C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene	biological_process	molecular_function	membrane, cytoplasm	839	BY4741	13_5	
5	A	3	YMR254C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	840	BY4741	13_5	
5	A	4	YMR255W	GFD1	-	Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress	nucleobase-containing compound transport, nuclear transport	molecular_function	nucleus, membrane, endomembrane system, cytoplasm	841	BY4741	13_5	
5	A	6	YMR256C	COX7	cytochrome c oxidase subunit VII	Subunit VII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	842	BY4741	13_5	
5	A	7	YMR257C	PET111	-	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	843	BY4741	13_5	
5	A	8	YMR258C	ROY1	-	GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p	protein targeting, endocytosis	enzyme regulator activity	nucleus, endomembrane system, endoplasmic reticulum, cytoplasm	844	BY4741	13_5	
5	A	9	YMR259C	TRM732	tRNA methylation protein TRM732	Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS)	tRNA processing, RNA modification	molecular_function	cytoplasm	845	BY4741	13_5	
5	A	10	YMR261C	TPS3	trehalose 6-phosphate synthase/phosphatase complex subunit	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication	carbohydrate metabolic process, oligosaccharide metabolic process	transferase activity, transferring glycosyl groups, phosphatase activity, transferase activity, hydrolase activity, enzyme regulator activity	cytoplasm	847	BY4741	13_5	
5	A	11	YMR262W	-	putative endodeoxyribonuclease	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene	biological_process	molecular_function	cellular_component	848	BY4741	13_5	
5	A	12	YNL047C	SLM2	phosphatidylinositol 4,5-bisphosphate-binding protein|LIT1	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication	endosomal transport, cytoskeleton organization, signaling	ion binding, lipid binding	membrane, plasma membrane	7372	BY4741	00_18	
5	B	1	YMR264W	CUE1	KIS4	Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane-bound ubiquitin ligase complexes that function in the ER-associated degradation (ERAD) pathway for misfolded proteins; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination and to promote diubiquitin elongation, facilitating polyubiquitin chain formation	response to chemical, proteolysis involved in cellular protein catabolic process	enzyme regulator activity, ubiquitin-like protein binding	endomembrane system, mitochondrion, membrane, endoplasmic reticulum, cytoplasm	850	BY4741	13_5	
5	B	2	YMR265C	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	851	BY4741	13_5	
5	B	3	YMR266W	RSN1	-	Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane	Golgi vesicle transport	molecular_function	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	852	BY4741	13_5	
5	B	4	YMR267W	PPA2	inorganic diphosphatase PPA2|IPP2	Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants	generation of precursor metabolites and energy, cellular respiration	hydrolase activity	mitochondrion, cytoplasm	853	BY4741	13_5	
5	B	5	YMR269W	TMA23	YMR268W-A	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan	ribosomal small subunit biogenesis	molecular_function	nucleus, nucleolus, ribosome, cytoplasm	855	BY4741	13_5	
5	B	6	YMR272C	SCS7	fatty acid alpha-hydroxylase|FAH1	Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth	lipid metabolic process	oxidoreductase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	858	BY4741	13_5	
5	B	7	YMR273C	ZDS1	OSS1|NRC1|CKM1|CES1	Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication	mitotic cell cycle, chromatin organization, nucleobase-containing compound transport, nuclear transport, regulation of cell cycle	enzyme regulator activity	cellular bud, site of polarized growth, cytoplasm	859	BY4741	13_5	
5	B	8	YMR274C	RCE1	CAAX prenyl protease	Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone	protein maturation, conjugation	peptidase activity, hydrolase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	860	BY4741	13_5	
5	B	9	YMR275C	BUL1	ubiquitin-ubiquitin ligase BUL1|SMM2|RDS1|DAG1	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication	mitochondrion organization, ion transport, nucleobase-containing compound transport, organelle inheritance, protein modification by small protein conjugation or removal	transferase activity	membrane, plasma membrane	861	BY4741	13_5	
5	B	10	YMR276W	DSK2	-	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress	response to chemical, cytoskeleton organization, proteolysis involved in cellular protein catabolic process	protein binding, bridging	nucleus	862	BY4741	13_5	
5	B	11	YMR278W	PRM15	PGM3|phosphoribomutase PRM15	Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential	nucleobase-containing small molecule metabolic process	isomerase activity	nucleus, cytoplasm	864	BY4741	13_5	
5	B	12	YMR280C	CAT8	DNA-binding transcription factor CAT8|MSP8|DIL1	Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress	carbohydrate metabolic process, response to chemical, transcription from RNA polymerase II promoter, monocarboxylic acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	866	BY4741	13_5	
5	C	1	YMR282C	AEP2	ATP13	Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader	translational initiation, mitochondrial translation, mitochondrion organization	molecular_function	mitochondrion, cytoplasm	868	BY4741	13_5	
5	C	2	YMR283C	RIT1	tRNA A64-2'-O-ribosylphosphate transferase	Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA	tRNA processing, RNA modification	transferase activity, transferring glycosyl groups, transferase activity	cytoplasm	869	BY4741	13_5	
5	C	3	YMR284W	YKU70	ATP-dependent DNA helicase YKU70|KU70|NES24|HDF1	Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair	DNA repair, telomere organization, chromatin organization, cellular response to DNA damage stimulus, DNA recombination	RNA binding, DNA binding	nucleus, endomembrane system, chromosome	870	BY4741	13_5	
5	C	4	YMR285C	NGL2	RNA exonuclease	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication	rRNA processing	nuclease activity, hydrolase activity	other	871	BY4741	13_5	
5	C	5	YMR286W	MRPL33	mitochondrial 54S ribosomal protein YmL33|YmL33	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	872	BY4741	13_5	
5	C	6	YMR287C	DSS1	MSU1	3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs	RNA catabolic process	nuclease activity, hydrolase activity	mitochondrion, cytoplasm	873	BY4741	13_5	
5	C	7	YMR289W	ABZ2	aminodeoxychorismate lyase ABZ2	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis	cofactor metabolic process, vitamin metabolic process	lyase activity	cytoplasm	875	BY4741	13_5	
5	C	8	YMR291W	TDA1	protein kinase TDA1	Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress	protein phosphorylation	kinase activity, transferase activity	nucleus, cytoplasm	878	BY4741	13_5	
5	C	9	YMR292W	GOT1	-	Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition	Golgi vesicle transport, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	879	BY4741	13_5	
5	C	10	YMR293C	HER2	QRS1|glutamyl-tRNA(Gln) amidotransferase subunit HER2|RRG6|GEP6|LRC6	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase	cellular amino acid metabolic process	ligase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	880	BY4741	13_5	
5	C	11	YMR294W	JNM1	PAC3|INS1	Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B	mitotic cell cycle, cytoskeleton organization	structural molecule activity	cell cortex, cytoskeleton, microtubule organizing center, cytoplasm	881	BY4741	13_5	
5	C	12	YMR294W-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	cellular_component	882	BY4741	13_5	
5	D	1	YMR295C	-	IBI2	Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud, site of polarized growth, ribosome, cytoplasm	883	BY4741	13_5	
5	D	2	YMR297W	PRC1	CPY1|carboxypeptidase C PRC1|CPY|LBC1	Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family	other	peptidase activity, hydrolase activity	endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	885	BY4741	13_5	
5	D	3	YMR299C	DYN3	dynein light intermediate chain	Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration	other	hydrolase activity	cytoskeleton, cytoplasm	887	BY4741	13_5	
5	D	4	YMR300C	ADE4	amidophosphoribosyltransferase	Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase	nucleobase-containing small molecule metabolic process	transferase activity, transferring glycosyl groups, transferase activity	cytoplasm	888	BY4741	13_5	
5	D	5	YMR302C	YME2	PRP12|RNA12	Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	890	BY4741	13_5	
5	D	6	YMR303C	ADH2	alcohol dehydrogenase ADH2|ADR2	Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1	cofactor metabolic process, nucleobase-containing small molecule metabolic process, cellular amino acid metabolic process	oxidoreductase activity	cytoplasm	891	BY4741	13_5	
5	D	7	YMR304W	UBP15	ubiquitin-specific protease UBP15	Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiquitinated forms of Pex5p; deubiquitinates Clb5p, counteracting APC activity, and facilitating both Clb5p accumulation and S phase entry; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences	protein modification by small protein conjugation or removal	peptidase activity, hydrolase activity	peroxisome, endomembrane system, endoplasmic reticulum, cytoplasm	892	BY4741	13_5	
5	D	8	YMR304C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 3' end of verified ORF SCW10/YMR305C	biological_process	molecular_function	cellular_component	893	BY4741	13_5	
5	D	9	YMR305C	SCW10	putative family 17 glucosidase	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; SWC10 has a paralog, SCW4, that arose from the whole genome duplication	conjugation	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cell wall, extracellular region, endomembrane system, endoplasmic reticulum, cytoplasm	894	BY4741	13_5	
5	D	10	YMR306C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF FKS3/YMR306W	biological_process	molecular_function	cellular_component	896	BY4741	13_5	
5	D	11	YMR307W	GAS1	1,3-beta-glucanosyltransferase GAS1|GGP1|CWH52	Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation	chromatin organization, cell wall organization or biogenesis	transferase activity	nucleus, cytoplasmic vesicle, endomembrane system, mitochondrion, cell wall, membrane, cytoplasm, plasma membrane	897	BY4741	13_5	
5	D	12	YMR310C	-	putative methyltransferase	Putative methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; not an essential gene; YMR310C has a paralog, YGR283C, that arose from the whole genome duplication	other	transferase activity, methyltransferase activity	nucleus	900	BY4741	13_5	
5	E	1	YNL339C	YRF1-6	Y' element ATP-dependent helicase protein 1 copy 6|YRF1	Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p	telomere organization, DNA recombination	helicase activity, hydrolase activity	nucleus	1105	BY4741	14_1	
5	E	2	YNL338W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is a telomeric X element core sequence on the left arm of chromosome XIV	biological_process	molecular_function	cellular_component	1106	BY4741	14_1	
5	E	3	YNL336W	COS1	-	Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins	protein targeting, proteolysis involved in cellular protein catabolic process, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	1108	BY4741	14_1	
5	E	4	YNL335W	DDI3	cyanamide hydratase	Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p	response to chemical	lyase activity	cellular_component	1109	BY4741	14_1	
5	E	5	YNL334C	SNO2	putative pyridoxal 5'-phosphate synthase	Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin	vitamin metabolic process	molecular_function	cellular_component	1110	BY4741	14_1	
5	E	6	YNL333W	SNZ2	pyridoxine biosynthesis protein SNZ2	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p	vitamin metabolic process	ligase activity	cellular_component	1111	BY4741	14_1	
5	E	7	YNL332W	THI12	4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase	Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP	vitamin metabolic process	molecular_function	cellular_component	1112	BY4741	14_1	
5	E	8	YNL330C	RPD3	histone deacetylase RPD3|MOF6|SDS6|SDI2|REC3	Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p	transcription from RNA polymerase I promoter, mitotic cell cycle, meiotic cell cycle, organelle fission, chromatin organization, DNA replication, DNA recombination, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation, regulation of organelle organization, histone modification, regulation of DNA metabolic process, nucleus organization, regulation of cell cycle	hydrolase activity, transcription factor activity, protein binding	nucleus, chromosome	1114	BY4741	14_1	
5	E	9	YNL329C	PEX6	AAA family ATPase peroxin 6|PAS8	AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death	protein targeting, transmembrane transport, peroxisome organization, signaling	ATPase activity, hydrolase activity	peroxisome, cytoplasm	1115	BY4741	14_1	
5	E	10	YNL328C	MDJ2	-	Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain	protein targeting, mitochondrion organization, transmembrane transport	protein transporter activity, enzyme regulator activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1116	BY4741	14_1	
5	E	11	YNL327W	EGT2	-	Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner	other	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cellular bud, cell wall, vacuole, cytoplasm	1117	BY4741	14_1	
5	E	12	YNL326C	PFA3	palmitoyltransferase PFA3	Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions	vacuole organization, protein acylation, organelle fusion, membrane fusion, protein lipidation	transferase activity	vacuole, membrane, cytoplasm	1118	BY4741	14_1	
5	F	1	YNL324W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1119	BY4741	14_1	
5	F	2	YNL325C	FIG4	phosphatidylinositol-3,5-bisphosphate 5-phosphatase	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder	lipid metabolic process	phosphatase activity, hydrolase activity	nucleus, membrane, vacuole, cytoplasm	1120	BY4741	14_1	
5	F	3	YNL323W	LEM3	ROS3|BRE3	Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p	vacuole organization, regulation of organelle organization, ion transport, lipid transport, signaling	hydrolase activity, ATPase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1121	BY4741	14_1	
5	F	4	YNL322C	KRE1	-	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor	cell wall organization or biogenesis	structural molecule activity	cell wall, membrane, vacuole, cytoplasm	1122	BY4741	14_1	
5	F	5	YNL321W	VNX1	-	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate	ion transport	transmembrane transporter activity	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	1123	BY4741	14_1	
5	F	6	YNL320W	-	-	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	vacuole, mitochondrion, cytoplasm	1124	BY4741	14_1	
5	F	7	YNL319W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14	biological_process	molecular_function	cellular_component	1125	BY4741	14_1	
5	F	8	YNL318C	HXT14	-	Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	carbohydrate transport	transmembrane transporter activity	membrane, vacuole, mitochondrion, plasma membrane, cytoplasm	1126	BY4741	14_1	
5	F	9	YNL314W	DAL82	DURM	Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain	response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	1130	BY4741	14_1	
5	F	10	YNL311C	SKP2	putative SCF ubiquitin ligase complex subunit SKP2	F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments	cellular amino acid metabolic process	protein binding, bridging, transferase activity	ribosome, cytoplasm	1133	BY4741	14_1	
5	F	11	YNL309W	STB1	-	Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication	mitotic cell cycle, transcription from RNA polymerase II promoter	transcription factor activity, protein binding, transcription factor binding	nucleus, chromosome, cytoplasm	1135	BY4741	14_1	
5	F	12	YNL053W	MSG5	tyrosine/serine/threonine protein phosphatase MSG5	Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p; MSG5 has a paralog, SDP1, that arose from the whole genome duplication	response to chemical, protein phosphorylation, protein dephosphorylation, regulation of transport, regulation of protein modification process, conjugation, cell wall organization or biogenesis, nuclear transport, signaling	phosphatase activity, hydrolase activity	nucleus, cytoplasm	7373	BY4741	00_18	
5	G	1	YNL305C	BXI1	YBH3	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p	response to chemical, signaling	molecular_function	endomembrane system, vacuole, mitochondrion, membrane, endoplasmic reticulum, cytoplasm	1139	BY4741	14_1	
5	G	2	YNL304W	YPT11	Rab family GTPase YPT11	Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed	mitochondrion organization, organelle inheritance	molecular_function	endomembrane system, mitochondrion, cellular bud, site of polarized growth, endoplasmic reticulum, cytoplasm	1140	BY4741	14_1	
5	G	3	YNL303W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1141	BY4741	14_1	
5	G	4	YNL302C	RPS19B	eS19|ribosomal 40S subunit protein S19B|S19e|rp55B|YS16B|S19B|S16aB|RP55B	Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication	cytoplasmic translation, nucleobase-containing compound transport, ribosomal small subunit biogenesis, nuclear transport	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	1142	BY4741	14_1	
5	G	5	YNL301C	RPL18B	eL18|ribosomal 60S subunit protein L18B|L18e|rp28B|L18B|RP28B	Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1143	BY4741	14_1	
5	G	6	YNL299W	TRF5	non-canonical poly(A) polymerase TRF5	Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p	RNA catabolic process, snoRNA processing	transferase activity, nucleotidyltransferase activity	nucleus, nucleolus	1145	BY4741	14_1	
5	G	7	YNL298W	CLA4	serine/threonine protein kinase CLA4|ERC10	Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication	vacuole organization, mitotic cell cycle, response to chemical, organelle fission, cytoskeleton organization, regulation of transport, lipid transport, transcription from RNA polymerase II promoter, protein targeting, protein phosphorylation, regulation of organelle organization, organelle inheritance, nuclear transport, regulation of cell cycle	kinase activity, transferase activity	nucleus, vacuole, cellular bud, cytoplasm	1146	BY4741	14_1	
5	G	8	YNL086W	SNN1	BLS1	Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes	vesicle organization	molecular_function	cytoplasmic vesicle, endomembrane system, cytoplasm	7377	BY4741	00_18	
5	G	9	YNL297C	MON2	YSL2	Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins	protein targeting, Golgi vesicle transport, endosomal transport, endocytosis	guanyl-nucleotide exchange factor activity	cytoplasmic vesicle, endomembrane system, membrane, Golgi apparatus, cytoplasm	1148	BY4741	14_1	
5	G	10	YNL295W	MRX6	-	Protein that associates with mitochondrial ribosome	biological_process	molecular_function	cellular_component	1149	BY4741	14_1	
5	G	11	YNL294C	RIM21	PAL2	pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH	vacuole organization, meiotic cell cycle, invasive growth in response to glucose limitation, sporulation, regulation of organelle organization, cell wall organization or biogenesis	molecular_function	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1150	BY4741	14_1	
5	G	12	YNL293W	MSB3	Rab GTPase-activating protein MSB3|GYP3	Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null	cytoskeleton organization, exocytosis, endocytosis	enzyme regulator activity	cell cortex, cytoplasmic vesicle, endomembrane system, vacuole, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	1151	BY4741	14_1	
5	H	1	YNL089C	-	-	Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins	biological_process	molecular_function	cellular_component	7378	BY4741	00_18	
5	H	3	YNL291C	MID1	-	N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer	ion transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	1153	BY4741	14_1	
5	H	4	YNL289W	PCL1	HCS26	Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth	regulation of protein modification process, protein phosphorylation, cytoskeleton organization, regulation of cell cycle	enzyme regulator activity	nucleus	1155	BY4741	14_1	
5	H	5	YNL288W	CAF40	CCR4-NOT core subunit CAF40	Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p	transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	molecular_function	other	1156	BY4741	14_1	
5	H	6	YNL286W	CUS2	U2 snRNP complex subunit CUS2	Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)	RNA splicing, mRNA processing	RNA binding	nucleus	1158	BY4741	14_1	
5	H	7	YNL285W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1159	BY4741	14_1	
5	H	8	YNL283C	WSC2	STA3	Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication	response to heat, cell wall organization or biogenesis, signaling	signal transducer activity	vacuole, cellular bud, site of polarized growth, cytoplasm	1161	BY4741	14_1	
5	H	9	YNL281W	HCH1	-	Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress	response to heat, protein folding	enzyme regulator activity	nucleus, cytoplasm	1163	BY4741	14_1	
5	H	10	YNL280C	ERG24	delta(14)-sterol reductase	C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions	lipid metabolic process	oxidoreductase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1164	BY4741	14_1	
5	H	11	YNL278W	CAF120	-	Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication	transcription from RNA polymerase II promoter	molecular_function	cellular_component	1166	BY4741	14_1	
5	H	12	YNL096C	RPS7B	eS7|ribosomal 40S subunit protein S7B|S7e|rp30|S7B	Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	7379	BY4741	00_18	
6	A	1	YNL276C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W	biological_process	molecular_function	cellular_component	1168	BY4741	14_1	
6	A	2	YNL275W	BOR1	-	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1	protein targeting, ion transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	1169	BY4741	14_1	
6	A	3	YNL273W	TOF1	-	Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia	mitotic cell cycle, DNA repair, organelle fission, DNA replication, cellular response to DNA damage stimulus, chromosome segregation, regulation of DNA metabolic process, regulation of cell cycle	molecular_function	nucleus, chromosome, cytoplasm	1171	BY4741	14_1	
6	A	4	YNL271C	BNI1	formin BNI1|SHE5|PPF3	Formin; polarisome component; nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; functionally redundant with BNR1	mitotic cell cycle, cell budding, cytoskeleton organization, regulation of organelle organization, cytokinesis, protein complex biogenesis	other	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	1173	BY4741	14_1	
6	A	5	YNL270C	ALP1	arginine permease ALP1|APL1	Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication	ion transport, amino acid transport	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1174	BY4741	14_1	
6	A	7	YNL269W	BSC4	-	Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment	biological_process	molecular_function	cellular_component	1175	BY4741	14_1	
6	A	8	YNL268W	LYP1	lysine permease	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids	ion transport, amino acid transport	transmembrane transporter activity	membrane, mitochondrion, plasma membrane, cytoplasm	1176	BY4741	14_1	
6	A	9	YNL266W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C	biological_process	molecular_function	cellular_component	1178	BY4741	14_1	
6	A	10	YNL265C	IST1	-	Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p	endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, cytoplasm	1179	BY4741	14_1	
6	A	11	YNL264C	PDR17	phosphatidylinositol transporter|SFH4|ISS1	Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition	response to chemical, ion transport, Golgi vesicle transport, lipid metabolic process, lipid transport	other	cytoplasmic vesicle, endomembrane system, cytoplasm	1180	BY4741	14_1	
6	A	12	YNL259C	ATX1	copper metallochaperone ATX1	Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1	response to chemical, cellular ion homeostasis, ion transport, response to oxidative stress	ion binding	cytoplasm	1185	BY4741	14_1	
6	B	1	YNL257C	SIP3	LAM3	Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p	lipid transport, transcription from RNA polymerase II promoter	transcription factor activity, protein binding	cell cortex, endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1187	BY4741	14_1	
6	B	2	YNL255C	GIS2	mRNA-binding translational activator GIS2	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2	regulation of translation	RNA binding, DNA binding, mRNA binding	ribosome, cytoplasm	1189	BY4741	14_1	
6	B	3	YNL254C	RTC4	-	Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus, cytoplasm	1190	BY4741	14_1	
6	B	4	YNL253W	TEX1	-	Protein involved in mRNA export; component of the transcription export (TREX) complex	nucleobase-containing compound transport, nuclear transport	RNA binding, mRNA binding	nucleus	1191	BY4741	14_1	
6	B	5	YNL249C	MPA43	-	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	1195	BY4741	14_1	
6	B	6	YNL248C	RPA49	DNA-directed RNA polymerase I subunit RPA49|A49	RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p	transcription from RNA polymerase I promoter, DNA-templated transcription, elongation	transferase activity, nucleotidyltransferase activity	nucleus, nucleolus	1196	BY4741	14_1	
6	B	7	YNL246W	VPS75	-	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia	peptidyl-amino acid modification, DNA repair, protein acylation, chromatin organization, cellular response to DNA damage stimulus, histone modification, regulation of protein modification process	histone binding, enzyme regulator activity	nucleus, chromosome, cytoplasm	1198	BY4741	14_1	
6	B	8	YOR001W	RRP6	exosome nuclease subunit RRP6	Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based	RNA catabolic process, snoRNA processing, rRNA processing	nuclease activity, hydrolase activity	nucleus, nucleolus	1777	BY4741	15_1	
6	B	9	YOR002W	ALG6	dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase	Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant	generation of precursor metabolites and energy, cellular respiration, protein glycosylation, lipid metabolic process	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1778	BY4741	15_1	
6	B	10	YOR003W	YSP3	putative subtilisin-like protease YSP3	Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication	other	peptidase activity, hydrolase activity	endomembrane system, endoplasmic reticulum, cytoplasm	1779	BY4741	15_1	
6	B	11	YOR005C	DNL4	DNA ligase (ATP) DNL4|LIG4	DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome	DNA repair, cellular response to DNA damage stimulus	ligase activity	nucleus, chromosome	1781	BY4741	15_1	
6	B	12	YOR006C	TSR3	-	Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress	rRNA processing, ribosomal small subunit biogenesis	transferase activity	nucleus, cytoplasm	1782	BY4741	15_1	
6	C	1	YOR007C	SGT2	-	Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress	response to heat, protein targeting	structural molecule activity	cytoplasm	1783	BY4741	15_1	
6	C	2	YOR008C	SLG1	WSC1|HCS77	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response	response to heat, cytoskeleton organization, regulation of transport, cell wall organization or biogenesis, response to osmotic stress, endocytosis, signaling	signal transducer activity	vacuole, plasma membrane, endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm	1784	BY4741	15_1	
6	C	3	YOR009W	TIR4	-	Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	biological_process	molecular_function	cell wall, vacuole, cytoplasm	1785	BY4741	15_1	
6	C	4	YOR010C	TIR2	putative GPI-anchored mannoprotein|SRP2	Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication	other	molecular_function	cell wall, vacuole, cytoplasm	1786	BY4741	15_1	
6	C	5	YOR011W	AUS1	ATP-binding cassette sterol transporter AUS1	Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication	lipid transport	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, cytoplasm, plasma membrane	1787	BY4741	15_1	
6	C	6	YOR012W	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	1788	BY4741	15_1	
6	C	7	YOR013W	IRC11	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci	DNA recombination	molecular_function	cellular_component	1789	BY4741	15_1	
6	C	8	YOR014W	RTS1	protein phosphatase 2A regulatory subunit RTS1|SCS1	B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A	mitotic cell cycle, meiotic cell cycle, organelle fission, protein dephosphorylation, cytoskeleton organization, regulation of organelle organization, cytokinesis, chromosome segregation, regulation of cell cycle	enzyme regulator activity	nucleus, cytoskeleton, chromosome, microtubule organizing center, cellular bud, site of polarized growth, cytoplasm	1790	BY4741	15_1	
6	C	9	YOR015W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene	biological_process	molecular_function	cellular_component	1791	BY4741	15_1	
6	C	10	YOR016C	ERP4	-	Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication	Golgi vesicle transport	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1792	BY4741	15_1	
6	C	11	YOR017W	PET127	-	Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane	mitochondrion organization	molecular_function	mitochondrial envelope, mitochondrion, cytoplasm	1793	BY4741	15_1	
6	C	12	YOR018W	ROD1	ART4	Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication	response to chemical, regulation of transport, conjugation, signaling, endocytosis	enzyme binding	membrane, cytoplasm, plasma membrane	1794	BY4741	15_1	
6	D	1	YOR019W	-	-	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome duplication	mitochondrion organization	molecular_function	ribosome, cytoplasm	1795	BY4741	15_1	
6	D	2	YOR021C	SFM1	protein-arginine N-methyltransferase SFM1	SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism	peptidyl-amino acid modification, protein alkylation	transferase activity, methyltransferase activity	cellular_component	1797	BY4741	15_1	
6	D	3	YOR022C	DDL1	putative carboxylic ester hydrolase	DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism	lipid metabolic process	hydrolase activity	mitochondrion, cytoplasm	1798	BY4741	15_1	
6	D	4	YOR023C	AHC1	-	Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification	transferase activity	nucleus	1799	BY4741	15_1	
6	D	5	YOR024W	-	IRC12	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1800	BY4741	15_1	
6	D	6	YOR025W	HST3	NAD-dependent histone deacetylase HST3	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism	lipid metabolic process, chromatin organization, monocarboxylic acid metabolic process, histone modification	hydrolase activity	nucleus	1801	BY4741	15_1	
6	D	7	YOR026W	BUB3	PAC9	Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression	mitotic cell cycle, organelle fission, regulation of organelle organization, chromosome segregation, regulation of cell cycle	ubiquitin-like protein binding	nucleus, chromosome	1802	BY4741	15_1	
6	D	8	YOR027W	STI1	Hsp90 cochaperone STI1	Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop	protein targeting, protein folding, mitochondrion organization	RNA binding, mRNA binding, enzyme regulator activity	cytoplasm	1803	BY4741	15_1	
6	D	9	YOR028C	CIN5	YAP4|HAL6	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication	response to chemical, transcription from RNA polymerase II promoter, response to osmotic stress	DNA binding, transcription factor binding	nucleus, cytoplasm	1804	BY4741	15_1	
6	D	10	YOR029W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YOR029W is not an essential gene	biological_process	molecular_function	cellular_component	1805	BY4741	15_1	
6	D	11	YOR030W	DFG16	ZRG12|ECM41	Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p	pseudohyphal growth, protein maturation	molecular_function	membrane, plasma membrane	1806	BY4741	15_1	
6	D	12	YOR031W	membrane, plasma membrane	membrane, plasma membrane	membrane, plasma membrane	-	-	-	1807	BY4741	15_1	
6	E	1	YOR032C	HMS1	-	bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant	pseudohyphal growth	nucleic acid binding transcription factor activity	cellular_component	1808	BY4741	15_1	
6	E	2	YOR033C	EXO1	Rad2 family nuclease EXO1|DHS1	5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication	meiotic cell cycle, DNA repair, telomere organization, cellular response to DNA damage stimulus, DNA recombination	hydrolase activity, nuclease activity	nucleus, cytoplasm	1809	BY4741	15_1	
6	E	3	YOR034C	AKR2	putative palmitoyltransferase AKR2	Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication	protein acylation, protein lipidation	transferase activity	endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	1810	BY4741	15_1	
6	E	4	YOR035C	SHE4	DIM1	Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization	cytoskeleton organization	cytoskeletal protein binding	cytoplasm	1811	BY4741	15_1	
6	E	5	YOR036W	PEP12	SNAP receptor PEP12|VPT13|VPS6|VPL6	Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin	vacuole organization, protein targeting, Golgi vesicle transport, organelle inheritance	other	cytoplasmic vesicle, endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	1812	BY4741	15_1	
6	E	6	YOR037W	CYC2	oxidoreductase	Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)	mitochondrion organization, protein complex biogenesis	oxidoreductase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	1813	BY4741	15_1	
6	E	7	YOR038C	HIR2	SPT1	Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia	chromatin organization, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	chromatin binding, DNA binding, transcription factor activity, protein binding	nucleus, cytoplasm	1814	BY4741	15_1	
6	E	8	YOR039W	CKB2	casein kinase 2 regulatory subunit CKB2	Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase	transcription from RNA polymerase I promoter, peptidyl-amino acid modification, protein phosphorylation, transcription from RNA polymerase III promoter, cellular response to DNA damage stimulus	enzyme regulator activity	nucleus, nucleolus	1815	BY4741	15_1	
6	E	9	YOR040W	GLO4	hydroxyacylglutathione hydrolase GLO4	Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication	monocarboxylic acid metabolic process	hydrolase activity	mitochondrion, cytoplasm	1816	BY4741	15_1	
6	E	10	YOR041C	-	SRF5	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance	biological_process	molecular_function	cellular_component	1817	BY4741	15_1	
6	E	11	YOR042W	CUE5	ubiquitin-binding protein CUE5	Ubiquitin-binding protein; functions as ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; serves as proteaphagy receptor for inactivated 26S proteasomes; contains CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE5 has a paralog, DON1, that arose from the whole genome duplication; human TOLLIP is a functional CUE-domain homolog, can complement yeast null mutant, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q	proteolysis involved in cellular protein catabolic process	protein binding, bridging, ubiquitin-like protein binding	cytoplasm	1818	BY4741	15_1	
6	E	12	YOR043W	WHI2	-	Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery	response to heat, mitochondrion organization, cytoskeleton organization, response to osmotic stress, endocytosis	enzyme regulator activity	other	1819	BY4741	15_1	
6	F	1	YOR044W	IRC23	-	Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	1820	BY4741	15_1	
6	F	2	YOR045W	TOM6	MOM8B|ISP6	Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex	protein targeting, mitochondrion organization, transmembrane transport, protein complex biogenesis	protein transporter activity, transmembrane transporter activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1821	BY4741	15_1	
6	F	3	YOR047C	STD1	SFS3|MSN3	Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication	carbohydrate metabolic process, nucleobase-containing small molecule metabolic process, transcription from RNA polymerase II promoter, response to osmotic stress, signaling	enzyme regulator activity	nucleus, membrane, plasma membrane	1823	BY4741	15_1	
6	F	4	YOR049C	RSB1	phospholipid-translocating ATPase RSB1	Putative sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation	ion transport, lipid transport	hydrolase activity, ATPase activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1825	BY4741	15_1	
6	F	5	YOR050C	-	YOR29-01	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant is viable	biological_process	molecular_function	cellular_component	1826	BY4741	15_1	
6	F	6	YOR051C	ETT1	NRO1|YOR29-02	Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough	other	molecular_function	nucleus	1827	BY4741	15_1	
6	F	7	YOR052C	TMC1	YOR29-03	AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress	response to chemical	molecular_function	nucleus	1828	BY4741	15_1	
6	F	8	YOR053W	-	YOR29-04	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C	biological_process	molecular_function	cellular_component	1829	BY4741	15_1	
6	F	9	YOR054C	VHS3	phosphopantothenoylcysteine decarboxylase complex subunit VHS3|YOR29-05	Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p)	cofactor metabolic process, cellular ion homeostasis, nucleobase-containing small molecule metabolic process	lyase activity, enzyme regulator activity	cytoplasm	1830	BY4741	15_1	
6	F	10	YOR055W	-	YOR29-06	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1831	BY4741	15_1	
6	F	11	YOR058C	ASE1	YOR29-09	Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress	mitotic cell cycle, organelle fission, cytoskeleton organization, organelle assembly, chromosome segregation	cytoskeletal protein binding	nucleus, cytoskeleton, cytoplasm	1834	BY4741	15_1	
6	F	12	YOR059C	LPL1	putative hydrolase|YOR29-10	Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress	other	hydrolase activity	endomembrane system, endoplasmic reticulum, cytoplasm	1835	BY4741	15_1	
6	G	1	YOR061W	CKA2	casein kinase 2 catalytic subunit CKA2|YOR29-12	Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching	transcription from RNA polymerase I promoter, peptidyl-amino acid modification, protein phosphorylation, transcription from RNA polymerase III promoter, cellular response to DNA damage stimulus, response to osmotic stress	kinase activity, transferase activity	nucleus, nucleolus	1837	BY4741	15_1	
6	G	2	YOR062C	-	YOR29-13	Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	1838	BY4741	15_1	
6	G	3	YOR064C	YNG1	YOR29-15	Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	transferase activity, histone binding	nucleus	1840	BY4741	15_1	
6	G	4	YOR065W	CYT1	ubiquinol--cytochrome-c reductase catalytic subunit CYT1|YOR29-16|CTC1	Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1841	BY4741	15_1	
6	G	5	YOR066W	MSA1	YOR29-17	Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication	mitotic cell cycle	molecular_function	nucleus, cytoplasm	1842	BY4741	15_1	
6	G	6	YOR067C	ALG8	dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase|YOR29-18	Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant	protein glycosylation, lipid metabolic process	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1843	BY4741	15_1	
6	G	7	YOR068C	VAM10	YOR29-19	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering	vacuole organization, membrane fusion, organelle fusion	molecular_function	membrane, vacuole, cytoplasm	1844	BY4741	15_1	
6	G	8	YOR069W	VPS5	sorting nexin 1|YOR29-20|VPT5|PEP10|GRD2	Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication	endosomal transport	protein transporter activity, lipid binding, ion binding	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	1845	BY4741	15_1	
6	G	9	YOR070C	GYP1	YOR29-21	Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion	other	enzyme regulator activity	endomembrane system, mitochondrion, cytoplasm, Golgi apparatus	1846	BY4741	15_1	
6	G	10	YOR071C	NRT1	nicotinamide riboside transporter|THI71|YOR29-22	High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity	transmembrane transport, nucleobase-containing compound transport	transmembrane transporter activity	membrane, plasma membrane	1847	BY4741	15_1	
6	G	11	YOR072W	-	YOR29-23	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive	biological_process	molecular_function	cellular_component	1848	BY4741	15_1	
6	G	12	YOR073W	SGO1	YOR29-24	Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension	mitotic cell cycle, meiotic cell cycle, organelle fission, regulation of organelle organization, chromosome segregation, regulation of cell cycle	molecular_function	nucleus, cytoskeleton, microtubule organizing center, chromosome	1849	BY4741	15_1	
6	H	1	YOR076C	SKI7	YOR29-27	GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication	RNA catabolic process	protein binding, bridging, ion binding	cytoplasm	1852	BY4741	15_1	
6	H	3	YOR078W	BUD21	YOR29-29|UTP16	Component of small ribosomal subunit (SSU) processosome; this complex contains U3 snoRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern	rRNA processing, ribosomal small subunit biogenesis	RNA binding	nucleus, nucleolus	1854	BY4741	15_1	
6	H	4	YOR079C	ATX2	Mn(2+) transporter ATX2|YOR29-30	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation	cellular ion homeostasis	transmembrane transporter activity	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	1855	BY4741	15_1	
6	H	5	YOR080W	DIA2	DNA-binding SCF ubiquitin ligase subunit DIA2|YOR29-31	Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth	invasive growth in response to glucose limitation, chromatin organization, DNA replication, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal, regulation of DNA metabolic process	transferase activity, DNA binding	nucleus, chromosome	1856	BY4741	15_1	
6	H	6	YOR081C	TGL5	STC2	Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication	lipid metabolic process	transferase activity, hydrolase activity	other	1857	BY4741	15_1	
6	H	7	YOR082C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR083W	biological_process	molecular_function	membrane	1858	BY4741	15_1	
6	H	8	YOR083W	WHI5	transcriptional repressor WHI5	Repressor of G1 transcription; binds to SCB binding factor (SBF) at SCB target promoters in early G1; dilution of Whi5p concentration during cell growth determines cell size; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5, and contributes to both the determination of critical cell size at START and cell fate; periodically expressed in G1	mitotic cell cycle	transcription factor activity, protein binding	nucleus, cytoplasm	1859	BY4741	15_1	
6	H	9	YOR084W	LPX1	triglyceride lipase	Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible	lipid metabolic process, peroxisome organization	hydrolase activity	peroxisome, cytoplasm	1860	BY4741	15_1	
6	H	10	YOR085W	OST3	dolichyl-diphosphooligosaccharide--protein glycotransferase OST3	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins	protein complex biogenesis, protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1861	BY4741	15_1	
6	H	11	YOR086C	TCB1	tricalbin	Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication	lipid metabolic process	lipid binding	cell cortex, endomembrane system, mitochondrion, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1862	BY4741	15_1	
6	H	12	YOR087W	YVC1	TRPY1|YOR088W	Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock	cellular ion homeostasis	transmembrane transporter activity	membrane, vacuole, cytoplasm	1863	BY4741	15_1	
7	A	1	YOR088W	membrane, vacuole, cytoplasm	membrane, vacuole, cytoplasm	membrane, vacuole, cytoplasm	-	-	-	1864	BY4741	15_1	
7	A	2	YOR089C	VPS21	Rab family GTPase VPS21|YPT51|YPT21|VPT12|VPS12	Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication	vacuole organization, Golgi vesicle transport, protein targeting, organelle assembly, vesicle organization, endosomal transport, organelle inheritance, endocytosis	GTPase activity, hydrolase activity	mitochondrion, cytoplasmic vesicle, endomembrane system, membrane, mitochondrial envelope, cytoplasm	1865	BY4741	15_1	
7	A	3	YOR090C	PTC5	type 2C protein phosphatase PTC5|PPP1	Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p	protein dephosphorylation	phosphatase activity, hydrolase activity	mitochondrial envelope, mitochondrion, cytoplasm	1866	BY4741	15_1	
7	A	4	YOR091W	TMA46	RBF46	Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p	cytoplasmic translation	RNA binding, mRNA binding	ribosome, cytoplasm	1867	BY4741	15_1	
7	A	5	YOR092W	ECM3	putative ATPase ECM3|YOR3165W	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication	biological_process	ATPase activity, hydrolase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1868	BY4741	15_1	
7	A	6	YOR093C	CMR2	-	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents	biological_process	molecular_function	cellular bud, membrane, site of polarized growth, cytoplasm	1869	BY4741	15_1	
7	A	8	YOR094W	ARF3	Arf family GTPase ARF3|ARL2	Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6	mitotic cell cycle, cytoskeleton organization, cytokinesis, lipid metabolic process, endocytosis	RNA binding, GTPase activity, hydrolase activity, enzyme regulator activity, mRNA binding	cellular bud, site of polarized growth, cytoplasm	1870	BY4741	15_1	
7	A	9	YOR289W	-	-	Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus, cytoplasm	1585	BY4741	15_4	
7	A	10	YOR290C	SNF2	SWI/SNF catalytic subunit SNF2|TYE3|SWI2|HAF1|GAM1	Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p	chromatin organization, DNA replication, DNA recombination, transcription from RNA polymerase II promoter, DNA repair, carbohydrate metabolic process, invasive growth in response to glucose limitation, cellular response to DNA damage stimulus, response to starvation, oligosaccharide metabolic process	chromatin binding, hydrolase activity, histone binding, DNA binding, ATPase activity, transcription factor binding	nucleus	1586	BY4741	15_4	
7	A	11	YOR291W	YPK9	putative acid anhydride hydrolase	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome	biological_process	molecular_function	membrane, vacuole, cytoplasm	1587	BY4741	15_4	
7	A	12	YOR292C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene	biological_process	molecular_function	membrane, vacuole, cytoplasm	1588	BY4741	15_4	
7	B	1	YOR293W	RPS10A	eS10|ribosomal 40S subunit protein S10A|S10e|S10A	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia	cytoplasmic translation, nucleobase-containing compound transport, nuclear transport	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1589	BY4741	15_4	
7	B	2	YOR295W	UAF30	-	Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication	transcription from RNA polymerase I promoter, chromatin organization	nucleic acid binding transcription factor activity, DNA binding	nucleus, nucleolus	1591	BY4741	15_4	
7	B	3	YOR296W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene	biological_process	molecular_function	cytoplasm	1592	BY4741	15_4	
7	B	4	YOR297C	TIM18	-	Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex	response to chemical, protein targeting, mitochondrion organization, transmembrane transport, response to oxidative stress, response to osmotic stress	protein transporter activity, transmembrane transporter activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1593	BY4741	15_4	
7	B	5	YOR298W	MUM3	-	Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases	meiotic cell cycle, lipid metabolic process, sporulation, cell wall organization or biogenesis	transferase activity	cellular_component	1594	BY4741	15_4	
7	B	6	YOR299W	BUD7	exomer complex subunit	Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication	mitotic cell cycle, carbohydrate metabolic process, cytokinesis, Golgi vesicle transport, cell wall organization or biogenesis	molecular_function	cytoplasmic vesicle, endomembrane system, Golgi apparatus, cytoplasm	1595	BY4741	15_4	
7	B	7	YOR301W	RAX1	-	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily	mitotic cell cycle, cytokinesis	molecular_function	vacuole, cellular bud, membrane, site of polarized growth, cytoplasm	1597	BY4741	15_4	
7	B	8	YOR302W	-	-	CPA1 uORF; Arginine attenuator peptide, regulates translation of the CPA1 mRNA	regulation of translation	other	cytoplasm	1598	BY4741	15_4	
7	B	9	YOR303W	CPA1	carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1	Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader	cellular amino acid metabolic process	ligase activity	cytoplasm	1599	BY4741	15_4	
7	B	10	YOR304C-A	BIL1	EDO1	Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck	cytoskeleton organization	molecular_function	cellular bud, site of polarized growth, cytoplasm	1600	BY4741	15_4	
7	B	11	YOR304W	ISW2	DNA translocase	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide	response to chemical, chromatin organization, DNA-templated transcription, termination, transcription from RNA polymerase II promoter	chromatin binding, hydrolase activity, DNA binding, ATPase activity	nucleus	1601	BY4741	15_4	
7	B	12	YOR305W	RRG7	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene	biological_process	molecular_function	mitochondrion, cytoplasm	1602	BY4741	15_4	
7	C	1	YOR307C	SLY41	-	Protein involved in ER-to-Golgi transport	Golgi vesicle transport	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1604	BY4741	15_4	
7	C	2	YOR308C	SNU66	U4/U6-U5 snRNP complex subunit SNU66	Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1	RNA splicing, rRNA processing, mRNA processing	molecular_function	nucleus	1605	BY4741	15_4	
7	C	3	YOR311C	DGK1	diacylglycerol kinase|HSD1	Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain	lipid metabolic process	kinase activity, transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1608	BY4741	15_4	
7	C	4	YOR312C	RPL20B	eL20|ribosomal 60S subunit protein L20B|L20e|L20B|L18B|RPL18A1	Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1609	BY4741	15_4	
7	C	5	YOR313C	SPS4	-	Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage	meiotic cell cycle, sporulation	molecular_function	other	1610	BY4741	15_4	
7	C	6	YOR314W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1611	BY4741	15_4	
7	C	7	YOR315W	SFG1	-	Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate	mitotic cell cycle, pseudohyphal growth	molecular_function	nucleus, cytoplasm	1612	BY4741	15_4	
7	C	8	YOR316C	COT1	metal cation transporter COT1	Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication	cellular ion homeostasis, ion transport	transmembrane transporter activity	membrane, vacuole, mitochondrion, cytoplasm	1613	BY4741	15_4	
7	C	9	YOR318C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo	biological_process	molecular_function	cellular_component	1615	BY4741	15_4	
7	C	10	YOR320C	GNT1	glucose N-acetyltransferase	N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, cytoplasm, Golgi apparatus	1617	BY4741	15_4	
7	C	11	YOR321W	PMT3	dolichyl-phosphate-mannose-protein mannosyltransferase PMT3	Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1618	BY4741	15_4	
7	C	12	YOR322C	LDB19	ART1	Alpha-arrestin involved in ubiquitin-dependent endocytosis; regulates endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its targets; involved in the basal internalization and turnover of alpha-factor receptor Ste2p; recruits ubiquitin ligase Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane	regulation of transport, endocytosis	enzyme binding	cytoplasmic vesicle, endomembrane system, membrane, Golgi apparatus, cytoplasm, plasma membrane	1619	BY4741	15_4	
7	D	1	YOR323C	PRO2	glutamate-5-semialdehyde dehydrogenase	Gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis	cellular amino acid metabolic process	oxidoreductase activity	nucleus, cytoplasm	1620	BY4741	15_4	
7	D	2	YOR324C	FRT1	HPH1	Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication	response to osmotic stress	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	1621	BY4741	15_4	
7	D	3	YOR327C	SNC2	SNAP receptor SNC2	Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication	organelle fusion, vesicle organization, membrane fusion, Golgi vesicle transport, exocytosis, endocytosis	other	cytoplasmic vesicle, endomembrane system, cellular bud, membrane, Golgi apparatus, cytoplasm	1624	BY4741	15_4	
7	D	4	YOR328W	PDR10	ATP-binding cassette multidrug transporter PDR10	ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p	response to chemical, transmembrane transport	hydrolase activity, transmembrane transporter activity, ATPase activity	vacuole, membrane, cytoplasm, plasma membrane	1625	BY4741	15_4	
7	D	5	YOR330C	MIP1	DNA-directed DNA polymerase gamma MIP1	Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases	DNA replication, mitochondrion organization	transferase activity, nucleotidyltransferase activity, hydrolase activity, nuclease activity	mitochondrion, cytoplasm	1627	BY4741	15_4	
7	D	6	YOR332W	VMA4	H(+)-transporting V1 sector ATPase subunit E	Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress	cellular ion homeostasis	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, vacuole, cytoplasm	1629	BY4741	15_4	
7	D	7	YOR334W	MRS2	-	Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA	ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	1631	BY4741	15_4	
7	D	8	YOR337W	TEA1	-	Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	other	DNA binding	nucleus, cell cortex, cytoplasm	1634	BY4741	15_4	
7	D	9	YOR338W	-	-	Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication	meiotic cell cycle, sporulation, transcription from RNA polymerase II promoter	molecular_function	cellular_component	1635	BY4741	15_4	
7	D	10	YOR339C	UBC11	putative E2 ubiquitin-protein ligase UBC11	Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2	protein modification by small protein conjugation or removal	transferase activity	cytoplasm	1636	BY4741	15_4	
7	D	11	YOR342C	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	1639	BY4741	15_4	
7	D	12	YOR343C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1640	BY4741	15_4	
7	E	1	YOR344C	TYE7	SGC1	Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix	carbohydrate metabolic process, cofactor metabolic process, nucleobase-containing small molecule metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus, chromosome	1641	BY4741	15_4	
7	E	2	YOR346W	REV1	deoxycytidyl transferase	Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress	DNA repair, cellular response to DNA damage stimulus	transferase activity, nucleotidyltransferase activity	nucleus, chromosome, mitochondrion, cytoplasm	1643	BY4741	15_4	
7	E	3	YOR347C	PYK2	pyruvate kinase PYK2	Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication	monocarboxylic acid metabolic process	transferase activity	mitochondrion, cytoplasm	1644	BY4741	15_4	
7	E	4	YOR348C	PUT4	proline permease PUT4	Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells	ion transport, amino acid transport	transmembrane transporter activity	membrane, plasma membrane	1645	BY4741	15_4	
7	E	5	YOR349W	CIN1	-	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl	protein folding, protein complex biogenesis	cytoskeletal protein binding	cellular_component	1646	BY4741	15_4	
7	E	6	YOR350C	MNE1	-	Protein involved in splicing Group I aI5-beta intron from COX1 mRNA; mitochondrial matrix protein	RNA splicing	molecular_function	mitochondrion, cytoplasm	1647	BY4741	15_4	
7	E	7	YOR351C	MEK1	serine/threonine protein kinase MEK1|MRE4	Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis	meiotic cell cycle, protein phosphorylation, organelle fission, regulation of organelle organization, regulation of cell cycle	kinase activity, transferase activity	nucleus	1648	BY4741	15_4	
7	E	8	YOR352W	TFB6	TFIIH complex subunit TFB6	Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus, cytoplasm	1649	BY4741	15_4	
7	E	9	YOR354C	MSC6	-	Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids	meiotic cell cycle, organelle fission, DNA recombination	RNA binding, mRNA binding	mitochondrion, cytoplasm	1651	BY4741	15_4	
7	E	10	YOR355W	GDS1	-	Protein of unknown function; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	generation of precursor metabolites and energy, cellular respiration	molecular_function	nucleus, mitochondrion, cytoplasm	1652	BY4741	15_4	
7	E	11	YOR356W	CIR2	putative electron-transferring-flavoprotein dehydrogenase	Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase	biological_process	molecular_function	mitochondrion, cytoplasm	1653	BY4741	15_4	
7	E	12	YOR357C	SNX3	GRD19	Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p	Golgi vesicle transport, endosomal transport	lipid binding, ion binding	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	1654	BY4741	15_4	
7	F	1	YOR358W	HAP5	-	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex	response to chemical, transcription from RNA polymerase II promoter, generation of precursor metabolites and energy, cellular respiration	nucleic acid binding transcription factor activity, DNA binding	nucleus	1655	BY4741	15_4	
7	F	2	YOR359W	VTS1	-	Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity	RNA catabolic process, regulation of DNA metabolic process	RNA binding, DNA binding	nucleus, cytoplasm	1656	BY4741	15_4	
7	F	3	YOR360C	PDE2	3',5'-cyclic-nucleotide phosphodiesterase PDE2|SRA5	High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon	signaling	hydrolase activity	nucleus, cytoplasm	1657	BY4741	15_4	
7	F	4	YOR363C	PIP2	oleate-activated transcription factor PIP2|OAF2	Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication	response to chemical, lipid metabolic process, transcription from RNA polymerase II promoter, monocarboxylic acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus, membrane	1660	BY4741	15_4	
7	F	5	YOR365C	-	putative flavin adenine dinucleotide transporter	Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication	lipid metabolic process, biological_process	molecular_function	membrane	1662	BY4741	15_4	
7	F	6	YOR367W	SCP1	-	Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin	cytoskeleton organization	protein binding, bridging, cytoskeletal protein binding	cell cortex, cytoskeleton, cytoplasm	1664	BY4741	15_4	
7	F	7	YOR368W	RAD17	-	Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins	meiotic cell cycle, DNA repair, organelle fission, DNA recombination, cellular response to DNA damage stimulus, regulation of cell cycle	DNA binding	nucleus, chromosome	1665	BY4741	15_4	
7	F	8	YOR371C	GPB1	KRH2	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication	response to chemical, invasive growth in response to glucose limitation, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal, pseudohyphal growth, signaling	enzyme regulator activity, signal transducer activity	membrane, cytoplasm, plasma membrane	1668	BY4741	15_4	
7	F	9	YOR374W	ALD4	aldehyde dehydrogenase (NADP(+)) ALD4|ALDH2|ALD7	Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant	cofactor metabolic process, nucleobase-containing small molecule metabolic process, monocarboxylic acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	1671	BY4741	15_4	
7	F	10	YOR375C	GDH1	glutamate dehydrogenase (NADP(+)) GDH1|DHE4|GDHA|GDH-A|URE1	NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication	cellular amino acid metabolic process	oxidoreductase activity	nucleus, cytoplasm	1672	BY4741	15_4	
7	F	11	YOR376W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YOR376W is not an essential gene	biological_process	molecular_function	membrane	1673	BY4741	15_4	
7	F	12	YOR377W	ATF1	alcohol O-acetyltransferase	Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism	generation of precursor metabolites and energy	transferase activity	endomembrane system, endoplasmic reticulum, cytoplasm	1674	BY4741	15_4	
7	G	1	YOR378W	AMF1	-	Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene	ion transport	transmembrane transporter activity	membrane, plasma membrane	1675	BY4741	15_4	
7	G	2	YOR380W	RDR1	-	Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	response to chemical	nucleic acid binding transcription factor activity, DNA binding	nucleus	1677	BY4741	15_4	
7	G	3	YOR381W	FRE3	ferric-chelate reductase	Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels	cellular ion homeostasis	oxidoreductase activity	membrane, vacuole, plasma membrane, cytoplasm	1678	BY4741	15_4	
7	G	4	YOR382W	FIT2	-	Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall 	other	molecular_function	cell wall, vacuole, cytoplasm	1679	BY4741	15_4	
7	G	5	YOR383C	FIT3	-	Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall 	other	molecular_function	cell wall, vacuole, cytoplasm	1680	BY4741	15_4	
7	G	6	YOR384W	FRE5	putative ferric-chelate reductase	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	oxidoreductase activity	membrane, mitochondrion, cytoplasm	1681	BY4741	15_5	
7	G	7	YOR385W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene	biological_process	molecular_function	cytoplasm	1682	BY4741	15_5	
7	G	8	YOR386W	PHR1	deoxyribodipyrimidine photo-lyase PHR1	DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p	DNA repair, cellular response to DNA damage stimulus	RNA binding, lyase activity, mRNA binding	nucleus, mitochondrion, cytoplasm	1683	BY4741	15_5	
7	G	9	YOL001W	PHO80	phoR|VAC5|TUP7|AGS3	Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling	vacuole organization, protein phosphorylation, organelle fusion, membrane fusion, cellular ion homeostasis, regulation of protein modification process, transcription from RNA polymerase II promoter, signaling, regulation of cell cycle	enzyme regulator activity	nucleus	1692	BY4741	15_5	
7	G	10	YOL002C	IZH2	PAQR-type receptor|PHO36	Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor	response to chemical, cellular ion homeostasis, transcription from RNA polymerase II promoter	other	vacuole, membrane, cytoplasm, plasma membrane	1693	BY4741	15_5	
7	G	11	YOL003C	PFA4	palmitoyltransferase PFA4	Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases	protein acylation, protein lipidation	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1694	BY4741	15_5	
7	G	12	YOL004W	SIN3	transcriptional regulator SIN3|UME4|SDS16|SDI1|RPD1|GAM2|CPE1	Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity	transcription from RNA polymerase I promoter, response to heat, mitotic cell cycle, meiotic cell cycle, DNA repair, chromatin organization, DNA replication, cellular response to DNA damage stimulus, histone modification, regulation of DNA metabolic process, transcription from RNA polymerase II promoter	transcription factor activity, protein binding	nucleus, chromosome	1695	BY4741	15_5	
7	H	1	YOL006C	TOP1	DNA topoisomerase 1|MAK17|MAK1	Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation	mitotic cell cycle, organelle fission, chromatin organization, DNA replication, chromosome segregation, DNA recombination, regulation of DNA metabolic process, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	isomerase activity	nucleus, chromosome, nucleolus	1697	BY4741	15_5	
7	H	3	YOL007C	CSI2	-	Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene	biological_process	molecular_function	cellular bud, site of polarized growth, vacuole, cytoplasm	1698	BY4741	15_5	
7	H	4	YOL008W	COQ10	ubiquinone-binding protein COQ10	Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A	cofactor metabolic process, generation of precursor metabolites and energy, cellular respiration	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1699	BY4741	15_5	
7	H	5	YOL009C	MDM12	ERMES complex subunit MDM12	Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase	mitochondrion organization, ion transport, protein complex biogenesis, lipid transport, organelle inheritance	molecular_function	nucleus, endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm, plasma membrane	1700	BY4741	15_5	
7	H	6	YOL011W	PLB3	lysophospholipase	Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication	lipid metabolic process	hydrolase activity	membrane, extracellular region, vacuole, plasma membrane, cytoplasm	1702	BY4741	15_5	
7	H	7	YOL012C	HTZ1	histone H2AZ|H2AZ|H2A.F/Z|HTA3	Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling	RNA catabolic process, chromatin organization, transcription from RNA polymerase II promoter	chromatin binding	nucleus, chromosome	1703	BY4741	15_5	
7	H	8	YOL013C	HRD1	E3 ubiquitin-protein ligase HRD1|DER3	Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon	response to chemical, proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal, cell wall organization or biogenesis, signaling	transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1704	BY4741	15_5	
7	H	9	YOL014W	-	-	Putative protein of unknown function; mCherry fusion protein localizes to the cytosol and nucleus	biological_process	molecular_function	cellular_component	1705	BY4741	15_5	
7	H	10	YOL015W	IRC10	-	Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	membrane	1706	BY4741	15_5	
7	H	11	YOL017W	ESC8	-	Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication	chromatin organization, chromosome segregation	molecular_function	nucleus	1708	BY4741	15_5	
7	H	12	YOL018C	TLG2	-	Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)	protein targeting, organelle fusion, vesicle organization, membrane fusion, Golgi vesicle transport, lipid metabolic process, endocytosis	other	cytoplasmic vesicle, endomembrane system, membrane, Golgi apparatus, cytoplasm	1709	BY4741	15_5	
8	A	1	YOL019W	-	TOS7	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication	biological_process	molecular_function	membrane, vacuole, plasma membrane, cytoplasm	1710	BY4741	15_5	
8	A	2	YOL020W	TAT2	aromatic amino acid transmembrane transporter TAT2|TAP2|SCM2|SAB2|LTG3	High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance	ion transport, amino acid transport	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1711	BY4741	15_5	
8	A	3	YOL023W	IFM1	translation initiation factor 2	Mitochondrial translation initiation factor 2	translational initiation, mitochondrial translation, mitochondrion organization	RNA binding, GTPase activity, hydrolase activity, translation factor activity, RNA binding	nucleus, mitochondrion, cytoplasm	1714	BY4741	15_5	
8	A	4	YOL024W	-	-	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	1715	BY4741	15_5	
8	A	5	YOL025W	LAG2	ECM36	Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1	regulation of protein modification process, protein modification by small protein conjugation or removal	molecular_function	mitochondrion, cytoplasm	1716	BY4741	15_5	
8	A	6	YOL027C	MDM38	ribosome-binding protein MDM38|MKH1	Mitochondrial protein; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, ion transport, protein complex biogenesis, cellular ion homeostasis	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1718	BY4741	15_5	
8	A	7	YOL028C	YAP7	-	Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication	transcription from RNA polymerase II promoter	DNA binding	nucleus	1719	BY4741	15_5	
8	A	9	YOL029C	-	-	Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens	biological_process	molecular_function	cellular_component	1720	BY4741	15_5	
8	A	10	YOL030W	GAS5	1,3-beta-glucanosyltransferase	1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall	carbohydrate metabolic process	transferase activity	cell wall, membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1721	BY4741	15_5	
8	A	11	YOL031C	SIL1	SLS1	Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein	protein targeting, transmembrane transport	enzyme regulator activity	endomembrane system, endoplasmic reticulum, cytoplasm	1722	BY4741	15_5	
8	A	12	YOL032W	OPI10	-	Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress	carbohydrate metabolic process	molecular_function	nucleus, cytoplasm	1723	BY4741	15_5	
8	B	1	YOL033W	MSE1	glutamate--tRNA ligase MSE1	Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated	mitochondrial translation, tRNA aminoacylation for protein translation, mitochondrion organization, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	1724	BY4741	15_5	
8	B	2	YOL035C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1726	BY4741	15_5	
8	B	3	YOL036W	-	-	Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	1727	BY4741	15_5	
8	B	4	YOL037C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W	biological_process	molecular_function	cellular_component	1728	BY4741	15_5	
8	B	5	YOL039W	RPP2A	P2A|ribosomal protein P2A|RPLA2|RPL44	Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	cytoplasmic translation	structural molecule activity, structural constituent of ribosome, enzyme regulator activity	ribosome, cytoplasm	1730	BY4741	15_5	
8	B	6	YOL041C	NOP12	-	Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p	rRNA processing, ribosomal large subunit biogenesis	RNA binding	nucleus, nucleolus	1732	BY4741	15_5	
8	B	7	YOL042W	NGL1	RNA exonuclease	Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	nuclease activity, hydrolase activity	mitochondrion, cytoplasm	1733	BY4741	15_5	
8	B	8	YOL043C	NTG2	bifunctional N-glycosylase/AP lyase NTG2|SCR2	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication	DNA repair, cellular response to DNA damage stimulus	lyase activity, nuclease activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds	nucleus	1734	BY4741	15_5	
8	B	9	YOL044W	PEX15	PAS21	Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly	protein targeting, transmembrane transport, peroxisome organization, signaling	other	peroxisome, membrane, cytoplasm	1735	BY4741	15_5	
8	B	10	YOL045W	PSK2	serine/threonine protein kinase PSK2	PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication	cytoplasmic translation, carbohydrate metabolic process, regulation of translation, protein phosphorylation, generation of precursor metabolites and energy	kinase activity, transferase activity	mitochondrion, cytoplasm	1736	BY4741	15_5	
8	B	11	YOL046C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene PSK2/YOL045W	biological_process	molecular_function	cellular_component	1737	BY4741	15_5	
8	B	12	YOL047C	LDS2	-	Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	cell wall, membrane, cytoplasm	1738	BY4741	15_5	
8	C	1	YOL048C	RRT8	-	Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	cell wall, membrane	1739	BY4741	15_5	
8	C	2	YOL049W	GSH2	glutathione synthase	Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock	other	ligase activity	other	1740	BY4741	15_5	
8	C	3	YOL050C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)	biological_process	molecular_function	cellular_component	1741	BY4741	15_5	
8	C	4	YOL051W	GAL11	MED15|ABE1|SPT13|SDS4|RAR3	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator	invasive growth in response to glucose limitation, DNA-templated transcription, initiation, transcription from RNA polymerase II promoter	transcription factor activity, protein binding, transcription factor binding	nucleus	1742	BY4741	15_5	
8	C	5	YOL052C	SPE2	adenosylmethionine decarboxylase SPE2	S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically	cofactor metabolic process, vitamin metabolic process, monocarboxylic acid metabolic process	lyase activity	nucleus, cytoplasm	1743	BY4741	15_5	
8	C	6	YOL053C-A	nucleus, cytoplasm	nucleus, cytoplasm	nucleus, cytoplasm	-	-	-	1744	BY4741	15_5	
8	C	7	YOL053W	AIM39	-	Protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion, cytoplasm	1745	BY4741	15_5	
8	C	8	YOL054W	PSH1	ubiquitin-protein ligase PSH1	E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p, preventing its mislocalization to euchromatin independent of Slx5p; ubiquitination of Cse4p may be antagonized by Scm3p	protein modification by small protein conjugation or removal, proteolysis involved in cellular protein catabolic process	transferase activity	nucleus, chromosome	1746	BY4741	15_5	
8	C	9	YOL055C	THI20	trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase	Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p	vitamin metabolic process	kinase activity, transferase activity, hydrolase activity	cytoplasm	1747	BY4741	15_5	
8	C	10	YOL056W	GPM3	phosphoglycerate mutase family protein GPM3	Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM3 has a paralog, GPM2, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm	1748	BY4741	15_5	
8	C	11	YOL057W	-	dipeptidyl-peptidase III	Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers	other	peptidase activity, hydrolase activity	nucleus, cytoplasm	1749	BY4741	15_5	
8	C	12	YOL058W	ARG1	argininosuccinate synthase|ARG10	Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate	cellular amino acid metabolic process	ligase activity	cytoplasm	1750	BY4741	15_5	
8	D	1	YOL059W	GPD2	glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2|GPD3	NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication	carbohydrate metabolic process, cofactor metabolic process, nucleobase-containing small molecule metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	1751	BY4741	15_5	
8	D	2	YOL060C	MAM3	-	Protein required for normal mitochondrial morphology; has similarity to hemolysins	mitochondrion organization, cellular ion homeostasis	molecular_function	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	1752	BY4741	15_5	
8	D	3	YOL061W	PRS5	ribose phosphate diphosphokinase subunit PRS5	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress	cell wall organization or biogenesis	transferase activity	cytoplasm	1753	BY4741	15_5	
8	D	4	YOL062C	APM4	AMP1	Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals	other	other	membrane, cytoplasmic vesicle, endomembrane system, plasma membrane, cytoplasm	1754	BY4741	15_5	
8	D	5	YOL063C	CRT10	HUS1	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat	transcription from RNA polymerase II promoter	molecular_function	cellular_component	1755	BY4741	15_5	
8	D	6	YOL064C	MET22	3'(2'),5'-bisphosphate nucleotidase|HAL2	Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant	response to osmotic stress, cellular amino acid metabolic process	phosphatase activity, hydrolase activity	cellular_component	1756	BY4741	15_5	
8	D	7	YOL065C	INP54	phosphoinositide 5-phosphatase INP54	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins	lipid metabolic process	phosphatase activity, hydrolase activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	1757	BY4741	15_5	
8	D	8	YOL067C	RTG1	-	Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization	response to chemical, transcription from RNA polymerase II promoter, signaling	nucleic acid binding transcription factor activity	nucleus, cytoplasm	1759	BY4741	15_5	
8	D	9	YOL068C	HST1	histone deacetylase HST1	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication	chromatin organization, DNA recombination, regulation of DNA metabolic process, histone modification	hydrolase activity	nucleus, chromosome	1760	BY4741	15_5	
8	D	10	YOL070C	NBA1	-	Protein of unknown function; localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate	biological_process	molecular_function	cellular bud, site of polarized growth, ribosome, cytoplasm	1762	BY4741	15_5	
8	D	11	YOL071W	SDH5	EMI5|succinate dehydrogenase assembly factor SDH5	Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)	meiotic cell cycle, sporulation, mitochondrion organization, generation of precursor metabolites and energy, protein complex biogenesis, cellular respiration, transcription from RNA polymerase II promoter	molecular_function	mitochondrion, cytoplasm	1763	BY4741	15_5	
8	D	12	YOL072W	THP1	BUD29	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding	mitotic cell cycle, DNA repair, cytokinesis, cellular response to DNA damage stimulus, nucleobase-containing compound transport, RNA catabolic process, mRNA processing, transcription from RNA polymerase II promoter, nuclear transport, DNA-templated transcription, elongation	RNA binding, DNA binding	nucleus, endomembrane system	1764	BY4741	15_5	
8	E	1	YOL075C	-	-	Putative ABC transporter	other	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, vacuole, cytoplasm	1766	BY4741	15_5	
8	E	2	YOL076W	MDM20	NAA25|DEC1	Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly	peptidyl-amino acid modification, protein acylation, organelle inheritance, mitochondrion organization, cytoskeleton organization, regulation of organelle organization	transferase activity	cytoplasm	1767	BY4741	15_5	
8	E	3	YOL079W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	membrane	1770	BY4741	15_5	
8	E	4	YOL080C	REX4	putative 3'-5' exonuclease	Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly	ribosome assembly, rRNA processing, organelle assembly, ribosomal large subunit biogenesis	nuclease activity, hydrolase activity	nucleus, nucleolus	1771	BY4741	15_5	
8	E	5	YOL081W	IRA2	Ras GTPase activating protein IRA2|GLC4|CCS1	GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis	response to chemical, response to oxidative stress, nucleobase-containing small molecule metabolic process, signaling	enzyme regulator activity	endomembrane system, mitochondrion, membrane, endoplasmic reticulum, cytoplasm	1772	BY4741	15_5	
8	E	6	YOL082W	ATG19	CVT19	Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p	response to chemical, protein targeting, vesicle organization, proteolysis involved in cellular protein catabolic process, protein maturation	protein binding, bridging	membrane, cytoplasm	1773	BY4741	15_5	
8	E	7	YOL083W	ATG34	ATG19-B	Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog	protein targeting, protein complex biogenesis	protein binding, bridging	cytoplasm	1774	BY4741	15_5	
8	E	8	YOL084W	PHM7	-	Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	1775	BY4741	15_5	
8	E	9	YOL085C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A	biological_process	molecular_function	cellular_component	1776	BY4741	15_5	
8	E	10	YPL274W	SAM3	bifunctional polyamine/amino acid permease SAM3	High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p	ion transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	1018	BY4741	16_1	
8	E	11	YPL273W	SAM4	S-adenosylmethionine-homocysteine S-methyltransferase SAM4	S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process, cellular amino acid metabolic process	transferase activity, methyltransferase activity	nucleus, cytoplasm	1019	BY4741	16_1	
8	E	12	YPL272C	PBI1	-	Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene	biological_process	molecular_function	cellular_component	1020	BY4741	16_1	
8	F	1	YPL271W	ATP15	F1F0 ATP synthase subunit epsilon|ATPEPSILON	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated	transmembrane transport, ion transport, nucleobase-containing small molecule metabolic process	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1021	BY4741	16_1	
8	F	2	YPL270W	MDL2	ATP-binding cassette permease MDL2	Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis	response to chemical, transmembrane transport, response to oxidative stress	hydrolase activity, transmembrane transporter activity, ATPase activity	vacuole, mitochondrion, membrane, mitochondrial envelope, cytoplasm	1022	BY4741	16_1	
8	F	3	YPL269W	KAR9	-	Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli	mitotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, chromosome segregation, regulation of cell cycle	molecular_function	nucleus, cell cortex, cytoskeleton, microtubule organizing center, chromosome, site of polarized growth, cytoplasm	1023	BY4741	16_1	
8	F	4	YPL267W	ACM1	-	Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C	mitotic cell cycle, regulation of protein modification process, protein modification by small protein conjugation or removal	enzyme regulator activity	nucleus, cytoplasm	1025	BY4741	16_1	
8	F	5	YPL265W	DIP5	-	Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress	ion transport, amino acid transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	1027	BY4741	16_1	
8	F	6	YPL264C	-	-	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene	biological_process	molecular_function	membrane	1028	BY4741	16_1	
8	F	7	YPL263C	KEL3	-	Cytoplasmic protein of unknown function	biological_process	molecular_function	cytoplasm	1029	BY4741	16_1	
8	F	8	YPL262W	FUM1	fumarase FUM1	Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria	generation of precursor metabolites and energy, cellular respiration	lyase activity	mitochondrion, cytoplasm	1030	BY4741	16_1	
8	F	9	YPL260W	CUB1	-	Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	1031	BY4741	16_1	
8	F	10	YPL261C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W	biological_process	molecular_function	cellular_component	1032	BY4741	16_1	
8	F	11	YPL259C	APM1	YAP54	Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex	Golgi vesicle transport	other	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	1033	BY4741	16_1	
8	F	12	YPL258C	THI21	bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase	Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p	vitamin metabolic process	kinase activity, transferase activity	cellular_component	1034	BY4741	16_1	
8	G	1	YPL257W	-	-	Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene	biological_process	molecular_function	membrane	1035	BY4741	16_1	
8	G	2	YPL256C	CLN2	cyclin CLN2	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1	response to chemical, protein phosphorylation, regulation of protein modification process, conjugation, signaling, regulation of cell cycle	enzyme regulator activity	nucleus, cytoplasm	1036	BY4741	16_1	
8	G	3	YPL254W	HFI1	GAN1|SRM12|SUP110|ADA1	Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions	peptidyl-amino acid modification, protein acylation, chromatin organization, transcription from RNA polymerase II promoter, histone modification	transcription factor activity, protein binding	nucleus	1038	BY4741	16_1	
8	G	4	YPL253C	VIK1	-	Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication	mitotic cell cycle, organelle fission, chromosome segregation	cytoskeletal protein binding	cytoskeleton, microtubule organizing center	1039	BY4741	16_1	
8	G	5	YPL250C	ATG41	ICY2	Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication	vacuole organization, protein targeting, mitochondrion organization, organelle assembly	molecular_function	cellular_component	1042	BY4741	16_1	
8	G	6	YPL249C	GYP5	-	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication	Golgi vesicle transport	enzyme regulator activity	cytoplasmic vesicle, endomembrane system, cellular bud, membrane, site of polarized growth, Golgi apparatus, cytoplasm, plasma membrane	1043	BY4741	16_1	
8	G	7	YPL248C	GAL4	galactose-responsive transcription factor GAL4|GAL81	DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p	carbohydrate metabolic process, response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding, transcription factor binding	nucleus	1044	BY4741	16_1	
8	G	8	YPL247C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest	biological_process	molecular_function	nucleus, cytoplasm	1045	BY4741	16_1	
8	G	9	YPL246C	RBD2	putative rhomboid protease RBD2	Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p	biological_process	molecular_function	nucleus, membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	1046	BY4741	16_1	
8	G	10	YPL245W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus, cytoplasm	1047	BY4741	16_1	
8	G	11	YPL244C	HUT1	-	Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1	ion transport, nucleobase-containing compound transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1048	BY4741	16_1	
8	G	12	YPL241C	CIN2	GTPase-activating protein CIN2	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant	protein folding, protein complex biogenesis	enzyme regulator activity	cellular_component	1051	BY4741	16_1	
8	H	1	YPL240C	HSP82	Hsp90 family chaperone HSP82|HSP90	Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication	telomere organization, protein targeting, mitochondrion organization, regulation of organelle organization, protein maturation, protein complex biogenesis, protein folding, regulation of DNA metabolic process, response to osmotic stress	hydrolase activity, unfolded protein binding, ATPase activity	cytoplasm	1052	BY4741	16_1	
8	H	3	YPL239W	YAR1	-	Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with nascent Rps3p during its translation in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock	response to chemical, ribosomal subunit export from nucleus, ribosomal small subunit biogenesis, response to oxidative stress, nuclear transport, response to osmotic stress	unfolded protein binding	nucleus, cytoplasm	1053	BY4741	16_1	
8	H	4	YPL236C	ENV7	putative serine/threonine protein kinase ENV7	Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)	vacuole organization, regulation of organelle organization, organelle fusion, protein maturation, membrane fusion	kinase activity, transferase activity	vacuole, membrane, cytoplasm	1056	BY4741	16_1	
8	H	5	YPL234C	VMA11	H(+)-transporting V0 sector ATPase subunit c'|TFP3|CLS9	Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen	cellular ion homeostasis	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, vacuole, cytoplasm	1058	BY4741	16_1	
8	H	6	YPL232W	SSO1	syntaxin	Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication	meiotic cell cycle, sporulation, organelle fusion, vesicle organization, membrane fusion	lipid binding, ion binding	vacuole, membrane, cytoplasm, plasma membrane	1060	BY4741	16_1	
8	H	7	YPL230W	USV1	NSF1	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication	response to chemical, transcription from RNA polymerase II promoter, response to osmotic stress	DNA binding	nucleus	1062	BY4741	16_1	
8	H	8	YPL229W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm	1063	BY4741	16_1	
8	H	9	YPL227C	ALG5	dolichyl-phosphate beta-glucosyltransferase	UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1065	BY4741	16_1	
8	H	10	YPL226W	NEW1	-	ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction	nucleobase-containing compound transport, ribosomal small subunit biogenesis, nuclear transport	RNA binding, hydrolase activity, ion binding, ATPase activity, mRNA binding	mitochondrion, cytoplasm	1066	BY4741	16_1	
8	H	11	YPL225W	-	-	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome, cytoplasm	1067	BY4741	16_1	
8	H	12	YPL223C	GRE1	-	Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm	1069	BY4741	16_1	
9	A	1	YPL222W	FMP40	-	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	1070	BY4741	16_1	
9	A	2	YPL221W	FLC1	flavin adenine dinucleotide transporter|BOP1|HUF1	Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication	ion transport, nucleobase-containing compound transport, lipid metabolic process, protein folding, cell wall organization or biogenesis	transmembrane transporter activity	endomembrane system, vacuole, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm	1071	BY4741	16_1	
9	A	3	YPL220W	RPL1A	uL1|PUB2|ribosomal 60S subunit protein L1A|L1|L1A|SSM1	Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1072	BY4741	16_1	
9	A	4	YPL219W	PCL8	-	Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication	carbohydrate metabolic process, generation of precursor metabolites and energy	enzyme regulator activity	other	1073	BY4741	16_1	
9	A	5	YPL216W	-	-	Putative protein of unknown function; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	1076	BY4741	16_1	
9	A	6	YPL215W	CBP3	-	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	other	vacuole, ribosome, mitochondrion, membrane, mitochondrial envelope, cytoplasm	1077	BY4741	16_1	
9	A	7	YPL214C	THI6	bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase	Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern	vitamin metabolic process	kinase activity, transferase activity	cytoplasm	1078	BY4741	16_1	
9	A	8	YPL213W	LEA1	U2 snRNP complex subunit LEA1	Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein	RNA splicing, mRNA processing	molecular_function	nucleus, cytoplasm	1079	BY4741	16_1	
9	A	10	YPL212C	PUS1	pseudouridine synthase PUS1	tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication	tRNA processing, RNA modification	RNA binding, mRNA binding, isomerase activity	nucleus	1080	BY4741	16_1	
9	A	11	YPL208W	RKM1	protein-lysine N-methyltransferase	SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (Rps18Ap and Rps18Bp)	peptidyl-amino acid modification, protein alkylation	transferase activity, methyltransferase activity	nucleus, cytoplasm	1084	BY4741	16_1	
9	A	12	YPL207W	TYW1	putative tRNA 4-demethylwyosine synthase	Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron	tRNA processing, RNA modification	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	1085	BY4741	16_1	
9	B	1	YPL206C	PGC1	phosphatidylglycerol phospholipase	Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs	lipid metabolic process	hydrolase activity	mitochondrion, cytoplasm	1086	BY4741	16_1	
9	B	2	YPL205C	-	-	Hypothetical protein; deletion of locus affects telomere length	meiotic cell cycle, sporulation, transcription from RNA polymerase II promoter	molecular_function	cellular_component	1087	BY4741	16_1	
9	B	3	YPL203W	TPK2	cAMP-dependent protein kinase catalytic subunit TPK2|PKA3|YKR1|PKA2	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia	protein phosphorylation, invasive growth in response to glucose limitation, signaling	kinase activity, transferase activity	nucleus, chromosome, cytoplasm	1089	BY4741	16_1	
9	B	4	YPL202C	AFT2	-	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication	response to chemical, transmembrane transport, ion transport, regulation of transport, response to oxidative stress, cellular ion homeostasis, lipid metabolic process, response to starvation, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, mitochondrion, cytoplasm	1090	BY4741	16_1	
9	B	5	YPL201C	YIG1	-	Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol	carbohydrate metabolic process	molecular_function	nucleus, cytoplasm	1091	BY4741	16_1	
9	B	6	YPL200W	CSM4	-	Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication	meiotic cell cycle, organelle fission, regulation of organelle organization, chromosome segregation, DNA recombination, regulation of DNA metabolic process, regulation of cell cycle	molecular_function	nucleus, endomembrane system, chromosome, membrane, endoplasmic reticulum, cytoplasm	1092	BY4741	16_1	
9	B	7	YPL199C	-	-	Putative protein of unknown function; predicted to be palmitoylated	biological_process	molecular_function	cytoplasm	1093	BY4741	16_1	
9	B	8	YPL198W	RPL7B	uL30|ribosomal 60S subunit protein L7B|YL8|L7B|L6B|L30|rp11	Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis	structural constituent of ribosome, structural molecule activity	nucleus, ribosome, nucleolus, cytoplasm	1094	BY4741	16_1	
9	B	9	YPL197C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ribosomal gene RPL7B	biological_process	molecular_function	cellular_component	1095	BY4741	16_1	
9	B	10	YPL196W	OXR1	-	Protein of unknown function required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes	response to chemical, response to oxidative stress	molecular_function	mitochondrion, cytoplasm	1096	BY4741	16_1	
9	B	11	YPL195W	APL5	YKS4	Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3	Golgi vesicle transport, protein targeting	other	membrane, cytoplasm	1097	BY4741	16_1	
9	B	12	YPL194W	DDC1	-	DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress	mitotic cell cycle, meiotic cell cycle, DNA repair, organelle fission, regulation of organelle organization, cellular response to DNA damage stimulus, DNA recombination, regulation of cell cycle	molecular_function	nucleus, chromosome	1098	BY4741	16_1	
9	C	1	YPL193W	RSA1	-	Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly	ribosome assembly, organelle assembly, ribosomal large subunit biogenesis	molecular_function	nucleus	1099	BY4741	16_1	
9	C	2	YPL192C	PRM3	pheromone-regulated protein PRM3	Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body	membrane fusion, conjugation, organelle fusion, nucleus organization	molecular_function	nucleus, membrane, cytoskeleton, microtubule organizing center, endomembrane system	1100	BY4741	16_1	
9	C	3	YPL191C	-	-	Protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	1101	BY4741	16_1	
9	C	4	YPL189W	GUP2	putative O-acyltransferase	Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication	carbohydrate transport	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1103	BY4741	16_1	
9	C	5	YPL188W	POS5	NADH kinase	Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress	response to chemical, cofactor metabolic process, response to oxidative stress, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	mitochondrion, cytoplasm	1104	BY4741	16_1	
9	C	6	YPL187W	MF(ALPHA)1	-	Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions	response to chemical, conjugation, signaling	ion binding	extracellular region	2065	BY4741	16_2	
9	C	7	YPL185W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C	biological_process	molecular_function	membrane	2066	BY4741	16_2	
9	C	8	YPL186C	UIP4	-	Protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope	biological_process	molecular_function	nucleus, membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	2067	BY4741	16_2	
9	C	9	YPL184C	MRN1	PTR69	RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation	RNA splicing, chromatin organization, mRNA processing	RNA binding, mRNA binding	nucleus, cytoplasm	2068	BY4741	16_2	
9	C	10	YPL181W	CTI6	RXT1	Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain	chromatin organization, DNA replication, regulation of DNA metabolic process	histone binding, transcription factor binding	nucleus, chromosome	2070	BY4741	16_2	
9	C	11	YPL182C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W	biological_process	molecular_function	cellular_component	2071	BY4741	16_2	
9	C	12	YPL180W	TCO89	-	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin	carbohydrate metabolic process, cell wall organization or biogenesis, signaling, response to osmotic stress	molecular_function	vacuole, membrane, cytoplasm, plasma membrane	2072	BY4741	16_2	
9	D	1	YPL179W	PPQ1	SAL6	Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family	response to chemical, protein dephosphorylation, conjugation, signaling	phosphatase activity, hydrolase activity	cytoplasm	2073	BY4741	16_2	
9	D	2	YPL178W	CBC2	CBP20|SAE1|MUD13	Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif	RNA splicing, mRNA processing	RNA binding	nucleus	2074	BY4741	16_2	
9	D	3	YPL177C	CUP9	-	Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	regulation of transport, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding, transcription factor binding	nucleus	2075	BY4741	16_2	
9	D	4	YPL176C	TRE1	-	Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication	protein targeting, endosomal transport, proteolysis involved in cellular protein catabolic process	molecular_function	vacuole, cytoplasm	2076	BY4741	16_2	
9	D	5	YPL174C	NIP100	PAC13	Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)	mitotic cell cycle, cytoskeleton organization	cytoskeletal protein binding	cell cortex, cytoskeleton, microtubule organizing center, cytoplasm	2078	BY4741	16_2	
9	D	6	YPL173W	MRPL40	mitochondrial 54S ribosomal protein YmL40|YmL40	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	2079	BY4741	16_2	
9	D	7	YPL172C	COX10	protoheme IX farnesyltransferase	Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders	cofactor metabolic process	transferase activity	membrane, mitochondrion, cytoplasm	2080	BY4741	16_2	
9	D	8	YPL171C	OYE3	NADPH dehydrogenase|ZRG6	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death	other	oxidoreductase activity	cellular_component	2081	BY4741	16_2	
9	D	9	YPL170W	DAP1	-	Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis	lipid metabolic process	other	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm	2082	BY4741	16_2	
9	D	10	YPL168W	MRX4	-	Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated	biological_process	molecular_function	mitochondrion, cytoplasm	2084	BY4741	16_2	
9	D	11	YPL167C	REV3	PSO1	Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p	DNA repair, cellular response to DNA damage stimulus	transferase activity, nucleotidyltransferase activity	nucleus, chromosome, mitochondrion, cytoplasm	2085	BY4741	16_2	
9	D	12	YPL166W	ATG29	-	Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	mitochondrion organization	molecular_function	nucleus, cytoplasm	2086	BY4741	16_2	
9	E	1	YPL165C	SET6	-	SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability	biological_process	molecular_function	cellular_component	2087	BY4741	16_2	
9	E	2	YPL164C	MLH3	mismatch repair protein MLH3	Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability	meiotic cell cycle, DNA repair, organelle fission, DNA recombination, cellular response to DNA damage stimulus	ATPase activity, hydrolase activity	nucleus	2088	BY4741	16_2	
9	E	3	YPL163C	SVS1	-	Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication	response to chemical	molecular_function	cell wall, vacuole, cytoplasm	2089	BY4741	16_2	
9	E	4	YPL162C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology	biological_process	molecular_function	membrane, vacuole, cytoplasm	2090	BY4741	16_2	
9	E	5	YPL161C	BEM4	ROM7	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length	cytoskeleton organization, signaling	molecular_function	nucleus, cytoplasm	2091	BY4741	16_2	
9	E	6	YPL159C	PET20	-	Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome	generation of precursor metabolites and energy, cellular respiration	molecular_function	mitochondrion, cytoplasm	2093	BY4741	16_2	
9	E	7	YPL157W	TGS1	RNA methyltransferase	Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p	meiotic cell cycle, telomere organization, organelle fission, regulation of organelle organization, tRNA processing, regulation of DNA metabolic process, RNA modification, nucleus organization	transferase activity, methyltransferase activity	nucleus, nucleolus	2095	BY4741	16_2	
9	E	8	YPL156C	PRM4	pheromone-regulated protein PRM4	Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift	biological_process	molecular_function	membrane, vacuole, cytoplasm	2096	BY4741	16_2	
9	E	9	YPL155C	KIP2	-	Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; functions as a microtubule polymerase and catastrophe inhibitor in vitro; Kip2p levels are controlled during the cell cycle	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis	hydrolase activity	cytoskeleton, mitochondrion, cytoplasm	2097	BY4741	16_2	
9	E	10	YPL154C	PEP4	proteinase A|yscA|PRA1|PHO9	Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates	protein targeting, proteolysis involved in cellular protein catabolic process, response to starvation	peptidase activity, hydrolase activity	endomembrane system, vacuole, mitochondrion, endoplasmic reticulum, cytoplasm	2098	BY4741	16_2	
9	E	11	YPL152W	RRD2	peptidylprolyl isomerase RRD2|YPA2	Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress	mitotic cell cycle, organelle fission, cytoskeleton organization, response to osmotic stress	isomerase activity, enzyme regulator activity	other	2100	BY4741	16_2	
9	E	12	YPL150W	-	non-specific serine/threonine protein kinase	Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study	protein phosphorylation	kinase activity, transferase activity	cellular_component	2102	BY4741	16_2	
9	F	1	YPL149W	ATG5	APG5	Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner	protein targeting, mitochondrion organization, protein lipidation	transferase activity, enzyme regulator activity	nucleus, vacuole, membrane, cytoplasm	2103	BY4741	16_2	
9	F	2	YPL147W	PXA1	ATP-binding cassette long-chain fatty acid transporter PXA1|SSH2|PAT2|PAL1|LPI1	Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant	ion transport, lipid transport	hydrolase activity, transmembrane transporter activity, ATPase activity	peroxisome, membrane, cytoplasm	2105	BY4741	16_2	
9	F	3	YPL145C	KES1	oxysterol-binding protein KES1|BSR3|OSH4|LPI3	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication	Golgi vesicle transport, lipid transport, lipid metabolic process, exocytosis, endocytosis	lipid binding, ion binding	endomembrane system, membrane, Golgi apparatus, cytoplasm	2107	BY4741	16_2	
9	F	4	YPL144W	POC4	DMP1|PBA4	Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)	protein complex biogenesis	molecular_function	cytoplasm	2108	BY4741	16_2	
9	F	5	YPL141C	FRK1	protein kinase FRK1	Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication	protein phosphorylation	kinase activity, transferase activity	cytoplasm	2111	BY4741	16_2	
9	F	6	YPL140C	MKK2	putative mitogen-activated protein kinase kinase MKK2|SSP33|LPI6	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication	protein phosphorylation, cell wall organization or biogenesis, signaling	kinase activity, transferase activity, signal transducer activity	cellular bud, site of polarized growth, cytoplasm	2112	BY4741	16_2	
9	F	7	YPL139C	UME1	WTM3	Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication	transcription from RNA polymerase I promoter, meiotic cell cycle, organelle fission, chromatin organization, regulation of organelle organization, transcription from RNA polymerase II promoter, regulation of cell cycle	transcription factor activity, protein binding	nucleus, chromosome, cytoplasm	2113	BY4741	16_2	
9	F	8	YPL138C	SPP1	SAF41|CPS40	Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia	peptidyl-amino acid modification, meiotic cell cycle, protein alkylation, organelle fission, chromatin organization, regulation of organelle organization, histone modification, regulation of cell cycle	chromatin binding, transferase activity, histone binding, methyltransferase activity	nucleus, cytoplasm	2114	BY4741	16_2	
9	F	9	YPL136W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C	biological_process	molecular_function	cellular_component	2115	BY4741	16_2	
9	F	10	YPL135W	ISU1	iron-binding protein ISU1|NUA1	Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant	cofactor metabolic process, cellular ion homeostasis, tRNA processing, RNA modification	ion binding	mitochondrion, cytoplasm	2117	BY4741	16_2	
9	F	11	YPL133C	RDS2	-	Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole	carbohydrate metabolic process, response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	2119	BY4741	16_2	
9	F	12	YPL130W	SPO19	-	Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication	meiotic cell cycle, organelle fission, sporulation	molecular_function	cell wall, membrane	2122	BY4741	16_2	
9	G	1	YPL129W	TAF14	TATA-binding protein-associated factor TAF14|TafII30|ANC1|TFG3|TAF30|SWP29	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification, DNA-templated transcription, initiation, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	nucleic acid binding transcription factor activity, hydrolase activity, transcription factor activity, protein binding, ATPase activity	nucleus, chromosome	2123	BY4741	16_2	
9	G	2	YPL127C	HHO1	histone H1	Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination	chromatin organization, DNA recombination, regulation of DNA metabolic process	DNA binding	nucleus, chromosome	2125	BY4741	16_2	
9	G	3	YPL125W	KAP120	LPH2	Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor	protein targeting, nuclear transport	protein transporter activity	nucleus, membrane, endomembrane system, cytoplasm	2127	BY4741	16_2	
9	G	4	YPL123C	RNY1	ribonuclease T2	Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing suring oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity	RNA catabolic process, cell morphogenesis	nuclease activity, hydrolase activity	extracellular region, vacuole, cytoplasm	2129	BY4741	16_2	
9	G	5	YPL121C	MEI5	LPH6	Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p	meiotic cell cycle, DNA repair, organelle fission, DNA recombination, cellular response to DNA damage stimulus	molecular_function	nucleus, chromosome	2131	BY4741	16_2	
9	G	6	YPL120W	VPS30	beclin 1|ATG6|VPT30|APG6	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant	protein targeting, lipid metabolic process, endosomal transport	molecular_function	membrane, vacuole, cytoplasm	2132	BY4741	16_2	
9	G	7	YPL119C	DBP1	putative DEAD-box ATP-dependent RNA helicase DBP1|LPH8	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication	translational initiation	RNA binding, mRNA binding, helicase activity, hydrolase activity	cytoplasm	2133	BY4741	16_2	
9	G	8	YPL118W	MRP51	mitochondrial 37S ribosomal protein MRP51	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences	translational initiation, mitochondrial translation, mitochondrion organization	structural constituent of ribosome, structural molecule activity	ribosome, mitochondrion, cytoplasm	2134	BY4741	16_2	
9	G	9	YPL116W	HOS3	histone deacetylase	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats	mitotic cell cycle, chromatin organization, histone modification, transcription from RNA polymerase II promoter	hydrolase activity	nucleus, cellular bud, membrane, site of polarized growth, cytoplasm	2136	BY4741	16_2	
9	G	10	YPL115C	BEM3	-	Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly	cytoskeleton organization, signaling	lipid binding, enzyme regulator activity, ion binding	cell cortex, cellular bud, site of polarized growth, cytoplasm	2137	BY4741	16_2	
9	G	11	YPL114W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index	biological_process	molecular_function	cellular_component	2138	BY4741	16_2	
9	G	12	YPL113C	-	glyoxylate reductase	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene	biological_process	oxidoreductase activity	cellular_component	2139	BY4741	16_2	
9	H	1	YPL112C	PEX25	-	Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication	protein targeting, transmembrane transport, peroxisome organization	molecular_function	peroxisome, membrane, cytoplasm	2140	BY4741	16_2	
9	H	3	YPL111W	CAR1	arginase|cargA|LPH15	Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance	cellular amino acid metabolic process	ion binding, hydrolase activity, enzyme regulator activity	nucleus, site of polarized growth, cytoplasm	2141	BY4741	16_2	
9	H	4	YPL110C	GDE1	glycerophosphocholine phosphodiesterase	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes	lipid metabolic process	hydrolase activity	ribosome, cytoplasm	2142	BY4741	16_2	
9	H	5	YPL109C	-	-	UbiB family protein; contains transmembrane domain and mitochondrial targeting sequence; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	2143	BY4741	16_2	
9	H	6	YPL108W	-	-	Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm	2144	BY4741	16_2	
9	H	7	YPL107W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene	biological_process	molecular_function	mitochondrion, cytoplasm	2145	BY4741	16_2	
9	H	8	YPL106C	SSE1	adenyl-nucleotide exchange factor SSE1|MSI3|LPG3	ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication	protein folding	ion binding, enzyme regulator activity	cytoplasm	2146	BY4741	16_2	
9	H	9	YPL105C	SYH1	MYR1	Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication	nucleus organization	molecular_function	membrane, ribosome, mitochondrion, cytoplasm	2147	BY4741	16_2	
9	H	10	YPL104W	MSD1	aspartate--tRNA ligase MSD1|LPG5	Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene	mitochondrial translation, tRNA aminoacylation for protein translation, mitochondrion organization, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	2148	BY4741	16_2	
9	H	11	YPL103C	FMP30	N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D	Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D	lipid metabolic process	hydrolase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2149	BY4741	16_2	
9	H	12	YPL101W	ELP4	Elongator subunit ELP4|KTI9|TOT7|HAP1	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4	tRNA processing, transcription from RNA polymerase II promoter, RNA modification	RNA binding, ATPase activity, hydrolase activity	cytoplasm	2150	BY4741	16_2	
10	A	1	YPL102C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4	biological_process	molecular_function	cellular_component	2151	BY4741	16_2	
10	A	2	YPL100W	ATG21	HSV1|MAI1	Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein	vacuole organization, protein targeting, mitochondrion organization, organelle assembly, vesicle organization, protein lipidation	lipid binding, ion binding	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	2152	BY4741	16_2	
10	A	3	YPL099C	INA17	AIM43|FMP14	F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect	mitochondrion organization, protein complex biogenesis	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2153	BY4741	16_2	
10	A	4	YPL098C	MGR2	-	Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their release into the inner membrane by the TIM23 complex; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)	protein targeting, mitochondrion organization, transmembrane transport	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2154	BY4741	16_2	
10	A	5	YPL097W	MSY1	tyrosine--tRNA ligase MSY1	Mitochondrial tyrosyl-tRNA synthetase	mitochondrial translation, tRNA aminoacylation for protein translation, mitochondrion organization, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	2155	BY4741	16_2	
10	A	6	YPL096W	PNG1	peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase	Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease	response to chemical, proteolysis involved in cellular protein catabolic process	hydrolase activity	nucleus, mitochondrion, cytoplasm	2156	BY4741	16_2	
10	A	7	YPL095C	EEB1	medium-chain fatty acid ethyl ester synthase/esterase	Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication	lipid metabolic process, monocarboxylic acid metabolic process	transferase activity, hydrolase activity	cellular_component	2157	BY4741	16_2	
10	A	8	YPL092W	SSU1	LPG16	Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein	ion transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	2160	BY4741	16_2	
10	A	9	YBR174C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective	biological_process	molecular_function	cellular_component	3314	BY4741	02_4	
10	A	11	YBR175W	SWD3	SAF35|CPS30	Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5	peptidyl-amino acid modification, meiotic cell cycle, telomere organization, protein alkylation, organelle fission, chromatin organization, regulation of organelle organization, histone modification, regulation of cell cycle	transferase activity, methyltransferase activity	nucleus	3315	BY4741	02_4	
10	A	12	YBR176W	ECM31	3-methyl-2-oxobutanoate hydroxymethyltransferase	Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate	cofactor metabolic process, vitamin metabolic process, monocarboxylic acid metabolic process	transferase activity	mitochondrion, cytoplasm	3316	BY4741	02_4	
10	B	1	YBR177C	EHT1	medium-chain fatty acid ethyl ester synthase/esterase	Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication	monocarboxylic acid metabolic process, lipid metabolic process	transferase activity, hydrolase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3317	BY4741	02_4	
10	B	2	YBR178W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C	biological_process	molecular_function	cellular_component	3318	BY4741	02_4	
10	B	3	YBR179C	FZO1	mitofusin	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system	mitochondrion organization, organelle fusion, membrane fusion	GTPase activity, hydrolase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3319	BY4741	02_4	
10	B	4	YBR180W	DTR1	-	Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation	meiotic cell cycle, sporulation, transmembrane transport, cell wall organization or biogenesis	transmembrane transporter activity	membrane	3320	BY4741	02_4	
10	B	5	YBR181C	RPS6B	eS6|ribosomal 40S subunit protein S6B|S6e|RPS102|RPS101|LPG18	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	3321	BY4741	02_4	
10	B	6	YBR182C	SMP1	-	MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication	transcription from RNA polymerase II promoter, response to osmotic stress	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	3322	BY4741	02_4	
10	B	7	YBR183W	YPC1	phytoceramidase	Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication	lipid metabolic process	transferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds	cell cortex, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	3323	BY4741	02_4	
10	B	8	YBR184W	-	-	Putative protein of unknown function; YBR184W is not an essential gene	biological_process	molecular_function	cellular_component	3324	BY4741	02_4	
10	B	9	YBR185C	MBA1	-	Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3325	BY4741	02_4	
10	B	10	YBR186W	PCH2	-	Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation	meiotic cell cycle, organelle fission, regulation of organelle organization, DNA recombination, regulation of cell cycle	hydrolase activity, ATPase activity	nucleus, nucleolus	3326	BY4741	02_4	
10	B	11	YBR187W	GDT1	putative ribosome biosynthesis protein GDT1	Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant	transmembrane transport, ion transport, cellular ion homeostasis	transmembrane transporter activity	endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	3327	BY4741	02_4	
10	B	12	YBR188C	NTC20	-	Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs	RNA splicing, mRNA processing	other	nucleus	3328	BY4741	02_4	
10	C	1	YBR194W	AIM4	SOY1	Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress	biological_process	molecular_function	cytoplasm	3334	BY4741	02_4	
10	C	2	YBR195C	MSI1	CAC3	Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase	chromatin organization	histone binding	nucleus, cytoplasm	3335	BY4741	02_4	
10	C	3	YBR197C	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	3337	BY4741	02_4	
10	C	4	YBR199W	KTR4	putative mannosyltransferase	Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, vacuole, cytoplasm, Golgi apparatus	3339	BY4741	02_4	
10	C	5	YBR200W	BEM1	phosphatidylinositol-3-phosphate-binding protein BEM1|SRO1	Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p	response to chemical, cell morphogenesis, conjugation	lipid binding, structural molecule activity, ion binding	mitochondrion, cellular bud, site of polarized growth, cytoplasm	3340	BY4741	02_4	
10	C	6	YBR201W	DER1	derlin	ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1	response to chemical, proteolysis involved in cellular protein catabolic process	other	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	3341	BY4741	02_4	
10	C	7	YBR203W	COS111	-	Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	signaling	molecular_function	mitochondrion, cytoplasm	3343	BY4741	02_4	
10	C	8	YBR204C	LDH1	triacylglycerol lipase	Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)	other	hydrolase activity	endomembrane system, endoplasmic reticulum, cytoplasm	3344	BY4741	02_4	
10	C	9	YBR205W	KTR3	mannosyltransferase KTR3	Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	nucleus, membrane, vacuole, cytoplasm	3345	BY4741	02_4	
10	C	10	YBR206W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3	biological_process	molecular_function	cellular_component	3346	BY4741	02_4	
10	C	11	YBR207W	FTH1	-	Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress	transmembrane transport, ion transport, endocytosis	transmembrane transporter activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	3347	BY4741	02_4	
10	C	12	YBR208C	DUR1,2	bifunctional urea carboxylase/allophanate hydrolase|DUR80	Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress	other	ligase activity, hydrolase activity	cytoplasm	3348	BY4741	02_4	
10	D	1	YBR209W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene	biological_process	molecular_function	cellular_component	3349	BY4741	02_4	"Hypothetical protein -- growth on -met, no growth on -lys, no growth on drop-in media"	
10	D	2	YBR210W	ERV15	-	Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication	mitotic cell cycle, cell budding, cytokinesis, Golgi vesicle transport	molecular_function	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	3350	BY4741	02_4	
10	D	3	YBR212W	NGR1	RBP1	RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase	regulation of translation, mitochondrion organization	RNA binding, mRNA binding	cytoplasm	3352	BY4741	02_4	
10	D	4	YBR213W	MET8	bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8	Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis	cofactor metabolic process	lyase activity, oxidoreductase activity	cellular_component	3353	BY4741	02_4	
10	D	5	YBR214W	SDS24	-	Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication	endocytosis	molecular_function	cytoplasm	3354	BY4741	02_4	
10	D	6	YBR215W	HPC2	-	Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes	mitotic cell cycle, chromatin organization, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	chromatin binding, DNA binding	nucleus	3355	BY4741	02_4	
10	D	7	YBR216C	YBP1	-	Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication	response to chemical, response to oxidative stress	molecular_function	cytoplasm	3356	BY4741	02_4	
10	D	8	YBR217W	ATG12	APG12	Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation	vacuole organization, protein targeting, mitochondrion organization, organelle assembly, protein lipidation	transferase activity, enzyme regulator activity	cytoplasm	3357	BY4741	02_4	
10	D	9	YBR218C	PYC2	pyruvate carboxylase 2	Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication	carbohydrate metabolic process	ligase activity	cytoplasm	3358	BY4741	02_4	
10	D	10	YBR219C	-	-	Putative protein of unknown function; YBR219C is not an essential gene	biological_process	molecular_function	membrane	3359	BY4741	02_4	
10	D	11	YBR220C	-	-	Putative protein of unknown function; YBR220C is not an essential gene	biological_process	molecular_function	membrane	3360	BY4741	02_4	
10	D	12	YBR221C	PDB1	pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria	cofactor metabolic process, monocarboxylic acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	3361	BY4741	02_4	
10	E	1	YBR222C	PCS60	FAT2	Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase	other	RNA binding, mRNA binding, ligase activity	peroxisome, membrane, cytoplasm	3362	BY4741	02_4	
10	E	2	YBR223C	TDP1	tyrosyl-DNA phosphodiesterase 1	Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)	DNA repair, cellular response to DNA damage stimulus	hydrolase activity	nucleus	3363	BY4741	02_4	
10	E	3	YBR224W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1	biological_process	molecular_function	membrane	3364	BY4741	02_4	
10	E	4	YBR225W	-	-	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components	biological_process	molecular_function	cellular_component	3365	BY4741	02_4	
10	E	5	YBR226C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W	biological_process	molecular_function	cellular_component	3366	BY4741	02_4	
10	E	6	YBR227C	MCX1	-	Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis	protein targeting, mitochondrion organization, transmembrane transport, regulation of protein modification process, protein folding	hydrolase activity, ion binding, ATPase activity	mitochondrion, cytoplasm	3367	BY4741	02_4	
10	E	7	YBR228W	SLX1	endonuclease	Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p	DNA replication	nuclease activity, hydrolase activity	nucleus, chromosome	3368	BY4741	02_4	
10	E	8	YBR229C	ROT2	glucan 1,3-alpha-glucosidase ROT2|GLS2	Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations	carbohydrate metabolic process, protein glycosylation, cell wall organization or biogenesis	hydrolase activity, hydrolase activity, acting on glycosyl bonds	endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	3369	BY4741	02_4	
10	E	9	YBR230C	OM14	-	Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources	protein targeting, mitochondrion organization	other	membrane, mitochondrial envelope, mitochondrion, cytoplasm	3370	BY4741	02_4	
10	E	10	YBR231C	SWC5	AOR1	Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia	chromatin organization	molecular_function	nucleus, chromosome, cytoplasm	3371	BY4741	02_4	
10	E	11	YBR233W	PBP2	HEK1	RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress	telomere organization	RNA binding, mRNA binding	nucleus, cytoplasm	3373	BY4741	02_4	
10	E	12	YBR235W	VHC1	-	Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family	transmembrane transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	3375	BY4741	02_4	
10	F	1	YBR238C	-	-	Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication	generation of precursor metabolites and energy, cellular respiration	RNA binding, mRNA binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3378	BY4741	02_4	
10	F	2	YBR239C	ERT1	-	Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins, similar to Rds2p	carbohydrate metabolic process, response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	3379	BY4741	02_4	
10	F	3	YBR240C	THI2	phoF|PHO6	Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type	vitamin metabolic process, transcription from RNA polymerase II promoter	DNA binding	nucleus	3380	BY4741	02_4	
10	F	4	YBR241C	-	-	Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene; YBR241C has a paralog, VPS73, that arose from the whole genome duplication	transmembrane transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	3381	BY4741	02_4	
10	F	5	YBR242W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	3382	BY4741	02_4	
10	F	6	YBR244W	GPX2	glutathione peroxidase GPX2|AMI1	Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress	response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, mitochondrion, membrane, mitochondrial envelope, cytoplasm	3384	BY4741	02_4	
10	F	7	YBR245C	ISW1	chromatin-remodeling ATPase ISW1|SGN2	ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK	transcription from RNA polymerase I promoter, chromatin organization, protein complex biogenesis, chromosome segregation, DNA-templated transcription, termination, DNA-templated transcription, initiation, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	chromatin binding, hydrolase activity, DNA binding, ATPase activity	nucleus, chromosome, nucleolus	3385	BY4741	02_4	
10	F	8	YBR246W	RRT2	DPH7|diphthamide synthase|ERE1	Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins	peptidyl-amino acid modification, endosomal transport	hydrolase activity	cytoplasmic vesicle, endomembrane system, cytoplasm	3386	BY4741	02_4	
10	F	9	YBR248C	HIS7	imidazoleglycerol-phosphate synthase	Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor	cellular amino acid metabolic process	transferase activity, transferring glycosyl groups, transferase activity, hydrolase activity	other	3388	BY4741	02_4	
10	F	10	YBR249C	ARO4	3-deoxy-7-phosphoheptulonate synthase ARO4	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress	other	transferase activity	nucleus, cytoplasm	3389	BY4741	02_4	
10	F	11	YBR250W	SPO23	-	Protein of unknown function; associates with meiosis-specific protein Spo1p	meiotic cell cycle, organelle fission	molecular_function	cellular_component	3390	BY4741	02_4	
10	F	12	YBR251W	MRPS5	mitochondrial 37S ribosomal protein MRPS5	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	3391	BY4741	02_4	
10	G	1	YBR255W	MTC4	-	Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1	biological_process	molecular_function	cytoplasm	3395	BY4741	02_4	
10	G	2	YBR258C	SHG1	CPS15	Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres	peptidyl-amino acid modification, protein alkylation, chromatin organization, histone modification	transferase activity, methyltransferase activity	nucleus	3398	BY4741	02_4	
10	G	3	YBR259W	-	-	Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress	biological_process	molecular_function	cellular_component	3399	BY4741	02_4	
10	G	4	YBR260C	RGD1	-	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization	signaling, response to osmotic stress	lipid binding, enzyme regulator activity, ion binding	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm	3400	BY4741	02_4	
10	G	5	YBR261C	TAE1	N-terminal protein methyltransferase|NTM1	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm	peptidyl-amino acid modification, cytoplasmic translation, protein alkylation	transferase activity, methyltransferase activity	cytoplasm	3401	BY4741	02_4	
10	G	6	YBR262C	MIC12	AIM5|MCS12|FMP51	Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	3402	BY4741	02_4	
10	G	7	YBR263W	SHM1	glycine hydroxymethyltransferase SHM1|TMP3|SHMT1	Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine	cellular amino acid metabolic process	transferase activity	mitochondrion, cytoplasm	3403	BY4741	02_4	
10	G	8	YBR264C	YPT10	Rab family GTPase YPT10	Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles	other	GTPase activity, hydrolase activity	membrane, vacuole, cytoplasm	3404	BY4741	02_4	
10	G	9	YBR266C	SLM6	-	Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase	endocytosis	molecular_function	cellular_component	3406	BY4741	02_4	
10	G	10	YBR267W	REI1	-	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network	mitotic cell cycle, cell budding, ribosomal large subunit biogenesis, nuclear transport	DNA binding	ribosome, cytoplasm	3407	BY4741	02_4	Incorrect -- PCR mating type A/Alpha	
10	G	11	YBR268W	MRPL37	mitochondrial 54S ribosomal protein YmL37|YmL37	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	3408	BY4741	02_4	
10	G	12	YDR049W	VMS1	-	Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans	response to chemical, proteolysis involved in cellular protein catabolic process	peptidase activity, hydrolase activity	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm	3985	BY4741	04_4	
10	H	1	YDR050C	TPI1	triose-phosphate isomerase TPI1	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, nucleobase-containing small molecule metabolic process	isomerase activity	mitochondrion, membrane, cytoplasm, plasma membrane	3986	BY4741	04_4	
10	H	3	YDR051C	DET1	acid phosphatase DET1	Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel	lipid transport	phosphatase activity, hydrolase activity	nucleus, cytoplasm	3987	BY4741	04_4	
10	H	4	YDR055W	PST1	HPF2	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication	cell wall organization or biogenesis	molecular_function	cell wall, membrane, vacuole, plasma membrane, cytoplasm	3991	BY4741	04_4	
10	H	5	YDR056C	EMC10	-	Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	3992	BY4741	04_4	
10	H	6	YDR057W	YOS9	-	ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family	response to chemical, proteolysis involved in cellular protein catabolic process, signaling	other	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	3993	BY4741	04_4	
10	H	7	YDR059C	UBC5	E2 ubiquitin-conjugating protein UBC5	Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication	response to heat, protein modification by small protein conjugation or removal	transferase activity	other	3994	BY4741	04_4	
10	H	8	YDR061W	-	-	Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance	biological_process	molecular_function	mitochondrion, cytoplasm	3996	BY4741	04_4	
10	H	9	YDR063W	AIM7	GMF1|GMF	Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis	molecular_function	nucleus, cell cortex, cytoskeleton, cytoplasm	3998	BY4741	04_4	
10	H	10	YDR065W	RRG1	-	Protein of unknown function; required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	cellular ion homeostasis, mitochondrion organization	molecular_function	mitochondrion, cytoplasm	4000	BY4741	04_4	
10	H	11	YDR066C	RTR2	putative protein-serine/threonine phosphatase	Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	4001	BY4741	04_4	
10	H	12	YDR067C	OCA6	protein-tyrosine-phosphatase	Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT	biological_process	molecular_function	cytoplasm	4002	BY4741	04_4	
11	A	1	YDR068W	DOS2	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm	4003	BY4741	04_4	
11	A	2	YDR069C	DOA4	ubiquitin-specific protease DOA4|UBP4|SSV7|NPI2|MUT4|DOS1	Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication	DNA replication, ion transport, vesicle organization, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, regulation of DNA metabolic process, endocytosis	peptidase activity, hydrolase activity	cytoplasmic vesicle, endomembrane system, mitochondrion, cytoplasm	4004	BY4741	04_4	
11	A	3	YDR070C	FMP16	-	Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	mitochondrion, cytoplasm	4005	BY4741	04_4	
11	A	4	YDR072C	IPT1	MIC2|inositolphosphotransferase|KTI6|SYR4	Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin	lipid metabolic process	transferase activity	membrane	4007	BY4741	04_4	
11	A	5	YDR073W	SNF11	-	Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions	transcription from RNA polymerase II promoter	ATPase activity, hydrolase activity	nucleus, cytoplasm	4008	BY4741	04_4	
11	A	6	YDR075W	PPH3	phosphoprotein phosphatase PP4 catalytic subunit PPH3	Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes	meiotic cell cycle, response to chemical, organelle fission, protein dephosphorylation, DNA recombination, DNA repair, regulation of organelle organization, cellular response to DNA damage stimulus, regulation of DNA metabolic process, regulation of cell cycle, signaling	phosphatase activity, hydrolase activity	nucleus, chromosome, cytoplasm	4010	BY4741	04_4	
11	A	7	YDR076W	RAD55	putative DNA-dependent ATPase RAD55	Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p	meiotic cell cycle, DNA repair, organelle fission, DNA recombination, cellular response to DNA damage stimulus	ATPase activity, hydrolase activity	nucleus	4011	BY4741	04_4	
11	A	8	YDR077W	SED1	-	Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog, SPI1, that arose from the whole genome duplication	mitochondrion organization, cell wall organization or biogenesis	structural molecule activity	cell wall, ribosome, mitochondrion, cytoplasm	4012	BY4741	04_4	
11	A	9	YDR078C	SHU2	-	Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both	DNA repair, DNA recombination, cellular response to DNA damage stimulus	molecular_function	chromosome	4013	BY4741	04_4	
11	A	10	YDR079W	PET100	-	Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme	mitochondrion organization, protein complex biogenesis	unfolded protein binding	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4014	BY4741	04_4	
11	A	12	YDR080W	VPS41	VPL20|VAM2|SVL2|FET2|CVT8	Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites	vacuole organization, regulation of transport, organelle fusion, protein maturation, protein targeting, regulation of organelle organization, vesicle organization, protein complex biogenesis, membrane fusion	enzyme binding, ion binding, lipid binding	vacuole, cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	4015	BY4741	04_4	
11	B	1	YDR083W	RRP8	25S rRNA (adenine645-N1)-methyltransferase	Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1	rRNA processing, ribosomal large subunit biogenesis, RNA modification	transferase activity, methyltransferase activity	nucleus, nucleolus	4018	BY4741	04_4	
11	B	2	YDR084C	TVP23	-	Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	other	molecular_function	membrane, endomembrane system, cytoplasm, Golgi apparatus	4019	BY4741	04_4	
11	B	3	YDR085C	AFR1	-	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication	response to chemical, cell morphogenesis, conjugation, signaling	signal transducer activity	other	4020	BY4741	04_4	
11	B	4	YDR089W	VTC5	-	Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress	cellular ion homeostasis	molecular_function	membrane, vacuole, cytoplasm	4024	BY4741	04_4	
11	B	5	YDR090C	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane	4025	BY4741	04_4	
11	B	6	YDR092W	UBC13	E2  ubiquitin-conjugating protein UBC13	E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus	DNA repair, protein modification by small protein conjugation or removal, cellular response to DNA damage stimulus, protein complex biogenesis	transferase activity	nucleus, cytoplasm	4027	BY4741	04_4	
11	B	7	YDR093W	DNF2	aminophospholipid-translocating P4-type ATPase DNF2	Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication	response to chemical, ion transport, lipid transport, conjugation, endocytosis	hydrolase activity, ATPase activity	endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm, plasma membrane	4028	BY4741	04_4	
11	B	8	YDR094W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2/YDR093W	biological_process	molecular_function	cellular_component	4029	BY4741	04_4	
11	B	9	YDR095C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4030	BY4741	04_4	
11	B	10	YDR096W	GIS1	histone demethylase GIS1	Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication	chromatin organization, histone modification, lipid metabolic process, response to starvation, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, oxidoreductase activity, DNA binding	nucleus, mitochondrion, cytoplasm	4031	BY4741	04_4	
11	B	11	YDR097C	MSH6	PMS6|mismatch repair ATPase MSH6|PMS3	Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p	meiotic cell cycle, DNA repair, organelle fission, DNA replication, cellular response to DNA damage stimulus, regulation of DNA metabolic process	hydrolase activity, DNA binding, ion binding, ATPase activity	nucleus, cytoplasm	4032	BY4741	04_4	
11	B	12	YDR098C	GRX3	monothiol glutaredoxin GRX3	Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication	response to chemical, chromatin organization, cytoskeleton organization, response to oxidative stress, histone modification, regulation of protein modification process, cellular ion homeostasis	oxidoreductase activity, transcription factor binding	nucleus, cytoplasm	4033	BY4741	04_4	
11	C	1	YDR099W	BMH2	14-3-3 family protein BMH2|SCD3	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; abundance relative to Bmh1p increases during sporulation	mitotic cell cycle, meiotic cell cycle, DNA replication, generation of precursor metabolites and energy, cell wall organization or biogenesis, carbohydrate metabolic process, sporulation, cellular response to DNA damage stimulus, regulation of protein modification process, protein modification by small protein conjugation or removal, pseudohyphal growth, signaling, regulation of cell cycle	ion binding, DNA binding	nucleus, plasma membrane, membrane, cytoplasm	4034	BY4741	04_4	
11	C	2	YDR100W	TVP15	-	Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p	other	molecular_function	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	4035	BY4741	04_4	
11	C	3	YDR101C	ARX1	putative hydrolase	Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex	ribosomal subunit export from nucleus, nuclear transport	molecular_function	nucleus, nucleolus, ribosome, cytoplasm	4036	BY4741	04_4	
11	C	4	YDR102C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YDR102C is not an essential gene; homozygous diploid deletion strain exhibits high budding index	biological_process	molecular_function	cellular_component	4037	BY4741	04_4	
11	C	5	YDR103W	STE5	NUL3|HMD3	Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation	response to chemical, protein phosphorylation, invasive growth in response to glucose limitation, transposition, regulation of protein modification process, conjugation, signaling	lipid binding, enzyme binding, structural molecule activity, ion binding	nucleus, membrane, site of polarized growth, cytoplasm, plasma membrane	4038	BY4741	04_4	
11	C	6	YDR104C	SPO71	-	Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation and closure; genetically antagonistic to SPO1; recruits Vps13p to the PSM during sporulation; interacts and functions cooperatively with Spo73p; mutants have defects in the PSM, aberrant spore wall formation and reduced PtdIns-phosphate pools in the PSM; contains three PH-like domains	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	membrane, plasma membrane	4039	BY4741	04_4	
11	C	7	YDR105C	TMS1	-	Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance	biological_process	molecular_function	membrane, vacuole, cytoplasm	4040	BY4741	04_4	
11	C	8	YDR107C	TMN2	-	Protein with a role in cellular adhesion and filamentous growth; similar to Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments; TMN2 has a paralog, EMP70, that arose from the whole genome duplication	cellular ion homeostasis, invasive growth in response to glucose limitation, pseudohyphal growth	molecular_function	membrane, vacuole, cytoplasm	4041	BY4741	04_4	
11	C	9	YDR108W	TRS85	GSG1|MUM1	Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role	vacuole organization, meiotic cell cycle, protein targeting, organelle fission, organelle assembly, vesicle organization, Golgi vesicle transport	molecular_function	cytoplasmic vesicle, endomembrane system, Golgi apparatus, cytoplasm	4042	BY4741	04_4	
11	C	10	YDR109C	-	putative phosphotransferase	Putative kinase	biological_process	molecular_function	cellular_component	4043	BY4741	04_4	
11	C	11	YDR110W	FOB1	replication fork barrier binding protein FOB1|HRM1	Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to replication fork barrier (RFB), and rDNA repeat segregation; related to retroviral integrases	chromatin organization, DNA replication, chromosome segregation, DNA recombination, regulation of DNA metabolic process, nucleus organization	DNA binding	nucleus, chromosome, nucleolus	4044	BY4741	04_4	
11	C	12	YDR111C	ALT2	alanine transaminase ALT2	Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication	biological_process	transferase activity	nucleus, cytoplasm	4045	BY4741	04_4	
11	D	1	YDR112W	IRC2	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ALT2/YDR111C; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	cellular_component	4046	BY4741	04_4	
11	D	2	YDR114C	-	-	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium	biological_process	molecular_function	cellular_component	4048	BY4741	04_4	
11	D	3	YDR115W	MRX14	putative mitochondrial 54S ribosomal protein	Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress	mitochondrial translation, mitochondrion organization	structural constituent of ribosome, structural molecule activity	nucleus, ribosome, mitochondrion, cytoplasm	4049	BY4741	04_4	
11	D	4	YDR116C	MRPL1	mitochondrial 54S ribosomal protein MRPL1	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4050	BY4741	04_4	
11	D	5	YDR117C	TMA64	RBF64	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity	rRNA processing	RNA binding	ribosome, cytoplasm	4051	BY4741	04_4	
11	D	6	YDR119W	VBA4	-	Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene	biological_process	molecular_function	membrane, vacuole, cytoplasm	4053	BY4741	04_4	
11	D	7	YDR120C	TRM1	tRNA (guanine26-N2)-dimethyltransferase	tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce modified base N2,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body (SPB) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB	tRNA processing, RNA modification	transferase activity, methyltransferase activity	nucleus, endomembrane system, mitochondrion, membrane, cytoplasm	4054	BY4741	04_4	
11	D	8	YDR121W	DPB4	DNA polymerase epsilon noncatalytic subunit	Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization	DNA repair, chromatin organization, DNA replication, cellular response to DNA damage stimulus	chromatin binding, transferase activity, nucleotidyltransferase activity, DNA binding	nucleus, chromosome	4055	BY4741	04_4	
11	D	9	YDR122W	KIN1	serine/threonine protein kinase KIN1	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication	protein phosphorylation, exocytosis	kinase activity, transferase activity	membrane, plasma membrane	4056	BY4741	04_4	
11	D	10	YDR123C	INO2	SCS1|DIE1	Transcription factor; component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion; involved in diauxic shift	lipid metabolic process, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity	nucleus	4057	BY4741	04_4	
11	D	11	YDR124W	-	-	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor	biological_process	molecular_function	cellular_component	4058	BY4741	04_4	
11	D	12	YDR125C	ECM18	alpha/beta hydrolase family protein	Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion, cytoplasm	4059	BY4741	04_4	
11	E	1	YDR126W	SWF1	palmitoyltransferase SWF1|PSL10	Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion	vacuole organization, meiotic cell cycle, protein acylation, cytoskeleton organization, regulation of transport, organelle fusion, cell wall organization or biogenesis, protein lipidation, sporulation, membrane fusion, exocytosis	transferase activity	cell cortex, cytoskeleton, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4060	BY4741	04_4	
11	E	2	YDR127W	ARO1	pentafunctional protein ARO1p	Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids	other	lyase activity, kinase activity, transferase activity, oxidoreductase activity	cytoplasm	4061	BY4741	04_4	
11	E	3	YDR128W	MTC5	SEA3	Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress	signaling	molecular_function	membrane, vacuole, cytoplasm	4062	BY4741	04_4	
11	E	4	YDR129C	SAC6	fimbrin|ABP67	Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant	cytoskeleton organization	protein binding, bridging, cytoskeletal protein binding	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	4063	BY4741	04_4	
11	E	5	YDR130C	FIN1	-	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress	mitotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, chromosome segregation, regulation of cell cycle	cytoskeletal protein binding, structural molecule activity	nucleus, cytoskeleton, microtubule organizing center, chromosome, cytoplasm	4064	BY4741	04_4	
11	E	6	YDR131C	-	-	F-box protein subunit of SCF ubiquitin ligase complex; substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex	proteolysis involved in cellular protein catabolic process	protein binding, bridging, transferase activity	other	4065	BY4741	04_4	
11	E	7	YDR132C	-	-	Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, mitochondrion, cytoplasm	4066	BY4741	04_4	
11	E	8	YDR133C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YDR134C	biological_process	molecular_function	cellular_component	4067	BY4741	04_4	
11	E	9	YDR134C	cellular_component	cellular_component	cellular_component	-	-	-	4068	BY4741	04_4	
11	E	10	YDR135C	YCF1	ATP-binding cassette glutathione S-conjugate transporter YCF1	Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR	vacuole organization, response to chemical, transmembrane transport, ion transport, organelle fusion, membrane fusion	hydrolase activity, transmembrane transporter activity, ATPase activity	vacuole, membrane, cytoplasm	4069	BY4741	04_4	
11	E	11	YDR136C	VPS61	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect	protein targeting	molecular_function	cellular_component	4070	BY4741	04_4	
11	E	12	YDR137W	RGP1	-	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p	endosomal transport	guanyl-nucleotide exchange factor activity	membrane, endomembrane system, cytoplasm, Golgi apparatus	4071	BY4741	04_4	
11	F	1	YPR021C	AGC1	amino acid transporter AGC1	Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant	ion transport, amino acid transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	7400	BY4741	00_18	"Hyperrecombination protein related to Top 1 p -- growth on -met, growth on -lys, mates poorly"	
11	F	2	YDR139C	RUB1	NEDD8 family protein RUB1	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)	protein modification by small protein conjugation or removal	other	cytoplasm	4073	BY4741	04_4	
11	F	3	YDR140W	MTQ2	S-adenosylmethionine-dependent methyltransferase	S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family	regulation of translation, protein alkylation	transferase activity, methyltransferase activity	nucleus, cytoplasm	4074	BY4741	04_4	
11	F	4	YDR142C	PEX7	PEB1|PAS7	Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)	protein targeting, transmembrane transport, peroxisome organization	other	peroxisome, cytoplasm	4076	BY4741	04_4	
11	F	5	YDR143C	SAN1	ubiquitin-protein ligase SAN1	Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins	response to chemical, protein modification by small protein conjugation or removal, proteolysis involved in cellular protein catabolic process	transferase activity	nucleus, cytoplasm	4077	BY4741	04_4	
11	F	6	YDR144C	MKC7	aspartyl protease|YPS2	GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication	cell wall organization or biogenesis, signaling	peptidase activity, hydrolase activity	cell wall, vacuole, cytoplasm	4078	BY4741	04_4	
11	F	7	YDR146C	SWI5	DNA-binding transcription factor SWI5	Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication	mitotic cell cycle, organelle fission	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding	nucleus, cytoplasm	4080	BY4741	04_4	"Transcription factor -- growth on -met, growth on -lys, mates poorly"	
11	F	8	YDR338C	-	-	Putative protein of unknown function; member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily	response to chemical	transmembrane transporter activity	membrane	4177	BY4741	04_7	
11	F	9	YDR340W	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	4179	BY4741	04_7	
11	F	10	YDR344C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains	biological_process	molecular_function	cellular_component	4181	BY4741	04_7	
11	F	11	YDR345C	HXT3	hexose transporter HXT3	Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication	transmembrane transport, carbohydrate transport	transmembrane transporter activity	membrane, plasma membrane	4182	BY4741	04_7	
11	F	12	YDR346C	SVF1	SGI1	Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance	response to chemical, response to oxidative stress	molecular_function	nucleus, cytoplasm	4183	BY4741	04_7	
11	G	1	YDR347W	MRP1	mitochondrial 37S ribosomal protein MRP1	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4184	BY4741	04_7	
11	G	2	YDR348C	PAL1	-	Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud, cell cortex, site of polarized growth, cytoplasm	4185	BY4741	04_7	
11	G	3	YDR349C	YPS7	putative aspartic endopeptidase	Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum	cell wall organization or biogenesis	peptidase activity, hydrolase activity	endomembrane system, endoplasmic reticulum, cytoplasm	4186	BY4741	04_7	
11	G	4	YDR350C	ATP22	TCM10	Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4187	BY4741	04_7	
11	G	5	YDR351W	SBE2	-	Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog, SBE22, that arose from the whole genome duplication	cell wall organization or biogenesis	molecular_function	endomembrane system, cytoplasm, Golgi apparatus	4188	BY4741	04_7	
11	G	6	YDR352W	YPQ2	-	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter	transmembrane transport, ion transport, amino acid transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	4189	BY4741	04_7	
11	G	7	YDR354W	TRP4	anthranilate phosphoribosyltransferase	Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis	cellular amino acid metabolic process	transferase activity, transferring glycosyl groups, transferase activity	nucleus, cytoplasm	4191	BY4741	04_7	
11	G	8	YDR357C	CNL1	BLC1	Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	vesicle organization	molecular_function	cytoplasm	4194	BY4741	04_7	
11	G	9	YDR358W	GGA1	ubiquitin-binding protein	Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication	Golgi vesicle transport, protein targeting, endosomal transport, proteolysis involved in cellular protein catabolic process	ubiquitin-like protein binding	endomembrane system, cytoplasm, Golgi apparatus	4195	BY4741	04_7	
11	G	10	YDR359C	EAF1	VID21	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1	DNA repair, chromatin organization, cellular response to DNA damage stimulus, protein complex biogenesis	molecular_function	nucleus	4196	BY4741	04_7	
11	G	11	YDR360W	OPI7	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C	biological_process	molecular_function	cellular_component	4197	BY4741	04_7	
11	G	12	YDR363W	ESC2	-	Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member	peptidyl-amino acid modification, mitotic cell cycle, DNA repair, organelle fission, chromatin organization, cellular response to DNA damage stimulus, chromosome segregation, regulation of protein modification process, protein modification by small protein conjugation or removal, DNA recombination, regulation of cell cycle	molecular_function	nucleus	4200	BY4741	04_7	
11	H	1	YDR364C	CDC40	SLU4|SLT15|PRP17	Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40	RNA splicing, mRNA processing	other	nucleus	4201	BY4741	04_7	
11	H	3	YDR368W	YPR1	trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1	NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant	carbohydrate metabolic process, response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, cytoplasm	4204	BY4741	04_7	
11	H	4	YDR369C	XRS2	-	Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling	meiotic cell cycle, DNA repair, telomere organization, organelle fission, sporulation, cellular response to DNA damage stimulus, DNA recombination	protein binding, bridging, DNA binding	nucleus	4205	BY4741	04_7	
11	H	5	YDR370C	DXO1	-	mRNA 5'-end-capping quality-control protein; has distributive, 5'-3' exoRNase activity; similar to Rai1p;	RNA catabolic process	nuclease activity, hydrolase activity	cytoplasm	4206	BY4741	04_7	
11	H	6	YDR371W	CTS2	putative chitinase	Putative chitinase; functionally complements A. gossypii cts2 mutant sporulation defect	sporulation	molecular_function	cytoplasm	4207	BY4741	04_7	
11	H	7	YDR372C	VPS74	MNN3|API1	Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33	response to chemical, Golgi vesicle transport, lipid metabolic process, signaling	lipid binding, enzyme binding, ion binding	nucleus, endomembrane system, membrane, Golgi apparatus, cytoplasm	4208	BY4741	04_7	
11	H	8	YDR374C	PHO92	mRNA-binding phosphate metabolism regulator	Posttranscriptional regulator of phosphate metabolism; facilitates PHO4 mRNA degradation by interacting with Pop2p; regulates PHO4 mRNA stability by binding to PHO4's 3'UTR in a phosphate-dependent manner; contains highly conserved YTH (YT521-B Homology) domain that exhibits RNA-binding activity; human homolog YTHDF2 can complement yeast null mutant	other	RNA binding, mRNA binding	cytoplasm	4210	BY4741	04_7	
11	H	9	YDR375C	BCS1	bifunctional AAA family ATPase chaperone/translocase BCS1	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases	mitochondrion organization, protein complex biogenesis	protein transporter activity, hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4211	BY4741	04_7	
11	H	10	YDR377W	ATP17	F1F0 ATP synthase subunit f	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis	transmembrane transport, ion transport, nucleobase-containing small molecule metabolic process	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4213	BY4741	04_7	
11	H	11	YDR378C	LSM6	U4/U6-U5 snRNP complex subunit LSM6	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA	RNA splicing, rRNA processing, ribosomal small subunit biogenesis, mRNA processing	RNA binding	nucleus, nucleolus, cytoplasm	4214	BY4741	04_7	
11	H	12	YDR379W	RGA2	-	GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication	cytoskeleton organization, signaling	enzyme regulator activity	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	4215	BY4741	04_7	
12	A	1	YDR380W	ARO10	phenylpyruvate decarboxylase ARO10	Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism	cellular amino acid metabolic process	lyase activity	cytoplasm	4216	BY4741	04_7	
12	A	2	YDR382W	RPP2B	ribosomal protein P2B|YP2beta|P2B|L45|YPA1|RPL45	Ribosomal protein P2 beta; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm	cytoplasmic translation, regulation of protein modification process, protein phosphorylation	structural molecule activity, structural constituent of ribosome, enzyme regulator activity	vacuole, ribosome, cytoplasm	4218	BY4741	04_7	
12	A	3	YDR383C	NKP1	-	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4	biological_process	molecular_function	chromosome	4219	BY4741	04_7	
12	A	4	YDR384C	ATO3	putative ammonium permease ATO3	Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters	transmembrane transport, ion transport	transmembrane transporter activity	membrane, mitochondrion, plasma membrane, cytoplasm	4220	BY4741	04_7	
12	A	5	YDR385W	EFT2	elongation factor 2	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication	regulation of translation, translational elongation	RNA binding, translation factor activity, RNA binding	ribosome, cytoplasm	4221	BY4741	04_7	
12	A	6	YDR386W	MUS81	SLX3	Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p	meiotic cell cycle, DNA repair, organelle fission, cellular response to DNA damage stimulus, chromosome segregation, DNA recombination	hydrolase activity, enzyme regulator activity, nuclease activity	nucleus	4222	BY4741	04_7	
12	A	7	YDR387C	CIN10	-	Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability	transmembrane transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	4223	BY4741	04_7	
12	A	8	YDR388W	RVS167	amphiphysin	Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin	endocytosis	cytoskeletal protein binding, lipid binding	cell cortex, site of polarized growth, cytoskeleton, cytoplasm	4224	BY4741	04_7	
12	A	9	YDR389W	SAC7	-	GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication	cytoskeleton organization, regulation of organelle organization, cell wall organization or biogenesis, signaling	enzyme regulator activity	cell cortex, cytoplasm	4225	BY4741	04_7	
12	A	10	YDR391C	-	-	Putative protein of unknown function; possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus, cytoplasm	4227	BY4741	04_7	
12	A	11	YDR392W	SPT3	transcriptional regulator SPT3	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia	peptidyl-amino acid modification, protein acylation, invasive growth in response to glucose limitation, chromatin organization, histone modification, pseudohyphal growth, transcription from RNA polymerase II promoter	transcription factor activity, protein binding	nucleus, cytoplasm	4228	BY4741	04_7	
12	B	1	YDR393W	SHE9	MDM33	Protein required for normal mitochondrial morphology; mitochondrial inner membrane protein; may be involved in fission of the inner membrane; forms a homo-oligomeric complex	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4229	BY4741	04_7	
12	B	2	YDR395W	SXM1	KAP108	Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1	nucleobase-containing compound transport, nuclear transport	protein transporter activity	nucleus, membrane, cytoplasm	4231	BY4741	04_7	
12	B	3	YDR399W	HPT1	hypoxanthine phosphoribosyltransferase|HGPRTase|HPRT|BRA6	Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	nucleobase-containing small molecule metabolic process	transferase activity, transferring glycosyl groups, transferase activity	nucleus, cytoplasm	4235	BY4741	04_7	
12	B	4	YDR400W	URH1	trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase	Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways	cofactor metabolic process, nucleobase-containing small molecule metabolic process	hydrolase activity, hydrolase activity, acting on glycosyl bonds	nucleus, cytoplasm	4236	BY4741	04_7	
12	B	5	YDR401W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4237	BY4741	04_7	
12	B	6	YDR402C	DIT2	putative cytochrome P450|CYP56	N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively	meiotic cell cycle, sporulation, cell wall organization or biogenesis	oxidoreductase activity	cellular_component	4238	BY4741	04_7	
12	B	7	YDR403W	DIT1	-	Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure	meiotic cell cycle, sporulation, cell wall organization or biogenesis	other	cellular_component	4239	BY4741	04_7	
12	B	8	YDR405W	MRP20	mitochondrial 54S ribosomal protein YmL41|YmL41|MRPL41	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4241	BY4741	04_7	
12	B	9	YDR406W	PDR15	ATP-binding cassette multidrug transporter PDR15	Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication	response to chemical	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane	4242	BY4741	04_7	
12	B	10	YDR408C	ADE8	phosphoribosylglycinamide formyltransferase	Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	nucleobase-containing small molecule metabolic process	transferase activity	nucleus, cytoplasm	4244	BY4741	04_7	
12	B	11	YDR409W	SIZ1	SUMO ligase SIZ1|ULL1	SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p	peptidyl-amino acid modification, chromosome segregation, regulation of protein modification process, protein modification by small protein conjugation or removal	transferase activity	nucleus, cell cortex, cytoskeleton, chromosome, cytoplasm	4245	BY4741	04_7	
12	B	12	YDR410C	STE14	protein-S-isoprenylcysteine carboxyl O-methyltransferase	Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane	protein alkylation, protein maturation	transferase activity, methyltransferase activity	nucleus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4246	BY4741	04_7	Sterile [expected phenotype]	
12	C	1	YDR411C	DFM1	-	Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p	response to chemical, proteolysis involved in cellular protein catabolic process, signaling	molecular_function	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4247	BY4741	04_7	
12	C	2	YDR414C	ERD1	LDB2	Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p)	protein glycosylation	molecular_function	membrane	4250	BY4741	04_7	
12	C	3	YDR415C	-	putative aminopeptidase	Putative aminopeptidase; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole	biological_process	molecular_function	vacuole, cytoplasm	4251	BY4741	04_7	
12	C	4	YDR418W	RPL12B	uL11|ribosomal 60S subunit protein L12B|L11|YL23|L15B|L12B	Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication	cytoplasmic translation, organelle assembly, ribosomal large subunit biogenesis, ribosome assembly	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	4254	BY4741	04_7	
12	C	5	YDR419W	RAD30	DNA-directed DNA polymerase eta|DBH1	DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV	mitotic cell cycle, DNA repair, organelle fission, cellular response to DNA damage stimulus, chromosome segregation	transferase activity, nucleotidyltransferase activity	nucleus, chromosome, mitochondrion, cytoplasm	4255	BY4741	04_7	
12	C	6	YDR420W	HKR1	-	Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection	mitotic cell cycle, carbohydrate metabolic process, cytokinesis, cell wall organization or biogenesis, signaling, response to osmotic stress	signal transducer activity	membrane, site of polarized growth, plasma membrane	4256	BY4741	04_7	
12	C	7	YDR421W	ARO80	-	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	transcription from RNA polymerase II promoter, cellular amino acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus	4257	BY4741	04_7	
12	C	8	YDR422C	SIP1	-	Alternate beta-subunit of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions	protein phosphorylation, signaling, protein complex biogenesis	kinase activity, transferase activity	vacuole, cytoplasm	4258	BY4741	04_7	
12	C	9	YDR423C	CAD1	YAP2	AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication	response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	4259	BY4741	04_7	
12	C	10	YDR425W	SNX41	-	Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p	endosomal transport	ion binding, lipid binding	cytoplasmic vesicle, endomembrane system, cytoplasm	4261	BY4741	04_7	
12	C	11	YDR426C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41	biological_process	molecular_function	cellular_component	4262	BY4741	04_7	
12	C	12	YDR428C	BNA7	arylformamidase	Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine	cofactor metabolic process, nucleobase-containing small molecule metabolic process	hydrolase activity	cellular_component	4264	BY4741	04_7	
12	D	1	YDR430C	CYM1	MOP112	Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology	proteolysis involved in cellular protein catabolic process	peptidase activity, hydrolase activity	mitochondrial envelope, mitochondrion, cytoplasm	4266	BY4741	04_7	
12	D	2	YDR431W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4267	BY4741	04_7	
12	D	3	YDR432W	NPL3	mRNA-binding protein NPL3|NAB1|NOP3|MTS1|MTR13	RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress	RNA splicing, regulation of translation, nucleobase-containing compound transport, DNA-templated transcription, termination, mRNA processing, transcription from RNA polymerase II promoter, nuclear transport, DNA-templated transcription, elongation	RNA binding, enzyme binding, mRNA binding	nucleus, cytoplasm	4268	BY4741	04_7	
12	D	4	YDR433W	-	KRE22	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	cellular response to DNA damage stimulus	molecular_function	cellular_component	4269	BY4741	04_7	
12	D	5	YDR435C	PPM1	leucine carboxy methyltransferase	Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth	protein alkylation, protein complex biogenesis	transferase activity, methyltransferase activity	cellular_component	4271	BY4741	04_7	
12	D	6	YDR436W	PPZ2	salt homeostasis regulator	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance	cellular ion homeostasis	phosphatase activity, hydrolase activity	cellular_component	4272	BY4741	04_7	
12	D	7	YEL001C	IRC22	-	Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	241	BY4741	05_2	
12	D	8	YEL003W	GIM4	tubulin-binding prefolding complex subunit GIM4|PFD2	Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it	protein complex biogenesis	cytoskeletal protein binding	cytoplasm	243	BY4741	05_2	
12	D	9	YEL004W	YEA4	-	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER	carbohydrate metabolic process, transmembrane transport, ion transport, nucleobase-containing compound transport, cell wall organization or biogenesis	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	244	BY4741	05_2	"Similar to K. lactis golgi uridine diphosphate-N-acetylglucosamine transporter -- growth on -met,  no growth on -lys, no growth on drop-in media, confirmed alpha -- CORRECT STRAIN CAN BE FOUND IN PLATE 121 D6"	
12	D	10	YEL005C	VAB2	VAB31	Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern	vesicle organization	molecular_function	cytoplasm	245	BY4741	05_2	
12	D	11	YEL006W	YEA6	NAD+ transporter|NDT2	Putative mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; YEA6 has a paralog, YIA6, that arose from the whole genome duplication	transmembrane transport, nucleobase-containing compound transport	other	membrane, mitochondrial envelope, mitochondrion, cytoplasm	246	BY4741	05_2	
12	D	12	YEL007W	MIT1	TOS9	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1	biological_process	molecular_function	nucleus, cytoplasm	247	BY4741	05_2	
12	E	1	YEL008W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism	biological_process	molecular_function	cellular_component	248	BY4741	05_2	
12	E	2	YEL009C	GCN4	amino acid starvation-responsive transcription factor GCN4|AAS101|ARG9|AAS3	bZIP transcriptional activator of amino acid biosynthetic genes;  activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	response to chemical, protein complex biogenesis, DNA-templated transcription, initiation, response to starvation, transcription from RNA polymerase II promoter	chromatin binding, nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding	nucleus	249	BY4741	05_2	
12	E	3	YEL010W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	250	BY4741	05_2	
12	E	4	YEL013W	VAC8	protein anchor VAC8|YEB3	Phosphorylated and palmitoylated vacuolar membrane protein; interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions	vacuole organization, protein targeting, organelle assembly, organelle fusion, vesicle organization, membrane fusion, organelle inheritance	other	vacuole, membrane, cytoplasm	253	BY4741	05_2	
12	E	5	YEL014C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains	biological_process	molecular_function	cellular_component	254	BY4741	05_2	
12	E	6	YEL015W	EDC3	LSM16|DCP3	Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress	RNA catabolic process, organelle assembly	RNA binding, mRNA binding	nucleus, cytoplasm	255	BY4741	05_2	
12	E	7	YEL016C	NPP2	nucleotide diphosphatase/phosphodiesterase NPP2	Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants	nucleobase-containing small molecule metabolic process	nuclease activity, hydrolase activity	endomembrane system, endoplasmic reticulum, cytoplasm	256	BY4741	05_2	
12	E	8	YEL017C-A	PMP2	proteolipid ATPase	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication	ion transport	molecular_function	membrane, vacuole, cytoplasm	257	BY4741	05_2	
12	E	9	YEL017W	GTT3	-	Protein of unknown function may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- and C-terminal fusion proteins localize to the cell periphery	biological_process	molecular_function	nucleus	258	BY4741	05_2	
12	E	10	YPR083W	MDM36	-	Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission	organelle fission, organelle inheritance, mitochondrion organization	molecular_function	mitochondrion, cytoplasm	7401	BY4741	00_18	
12	E	11	YEL020C	PXP1	putative indolepyruvate decarboxylase family protein	Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5p; contains low sequence identity with Pdc1p; mRNA identified as translated by ribosome profiling data	biological_process	molecular_function	peroxisome, cytoplasm	261	BY4741	05_2	
12	E	12	YEL023C	-	-	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene	biological_process	molecular_function	cellular_component	264	BY4741	05_2	
12	F	1	YEL024W	RIP1	ubiquinol--cytochrome-c reductase catalytic subunit RIP1	Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	molecular_function	mitochondrion, membrane, mitochondrial envelope, cytoplasm	265	BY4741	05_2	
12	F	2	YEL025C	-	SRI1	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus, cytoplasm	266	BY4741	05_2	
12	F	3	YEL027W	VMA3	H(+)-transporting V0 sector ATPase subunit c|CUP5|GEF2|CLS7	Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis	vacuole organization, protein targeting, ion transport, cellular ion homeostasis, endocytosis	transmembrane transporter activity	vacuole, membrane, cytoplasm	268	BY4741	05_2	
12	F	4	YEL028W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YEL028C is not an essential gene	biological_process	molecular_function	cellular_component	269	BY4741	05_2	
12	F	5	YEL030W	ECM10	Hsp70 family ATPase ECM10|SSC3	Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication	protein targeting, protein folding, mitochondrion organization	molecular_function	mitochondrion, cytoplasm	271	BY4741	05_2	
12	F	6	YEL031W	SPF1	ion-transporting P-type ATPase SPF1|PER9|PIO1|COD1	P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1	transmembrane transport, cellular ion homeostasis	hydrolase activity, transmembrane transporter activity, ATPase activity	endomembrane system, mitochondrion, membrane, endoplasmic reticulum, cytoplasm	272	BY4741	05_2	
12	F	7	YEL033W	MTC7	-	Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant	biological_process	molecular_function	cellular_component	274	BY4741	05_2	
12	F	8	YPR091C	NVJ2	-	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments	biological_process	lipid binding	endomembrane system, ribosome, endoplasmic reticulum, cytoplasm	7403	BY4741	00_18	
12	F	9	YEL037C	RAD23	-	Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage	response to chemical, proteolysis involved in cellular protein catabolic process, transcription from RNA polymerase II promoter	protein binding, bridging, hydrolase activity, DNA binding, ubiquitin-like protein binding	nucleus, mitochondrion, cytoplasm	278	BY4741	05_2	
12	F	10	YEL038W	UTR4	putative acireductone synthase UTR4	Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus	cellular amino acid metabolic process	phosphatase activity, hydrolase activity	nucleus, cytoplasm	279	BY4741	05_2	
12	F	11	YEL039C	CYC7	cytochrome c isoform 2	Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication	nucleobase-containing small molecule metabolic process, generation of precursor metabolites and energy, cellular respiration	other	mitochondrial envelope, mitochondrion, cytoplasm	280	BY4741	05_2	
12	F	12	YEL040W	UTR2	CRH2	Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck	carbohydrate metabolic process, cell wall organization or biogenesis	transferase activity, transferring glycosyl groups, transferase activity	cell cortex, cytoskeleton, cell wall, cellular bud, site of polarized growth, cytoplasm	281	BY4741	05_2	
12	G	1	YEL041W	YEF1	NADH/NAD(+) kinase	ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	cellular_component	282	BY4741	05_2	
12	G	2	YEL042W	GDA1	guanosine diphosphatase	Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies	protein glycosylation	hydrolase activity	endomembrane system, cytoplasm, Golgi apparatus	283	BY4741	05_2	
12	G	3	YEL043W	-	-	Predicted cytoskeleton protein involved in intracellular signaling; based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold	biological_process	molecular_function	endomembrane system, ribosome, endoplasmic reticulum, cytoplasm	284	BY4741	05_2	
12	G	4	YEL045C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress	biological_process	molecular_function	membrane	286	BY4741	05_2	"Similar to cytochrome c oxidase III of T. brucei kinetoplast -- no growth on -met, super slow growth on -lys, super slow growth on drop in media"	
12	G	5	YEL046C	GLY1	threonine aldolase GLY1	Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis	cellular amino acid metabolic process	lyase activity	cytoplasm	287	BY4741	05_2	"L-threonine aldolase -- no growth on -met, super slow growth on -lys, super slow growth on drop in media"	
12	G	6	YEL047C	FRD1	fumarate reductase|FRDS1	Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication	response to chemical	oxidoreductase activity	membrane, ribosome, mitochondrion, plasma membrane, cytoplasm	288	BY4741	05_2	
12	G	7	YEL048C	TCA17	-	Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder	protein complex biogenesis, Golgi vesicle transport, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, Golgi apparatus, cytoplasm	289	BY4741	05_2	
12	G	8	YEL049W	PAU2	seripauperin PAU2	Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme 	biological_process	molecular_function	cellular_component	290	BY4741	05_2	
12	G	9	YEL050C	RML2	mitochondrial 54S ribosomal protein RML2	Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	291	BY4741	05_2	
12	G	10	YEL051W	VMA8	H(+)-transporting V1 sector ATPase subunit D	Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits	cellular ion homeostasis	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, vacuole, cytoplasm	292	BY4741	05_2	
12	G	11	YEL052W	AFG1	-	Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain	response to chemical, protein targeting, transmembrane transport, proteolysis involved in cellular protein catabolic process, peroxisome organization, response to oxidative stress	molecular_function	mitochondrion, membrane, mitochondrial envelope, cytoplasm	293	BY4741	05_2	
12	G	12	YEL053C	MAK10	NAA35	Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele	protein acylation	transferase activity	cytoplasm	294	BY4741	05_2	
12	H	1	YEL054C	RPL12A	uL11|ribosomal 60S subunit protein L12A|L11|YL23|L15A|L12A	Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication	cytoplasmic translation, organelle assembly, ribosomal large subunit biogenesis, ribosome assembly	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	295	BY4741	05_2	
12	H	3	YEL056W	HAT2	-	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification	transferase activity, histone binding	nucleus, cytoplasm	297	BY4741	05_2	
12	H	4	YEL057C	SDD1	-	Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation	biological_process	molecular_function	cellular_component	298	BY4741	05_2	
12	H	5	YEL059W	HHY1	ENV6	Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking	biological_process	molecular_function	membrane	301	BY4741	05_2	
12	H	6	YEL060C	PRB1	proteinase B|CVT1	Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication	sporulation, response to starvation	peptidase activity, hydrolase activity	vacuole, cytoplasm	302	BY4741	05_2	
12	H	7	YEL061C	CIN8	kinesin motor protein CIN8|SDS15|KSL2	Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation	mitotic cell cycle, organelle fission, cytoskeleton organization, organelle assembly, chromosome segregation	hydrolase activity, ATPase activity	nucleus, cytoskeleton, chromosome, mitochondrion, cytoplasm	303	BY4741	05_2	
12	H	8	YEL062W	NPR2	nitrogen permease regulating protein NPR2	Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2	vacuole organization, response to chemical, regulation of organelle organization, organelle assembly, ion transport, response to starvation, amino acid transport, signaling	molecular_function	vacuole, membrane, cytoplasm	304	BY4741	05_2	
12	H	9	YEL063C	CAN1	arginine permease CAN1	Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication	transmembrane transport, ion transport, amino acid transport	transmembrane transporter activity	endomembrane system, mitochondrion, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	305	BY4741	05_2	
12	H	10	YEL064C	AVT2	-	Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	306	BY4741	05_2	
12	H	11	YEL065W	SIT1	siderophore transporter|ARN3	Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p	transmembrane transport, cellular ion homeostasis	transmembrane transporter activity	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	307	BY4741	05_2	
12	H	12	YEL066W	HPA3	D-amino-acid N-acetyltransferase	D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates	response to chemical, cellular amino acid metabolic process	transferase activity	nucleus, cytoplasm	308	BY4741	05_2	
13	A	1	YEL067C	-	-	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	309	BY4741	05_2	
13	A	2	YEL068C	-	-	Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	310	BY4741	05_2	
13	A	3	YEL071W	DLD3	D-lactate dehydrogenase	2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm	monocarboxylic acid metabolic process	ion binding, oxidoreductase activity	cytoplasm	313	BY4741	05_2	
13	A	4	YEL072W	RMD6	-	Protein required for sporulation	biological_process	molecular_function	cellular_component	314	BY4741	05_2	Hypothetical protein -- mates like alpha PCR mating type alpha	
13	A	5	YER001W	MNN1	alpha-1,3-mannosyltransferase MNN1	Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, cytoplasm, Golgi apparatus	322	BY4741	05_2	
13	A	6	YER002W	NOP16	-	Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis	ribosomal large subunit biogenesis	molecular_function	nucleus, nucleolus	323	BY4741	05_2	
13	A	7	YER004W	FMP52	-	Protein of unknown function; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	325	BY4741	05_2	
13	A	8	YER005W	YND1	apyrase|YEJ5|APY1	Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity	protein glycosylation	hydrolase activity	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	326	BY4741	05_2	
13	A	9	YER007C-A	TMA20	RBF20	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress	other	RNA binding	ribosome, cytoplasm	328	BY4741	05_2	
13	A	10	YER007W	PAC2	-	Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl	protein folding, protein complex biogenesis	cytoskeletal protein binding	cellular_component	329	BY4741	05_2	
13	A	11	YER010C	-	bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase	Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate	monocarboxylic acid metabolic process	lyase activity	cellular_component	332	BY4741	05_2	
13	A	12	YER011W	TIR1	GPI-anchored mannoprotein|SRP1	Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins	biological_process	structural molecule activity	cell wall, vacuole, cytoplasm	333	BY4741	05_2	
13	B	2	YPR011C	-	-	Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	transmembrane transport, ion transport, nucleobase-containing compound transport	transmembrane transporter activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	7399	BY4741	00_18	
13	B	3	YER017C	AFG3	AAA family ATPase AFG3|YTA10	Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant	cytoplasmic translation, protein targeting, mitochondrion organization, transmembrane transport, protein maturation, protein complex biogenesis	peptidase activity, hydrolase activity, ATPase activity	vacuole, mitochondrion, membrane, mitochondrial envelope, cytoplasm	148	BY4741	05_3	
13	B	4	YER019W	ISC1	inositol phosphosphingolipid phospholipase	Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; ortholog of mammalian neutral sphingomyelinase type 2	lipid metabolic process, response to osmotic stress	hydrolase activity	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm	150	BY4741	05_3	
13	B	5	YER019C-A	SBH2	Arf family guanine nucleotide exchange factor SBH2|SEB2	Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication	protein targeting	guanyl-nucleotide exchange factor activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	151	BY4741	05_3	
13	B	6	YER020W	GPA2	guanine nucleotide-binding protein subunit alpha|SSP101	Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus	meiotic cell cycle, response to chemical, sporulation, pseudohyphal growth, signaling	GTPase activity, hydrolase activity	mitochondrion, membrane, cytoplasm, plasma membrane	152	BY4741	05_3	
13	B	7	YER024W	YAT2	carnitine O-acetyltransferase YAT2	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane	other	transferase activity	cytoplasm	156	BY4741	05_3	
13	B	8	YER030W	CHZ1	-	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress	chromatin organization	histone binding	nucleus	162	BY4741	05_3	
13	B	9	YER032W	FIR1	PIP1	Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate	mRNA processing	molecular_function	cellular bud, site of polarized growth	164	BY4741	05_3	
13	B	10	YER033C	ZRG8	-	Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency	cell wall organization or biogenesis	molecular_function	cellular bud, site of polarized growth, mitochondrion, cytoplasm	165	BY4741	05_3	
13	B	11	YER034W	-	-	Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	166	BY4741	05_3	
13	B	12	YER035W	EDC2	-	RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication	RNA catabolic process, regulation of translation	RNA binding, mRNA binding	nucleus, nucleolus, cytoplasm	167	BY4741	05_3	
13	C	1	YER038W-A	FMP49	-	Mitochondrial protein of unknown function; almost completely overlaps ORF HVG1/YER039C	biological_process	molecular_function	mitochondrion, cytoplasm	171	BY4741	05_3	
13	C	2	YER039C	HVG1	putative GDP-mannose transporter|YEM9	Protein of unknown function; HVG1 has a paralog, VRG4, that arose from the whole genome duplication	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	172	BY4741	05_3	
13	C	3	YER040W	GLN3	nitrogen-responsive transcriptional regulator GLN3	Transcriptional activator of genes regulated by nitrogen catabolite repression; localization and activity regulated by quality of nitrogen source and Ure2p	response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	173	BY4741	05_3	
13	C	4	YER041W	YEN1	crossover junction endodeoxyribonuclease	Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p	DNA repair, cellular response to DNA damage stimulus	nuclease activity, hydrolase activity	nucleus, cytoplasm	174	BY4741	05_3	
13	C	5	YER042W	MXR1	peptide-methionine-S-sulfoxide reductase|msrA	Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease	response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, cytoplasm	175	BY4741	05_3	
13	C	6	YER044C-A	MEI4	-	Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores	meiotic cell cycle, organelle fission	molecular_function	nucleus, chromosome	178	BY4741	05_3	
13	C	7	YER045C	ACA1	-	ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication	transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	179	BY4741	05_3	
13	C	8	YER046W-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SAP1/YER047C	biological_process	molecular_function	cellular_component	181	BY4741	05_3	
13	C	9	YER047C	SAP1	putative AAA family ATPase SAP1	Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system	biological_process	ATPase activity, hydrolase activity	cytoplasm	182	BY4741	05_3	
13	C	10	YER048C	CAJ1	-	Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly	protein folding	molecular_function	nucleus	183	BY4741	05_3	
13	C	11	YER049W	TPA1	oxidative DNA demethylase	Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate	RNA catabolic process, DNA repair, cellular response to DNA damage stimulus	RNA binding, ion binding, oxidoreductase activity	nucleus	184	BY4741	05_3	
13	C	12	YER050C	RSM18	mitochondrial 37S ribosomal protein RSM18	Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	185	BY4741	05_3	
13	D	1	YER051W	JHD1	[Histone H3]-lysine-36 demethylase|KDM2|JHDM1	JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe	chromatin organization, transcription from RNA polymerase II promoter, histone modification, DNA-templated transcription, elongation	histone binding, oxidoreductase activity	cellular_component	186	BY4741	05_3	
13	D	2	YER052C	HOM3	aspartate kinase|THR3|SIL4|BOR1	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	cellular amino acid metabolic process	kinase activity, transferase activity	cytoplasm	187	BY4741	05_3	
13	D	3	YER053C	PIC2	Cu/Pi carrier	Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature	cellular ion homeostasis, transmembrane transport, ion transport	transmembrane transporter activity	membrane, mitochondrion, cytoplasm	188	BY4741	05_3	
13	D	4	YER054C	GIP2	-	Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication	carbohydrate metabolic process, protein dephosphorylation, generation of precursor metabolites and energy	enzyme regulator activity	cytoplasm	189	BY4741	05_3	
13	D	5	YER056C	FCY2	purine-cytosine permease|BRA7	Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress	transmembrane transport, nucleobase-containing compound transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	191	BY4741	05_3	
13	D	6	YER056C-A	RPL34A	eL34|ribosomal 60S subunit protein L34A|L34e|L34A	Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	other	192	BY4741	05_3	
13	D	7	YER057C	HMF1	putative isoleucine biosynthesis protein HMF1|HIG1	Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, mitochondrial envelope, mitochondrion, cytoplasm	193	BY4741	05_3	
13	D	8	YER058W	PET117	-	Protein required for assembly of cytochrome c oxidase	mitochondrion organization, protein complex biogenesis	molecular_function	mitochondrion, cytoplasm	194	BY4741	05_3	
13	D	9	YER059W	PCL6	-	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication	carbohydrate metabolic process, generation of precursor metabolites and energy	enzyme regulator activity	other	195	BY4741	05_3	
13	D	10	YER060W	FCY21	purine-cytosine permease	Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function	transmembrane transport	transmembrane transporter activity	membrane, plasma membrane	196	BY4741	05_3	
13	D	11	YER060W-A	FCY22	purine-cytosine permease	Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function	transmembrane transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	197	BY4741	05_3	"similar to Fcy2p -- growth on -met, no growth on -lys, no growth on drop-in media"	
13	D	12	YER061C	CEM1	fatty acid synthase CEM1	Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant	lipid metabolic process, monocarboxylic acid metabolic process	transferase activity	mitochondrion, cytoplasm	198	BY4741	05_3	
13	E	1	YER062C	GPP2	HOR2|glycerol-1-phosphatase HOR2	DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication	carbohydrate metabolic process, response to osmotic stress	phosphatase activity, hydrolase activity	nucleus, cytoplasm	199	BY4741	05_3	
13	E	2	YER065C	ICL1	isocitrate lyase 1	Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose	carbohydrate metabolic process, monocarboxylic acid metabolic process	lyase activity	cytoplasm	202	BY4741	05_3	
13	E	3	YER066C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YER067W	biological_process	molecular_function	cellular_component	204	BY4741	05_3	
13	E	4	YER067W	RGI1	-	Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog, RGI2, that arose from the whole genome duplication	generation of precursor metabolites and energy	molecular_function	nucleus, cytoplasm	205	BY4741	05_3	
13	E	5	YER067C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF RGI1/YER067W	biological_process	molecular_function	cellular_component	206	BY4741	05_3	
13	E	6	YER068W	MOT2	CCR4-NOT core ubiquitin-protein ligase subunit MOT2|SIG1|NOT4	Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication	proteolysis involved in cellular protein catabolic process, RNA catabolic process, protein modification by small protein conjugation or removal, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	transferase activity, DNA binding	cytoplasm	207	BY4741	05_3	
13	E	7	YER068C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARG5,6/YER069W	biological_process	molecular_function	cellular_component	208	BY4741	05_3	
13	E	8	YER069W	ARG5,6	argC|argB|bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine	cellular amino acid metabolic process	kinase activity, transferase activity, oxidoreductase activity	mitochondrion, cytoplasm	209	BY4741	05_3	
13	E	9	YPR118W	MRI1	S-methyl-5-thioribose-1-phosphate isomerase MRI1	5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway	cellular amino acid metabolic process	isomerase activity	nucleus, cytoplasm	7405	BY4741	00_18	
13	E	10	YER071C	TDA2	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	site of polarized growth, cytoplasm	211	BY4741	05_3	
13	E	11	YER072W	VTC1	PHM4|NRF1	Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress	vacuole organization, organelle fusion, membrane fusion	RNA binding, mRNA binding	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	212	BY4741	05_3	
13	E	12	YER073W	ALD5	aldehyde dehydrogenase (NAD(P)(+)) ALD5	Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed	monocarboxylic acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	213	BY4741	05_3	
13	F	1	YER074W	RPS24A	eS24|ribosomal 40S subunit protein S24A|S24e|S24A|RPS24EA	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis	structural constituent of ribosome, structural molecule activity	ribosome, mitochondrion, cytoplasm	214	BY4741	05_3	
13	F	2	YER075C	PTP3	tyrosine protein phosphatase PTP3	Phosphotyrosine-specific protein phosphatase; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm	response to chemical, protein phosphorylation, sporulation, protein dephosphorylation, regulation of protein modification process, conjugation, signaling, response to osmotic stress	phosphatase activity, hydrolase activity	nucleus, cytoplasm	215	BY4741	05_3	
13	F	3	YER079W	-	-	Putative protein of unknown function	biological_process	molecular_function	nucleus, cytoplasm	219	BY4741	05_3	
13	F	4	YER080W	AIM9	FMP29	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion, cytoplasm	220	BY4741	05_3	
13	F	5	YER081W	SER3	phosphoglycerate dehydrogenase SER3	3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER3 has a paralog, SER33, that arose from the whole genome duplication	cellular amino acid metabolic process	oxidoreductase activity	cytoplasm	221	BY4741	05_3	
13	F	6	YER083C	GET2	GET complex subunit GET2|RMD7|HUR2	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division	Golgi vesicle transport	other	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	223	BY4741	05_3	
13	F	7	YER084W	-	-	Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component	224	BY4741	05_3	
13	F	8	YER085C	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	225	BY4741	05_3	
13	F	9	YER086W	ILV1	threonine ammonia-lyase ILV1|ISO1	Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation	cellular amino acid metabolic process	lyase activity	mitochondrion, cytoplasm	226	BY4741	05_3	
13	F	10	YER087C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF AIM10/YER087W	biological_process	molecular_function	cellular_component	228	BY4741	05_3	
13	F	11	YGR123C	PPT1	protein serine/threonine phosphatase	Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth	protein dephosphorylation	phosphatase activity, hydrolase activity	nucleus, cytoplasm	4753	BY4741	07_5	
13	F	12	YGR124W	ASN2	asparagine synthase (glutamine-hydrolyzing) 2	Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication	monocarboxylic acid metabolic process, cellular amino acid metabolic process	ligase activity	cytoplasm	4754	BY4741	07_5	
13	G	1	YGR125W	-	-	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	membrane, vacuole, cytoplasm	4755	BY4741	07_5	
13	G	2	YGR126W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus, cytoplasm	4756	BY4741	07_5	
13	G	3	YGR127W	-	-	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response	biological_process	molecular_function	cellular_component	4757	BY4741	07_5	
13	G	4	YGR129W	SYF2	NTC31	Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest	RNA splicing, mRNA processing	other	nucleus, cytoplasm	4759	BY4741	07_5	
13	G	5	YGR130C	-	-	Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)	biological_process	molecular_function	membrane, cytoplasm	4760	BY4741	07_5	
13	G	6	YGR131W	FHN1	-	Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication	other	molecular_function	membrane	4761	BY4741	07_5	
13	G	7	YGR132C	PHB1	prohibitin subunit PHB1	Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)	protein folding, organelle inheritance, mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4762	BY4741	07_5	
13	G	8	YGR133W	PEX4	E2 ubiquitin-protein ligase peroxin 4|UBC10|PAS2	Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis	protein targeting, protein modification by small protein conjugation or removal, transmembrane transport, peroxisome organization, signaling	transferase activity	peroxisome, cytoplasm	4763	BY4741	07_5	
13	G	9	YGR135W	PRE9	proteasome core particle subunit alpha 3	Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform	proteolysis involved in cellular protein catabolic process, protein complex biogenesis	molecular_function	nucleus, membrane, endomembrane system, cytoplasm	4765	BY4741	07_5	
13	G	10	YGR136W	LSB1	-	Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis	molecular_function	nucleus, cell cortex, cytoskeleton, cytoplasm	4766	BY4741	07_5	
13	G	11	YGR137W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4767	BY4741	07_5	
13	G	12	YGR138C	TPO2	spermine transporter	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication	ion transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	4768	BY4741	07_5	
13	H	1	YGR139W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4769	BY4741	07_5	
13	H	3	YGR141W	VPS62	-	Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication	protein targeting	molecular_function	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	4771	BY4741	07_5	
13	H	4	YGR142W	BTN2	-	v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; contributes to prion curing; preferentially expressed after severe ethanol stress	ion transport, protein folding, endosomal transport, amino acid transport	other	nucleus, cytoplasmic vesicle, endomembrane system, cytoplasm	4772	BY4741	07_5	
13	H	5	YGR143W	SKN1	beta-glucan synthesis-associated protein SKN1	Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication	carbohydrate metabolic process, lipid metabolic process, cell wall organization or biogenesis	hydrolase activity, hydrolase activity, acting on glycosyl bonds	membrane	4773	BY4741	07_5	
13	H	6	YGR144W	THI4	thiamine thiazole synthase|MOL1|ESP35	Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents	mitochondrion organization, vitamin metabolic process	ion binding	cytoplasm	4774	BY4741	07_5	
13	H	7	YGR146C	ECL1	-	Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation	biological_process	molecular_function	cellular_component	4776	BY4741	07_5	
13	H	8	YGR148C	RPL24B	eL24|ribosomal 60S subunit protein L24B|L24e|rp29|YL21|L30B|L24B|RPL30B	Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication	cytoplasmic translation	RNA binding, structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	4778	BY4741	07_5	
13	H	9	YGR149W	GPC1	-	Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acetyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integal membrane protein	lipid metabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4779	BY4741	07_5	
13	H	10	YGR150C	CCM1	DMR1|RRG2	Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport	RNA splicing, mitochondrion organization	RNA binding, rRNA binding	mitochondrion, cytoplasm	4780	BY4741	07_5	
13	H	11	YGR151C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	4781	BY4741	07_5	
13	H	12	YGR152C	RSR1	Ras family GTPase RSR1|BUD1	GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases	mitotic cell cycle, cell budding, cytokinesis, conjugation, signaling	GTPase activity, hydrolase activity, signal transducer activity	endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm, plasma membrane	4782	BY4741	07_5	
14	A	1	YGR153W	-	TOS10	Putative protein of unknown function	biological_process	molecular_function	cellular_component	4783	BY4741	07_5	
14	A	2	YGR154C	GTO1	omega-class glutathione transferase	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization	other	transferase activity	peroxisome, cytoplasm	4784	BY4741	07_5	
14	A	3	YGR157W	CHO2	phosphatidylethanolamine N-methyltransferase|PEM1	Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis	lipid metabolic process	transferase activity, methyltransferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4787	BY4741	07_5	
14	A	4	YGR159C	NSR1	SHE5	Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by polyphosphorylation	rRNA processing, organelle assembly, ribosomal small subunit biogenesis, ribosome assembly	RNA binding, DNA binding, mRNA binding	nucleus, endomembrane system, mitochondrion, nucleolus, cytoplasm	4789	BY4741	07_5	
14	A	5	YGR160W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4790	BY4741	07_5	
14	A	6	YGR161C	RTS3	-	Putative component of the protein phosphatase type 2A complex	biological_process	molecular_function	nucleus, cytoplasm	4791	BY4741	07_5	
14	A	7	YGR163W	GTR2	-	Subunit of a TORC1-stimulating GTPase complex; subunit of the Gtr1-Gtr2 GTPase complex that stimulates TORC1 in response to amino acid stimulation; stimulates the GTPase activity of Gtr1p; negatively regulates the Ran/Tc4 GTPase cycle; activates transcription; tethered to the vacuolar membrane as part of the EGO complex (EGOC); required for sorting of Gap1p; activated by the the Lst4p-Lst7p GAP complex; localizes to cytoplasm and to chromatin; homolog of human RagC and	transcription from RNA polymerase II promoter, signaling	GTPase activity, hydrolase activity, ion binding	nucleus, cytoplasmic vesicle, endomembrane system, chromosome, vacuole, membrane, cytoplasm	4793	BY4741	07_5	
14	A	8	YGR164W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4794	BY4741	07_5	
14	A	9	YGR165W	MRPS35	mitochondrial 37S ribosomal protein MRPS35	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4795	BY4741	07_5	
14	A	10	YGR166W	TRS65	KRE11	Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response	Golgi vesicle transport, protein complex biogenesis	guanyl-nucleotide exchange factor activity	cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	4796	BY4741	07_5	
14	A	11	YOL153C	cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	-	-	-	7133	BY4741	00_15	
14	A	12	YGR168C	-	-	Putative protein of unknown function; YGR168C is not an essential gene	biological_process	molecular_function	peroxisome, membrane, cytoplasm	4798	BY4741	07_5	"Hypothetical protein -- growth on -met, no growth on -lys, no growth on drop-in media"	
14	B	1	YGR169C	PUS6	pseudouridine synthase PUS6	tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability	tRNA processing, RNA modification	isomerase activity	mitochondrion, cytoplasm	4799	BY4741	07_5	
14	B	3	YGR170W	PSD2	phosphatidylserine decarboxylase 2	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected	lipid metabolic process	lyase activity	cytoplasmic vesicle, endomembrane system, cytoplasm	4800	BY4741	07_5	
14	B	4	YGR171C	MSM1	methionine--tRNA ligase MSM1	Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p	tRNA aminoacylation for protein translation, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	4801	BY4741	07_5	
14	B	5	YGR173W	RBG2	GIR1	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein	cytoplasmic translation, response to starvation	ion binding	cytoplasm	4803	BY4741	07_5	
14	B	6	YGR174C	CBP4	-	Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex	mitochondrion organization, protein complex biogenesis	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4804	BY4741	07_5	
14	B	7	YGR176W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4806	BY4741	07_5	
14	B	8	YGR177C	ATF2	alcohol O-acetyltransferase	Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking	response to chemical, generation of precursor metabolites and energy, lipid metabolic process	transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4807	BY4741	07_5	
14	B	9	YGR178C	PBP1	MRS16	Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress	regulation of translation, organelle assembly, mRNA processing	RNA binding, mRNA binding	nucleus, mitochondrion, cytoplasm	4808	BY4741	07_5	
14	B	10	YGR180C	RNR4	ribonucleotide-diphosphate reductase subunit RNR4|PSO3|CRT3	Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process	oxidoreductase activity	nucleus, cytoplasm	4810	BY4741	07_5	
14	B	11	YGR181W	TIM13	protein translocase subunit TIM13	Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane	protein targeting, mitochondrion organization, transmembrane transport	protein transporter activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4811	BY4741	07_5	
14	B	12	YGR182C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W	biological_process	molecular_function	cellular_component	4812	BY4741	07_5	
14	C	1	YGR183C	QCR9	ubiquinol--cytochrome-c reductase subunit 9|UCR9	Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex	mitochondrion organization, generation of precursor metabolites and energy, protein complex biogenesis, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4813	BY4741	07_5	
14	C	2	YGR184C	UBR1	E3 ubiquitin-protein ligase UBR1|PTR1	E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to recognize and ubiquitinate substrates of the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)	response to chemical, protein modification by small protein conjugation or removal, regulation of transport, proteolysis involved in cellular protein catabolic process	transferase activity	cytoplasm	4814	BY4741	07_5	
14	C	3	YGR187C	HGH1	-	Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	4817	BY4741	07_5	
14	C	4	YGR189C	CRH1	transglycosylase	Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress	carbohydrate metabolic process, cell wall organization or biogenesis	transferase activity, transferring glycosyl groups, transferase activity	cell wall	4819	BY4741	07_5	
14	C	5	YGR192C	TDH3	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3|GAPDH|GPD|SSS2|HSP36|HSP35|GLD1	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria; binds AU-rich RNA	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, nucleobase-containing small molecule metabolic process	RNA binding, oxidoreductase activity	nucleus, mitochondrion, cell wall, membrane, cytoplasm, plasma membrane	4822	BY4741	07_5	
14	C	6	YGR193C	PDX1	-	E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core	cofactor metabolic process, monocarboxylic acid metabolic process	structural molecule activity	mitochondrion, cytoplasm	4823	BY4741	07_5	
14	C	7	YGR194C	XKS1	xylulokinase	Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains	carbohydrate metabolic process	kinase activity, transferase activity	cytoplasm	4824	BY4741	07_5	
14	C	8	YGR196C	FYV8	-	Protein of unknown function; required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cytoplasm	4826	BY4741	07_5	
14	C	9	YGR197C	SNG1	-	Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication	ion transport, regulation of transport, nucleobase-containing compound transport, lipid transport, cell wall organization or biogenesis	molecular_function	vacuole, membrane, cytoplasm, plasma membrane	4827	BY4741	07_5	
14	C	10	YGR199W	PMT6	dolichyl-phosphate-mannose-protein mannosyltransferase PMT6	Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4829	BY4741	07_5	
14	C	11	YGR200C	ELP2	Elongator subunit ELP2|KTI3|TOT2	Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 &#946; propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin	tRNA processing, protein modification by small protein conjugation or removal, transcription from RNA polymerase II promoter, RNA modification	cytoskeletal protein binding	nucleus, cytoplasm	4830	BY4741	07_5	
14	C	12	YGR202C	PCT1	choline-phosphate cytidylyltransferase|CCT1|BSR2	Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity	lipid metabolic process	transferase activity, nucleotidyltransferase activity	nucleus, endomembrane system, cytoplasm, Golgi apparatus	4832	BY4741	07_5	
14	D	1	YGR203W	YCH1	phosphatase YCH1	Phosphatase with sequence similarity to Cdc25p; Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	other	phosphatase activity, transferase activity, hydrolase activity	nucleus, cytoplasm	4833	BY4741	07_5	
14	D	2	YGR205W	TDA10	putative ATP-dependent kinase	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele	biological_process	ion binding	nucleus, cytoplasm	4835	BY4741	07_5	
14	D	3	YGR206W	MVB12	ubiquitin-binding ESCRT-I subunit protein MVB12	ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin	protein targeting, ion transport, nucleobase-containing compound transport, protein complex biogenesis, endosomal transport	ubiquitin-like protein binding	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	4836	BY4741	07_5	
14	D	4	YGR207C	CIR1	-	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response	biological_process	molecular_function	mitochondrion, cytoplasm	4837	BY4741	07_5	
14	D	5	YGR208W	SER2	phosphoserine phosphatase	Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source	cellular amino acid metabolic process	phosphatase activity, hydrolase activity	nucleus, cytoplasm	4838	BY4741	07_5	
14	D	6	YGR209C	TRX2	thioredoxin TRX2|LMA1	Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication	vacuole organization, organelle fusion, Golgi vesicle transport, membrane fusion, organelle inheritance	oxidoreductase activity	vacuole, cytoplasm	4839	BY4741	07_5	
14	D	7	YGR212W	SLI1	N-acetyltransferase	N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin	response to chemical	transferase activity	nucleus, membrane, endomembrane system, plasma membrane	4842	BY4741	07_5	
14	D	8	YGR213C	RTA1	-	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	4843	BY4741	07_5	
14	D	9	YGR214W	RPS0A	uS2|ribosomal 40S subunit protein S0A|S2|S0A|YST1|NAB1A|NAB1	Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication;	cytoplasmic translation, rRNA processing, organelle assembly, nucleobase-containing compound transport, ribosomal small subunit biogenesis, ribosome assembly, nuclear transport	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	4844	BY4741	07_5	
14	D	10	YGR215W	RSM27	mitochondrial 37S ribosomal protein RSM27	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4845	BY4741	07_5	
14	D	11	YGR217W	CCH1	-	Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function	ion transport	transmembrane transporter activity	membrane, plasma membrane	4847	BY4741	07_5	
14	D	12	YHL047C	ARN2	siderophore transporter|TAF1	Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C	cofactor metabolic process, cellular ion homeostasis	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	916	BY4741	08_1	
14	E	1	YHL046C	PAU13	seripauperin PAU13	Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively	biological_process	molecular_function	cellular_component	917	BY4741	08_1	
14	E	2	YHL045W	-	-	Putative protein of unknown function; not an essential gene	biological_process	molecular_function	cellular_component	918	BY4741	08_1	
14	E	3	YHL044W	-	DUP240 family protein	Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern	biological_process	molecular_function	membrane, plasma membrane	919	BY4741	08_1	
14	E	4	YHL043W	ECM34	-	Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol	biological_process	molecular_function	cytoplasm	920	BY4741	08_1	
14	E	5	YHL042W	-	-	Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP and mCherry fusion proteins localize to the vacuole	biological_process	molecular_function	vacuole, cytoplasm	921	BY4741	08_1	
14	E	6	YHL041W	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains	biological_process	molecular_function	cellular_component	922	BY4741	08_1	
14	E	7	YHL040C	ARN1	siderophore transporter	ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress	other	transmembrane transporter activity	nucleus, cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm, plasma membrane	923	BY4741	08_1	
14	E	8	YHL038C	CBP2	-	Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene	RNA splicing	RNA binding	mitochondrion, cytoplasm	925	BY4741	08_1	
14	E	9	YHL037C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains	biological_process	molecular_function	cellular_component	926	BY4741	08_1	
14	E	10	YHL036W	MUP3	-	Low affinity methionine permease; similar to Mup1p	ion transport, amino acid transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	927	BY4741	08_1	
14	E	11	YHL035C	VMR1	putative ATP-binding cassette multidrug transporter VMR1	Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication	response to chemical	hydrolase activity, transmembrane transporter activity, ATPase activity	vacuole, ribosome, mitochondrion, membrane, cytoplasm	928	BY4741	08_1	
14	E	12	YHL034C	SBP1	SSB1|SSBR1	Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication	regulation of translation	RNA binding, mRNA binding	nucleus, nucleolus, cytoplasm	929	BY4741	08_1	
14	F	1	YHL033C	RPL8A	eL8|ribosomal 60S subunit protein L8A|L8e|rp6|YL5|L8A|L4A|MAK7	Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	930	BY4741	08_1	
14	F	2	YHL032C	GUT1	glycerol kinase	Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p	carbohydrate metabolic process	kinase activity, transferase activity	mitochondrion, cytoplasm	931	BY4741	08_1	
14	F	3	YHL031C	GOS1	-	v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28	membrane fusion, Golgi vesicle transport, organelle fusion, vesicle organization	other	membrane, endomembrane system, cytoplasm, Golgi apparatus	932	BY4741	08_1	
14	F	4	YHL030W	ECM29	-	Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress	protein complex biogenesis	structural molecule activity	nucleus, cytoplasm	933	BY4741	08_1	"Cell wall biogenesis & architecture -- growth on -met, no growth on -lys, no growth on drop-in media -- APPEARS ALPHA "	
14	F	5	YHL029C	OCA5	-	Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts	biological_process	molecular_function	cytoplasm	934	BY4741	08_1	
14	F	6	YHL028W	WSC4	YFW1|YHC8	Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3	response to heat, protein targeting	protein transporter activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	935	BY4741	08_1	
14	F	7	YHL027W	RIM101	alkaline-responsive transcriptional regulator RIM101|RIM1	Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC	mitotic cell cycle, meiotic cell cycle, response to chemical, organelle fission, sporulation, cytokinesis, cell wall organization or biogenesis, transcription from RNA polymerase II promoter, regulation of cell cycle	nucleic acid binding transcription factor activity, DNA binding	nucleus	936	BY4741	08_1	
14	F	8	YHL026C	-	-	Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)	biological_process	molecular_function	other	937	BY4741	08_1	
14	F	9	YHL023C	NPR3	RMD11	Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog	vacuole organization, meiotic cell cycle, organelle fission, regulation of organelle organization, organelle assembly, response to starvation, pseudohyphal growth, signaling	molecular_function	vacuole, membrane, cytoplasm	940	BY4741	08_1	
14	F	10	YHL022C	SPO11	-	Meiosis-specific protein that initiates meiotic recombination; initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation	meiotic cell cycle, organelle fission	chromatin binding, nuclease activity, hydrolase activity	nucleus, chromosome	941	BY4741	08_1	
14	F	11	YHL021C	AIM17	FMP12	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	mitochondrion organization	molecular_function	mitochondrion, cytoplasm	942	BY4741	08_1	
14	F	12	YHL020C	OPI1	transcriptional regulator OPI1	Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid	response to chemical, lipid metabolic process, transcription from RNA polymerase II promoter, signaling	lipid binding, ion binding, transcription factor activity, protein binding	nucleus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	943	BY4741	08_1	
14	G	1	YHL019C	APM2	-	Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport	Golgi vesicle transport	other	nucleus, membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	944	BY4741	08_1	
14	G	2	YHL017W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication	biological_process	molecular_function	membrane, cytoplasmic vesicle, cytoplasm	946	BY4741	08_1	
14	G	3	YHL016C	DUR3	-	Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway	ion transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	947	BY4741	08_1	
14	G	4	YHL014C	YLF2	YLF1	Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	ion binding	mitochondrion, cytoplasm	949	BY4741	08_1	
14	G	5	YHL013C	OTU2	-	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	ribosome, cytoplasm	950	BY4741	08_1	
14	G	6	YHL012W	-	UTP--glucose-1-phosphate uridylyltransferase	Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	951	BY4741	08_1	
14	G	7	YHL010C	ETP1	BRP2	Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences	response to chemical	ubiquitin-like protein binding	cellular_component	953	BY4741	08_1	
14	G	8	YHL009C	YAP3	-	Basic leucine zipper (bZIP) transcription factor	transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	954	BY4741	08_1	
14	G	9	YHL008C	-	-	Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	ion transport	other	membrane, vacuole, cytoplasm	955	BY4741	08_1	
14	G	10	YHL007C	STE20	mitogen-activated protein kinase kinase kinase kinase STE20	Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family	vacuole organization, response to heat, mitotic cell cycle, response to chemical, organelle fission, regulation of transport, lipid transport, conjugation, transcription from RNA polymerase II promoter, response to osmotic stress, protein phosphorylation, cell budding, invasive growth in response to glucose limitation, regulation of organelle organization, cytokinesis, organelle assembly, regulation of protein modification process, organelle inheritance, pseudohyphal growth, signaling, regulation of cell cycle	RNA binding, signal transducer activity, kinase activity, transferase activity, mRNA binding	nucleus, plasma membrane, membrane, site of polarized growth, cytoplasm	956	BY4741	08_1	Sterile [expected phenotype]	
14	G	11	YHL006C	SHU1	-	Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments	DNA repair, DNA recombination, cellular response to DNA damage stimulus	molecular_function	nucleus, nucleolus, chromosome	957	BY4741	08_1	
14	G	12	YHL005C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene	biological_process	molecular_function	cellular_component	959	BY4741	08_1	"Hypothetical protein -- growth on -met, no growth on -lys, no growth on drop-in media, petite -- APPEARS ALPHA"	
14	H	1	YHL003C	LAG1	sphingosine N-acyltransferase LAG1	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication	lipid metabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	960	BY4741	08_1	"Longevity assurance protein -- growth on -met, no growth on -lys, no growth on drop-in media -- APPEARS ALPHA"	
14	H	3	YHR001W-A	QCR10	ubiquinol--cytochrome-c reductase subunit 10	Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	964	BY4741	08_1	
14	H	4	YHR011W	DIA4	putative serine--tRNA ligase DIA4	Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth	mitochondrial translation, tRNA aminoacylation for protein translation, mitochondrion organization, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	974	BY4741	08_1	
14	H	5	YHR012W	VPS29	retromer subunit VPS29|VPT6|PEP11	Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval	endosomal transport	protein transporter activity	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm	975	BY4741	08_1	
14	H	6	YHR013C	ARD1	peptide alpha-N-acetyltransferase complex A subunit ARD1|NAA10	Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification	transferase activity	ribosome, cytoplasm	976	BY4741	08_1	
14	H	7	YHR014W	SPO13	-	Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells	meiotic cell cycle, organelle fission, regulation of organelle organization, chromosome segregation, regulation of cell cycle	molecular_function	nucleus, cytoskeleton, chromosome	977	BY4741	08_1	
14	H	8	YHR015W	MIP6	-	Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication	nucleobase-containing compound transport, nuclear transport	RNA binding	cellular_component	978	BY4741	08_1	
14	H	9	YHR018C	ARG4	argininosuccinate lyase ARG4	Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway	cellular amino acid metabolic process	lyase activity	cytoplasm	981	BY4741	08_1	
14	H	10	YHR022C	-	-	Putative protein of unknown function; YHR022C is not an essential gene	biological_process	molecular_function	cellular_component	985	BY4741	08_1	
14	H	11	YHR029C	YHI9	-	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production	response to chemical, signaling	molecular_function	cellular_component	992	BY4741	08_1	
14	H	12	YHR030C	SLT2	mitogen-activated serine/threonine-protein kinase SLT2|LYT2|SLK2|MPK1|BYC2	Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway	mitotic cell cycle, response to chemical, regulation of transport, mRNA processing, cell wall organization or biogenesis, protein targeting, RNA splicing, protein phosphorylation, cytokinesis, protein complex biogenesis, nuclear transport, signaling, regulation of cell cycle	signal transducer activity, kinase activity, transferase activity	nucleus, mitochondrion, cellular bud, site of polarized growth, cytoplasm	993	BY4741	08_1	
15	A	1	YHR031C	RRM3	RTT104	DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p	DNA replication, mitochondrion organization, regulation of DNA metabolic process	hydrolase activity, ATPase activity, helicase activity	nucleus, chromosome	994	BY4741	08_1	
15	A	2	YHR034C	PIH1	NOP17	Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II	protein folding, rRNA processing	other	nucleus, cytoplasm	997	BY4741	08_1	
15	A	3	YHR035W	NEL1	-	Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene	biological_process	enzyme regulator activity	cytoplasm	998	BY4741	08_1	
15	A	4	YHR037W	PUT2	1-pyrroline-5-carboxylate dehydrogenase	Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant	cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	1000	BY4741	08_1	
15	A	5	YHR038W	RRF1	FIL1|KIM4	Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria	mitochondrial translation, mitochondrion organization	RNA binding, translation factor activity, RNA binding	mitochondrion, cytoplasm	1001	BY4741	08_1	
15	A	6	YHR039C	MSC7	meiotic recombination directing protein	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids	meiotic cell cycle, organelle fission, DNA recombination	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1002	BY4741	08_1	
15	A	7	YHR043C	DOG2	2-deoxyglucose-6-phosphatase	2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae	carbohydrate metabolic process	phosphatase activity, hydrolase activity	nucleus, cytoplasm	1006	BY4741	08_1	
15	A	8	YHR044C	DOG1	2-deoxyglucose-6-phosphatase	2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae	carbohydrate metabolic process	phosphatase activity, hydrolase activity	cellular_component	1007	BY4741	08_1	
15	A	9	YHR046C	INM1	inositol monophosphate 1-phosphatase INM1	Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate	carbohydrate metabolic process	phosphatase activity, hydrolase activity	nucleus, cytoplasm	1873	BY4741	08_2	
15	A	10	YHR047C	AAP1	arginine/alanine aminopeptidase|AAP1'	Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication	carbohydrate metabolic process, generation of precursor metabolites and energy	peptidase activity, hydrolase activity	nucleus, cytoplasm	1874	BY4741	08_2	
15	A	11	YHR048W	YHK8	-	Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles	response to chemical	molecular_function	membrane, plasma membrane	1875	BY4741	08_2	
15	A	12	YHR049W	FSH1	putative serine hydrolase	Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	nucleus, cytoplasm	1876	BY4741	08_2	
15	B	1	YHR049C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1877	BY4741	08_2	
15	B	2	YHR050W	SMF2	divalent metal ion transporter SMF2	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins	ion transport, cellular ion homeostasis	transmembrane transporter activity	cytoplasmic vesicle, endomembrane system, mitochondrion, membrane, Golgi apparatus, cytoplasm	1878	BY4741	08_2	
15	B	4	YHR051W	COX6	cytochrome c oxidase subunit VI	Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1879	BY4741	08_2	APPEARS TO BE ALPHA	
15	B	5	YHR057C	CPR2	peptidylprolyl isomerase CPR2|CYP2	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema	biological_process	isomerase activity	vacuole, cytoplasm	1885	BY4741	08_2	
15	B	6	YHR060W	VMA22	VPH6|CEV1	Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	protein complex biogenesis, cellular ion homeostasis	unfolded protein binding	nucleus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1888	BY4741	08_2	
15	B	7	YHR061C	GIC1	-	Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress; GIC1 has a paralog, GIC2, that arose from the whole genome duplication	mitotic cell cycle, organelle fission, chromatin organization, cytoskeleton organization, regulation of organelle organization, regulation of cell cycle	enzyme regulator activity, enzyme binding	nucleus, cellular bud, site of polarized growth, cytoplasm	1889	BY4741	08_2	
15	B	8	YHR066W	SSF1	rRNA-binding ribosome biosynthesis protein	Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication	ribosome assembly, rRNA processing, conjugation, organelle assembly, ribosomal large subunit biogenesis	RNA binding, rRNA binding	nucleus, nucleolus	1894	BY4741	08_2	
15	B	9	YHR073W	OSH3	oxysterol-binding protein related protein OSH3	Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding	organelle fusion, lipid transport, conjugation, invasive growth in response to glucose limitation, exocytosis, pseudohyphal growth, endocytosis, nucleus organization	ion binding, lipid binding	cell cortex, plasma membrane, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1901	BY4741	08_2	
15	B	10	YHR075C	PPE1	carboxylesterase-mitochondrial 37S ribosomal protein YmS2|YmS2|MRPS2	Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein	mitochondrial translation, mitochondrion organization	structural constituent of ribosome, hydrolase activity, structural molecule activity	ribosome, mitochondrion, cytoplasm	1903	BY4741	08_2	
15	B	11	YHR076W	PTC7	type 2C protein phosphatase PTC7	Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p	protein dephosphorylation	phosphatase activity, hydrolase activity	nucleus, endomembrane system, mitochondrion, cytoplasm	1904	BY4741	08_2	
15	B	12	YHR077C	NMD2	SUP111|UPF2|SUA1|IFS1	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance	RNA catabolic process, DNA recombination	molecular_function	cytoplasm	1905	BY4741	08_2	
15	C	1	YHR078W	-	-	High osmolarity-regulated gene of unknown function	biological_process	molecular_function	membrane	1906	BY4741	08_2	
15	C	2	YHR079C	IRE1	bifunctional endoribonuclease/protein kinase IRE1|ERN1	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress	response to chemical, Golgi vesicle transport, cell wall organization or biogenesis, carbohydrate metabolic process, protein targeting, protein phosphorylation, protein complex biogenesis, signaling	hydrolase activity, unfolded protein binding, kinase activity, transferase activity, nuclease activity	nucleus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1907	BY4741	08_2	
15	C	3	YHR080C	LAM4	LTC3	Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	lipid transport	lipid binding	cell cortex, endomembrane system, ribosome, mitochondrion, endoplasmic reticulum, cytoplasm	1908	BY4741	08_2	
15	C	4	YHR081W	LRP1	RRP47|YC1D	Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination	RNA catabolic process, snoRNA processing, rRNA processing	RNA binding, DNA binding, enzyme regulator activity	nucleus	1909	BY4741	08_2	
15	C	5	YHR082C	KSP1	putative serine/threonine protein kinase KSP1	Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress	protein phosphorylation, pseudohyphal growth, signaling	RNA binding, kinase activity, transferase activity, mRNA binding	nucleus, cytoplasm	1910	BY4741	08_2	
15	C	6	YHR086W	NAM8	MUD15|MRE2	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function	RNA splicing, mRNA processing	RNA binding, mRNA binding	nucleus, cytoplasm	1914	BY4741	08_2	
15	C	7	YHR087W	RTC3	HGI1	Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress	other	molecular_function	nucleus, cytoplasm	1915	BY4741	08_2	
15	C	8	YHR091C	MSR1	arginine--tRNA ligase MSR1	Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication	mitochondrial translation, tRNA aminoacylation for protein translation, mitochondrion organization, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	1919	BY4741	08_2	
15	C	9	YHR092C	HXT4	hexose transporter HXT4|RAG1|LGT1	High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication	carbohydrate transport	transmembrane transporter activity	membrane, plasma membrane	1920	BY4741	08_2	
15	C	10	YHR093W	AHT1	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region	biological_process	molecular_function	cellular_component	1921	BY4741	08_2	
15	C	11	YHR094C	HXT1	hexose transporter HXT1|HOR4	Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication	carbohydrate transport	transmembrane transporter activity	membrane, plasma membrane	1922	BY4741	08_2	
15	C	12	YHR095W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1923	BY4741	08_2	
15	D	1	YHR096C	HXT5	hexose transporter HXT5	Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication	carbohydrate transport	transmembrane transporter activity	membrane, plasma membrane	1924	BY4741	08_2	
15	D	2	YHR097C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	1925	BY4741	08_2	
15	D	3	YHR100C	GEP4	phosphatidylglycerophosphatase	Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT	carbohydrate metabolic process, lipid metabolic process	phosphatase activity, hydrolase activity	mitochondrion, cytoplasm	1928	BY4741	08_2	
15	D	4	YHR103W	SBE22	-	Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication	cell wall organization or biogenesis	molecular_function	cytoplasm	1931	BY4741	08_2	
15	D	5	YHR104W	GRE3	trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))	Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress	carbohydrate metabolic process, response to chemical, response to oxidative stress, response to osmotic stress	RNA binding, oxidoreductase activity, mRNA binding	nucleus, cytoplasm	1932	BY4741	08_2	
15	D	6	YHR105W	YPT35	-	Endosomal protein of unknown function; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport	biological_process	ion binding, lipid binding	cytoplasmic vesicle, endomembrane system, cytoplasm	1933	BY4741	08_2	
15	D	7	YHR106W	TRR2	thioredoxin-disulfide reductase TRR2	Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication	response to chemical, response to oxidative stress	oxidoreductase activity	mitochondrion, cytoplasm	1934	BY4741	08_2	
15	D	8	YHR108W	GGA2	phosphatidylinositol 4-phosphate-binding protein	Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication	protein targeting, proteolysis involved in cellular protein catabolic process, Golgi vesicle transport, endosomal transport	lipid binding, ubiquitin-like protein binding, ion binding	endomembrane system, Golgi apparatus, cytoplasm	1936	BY4741	08_2	
15	D	9	YHR109W	CTM1	cytochrome c lysine N-methyltransferase	Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth	peptidyl-amino acid modification, protein alkylation	transferase activity, methyltransferase activity	cytoplasm	1937	BY4741	08_2	
15	D	10	YHR110W	ERP5	-	Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport	other	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1938	BY4741	08_2	
15	D	11	YHR111W	UBA4	YHR1	E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p	response to chemical, invasive growth in response to glucose limitation, cell budding, response to oxidative stress, tRNA processing, protein modification by small protein conjugation or removal, pseudohyphal growth, RNA modification	transferase activity, nucleotidyltransferase activity, ligase activity	cytoplasm	1939	BY4741	08_2	
15	D	12	YHR112C	-	putative cystathionine beta-lyase	Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway	other	lyase activity	nucleus, cytoplasm	1940	BY4741	08_2	
15	E	1	YHR113W	APE4	aspartyl aminopeptidase	Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family	other	peptidase activity, hydrolase activity	vacuole, ribosome, cytoplasm	1941	BY4741	08_2	
15	E	2	YHR114W	BZZ1	LSB7	SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis, response to osmotic stress, endocytosis	enzyme regulator activity	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	1942	BY4741	08_2	
15	E	3	YHR115C	DMA1	ubiquitin-conjugating protein DMA1|CHF1	Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication	mitotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, organelle assembly, cytokinesis, proteolysis involved in cellular protein catabolic process, protein complex biogenesis, chromosome segregation, protein modification by small protein conjugation or removal, regulation of cell cycle	transferase activity	cytoplasm	1943	BY4741	08_2	
15	E	4	YHR116W	COX23	-	Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs	mitochondrion organization, protein complex biogenesis	molecular_function	mitochondrion, cytoplasm	1944	BY4741	08_2	
15	E	5	YHR117W	TOM71	protein channel TOM71|TOM72	Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication	protein targeting, mitochondrion organization	protein transporter activity, transmembrane transporter activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1945	BY4741	08_2	
15	E	6	YHR120W	MSH1	mismatch repair ATPase MSH1	DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis	DNA repair, mitochondrion organization, cellular response to DNA damage stimulus	hydrolase activity, DNA binding, ATPase activity	mitochondrion, cytoplasm	1948	BY4741	08_2	
15	E	7	YHR121W	LSM12	-	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress	other	RNA binding	nucleus, ribosome, cytoplasm	1949	BY4741	08_2	
15	E	8	YHR123W	EPT1	bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication	lipid metabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	1951	BY4741	08_2	
15	E	9	YHR124W	NDT80	transcription factor NDT80	Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) 	meiotic cell cycle, organelle fission, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, chromosome	1952	BY4741	08_2	
15	E	10	YHR125W	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains	biological_process	molecular_function	cellular_component	1953	BY4741	08_2	
15	E	11	YHR126C	ANS1	-	Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p	biological_process	molecular_function	vacuole, cytoplasm	1954	BY4741	08_2	
15	E	12	YHR129C	ARP1	actin-related protein 1|ACT5	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin	mitotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, chromosome segregation, regulation of cell cycle	structural molecule activity	cell cortex, cytoskeleton, microtubule organizing center, cytoplasm	1957	BY4741	08_2	
15	F	1	YHR130C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YHR130C is not an essential gene	biological_process	molecular_function	cellular_component	1958	BY4741	08_2	
15	F	2	YHR132C	ECM14	putative metallocarboxypeptidase	Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly	other	peptidase activity, hydrolase activity	vacuole, cytoplasm	1960	BY4741	08_2	
15	F	3	YHR133C	NSG1	-	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication	lipid metabolic process	unfolded protein binding	nucleus, membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1961	BY4741	08_2	
15	F	4	YHR134W	WSS1	metalloendopeptidase WSS1	SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan	peptidyl-amino acid modification, DNA repair, protein modification by small protein conjugation or removal, cellular response to DNA damage stimulus	peptidase activity, hydrolase activity	nucleus, endomembrane system	1962	BY4741	08_2	
15	F	5	YHR135C	YCK1	serine/threonine protein kinase YCK1|CKI2	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication	response to chemical, protein phosphorylation, cell morphogenesis, signaling, endocytosis	kinase activity, transferase activity	endomembrane system, mitochondrion, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1963	BY4741	08_2	
15	F	6	YHR136C	SPL2	-	Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm	protein targeting	enzyme regulator activity	cytoplasm	1964	BY4741	08_2	
15	F	7	YHR137W	ARO9	aromatic-amino-acid:2-oxoglutarate transaminase	Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism	cellular amino acid metabolic process	transferase activity	nucleus, cytoplasm	1965	BY4741	08_2	
15	F	8	YHR138C	-	-	Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress	vacuole organization, membrane fusion, organelle fusion	enzyme regulator activity	cellular_component	1966	BY4741	08_2	
15	F	9	YHR139C	SPS100	-	Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog, YGP1, that arose from the whole genome duplication	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	cell wall	1967	BY4741	08_2	
15	F	10	YHR139C-A	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains	biological_process	molecular_function	cellular_component	1968	BY4741	08_2	
15	F	11	YHR142W	CHS7	-	Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress	carbohydrate metabolic process, Golgi vesicle transport, protein folding, cell wall organization or biogenesis	unfolded protein binding	endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm	2835	BY4741	08_3	
15	F	12	YHR143W	DSE2	-	Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP	pseudohyphal growth	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cell wall, extracellular region, vacuole, cytoplasm	2836	BY4741	08_3	
15	G	1	YHR147C	MRPL6	mitochondrial 54S ribosomal protein YmL16|YmL16	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	2841	BY4741	08_3	
15	G	2	YHR150W	PEX28	-	Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p	peroxisome organization	molecular_function	peroxisome, membrane, cytoplasm	2844	BY4741	08_3	
15	G	3	YHR151C	MTC6	-	Protein of unknown function; mtc6 is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum	biological_process	molecular_function	vacuole, cytoplasm	2845	BY4741	08_3	
15	G	4	YHR152W	SPO12	SDB21	Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication	mitotic cell cycle, meiotic cell cycle, organelle fission, regulation of organelle organization, regulation of cell cycle	molecular_function	nucleus, nucleolus	2846	BY4741	08_3	
15	G	5	YHR153C	SPO16	-	Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation	peptidyl-amino acid modification, meiotic cell cycle, organelle fission, sporulation, regulation of organelle organization, chromosome segregation, regulation of protein modification process, protein modification by small protein conjugation or removal, DNA recombination, regulation of DNA metabolic process, regulation of cell cycle	molecular_function	nucleus, chromosome	2847	BY4741	08_3	
15	G	6	YHR154W	RTT107	ESC4	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress	DNA repair, regulation of DNA metabolic process, cellular response to DNA damage stimulus, transposition, regulation of cell cycle	molecular_function	nucleus	2848	BY4741	08_3	
15	G	7	YHR155W	LAM1	YSP1	Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains	lipid transport	other	cell cortex, endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	2849	BY4741	08_3	
15	G	8	YHR156C	LIN1	U5 snRNP complex subunit LIN1|SNU40	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication	biological_process	other	nucleus, chromosome	2850	BY4741	08_3	
15	G	9	YHR157W	REC104	-	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination	meiotic cell cycle, organelle fission, DNA recombination	molecular_function	nucleus, chromosome	2851	BY4741	08_3	
15	G	10	YHR158C	KEL1	-	Protein required for proper cell fusion and cell morphology; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate	mitotic cell cycle, organelle fission, cell morphogenesis, cytoskeleton organization, regulation of organelle organization, cytokinesis, regulation of transport, conjugation, regulation of cell cycle	molecular_function	cell cortex, cellular bud, membrane, site of polarized growth, cytoplasm	2852	BY4741	08_3	
15	G	11	YHR159W	TDA11	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele	biological_process	molecular_function	cytoplasm	2853	BY4741	08_3	
15	G	12	YHR160C	PEX18	-	Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth	protein targeting, transmembrane transport, peroxisome organization	other	peroxisome, cytoplasm	2854	BY4741	08_3	
15	H	1	YHR161C	YAP1801	-	Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication	endocytosis	other	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm	2855	BY4741	08_3	
15	H	3	YHR163W	SOL3	6-phosphogluconolactonase SOL3	6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process	hydrolase activity	nucleus, cytoplasm	2857	BY4741	08_3	
15	H	4	YHR167W	THP2	-	Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance	telomere organization, nucleobase-containing compound transport, DNA recombination, nuclear transport, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	other	nucleus	2861	BY4741	08_3	
15	H	5	YHR176W	FMO1	N,N-dimethylaniline monooxygenase	Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins	protein folding	oxidoreductase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2870	BY4741	08_3	
15	H	6	YHR177W	-	GON3	Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest	transcription from RNA polymerase II promoter	DNA binding	nucleus	2871	BY4741	08_3	
15	H	7	YHR178W	STB5	-	Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro	response to chemical, transcription from RNA polymerase II promoter, response to oxidative stress	nucleic acid binding transcription factor activity, DNA binding	nucleus	2872	BY4741	08_3	
15	H	8	YHR179W	OYE2	NADPH dehydrogenase	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress	other	oxidoreductase activity	nucleus, mitochondrion, cytoplasm	2873	BY4741	08_3	
15	H	9	YHR182W	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud, site of polarized growth, cytoplasm	2876	BY4741	08_3	
15	H	10	YHR183W	GND1	phosphogluconate dehydrogenase (decarboxylating) GND1	6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication	response to chemical, cofactor metabolic process, nucleobase-containing small molecule metabolic process, response to oxidative stress	oxidoreductase activity	mitochondrion, cytoplasm	2877	BY4741	08_3	
15	H	11	YHR184W	SSP1	SPO3	Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis	meiotic cell cycle, sporulation, cell wall organization or biogenesis, protein complex biogenesis	molecular_function	membrane	2878	BY4741	08_3	
15	H	12	YHR189W	PTH1	aminoacyl-tRNA hydrolase|PTH	One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2	mitochondrial translation, mitochondrion organization	hydrolase activity	mitochondrion, cytoplasm	2883	BY4741	08_3	
16	A	1	YHR195W	NVJ1	VAB36	Nuclear envelope protein; anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)	other	other	nucleus, endomembrane system	2889	BY4741	08_3	
16	A	2	YHR198C	AIM18	FMP22	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion, cytoplasm	2892	BY4741	08_3	
16	A	3	YHR199C	AIM46	FMP34	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion, cytoplasm	2893	BY4741	08_3	
16	A	4	YHR200W	RPN10	proteasome regulatory particle base subunit RPN10|SUN1|MCB1	Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein	proteolysis involved in cellular protein catabolic process	ubiquitin-like protein binding, structural molecule activity	other	2894	BY4741	08_3	
16	A	5	YHR202W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization	biological_process	molecular_function	vacuole, cytoplasm	2896	BY4741	08_3	
16	A	6	YHR203C	RPS4B	eS4|ribosomal 40S subunit protein S4B|S4e|rp5|YS6|S7B|S4B	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	2897	BY4741	08_3	
16	A	7	YHR204W	MNL1	alpha-1,2-mannosidase MNL1|HTM1	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant	response to chemical	hydrolase activity, hydrolase activity, acting on glycosyl bonds	endomembrane system, endoplasmic reticulum, cytoplasm	2898	BY4741	08_3	
16	A	8	YHR206W	SKN7	kinase-regulated stress-responsive transcription factor SKN7|POS9|BRY1	Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication	response to chemical, response to oxidative stress, transcription from RNA polymerase II promoter, signaling, response to osmotic stress	nucleic acid binding transcription factor activity, DNA binding, signal transducer activity	nucleus, cytoplasm	2900	BY4741	08_3	
16	A	9	YHR207C	SET5	S-adenosylmethionine-dependent methyltransferase	Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus	peptidyl-amino acid modification, protein alkylation, chromatin organization, histone modification	transferase activity, methyltransferase activity	nucleus, chromosome, cytoplasm	2901	BY4741	08_3	
16	A	10	YHR209W	CRG1	S-adenosylmethionine-dependent methyltransferase	S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin	other	RNA binding, transferase activity, methyltransferase activity, mRNA binding	cellular_component	2903	BY4741	08_3	
16	A	11	YHR210C	-	aldose 1-epimerase superfamily protein	Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions	biological_process	molecular_function	cellular_component	2904	BY4741	08_3	
16	A	12	YCL001W	RER1	protein retrieval receptor	Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER	Golgi vesicle transport	molecular_function	membrane, cytoplasmic vesicle, endomembrane system, vacuole, cytoplasm, Golgi apparatus	3409	BY4741	03_1	
16	B	1	YCL002C	-	-	Putative protein of unknown function; YCL002C is not an essential gene	biological_process	molecular_function	nucleus, membrane, cytoplasm	3410	BY4741	03_1	
16	B	2	YCL005W	LDB16	-	Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the membrane; null mutants have decreased net negative cell surface charge and localized accumulation of phosphatidic acid (PA) marker proteins; GFP-fusion protein expression is induced in response to MMS; null mutant can be complemented by the human seipin, BSCL2	other	molecular_function	membrane, endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	3413	BY4741	03_1	
16	B	3	YMR118C	SHH3	protein SHH3	Putative mitochondrial inner membrane protein of unknown function; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog, SDH3, that arose from the whole genome duplication	biological_process	molecular_function	membrane, mitochondrion, cytoplasm	7121	BY4741	00_15	
16	B	5	YCL008C	STP22	ubiquitin-binding ESCRT-I subunit protein STP22|AGS1|VPL15|VPS23	Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;	protein targeting, ion transport, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, regulation of protein modification process, protein modification by small protein conjugation or removal, endosomal transport	ubiquitin-like protein binding	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm, plasma membrane	3416	BY4741	03_1	
16	B	6	YCL009C	ILV6	acetolactate synthase regulatory subunit	Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria	cellular amino acid metabolic process	transferase activity, enzyme regulator activity	mitochondrion, cytoplasm	3417	BY4741	03_1	
16	B	7	YCL010C	SGF29	-	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation	peptidyl-amino acid modification, protein acylation, chromatin organization, transcription from RNA polymerase II promoter, histone modification	histone binding, transcription factor activity, protein binding	nucleus	3418	BY4741	03_1	
16	B	8	YCL011C	GBP2	single-stranded telomeric DNA-binding/mRNA-binding protein|RLF6	Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication	telomere organization, nucleobase-containing compound transport, RNA catabolic process, nuclear transport	RNA binding, DNA binding, mRNA binding	nucleus, cytoplasm	3419	BY4741	03_1	
16	B	9	YCL012W	nucleus, cytoplasm	nucleus, cytoplasm	nucleus, cytoplasm	-	-	-	3420	BY4741	03_1	
16	B	10	YCL013W	-	-	-	-	-	-	3421	BY4741	03_1	
16	B	11	YCL014W	BUD3	YCL012W	Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern observed in haploids; localizes with septins to the bud neck contractile ring in mitosis	mitotic cell cycle, cell budding, cytokinesis, conjugation	guanyl-nucleotide exchange factor activity	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	3422	BY4741	03_1	
16	B	12	YCL016C	DCC1	-	Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance	mitotic cell cycle, organelle fission, cellular response to DNA damage stimulus, chromosome segregation	molecular_function	chromosome	3423	BY4741	03_1	
16	C	1	YCL023C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4	biological_process	molecular_function	cellular_component	3430	BY4741	03_1	
16	C	2	YCL024W	KCC4	serine/threonine protein kinase	Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication	mitotic cell cycle, cytoskeleton organization, cell budding, protein phosphorylation, organelle assembly, protein complex biogenesis, regulation of cell cycle	ion binding, kinase activity, transferase activity, lipid binding	cell cortex, cytoskeleton, plasma membrane, cellular bud, membrane, site of polarized growth, cytoplasm	3431	BY4741	03_1	
16	C	3	YCL025C	AGP1	amino acid transporter AGP1|YCC5	Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication	transmembrane transport, ion transport, amino acid transport	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	3432	BY4741	03_1	
16	C	4	YCL026C	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	-	-	-	3433	BY4741	03_1	
16	C	5	YCL027W	FUS1	-	Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate	response to chemical, cell morphogenesis, conjugation	molecular_function	endomembrane system, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm, plasma membrane	3434	BY4741	03_1	
16	C	6	YCL028W	RNQ1	prion domain-containing protein RNQ1|[PIN(+)]	[PIN(+)] prion; an infectious protein conformation that is generally an ordered protein aggregate	biological_process	molecular_function	cytoplasm	3435	BY4741	03_1	
16	C	7	YCL029C	BIK1	PAC14|ARM5	Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170	mitotic cell cycle, organelle fission, cytoskeleton organization, organelle fusion, conjugation, regulation of organelle organization, chromosome segregation, protein complex biogenesis, nucleus organization	cytoskeletal protein binding	nucleus, cell cortex, cytoskeleton, chromosome, microtubule organizing center, site of polarized growth, cytoplasm	3436	BY4741	03_1	
16	C	8	YCL030C	HIS4	trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis	cellular amino acid metabolic process	hydrolase activity, oxidoreductase activity	cytoplasm	3437	BY4741	03_1	
16	C	9	YCL032W	STE50	-	Adaptor protein for various signaling pathways; involved in mating response, invasive/filamentous growth, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction	response to heat, response to chemical, protein phosphorylation, conjugation, response to osmotic stress, signaling	enzyme regulator activity	cytoplasm	3439	BY4741	03_1	
16	C	10	YCL033C	MXR2	MSRB	Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan	response to chemical, response to oxidative stress	oxidoreductase activity	mitochondrion, cytoplasm	3440	BY4741	03_1	
16	C	11	YCL034W	LSB5	-	Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat	cytoskeleton organization, endocytosis	molecular_function	cell cortex, cytoskeleton, cytoplasm	3441	BY4741	03_1	
16	C	12	YCL036W	GFD2	YCD6	Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	3443	BY4741	03_1	
16	D	1	YCL037C	SRO9	-	Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication	cytoplasmic translation	RNA binding, mRNA binding	cytoplasm	3444	BY4741	03_1	
16	D	2	YCL039W	GID7	glucose-induced degradation complex subunit GID7|MOH2	Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions	carbohydrate metabolic process, proteolysis involved in cellular protein catabolic process	molecular_function	nucleus, cytoplasm	3446	BY4741	03_1	
16	D	3	YCL040W	GLK1	glucokinase|HOR3	Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, carbohydrate transport, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	membrane, cytoplasm, plasma membrane	3447	BY4741	03_1	
16	D	4	YCL042W	-	-	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm	3449	BY4741	03_1	
16	D	5	YCL044C	MGR1	-	Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA	proteolysis involved in cellular protein catabolic process	other	membrane, mitochondrial envelope, mitochondrion, cytoplasm	3451	BY4741	03_1	
16	D	6	YCL045C	EMC1	-	Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090	protein folding	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	3452	BY4741	03_1	
16	D	7	YCL046W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C	biological_process	molecular_function	cellular_component	3453	BY4741	03_1	
16	D	8	YCL047C	POF1	nicotinamide-nucleotide adenylyltransferase	Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion	response to chemical, cofactor metabolic process, invasive growth in response to glucose limitation, proteolysis involved in cellular protein catabolic process, pseudohyphal growth, nucleobase-containing small molecule metabolic process	transferase activity, nucleotidyltransferase activity, hydrolase activity, ATPase activity	nucleus, cytoplasm	3454	BY4741	03_1	
16	D	9	YCL048W	SPS22	-	Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	membrane, plasma membrane, cytoplasm	3455	BY4741	03_1	
16	D	10	YCL049C	-	-	Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene	biological_process	molecular_function	membrane	3456	BY4741	03_1	
16	D	11	YCL050C	APA1	bifunctional AP-4-A phosphorylase/ADP sulfurylase|DTP1	AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication	nucleobase-containing small molecule metabolic process	transferase activity, nucleotidyltransferase activity, hydrolase activity	nucleus, cytoplasm	3457	BY4741	03_1	
16	D	12	YCL051W	LRE1	-	Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication	regulation of protein modification process, protein phosphorylation, cell wall organization or biogenesis	enzyme regulator activity	cellular bud, site of polarized growth	3458	BY4741	03_1	
16	E	1	YCL055W	KAR4	-	Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone	meiotic cell cycle, response to chemical, organelle fission, organelle fusion, conjugation, transcription from RNA polymerase II promoter, nucleus organization	nucleic acid binding transcription factor activity	nucleus, cytoplasm	3462	BY4741	03_1	
16	E	2	YCL056C	PEX34	-	Protein that regulates peroxisome populations; peroxisomal integral membrane protein; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation	peroxisome organization	molecular_function	peroxisome, membrane, cytoplasm	3463	BY4741	03_1	
16	E	3	YCL057W	PRD1	metalloendopeptidase	Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress	other	peptidase activity, hydrolase activity	endomembrane system, vacuole, mitochondrion, mitochondrial envelope, Golgi apparatus, cytoplasm	3464	BY4741	03_1	
16	E	4	YCL060C	endomembrane system, vacuole, mitochondrion, mitochondrial envelope, Golgi apparatus, cytoplasm	endomembrane system, vacuole, mitochondrion, mitochondrial envelope, Golgi apparatus, cytoplasm	endomembrane system, vacuole, mitochondrion, mitochondrial envelope, Golgi apparatus, cytoplasm	-	-	-	3467	BY4741	03_1	
16	E	5	YCL061C	MRC1	chromatin-modulating protein MRC1|YCL060C	S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; mammalian claspin homolog	mitotic cell cycle, DNA repair, telomere organization, organelle fission, chromatin organization, DNA replication, cellular response to DNA damage stimulus, chromosome segregation, regulation of DNA metabolic process, regulation of cell cycle	molecular_function	nucleus, chromosome	3468	BY4741	03_1	
16	E	6	YCL062W	nucleus, chromosome	nucleus, chromosome	nucleus, chromosome	-	-	-	3469	BY4741	03_1	
16	E	7	YCL063W	VAC17	YCL062W	Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulation of asymmetric inheritance of aggregated/misfolded proteins and age reset	vacuole organization, organelle inheritance	other	membrane, vacuole, cytoplasm	3470	BY4741	03_1	
16	E	8	YCL064C	CHA1	L-serine/L-threonine ammonia-lyase CHA1	Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine	cellular amino acid metabolic process	lyase activity	mitochondrion, cytoplasm	3471	BY4741	03_1	
16	E	9	YCL069W	VBA3	basic amino acid transporter	Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication	transmembrane transport, ion transport, amino acid transport	transmembrane transporter activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	3476	BY4741	03_1	
16	E	10	YCR001W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YCR001W is not an essential gene	biological_process	molecular_function	cellular_component	3481	BY4741	03_1	
16	E	11	YCR002C	CDC10	septin CDC10	Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress	mitotic cell cycle, organelle fission, cytoskeleton organization, sporulation, cytokinesis, organelle assembly, protein complex biogenesis	GTPase activity, hydrolase activity, ion binding, lipid binding, structural molecule activity	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm	3482	BY4741	03_1	
16	E	12	YCR003W	MRPL32	mitochondrial 54S ribosomal protein YmL32|YmL32	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress	mitochondrial translation, mitochondrion organization	structural constituent of ribosome, structural molecule activity	ribosome, mitochondrion, membrane, mitochondrial envelope, cytoplasm	3483	BY4741	03_1	
16	F	1	YCR004C	YCP4	flavodoxin-like fold family protein	Protein of unknown function; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	other	membrane, mitochondrion, plasma membrane, cytoplasm	3484	BY4741	03_1	
16	F	2	YCR005C	CIT2	citrate (Si)-synthase CIT2	Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication	carbohydrate metabolic process, monocarboxylic acid metabolic process, cellular amino acid metabolic process	transferase activity	peroxisome, mitochondrion, cytoplasm	3485	BY4741	03_1	
16	F	3	YCR006C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YCR006C is not an essential gene	biological_process	molecular_function	cellular_component	3486	BY4741	03_1	
16	F	4	YCR007C	-	DUP240 family protein	Putative integral membrane protein; member of DUP240 gene family; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCR007C is not an essential gene	biological_process	molecular_function	vacuole, cytoplasm	3487	BY4741	03_1	
16	F	5	YCR008W	SAT4	serine/threonine protein kinase SAT4|HAL4	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion	mitotic cell cycle, cofactor metabolic process, protein phosphorylation, protein dephosphorylation, cellular ion homeostasis	kinase activity, transferase activity	mitochondrion, cytoplasm	3488	BY4741	03_1	
16	F	6	YCR009C	RVS161	amphiphysin-like protein RVS161|SPE161|FUS7|END6	Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress	cytoskeleton organization, conjugation, response to starvation, response to osmotic stress, endocytosis	lipid binding, cytoskeletal protein binding	cell cortex, cytoskeleton, membrane, site of polarized growth, cytoplasm	3489	BY4741	03_1	
16	F	7	YCR010C	ADY2	ATO1	Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication	transmembrane transport, ion transport	transmembrane transporter activity	membrane, mitochondrion, plasma membrane, cytoplasm	3490	BY4741	03_1	
16	F	8	YCR011C	ADP1	putative ATP-dependent permease ADP1	Putative ATP-dependent permease of the ABC transporter family	transmembrane transport	hydrolase activity, transmembrane transporter activity, ATPase activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	3491	BY4741	03_1	
16	F	9	YCR014C	POL4	DNA-directed DNA polymerase IV|POLX	DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta	DNA repair, cellular response to DNA damage stimulus	transferase activity, nucleotidyltransferase activity	nucleus	3494	BY4741	03_1	
16	F	10	YCR015C	CTO1	-	Protein required for cold tolerance; involved in phosphate uptake; YCR015C is not an essential gene	other	molecular_function	cellular_component	3495	BY4741	03_1	
16	F	11	YCR016W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleus, nucleolus	3496	BY4741	03_1	
16	F	12	YCR017C	CWH43	-	GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion	lipid metabolic process, cell wall organization or biogenesis, protein lipidation	molecular_function	endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm, plasma membrane	3497	BY4741	03_1	
16	G	1	YCR019W	MAK32	-	Protein necessary for stability of L-A dsRNA-containing particles	other	molecular_function	cellular_component	3499	BY4741	03_1	
16	G	2	YCR020C	PET18	HIT2	Protein of unknown function; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin	vitamin metabolic process	molecular_function	cytoplasm	3500	BY4741	03_1	
16	G	3	YCR020C-A	MAK31	NAA38|SMX1|LSM9	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family	protein acylation	transferase activity	cytoplasm	3501	BY4741	03_1	
16	G	4	YCR021C	HSP30	YRO1	Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase	response to heat, response to chemical, cellular response to DNA damage stimulus, response to oxidative stress, response to osmotic stress	molecular_function	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	3502	BY4741	03_1	
16	G	5	YCR022C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YCR022C is not an essential gene	biological_process	molecular_function	cellular_component	3503	BY4741	03_1	
16	G	6	YCR023C	-	-	Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene	biological_process	molecular_function	membrane, vacuole, cytoplasm	3504	BY4741	03_1	
16	G	7	YLR420W	URA4	dihydroorotase	Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate	nucleobase-containing small molecule metabolic process	hydrolase activity	nucleus, cytoplasm	4081	BY4741	12_3	
16	G	8	YLR451W	LEU3	leucine-responsive transcriptional regulator LEU3	Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation	transcription from RNA polymerase II promoter, cellular amino acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus	4082	BY4741	12_3	
16	G	9	YLR126C	-	putative amidotransferase	Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	cellular ion homeostasis	molecular_function	nucleus, cytoplasm	4083	BY4741	12_3	
16	G	10	YLR128W	DCN1	NEDD8 ligase DCN1	Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation	regulation of protein modification process, protein modification by small protein conjugation or removal	enzyme binding, protein binding, bridging, ubiquitin-like protein binding	cellular_component	4085	BY4741	12_3	
16	G	11	YLR130C	ZRT2	low-affinity Zn(2+) transporter ZRT2	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor	transmembrane transport, ion transport	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	4087	BY4741	12_3	
16	G	12	YLR131C	ACE2	DNA-binding transcription factor ACE2	Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication	mitotic cell cycle, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	4088	BY4741	12_3	
16	H	1	YLR133W	CKI1	bifunctional choline kinase/ethanolamine kinase CKI1	Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication	lipid metabolic process	kinase activity, transferase activity	cytoplasm	4090	BY4741	12_3	
16	H	3	YLR134W	PDC5	indolepyruvate decarboxylase 5	Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, cellular amino acid metabolic process, nucleobase-containing small molecule metabolic process	lyase activity	nucleus, cytoplasm	4091	BY4741	12_3	
16	H	4	YLR135W	SLX4	-	Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor	meiotic cell cycle, DNA repair, organelle fission, DNA replication, regulation of organelle organization, cellular response to DNA damage stimulus, DNA recombination, regulation of DNA metabolic process, regulation of cell cycle	hydrolase activity, nuclease activity	nucleus, chromosome	4092	BY4741	12_3	
16	H	5	YLR136C	TIS11	CTH2	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication	RNA catabolic process, cellular ion homeostasis	RNA binding, mRNA binding	nucleus, cytoplasm	4093	BY4741	12_3	
16	H	6	YLR137W	RKM5	S-adenosylmethionine-dependent methyltransferase	Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species	protein alkylation	transferase activity, methyltransferase activity	cellular_component	4094	BY4741	12_3	
16	H	7	YLR138W	NHA1	-	Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH	transmembrane transport, ion transport, cellular ion homeostasis, response to osmotic stress	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	4095	BY4741	12_3	
16	H	8	YLR139C	SLS1	-	Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery	mitochondrial translation, mitochondrion organization, generation of precursor metabolites and energy, cellular respiration	molecular_function	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4096	BY4741	12_3	
16	H	9	YLR142W	PUT1	proline dehydrogenase	Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source	cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	4099	BY4741	12_3	
16	H	10	YLR143W	DPH6	diphthine--ammonia ligase	Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene	peptidyl-amino acid modification	ligase activity	cytoplasm	4100	BY4741	12_3	
16	H	11	YLR144C	ACF2	PCA1|ENG2	Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress	cytoskeleton organization	hydrolase activity, hydrolase activity, acting on glycosyl bonds	other	4101	BY4741	12_3	
16	H	12	YMR074C	SDD2	-	Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress	response to chemical, response to oxidative stress	molecular_function	nucleus, cytoplasm	7118	BY4741	00_15	
17	A	1	YLR149C	-	-	Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cellular_component	4106	BY4741	12_3	
17	A	2	YLR150W	STM1	MPT4	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery	translational initiation, telomere organization, regulation of translation, translational elongation, signaling	DNA binding	cytoplasm	4107	BY4741	12_3	
17	A	3	YLR151C	PCD1	8-oxo-dGTP diphosphatase	8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1	DNA repair, cofactor metabolic process, nucleobase-containing small molecule metabolic process, cellular response to DNA damage stimulus	hydrolase activity	peroxisome, cytoplasm	4108	BY4741	12_3	
17	A	4	YLR152C	-	-	Putative protein of unknown function; YLR152C is not an essential gene	biological_process	molecular_function	membrane	4109	BY4741	12_3	
17	A	5	YLR154C	RNH203	Rnh2C	Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome	RNA catabolic process, DNA replication	nuclease activity, hydrolase activity	nucleus, cytoplasm	4111	BY4741	12_3	
17	A	6	YLR164W	SHH4	protein SHH4	Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4113	BY4741	12_3	
17	A	7	YLR165C	PUS5	pseudouridine synthase PUS5	Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability	rRNA processing, RNA modification	lyase activity	mitochondrion, cytoplasm	4114	BY4741	12_3	
17	A	8	YLR168C	UPS2	GEP1|AIM30|MSF1|MSF1'	Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication	mitochondrion organization, ion transport, lipid metabolic process, lipid transport	molecular_function	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4117	BY4741	12_3	
17	A	9	YLR169W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4118	BY4741	12_3	
17	A	10	YLR170C	APS1	YAP19	Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex	Golgi vesicle transport	other	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	4119	BY4741	12_3	
17	A	11	YLR171W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	membrane	4120	BY4741	12_3	
17	A	12	YLR172C	DPH5	diphthine synthase	Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm	peptidyl-amino acid modification	transferase activity, methyltransferase activity	cytoplasm	4121	BY4741	12_3	
17	B	1	YLR173W	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane, vacuole, cytoplasm	4122	BY4741	12_3	
17	B	2	YLR174W	IDP2	isocitrate dehydrogenase (NADP(+)) IDP2	Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication	other	oxidoreductase activity	cytoplasm	4123	BY4741	12_3	
17	B	3	YLR176C	RFX1	CRT1	Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins	transcription from RNA polymerase II promoter	DNA binding	nucleus, cytoplasm	4125	BY4741	12_3	
17	B	4	YLR177W	-	-	Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm	4126	BY4741	12_3	
17	B	6	YLR178C	TFS1	DKA1	Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress	signaling	ion binding, lipid binding, enzyme regulator activity	membrane, vacuole, cytoplasm	4127	BY4741	12_3	
17	B	7	YLR179C	-	-	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus	biological_process	molecular_function	nucleus, cytoplasm	4128	BY4741	12_3	
17	B	8	YLR180W	SAM1	methionine adenosyltransferase SAM1|ETH10	S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication	cofactor metabolic process, cellular amino acid metabolic process	transferase activity	cytoplasm	4129	BY4741	12_3	
17	B	9	YLR181C	VTA1	-	Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain	endosomal transport, protein complex biogenesis	enzyme regulator activity	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm	4130	BY4741	12_3	
17	B	10	YLR182W	SWI6	transcriptional regulator SWI6|SDS11|PSL8	Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators	response to heat, mitotic cell cycle, meiotic cell cycle, organelle fission, regulation of organelle organization, DNA recombination, regulation of DNA metabolic process, transcription from RNA polymerase II promoter, regulation of cell cycle	transcription factor activity, protein binding	nucleus, cytoplasm	4131	BY4741	12_3	
17	B	11	YLR183C	TOS4	-	Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress	cellular response to DNA damage stimulus	chromatin binding	nucleus, chromosome, mitochondrion, cytoplasm	4132	BY4741	12_3	
17	B	12	YLR184W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4133	BY4741	12_3	
17	C	1	YLR185W	RPL37A	eL37|ribosomal 60S subunit protein L37A|L37e|YL35|L43|L37A	Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal large subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	4134	BY4741	12_3	
17	C	2	YLR187W	SKG3	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication	biological_process	molecular_function	cellular bud, site of polarized growth, cytoplasm	4136	BY4741	12_3	
17	C	3	YLR188W	MDL1	ATP-binding cassette permease MDL1	Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress	transmembrane transport	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4137	BY4741	12_3	
17	C	4	YLR189C	ATG26	UGT51	UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy	meiotic cell cycle, lipid metabolic process, sporulation	transferase activity, transferring glycosyl groups, transferase activity	cytoplasm	4138	BY4741	12_3	
17	C	5	YLR190W	MMR1	-	Phosphorylated protein of the mitochondrial outer membrane; localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p	mitochondrion organization, organelle inheritance	molecular_function	mitochondrion, cellular bud, membrane, site of polarized growth, mitochondrial envelope, cytoplasm	4139	BY4741	12_3	
17	C	6	YLR191W	PEX13	peroxin PEX13|PAS20	Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant	protein targeting, transmembrane transport, peroxisome organization	protein binding, bridging	peroxisome, membrane, cytoplasm	4140	BY4741	12_3	
17	C	7	YLR193C	UPS1	-	Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI	ion transport, lipid metabolic process, lipid transport	other	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4142	BY4741	12_3	
17	C	8	YLR194C	NCW2	-	Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition	cell wall organization or biogenesis	structural molecule activity	cellular bud, cell wall, membrane, site of polarized growth, vacuole, plasma membrane, cytoplasm	4143	BY4741	12_3	
17	C	9	YLR199C	PBA1	POC1	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly	protein complex biogenesis	molecular_function	cytoplasm	4148	BY4741	12_3	
17	C	10	YLR200W	YKE2	tubulin-binding prefolding complex subunit YKE2|PFD6|GIM1	Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation	protein folding, transcription from RNA polymerase II promoter, protein complex biogenesis, DNA-templated transcription, elongation	cytoskeletal protein binding	cytoplasm	4149	BY4741	12_3	
17	C	11	YLR201C	COQ9	ubiquinone biosynthesis protein COQ9|FMP53	Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant	cofactor metabolic process	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4150	BY4741	12_3	
17	C	12	YLR202C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron	biological_process	molecular_function	cellular_component	4151	BY4741	12_3	
17	D	1	YLR203C	MSS51	-	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	other	vacuole, mitochondrion, membrane, mitochondrial envelope, cytoplasm	4152	BY4741	12_3	
17	D	2	YLR204W	QRI5	COX24	Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA	mRNA processing	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4153	BY4741	12_3	
17	D	3	YLR205C	HMX1	-	ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants	cofactor metabolic process, response to oxidative stress, cellular ion homeostasis	oxidoreductase activity	nucleus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4154	BY4741	12_3	
17	D	4	YLR206W	ENT2	epsin	Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that arose from the whole genome duplication	cytoskeleton organization, endocytosis	other	site of polarized growth	4155	BY4741	12_3	
17	D	5	YLR207W	HRD3	ubiquitin ligase complex subunit HRD3	ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events	response to chemical, proteolysis involved in cellular protein catabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4156	BY4741	12_3	
17	D	6	YLR209C	PNP1	purine-nucleoside phosphorylase	Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway	cofactor metabolic process, nucleobase-containing small molecule metabolic process	transferase activity, transferring glycosyl groups, transferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds	other	4158	BY4741	12_3	
17	D	7	YLR210W	CLB4	B-type cyclin CLB4	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication	mitotic cell cycle, protein phosphorylation, organelle fission, cytoskeleton organization, regulation of organelle organization, organelle assembly, regulation of protein modification process, regulation of cell cycle	enzyme regulator activity	nucleus, cytoskeleton, microtubule organizing center, cytoplasm	4159	BY4741	12_3	
17	D	8	YLR211C	ATG38	-	Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy	other	structural molecule activity	membrane, vacuole, cytoplasm	4160	BY4741	12_3	
17	D	9	YLR213C	CRR1	putative glycosylase	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation	meiotic cell cycle, sporulation, cell wall organization or biogenesis	hydrolase activity	cell wall, vacuole, cytoplasm	4162	BY4741	12_3	
17	D	10	YLR214W	FRE1	ferric/cupric-chelate reductase	Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels	ion transport	oxidoreductase activity	membrane, plasma membrane	4163	BY4741	12_3	
17	D	11	YLR216C	CPR6	peptidylprolyl isomerase CPR6|CYP40	Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress	protein folding	unfolded protein binding, isomerase activity	cytoplasm	4165	BY4741	12_3	
17	D	12	YLR217W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6	biological_process	molecular_function	cellular_component	4166	BY4741	12_3	
17	E	1	YLR218C	COA4	CMC3	Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors	mitochondrion organization, protein complex biogenesis	molecular_function	nucleus, mitochondrial envelope, mitochondrion, cytoplasm	4167	BY4741	12_3	
17	E	2	YLR219W	MSC3	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress	meiotic cell cycle, organelle fission, DNA recombination	molecular_function	cellular_component	4168	BY4741	12_3	
17	E	3	YLR220W	CCC1	-	Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress	ion transport, cellular ion homeostasis	transmembrane transporter activity	endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	4169	BY4741	12_3	
17	E	4	YLR221C	RSA3	-	Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus	ribosome assembly, organelle assembly, ribosomal large subunit biogenesis	molecular_function	nucleus, nucleolus	4170	BY4741	12_3	
17	E	5	YLR224W	UCC1	-	F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds	response to chemical, proteolysis involved in cellular protein catabolic process	protein binding, bridging, transferase activity	other	4173	BY4741	12_3	
17	E	6	YLR225C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog, YDR222W, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm	4174	BY4741	12_3	
17	E	7	YLR227C	ADY4	-	Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane	sporulation	structural molecule activity	cytoskeleton, microtubule organizing center	4176	BY4741	12_3	
17	E	8	YKL001C	MET14	adenylyl-sulfate kinase	Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant	cellular amino acid metabolic process	kinase activity, transferase activity	cytoplasm	4849	BY4741	11_1	
17	E	9	YKL002W	DID4	ESCRT-III subunit protein DID4|VPS14|CHM2|VPS2|VPT14|VPL2|REN1|GRD7	Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis	ion transport, vesicle organization, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	4850	BY4741	11_1	
17	E	10	YKL003C	MRP17	mitochondrial 37S ribosomal protein YmS16	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4851	BY4741	11_1	
17	E	11	YKL006W	RPL14A	eL14|ribosomal 60S subunit protein L14A|L14e|L14A	Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication	cytoplasmic translation	RNA binding, structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	4855	BY4741	11_1	
17	E	12	YKL007W	CAP1	-	Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis	cytoskeletal protein binding	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	4856	BY4741	11_1	
17	F	1	YKL008C	LAC1	sphingosine N-acyltransferase LAC1|DGT1	Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication	lipid metabolic process	transferase activity	nucleus, membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4857	BY4741	11_1	
17	F	2	YKL009W	MRT4	-	Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus	rRNA processing, organelle assembly, ribosomal large subunit biogenesis, RNA catabolic process, ribosome assembly	RNA binding, rRNA binding	nucleus, nucleolus	4858	BY4741	11_1	
17	F	3	YKL010C	UFD4	putative ubiquitin-protein ligase UFD4	Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress	protein modification by small protein conjugation or removal, regulation of DNA metabolic process, protein complex biogenesis	transferase activity	nucleus, mitochondrion, cytoplasm	4859	BY4741	11_1	
17	F	4	YKL011C	CCE1	cruciform cutting endonuclease|MGT1	Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication	mitochondrion organization	nuclease activity, hydrolase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4860	BY4741	11_1	
17	F	5	YKL015W	PUT3	-	Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain	transcription from RNA polymerase II promoter, cellular amino acid metabolic process	nucleic acid binding transcription factor activity, DNA binding	nucleus	4864	BY4741	11_1	
17	F	6	YKL016C	ATP7	F1F0 ATP synthase subunit d	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis	transmembrane transport, ion transport, nucleobase-containing small molecule metabolic process	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4865	BY4741	11_1	
17	F	7	YKL017C	HCS1	ATP-dependent 5'-3' DNA helicase HCS1|DIP1	Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities	DNA replication	helicase activity, ATPase activity, hydrolase activity	nucleus, chromosome	4866	BY4741	11_1	
17	F	8	YKL020C	SPT23	-	ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication	chromatin organization, monocarboxylic acid metabolic process, lipid metabolic process, transcription from RNA polymerase II promoter	DNA binding	nucleus, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4869	BY4741	11_1	
17	F	9	YKL023W	-	-	Putative protein of unknown function; predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm	4872	BY4741	11_1	
17	F	10	YKL025C	PAN3	ECM35	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes	RNA catabolic process, DNA repair, cellular response to DNA damage stimulus	RNA binding, nuclease activity, hydrolase activity	cytoplasm	4874	BY4741	11_1	
17	F	11	YKL026C	GPX1	glutathione peroxidase GPX1	Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog, HYR1, that arose from the whole genome duplication	response to chemical, peroxisome organization, response to oxidative stress	oxidoreductase activity	peroxisome, mitochondrion, membrane, mitochondrial envelope, cytoplasm	4875	BY4741	11_1	
17	F	12	YKL027W	TCD2	tRNA threonylcarbamoyladenosine dehydratase	tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication	tRNA processing, RNA modification	lyase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4876	BY4741	11_1	
17	G	1	YKL029C	MAE1	malate dehydrogenase (oxaloacetate-decarboxylating)	Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids	monocarboxylic acid metabolic process, cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	4878	BY4741	11_1	
17	G	2	YKL031W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species	biological_process	molecular_function	cellular_component	4880	BY4741	11_1	
17	G	3	YKL032C	IXR1	DNA-binding transcription repressor IXR1|ORD1	Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication	DNA repair, response to chemical, cellular response to DNA damage stimulus, transcription from RNA polymerase II promoter	DNA binding	nucleus, chromosome	4881	BY4741	11_1	
17	G	4	YKL034W	TUL1	ubiquitin-protein ligase TUL1	Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1	proteolysis involved in cellular protein catabolic process, protein modification by small protein conjugation or removal	transferase activity	endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	4883	BY4741	11_1	
17	G	5	YKL037W	AIM26	-	Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT	mitochondrion organization	molecular_function	membrane, mitochondrion, cytoplasm	4886	BY4741	11_1	
17	G	6	YKL038W	RGT1	-	Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog, EDS1, that arose from the whole genome duplication	carbohydrate metabolic process, carbohydrate transport, regulation of transport, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding	nucleus	4887	BY4741	11_1	
17	G	7	YKL039W	PTM1	-	Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication	biological_process	molecular_function	membrane	4888	BY4741	11_1	
17	G	8	YKL040C	NFU1	NUB1	Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1)	cofactor metabolic process, cellular ion homeostasis, protein maturation	molecular_function	mitochondrion, cytoplasm	4889	BY4741	11_1	
17	G	9	YKL041W	VPS24	ESCRT-III subunit protein VPS24|VPL26|DID3	One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway	ion transport, vesicle organization, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	4890	BY4741	11_1	
17	G	10	YKL043W	PHD1	-	Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication	pseudohyphal growth, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	4892	BY4741	11_1	
17	G	11	YKL044W	MMO1	-	Protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling data; MMO1 is a non-essential gene	biological_process	molecular_function	mitochondrion, cytoplasm	4893	BY4741	11_1	
17	G	12	YKL046C	DCW1	putative mannan endo-1,6-alpha-mannosidase	Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p	cell budding, cell wall organization or biogenesis	molecular_function	cellular bud, membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	4895	BY4741	11_1	
17	H	1	YKL047W	ANR2	-	Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	4896	BY4741	11_1	
17	H	3	YKL048C	ELM1	serine/threonine protein kinase ELM1|LDB9	Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf4p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis	mitotic cell cycle, response to chemical, cytoskeleton organization, carbohydrate metabolic process, cell budding, cell morphogenesis, protein phosphorylation, cytokinesis, organelle assembly, protein complex biogenesis, regulation of protein modification process, pseudohyphal growth	kinase activity, transferase activity	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	4897	BY4741	11_1	
17	H	4	YKL050C	-	-	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p; YKL050C has a paralog, EIS1, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	4899	BY4741	11_1	
17	H	5	YKL051W	SFK1	-	Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane	vacuole organization, cytoskeleton organization, signaling	molecular_function	membrane, plasma membrane	4900	BY4741	11_1	
17	H	6	YKL053W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1	biological_process	molecular_function	membrane	4902	BY4741	11_1	
17	H	7	YKL054C	DEF1	DNA damage-responsive RNA polymerase-degradation factor DEF1|VID31	RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis	DNA repair, telomere organization, protein modification by small protein conjugation or removal, cellular response to DNA damage stimulus, proteolysis involved in cellular protein catabolic process	molecular_function	nucleus	4903	BY4741	11_1	
17	H	8	YKL055C	OAR1	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant	generation of precursor metabolites and energy, monocarboxylic acid metabolic process, cellular respiration, lipid metabolic process	transferase activity, oxidoreductase activity	mitochondrion, cytoplasm	4904	BY4741	11_1	
17	H	9	YKL056C	TMA19	MMI1|RBF18	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress	cytoplasmic translation, response to chemical, response to oxidative stress	molecular_function	ribosome, mitochondrion, cytoplasm	4905	BY4741	11_1	
17	H	10	YKL057C	NUP120	RAT2	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160	response to heat, DNA repair, protein targeting, chromatin organization, cellular response to DNA damage stimulus, ribosomal subunit export from nucleus, nucleobase-containing compound transport, transcription from RNA polymerase II promoter, nuclear transport, nucleus organization	structural molecule activity	nucleus, endomembrane system, membrane	4906	BY4741	11_1	
17	H	11	YKL061W	BLI1	-	Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome	vesicle organization	molecular_function	cytoplasmic vesicle, endomembrane system, cytoplasm	4910	BY4741	11_1	
17	H	12	YKL062W	MSN4	stress-responsive transcriptional activator MSN4	Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift	response to heat, response to chemical, chromatin organization, response to oxidative stress, response to starvation, transcription from RNA polymerase II promoter, response to osmotic stress	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	4911	BY4741	11_1	
18	A	1	YKL063C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi	biological_process	molecular_function	endomembrane system, cytoplasm, Golgi apparatus	4912	BY4741	11_1	
18	A	2	YKL064W	MNR2	putative Mg(2+) transporter MNR2	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)	cellular ion homeostasis	transmembrane transporter activity	membrane, vacuole, cytoplasm	4913	BY4741	11_1	
18	A	3	YKL065C	YET1	-	Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole genome duplication	biological_process	molecular_function	membrane, endomembrane system, ribosome, endoplasmic reticulum, cytoplasm	4914	BY4741	11_1	
18	A	4	YKL066W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1	biological_process	molecular_function	cellular_component	4915	BY4741	11_1	
18	A	5	YKL067W	YNK1	nucleoside diphosphate kinase|NDK1	Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress	nucleobase-containing small molecule metabolic process, cellular response to DNA damage stimulus	kinase activity, transferase activity	mitochondrial envelope, mitochondrion, cytoplasm	4916	BY4741	11_1	
18	A	6	YKL068W	NUP100	FG-nucleoporin NUP100|[NUP100+]|NSP100	FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication	response to heat, protein targeting, nucleobase-containing compound transport, nuclear transport, nucleus organization	structural molecule activity	nucleus, endomembrane system, membrane	4917	BY4741	11_1	
18	A	7	YKL069W	-	L-methionine (R)-S-oxide reductase|fRMsr|YKG9	Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress	response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, cytoplasm	4918	BY4741	11_1	
18	A	8	YKL070W	-	-	Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	4919	BY4741	11_1	
18	A	9	YKL071W	-	-	Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	membrane, cytoplasm	4920	BY4741	11_1	
18	A	10	YKL072W	STB6	-	Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	4921	BY4741	11_1	
18	A	11	YKL073W	LHS1	Hsp70 family chaperone LHS1|SSI1|CER1	Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway	response to chemical, protein targeting, transmembrane transport	enzyme regulator activity, ion binding, unfolded protein binding	endomembrane system, endoplasmic reticulum, cytoplasm	4922	BY4741	11_1	
18	A	12	YKL074C	MUD2	-	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65	RNA splicing, mRNA processing	RNA binding, mRNA binding	nucleus	4923	BY4741	11_1	
18	B	1	YKL075C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin	response to chemical	molecular_function	cytoplasm	4924	BY4741	11_1	
18	B	2	YKL076C	PSY1	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C	biological_process	molecular_function	cellular_component	4925	BY4741	11_1	
18	B	3	YKL077W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole	biological_process	molecular_function	endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	4926	BY4741	11_1	
18	B	4	YKL079W	SMY1	-	Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics	exocytosis	hydrolase activity	cellular bud, site of polarized growth	4928	BY4741	11_1	
18	B	5	YKL080W	VMA5	H(+)-transporting V1 sector ATPase subunit C|VAT3|CSL5	Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits	cellular ion homeostasis	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, vacuole, cytoplasm	4929	BY4741	11_1	
18	B	7	YKL081W	TEF4	translation elongation factor EF1B gamma|EFC1	Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex	translational elongation	guanyl-nucleotide exchange factor activity, RNA binding, translation factor activity, RNA binding	ribosome, mitochondrion, cytoplasm	4930	BY4741	11_1	
18	B	8	YKL084W	HOT13	-	Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc	protein targeting, mitochondrion organization, transmembrane transport	ion binding	mitochondrial envelope, mitochondrion, cytoplasm	4933	BY4741	11_1	
18	B	9	YKL085W	MDH1	malate dehydrogenase MDH1	Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated	generation of precursor metabolites and energy, cellular respiration	RNA binding, mRNA binding, oxidoreductase activity	mitochondrion, cytoplasm	4934	BY4741	11_1	
18	B	10	YKL086W	SRX1	sulfiredoxin	Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress	response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, cytoplasm	4935	BY4741	11_1	
18	B	11	YKL087C	CYT2	cytochrome c1 heme lyase CYT2|CC1HL	Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant	protein complex biogenesis	lyase activity	mitochondrial envelope, mitochondrion, cytoplasm	4936	BY4741	11_1	
18	B	12	YKL090W	CUE2	-	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination	biological_process	ubiquitin-like protein binding	cellular_component	4939	BY4741	11_1	
18	C	1	YKL091C	-	phosphatidylinositol/phosphatidylcholine-binding protein|SFH1	Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication	biological_process	ion binding, lipid binding	nucleus	4940	BY4741	11_1	
18	C	2	YKL092C	BUD2	ERC25|CLA2	GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains	mitotic cell cycle, organelle fission, cell budding, regulation of organelle organization, cytokinesis, chromosome segregation, regulation of cell cycle	enzyme regulator activity	cellular bud, membrane, site of polarized growth, cytoplasm	4941	BY4741	11_1	
18	C	3	YKL093W	MBR1	-	Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication	generation of precursor metabolites and energy, cellular respiration	molecular_function	cellular_component	4942	BY4741	11_1	
18	C	4	YKL094W	YJU3	acylglycerol lipase	Monoglyceride lipase (MGL); functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family	lipid metabolic process	hydrolase activity	endomembrane system, mitochondrion, membrane, mitochondrial envelope, endoplasmic reticulum, cytoplasm, plasma membrane	4943	BY4741	11_1	
18	C	5	YKL096W	CWP1	YJU1	Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance	meiotic cell cycle, sporulation, cell wall organization or biogenesis	structural molecule activity	vacuole, cell wall, membrane, cytoplasm	4945	BY4741	11_2	
18	C	6	YKL097C	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species	biological_process	molecular_function	cellular_component	4946	BY4741	11_2	
18	C	7	YKL098W	MTC2	-	Protein of unknown function; mtc2 is synthetically sick with cdc13-1	biological_process	molecular_function	cellular_component	4948	BY4741	11_2	
18	C	8	YKL100C	YPF1	aspartic endopeptidase	Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)	proteolysis involved in cellular protein catabolic process, response to starvation	peptidase activity, hydrolase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4950	BY4741	11_2	
18	C	9	YKL101W	HSL1	protein kinase HSL1|ELM2|NIK1	Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p	peptidyl-amino acid modification, mitotic cell cycle, protein phosphorylation, regulation of cell cycle	kinase activity, transferase activity	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	4951	BY4741	11_2	
18	C	10	YKL102C	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site	biological_process	molecular_function	cellular_component	4952	BY4741	11_2	
18	C	11	YKL103C	APE1	metalloaminopeptidase APE1|LAP4|API|YSC1	Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress	other	peptidase activity, hydrolase activity	vacuole, cytoplasm	4953	BY4741	11_2	
18	C	12	YKL105C	SEG2	-	Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; similar to <i>A. gossypii</i> SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog, SEG1, that arose from the whole genome duplication	biological_process	molecular_function	other	4955	BY4741	11_2	
18	D	1	YKL106W	AAT1	aspartate transaminase AAT1	Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis	monocarboxylic acid metabolic process, cellular amino acid metabolic process	transferase activity	mitochondrion, cytoplasm	4956	BY4741	11_2	
18	D	2	YKL107W	-	putative short-chain dehydrogenase/reductase	Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein	biological_process	molecular_function	cellular_component	4957	BY4741	11_2	
18	D	3	YKL109W	HAP4	transcription factor HAP4	Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift	response to chemical, generation of precursor metabolites and energy, cellular respiration, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, transcription factor activity, protein binding, transcription factor binding	nucleus	4959	BY4741	11_2	
18	D	4	YKL110C	KTI12	TOT4	Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p	tRNA processing, transcription from RNA polymerase II promoter, RNA modification	chromatin binding	nucleus, cytoplasm	4960	BY4741	11_2	
18	D	5	YKL113C	RAD27	multifunctional nuclease RAD27|FEN1|RTH1|ERC11	5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia	DNA repair, DNA replication, cellular response to DNA damage stimulus, RNA catabolic process, DNA recombination	hydrolase activity, nuclease activity	nucleus, mitochondrion, cytoplasm	4963	BY4741	11_2	
18	D	6	YKL114C	APN1	DNA-(apurinic or apyrimidinic site) lyase APN1	Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity	DNA repair, cellular response to DNA damage stimulus	lyase activity, nuclease activity, hydrolase activity	nucleus, mitochondrion, cytoplasm	4964	BY4741	11_2	
18	D	7	YKL116C	PRR1	serine/threonine protein kinase PRR1	Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor	response to chemical, protein phosphorylation, conjugation, transcription from RNA polymerase II promoter	kinase activity, transferase activity, signal transducer activity	cytoplasm	4966	BY4741	11_2	
18	D	8	YKL117W	SBA1	Hsp90 cochaperone SBA1|CST18	Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress	telomere organization, protein folding, regulation of organelle organization, regulation of DNA metabolic process	other	nucleus, cytoplasm	4967	BY4741	11_2	
18	D	9	YKL118W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPH2	biological_process	molecular_function	cellular_component	4968	BY4741	11_2	
18	D	10	YKL119C	VPH2	VMA12|CLS10	Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner	cellular ion homeostasis, protein complex biogenesis	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4969	BY4741	11_2	
18	D	11	YKL120W	OAC1	-	Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family	ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4970	BY4741	11_2	
18	D	12	YKL121W	DGR2	-	Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	4971	BY4741	11_2	
18	E	1	YKL123W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SSH4	biological_process	molecular_function	cellular_component	4973	BY4741	11_2	
18	E	2	YKL124W	SSH4	MLF4	Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases	protein targeting, proteolysis involved in cellular protein catabolic process, endosomal transport	molecular_function	endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	4974	BY4741	11_2	
18	E	3	YKL126W	YPK1	serine/threonine protein kinase YPK1|SLI2	S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant	peptidyl-amino acid modification, response to chemical, protein phosphorylation, ion transport, regulation of transport, lipid transport, lipid metabolic process, conjugation	kinase activity, transferase activity	cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	4976	BY4741	11_2	
18	E	4	YKL127W	PGM1	phosphoglucomutase PGM1	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication	carbohydrate metabolic process, generation of precursor metabolites and energy, oligosaccharide metabolic process	isomerase activity	cytoplasm	4977	BY4741	11_2	
18	E	5	YKL128C	PMU1	putative phosphomutase	Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant	biological_process	molecular_function	nucleus, cytoplasm	4978	BY4741	11_2	
18	E	6	YKL129C	MYO3	myosin 3	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication	mitotic cell cycle, cell budding, cytokinesis, exocytosis, cell wall organization or biogenesis, response to osmotic stress, endocytosis	hydrolase activity	cell cortex, cytoskeleton, cytoplasm	4979	BY4741	11_2	
18	E	7	YKL130C	SHE2	-	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER	other	RNA binding, lipid binding, mRNA binding	endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm	4980	BY4741	11_2	
18	E	8	YKL131W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4981	BY4741	11_2	
18	E	9	YKL132C	RMA1	putative tetrahydrofolate synthase	Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication	biological_process	ligase activity	mitochondrion, cytoplasm	4982	BY4741	11_2	
18	E	10	YKL133C	-	-	Putative protein of unknown function; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, MGR3, that arose from the whole genome duplication	biological_process	molecular_function	mitochondrion, cytoplasm	4983	BY4741	11_2	
18	E	11	YKL134C	OCT1	metalloendopeptidase	Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis	protein targeting, mitochondrion organization, protein maturation, cellular ion homeostasis	peptidase activity, hydrolase activity	mitochondrion, cytoplasm	4984	BY4741	11_2	
18	E	12	YKL135C	APL2	-	Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress	Golgi vesicle transport	other	membrane, cytoplasmic vesicle, endomembrane system, cytoplasm, Golgi apparatus	4985	BY4741	11_2	"AP! complex subunit B 1 adaptin -- growth on -met, super slow growth on -lys, super slow growth on drop in media, mates like alpha. Confirmed Alpha -- CORRECT STRAIN CAN BE FOUND IN PLATE 121 F8"	
18	F	1	YKL136W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C	biological_process	molecular_function	cellular_component	4986	BY4741	11_2	
18	F	2	YKL137W	CMC1	-	Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif	mitochondrion organization, protein complex biogenesis	ion binding	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4987	BY4741	11_2	
18	F	3	YKL138C	MRPL31	mitochondrial 54S ribosomal protein YmL31|YmL31	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4988	BY4741	11_2	
18	F	4	YKL140W	TGL1	YKL5	Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes	lipid metabolic process	hydrolase activity	membrane	4990	BY4741	11_2	
18	F	5	YKL142W	MRP8	YKL3	Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis	biological_process	molecular_function	cytoplasm	4992	BY4741	11_2	
18	F	6	YKL143W	LTV1	YKL2	Component of the GSE complex; GSE is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature	response to chemical, ion transport, ribosomal subunit export from nucleus, nucleobase-containing compound transport, ribosomal small subunit biogenesis, response to oxidative stress, nuclear transport, response to osmotic stress	molecular_function	nucleus, cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	4993	BY4741	11_2	
18	F	7	YKL146W	AVT3	-	Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters	transmembrane transport, ion transport, amino acid transport	transmembrane transporter activity	membrane, vacuole, cytoplasm	4996	BY4741	11_2	
18	F	8	YKL147C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3	biological_process	molecular_function	cellular_component	4997	BY4741	11_2	
18	F	9	YKL148C	SDH1	succinate dehydrogenase flavoprotein subunit SDH1|SDHA	Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	oxidoreductase activity, ion binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4998	BY4741	11_2	
18	F	10	YKL149C	DBR1	RNA lariat debranching enzyme|PRP26	RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant	RNA catabolic process, RNA splicing, pseudohyphal growth, mRNA processing, transposition	nuclease activity, hydrolase activity	nucleus	4999	BY4741	11_2	
18	F	11	YKL150W	MCR1	cytochrome-b5 reductase	Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis	response to chemical, response to oxidative stress, lipid metabolic process	oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	5000	BY4741	11_2	
18	F	12	YKL151C	NNR2	NADHX dehydratase	Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli	cofactor metabolic process, nucleobase-containing small molecule metabolic process	lyase activity	cytoplasm	5001	BY4741	11_2	
18	G	1	YPR151C	SUE1	-	Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria	other	molecular_function	mitochondrial envelope, mitochondrion, cytoplasm	7407	BY4741	00_18	
18	G	2	YKL156W	RPS27A	eS27|ribosomal 40S subunit protein S27A|S27e|rp61|YS20|S27A	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation, rRNA processing, organelle assembly, ribosomal small subunit biogenesis, ribosome assembly	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	5006	BY4741	11_2	
18	G	3	YKL157W	APE2	metallo-aminopeptidase|YKL158W|LAP1	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication	other	peptidase activity, hydrolase activity	nucleus, extracellular region, mitochondrion, cytoplasm	5007	BY4741	11_2	
18	G	4	YKL158W	nucleus, extracellular region, mitochondrion, cytoplasm	nucleus, extracellular region, mitochondrion, cytoplasm	nucleus, extracellular region, mitochondrion, cytoplasm	-	-	-	5008	BY4741	11_2	
18	G	5	YKL159C	RCN1	-	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region	signaling	enzyme binding, enzyme regulator activity	cytoplasm	5009	BY4741	11_2	
18	G	6	YKL160W	ELF1	-	Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression	chromatin organization, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	enzyme binding	nucleus	5010	BY4741	11_2	
18	G	7	YKL161C	KDX1	putative protein kinase KDX1|MLP1	Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication	biological_process	kinase activity, transferase activity	cellular_component	5011	BY4741	11_2	
18	G	8	YKL162C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion, cytoplasm	5012	BY4741	11_2	
18	G	9	YKL163W	PIR3	beta-1,3-glucan linked protein|CCW8	O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication	cell wall organization or biogenesis	structural molecule activity	cell wall	5013	BY4741	11_2	
18	G	10	YKL164C	PIR1	beta-1,3-glucan linked protein|CCW6	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication	cell wall organization or biogenesis	structural molecule activity	cell wall, nucleus	5014	BY4741	11_2	
18	G	11	YKL166C	TPK3	cAMP-dependent protein kinase catalytic subunit TPK3	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication	protein phosphorylation, mitochondrion organization, signaling	kinase activity, transferase activity	nucleus, cytoplasm	5016	BY4741	11_2	
18	G	12	YKL167C	MRP49	mitochondrial 54S ribosomal protein MRP49	Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	5017	BY4741	11_2	
18	H	1	YKL168C	KKQ8	putative serine/threonine protein kinase KKQ8	Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication	biological_process	kinase activity, transferase activity	cytoplasm	5018	BY4741	11_2	
18	H	3	YKL169C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38	biological_process	molecular_function	cellular_component	5019	BY4741	11_2	
18	H	4	YKL170W	MRPL38	mitochondrial 54S ribosomal protein YmL38/YmL34|YmL38|YmL34|MRPL34	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	5020	BY4741	11_2	
18	H	5	YKL171W	NNK1	protein kinase NNK1	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm	protein phosphorylation	kinase activity, transferase activity	cytoplasm	5021	BY4741	11_2	
18	H	6	YKL174C	TPO5	-	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles	other	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm, Golgi apparatus	5024	BY4741	11_2	
18	H	7	YKL175W	ZRT3	Zn(2+) transporter ZRT3	Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency	ion transport, cellular ion homeostasis	transmembrane transporter activity	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	5025	BY4741	11_2	
18	H	8	YKL176C	LST4	-	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface	signaling	enzyme regulator activity	membrane, vacuole, cytoplasm	5026	BY4741	11_2	
18	H	9	YKL177W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3	biological_process	molecular_function	cellular_component	5027	BY4741	11_2	
18	H	10	YKL178C	STE3	DAF2	Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR	response to chemical, conjugation, signaling	signal transducer activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	5028	BY4741	11_2	
18	H	11	YKL179C	COY1	-	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function	Golgi vesicle transport	molecular_function	membrane, endomembrane system, cytoplasm, Golgi apparatus	5029	BY4741	11_2	
18	H	12	YKL183W	LOT5	-	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	5033	BY4741	11_2	
19	A	1	YKL184W	SPE1	ornithine decarboxylase SPE1|SPE10|ORD1	Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation	cofactor metabolic process, vitamin metabolic process, monocarboxylic acid metabolic process	lyase activity	cytoplasm	5034	BY4741	11_2	
19	A	2	YKL185W	ASH1	DNA-binding transcription repressor ASH1	Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate	mitotic cell cycle, pseudohyphal growth, transcription from RNA polymerase II promoter, regulation of cell cycle	nucleic acid binding transcription factor activity, DNA binding	cellular bud, nucleus, chromosome	5035	BY4741	11_2	
19	A	3	YKL187C	FAT3	-	Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog, YLR413W, that arose from the whole genome duplication	lipid transport, ion transport	molecular_function	membrane, mitochondrion, cytoplasm	5037	BY4741	11_2	
19	A	4	YKL188C	PXA2	ATP-binding cassette long-chain fatty acid transporter PXA2|PAT1	Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant	transmembrane transport, ion transport, lipid transport	hydrolase activity, transmembrane transporter activity, ATPase activity	peroxisome, membrane, cytoplasm	5038	BY4741	11_2	
19	A	5	YKL190W	CNB1	calcineurin regulatory subunit B|YCN2|CRV1	Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress	response to chemical, cellular ion homeostasis, conjugation, cell wall organization or biogenesis, signaling	phosphatase activity, hydrolase activity, ion binding	other	5040	BY4741	11_2	
19	A	6	YGR027C	RPS25A	eS25|ribosomal 40S subunit protein S25A|S25e|rp45|YS23|S31A|S25A|RPS31A	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	4657	BY4741	07_4	
19	A	7	YGR031W	IMO32	-	Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1	biological_process	molecular_function	mitochondrion, cytoplasm	4661	BY4741	07_4	
19	A	8	YGR033C	TIM21	FMP17	Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity	protein targeting, mitochondrion organization, transmembrane transport	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4663	BY4741	07_4	
19	A	9	YGR034W	RPL26B	uL24|ribosomal 60S subunit protein L26B|L24|YL33|L33B|L26B	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication	cytoplasmic translation	RNA binding, structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	4664	BY4741	07_4	
19	A	10	YGR035C	-	-	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	4665	BY4741	07_4	
19	A	11	YGR036C	CAX4	CWH8	Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation	protein glycosylation, lipid metabolic process	hydrolase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4666	BY4741	07_4	
19	A	12	YGR037C	ACB1	long-chain fatty acid transporter ACB1	Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress	lipid transport, ion transport	ion binding	nucleus, extracellular region, cytoplasm	4667	BY4741	07_4	
19	B	1	YGR039W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YGR039W is not an essential gene	biological_process	molecular_function	cellular_component	4669	BY4741	07_4	
19	B	2	YGR041W	BUD9	-	Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication	mitotic cell cycle, cytokinesis	molecular_function	cellular bud, membrane, site of polarized growth, plasma membrane	4671	BY4741	07_4	
19	B	3	YGR042W	MTE1	-	Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress	telomere organization, regulation of organelle organization, regulation of DNA metabolic process	molecular_function	nucleus, chromosome, cytoplasm	4672	BY4741	07_4	
19	B	4	YGR043C	NQM1	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1	Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication	response to chemical, response to oxidative stress	transferase activity	nucleus	4673	BY4741	07_4	
19	B	5	YGR044C	RME1	CSP1	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress	mitotic cell cycle, meiotic cell cycle, organelle fission, invasive growth in response to glucose limitation, regulation of organelle organization, transcription from RNA polymerase II promoter, regulation of cell cycle	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	4674	BY4741	07_4	
19	B	6	YGR045C	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains	biological_process	molecular_function	membrane	4675	BY4741	07_4	
19	B	8	YGR049W	SCM4	-	Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication	biological_process	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4679	BY4741	07_4	
19	B	9	YGR051C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene	biological_process	molecular_function	cellular_component	4681	BY4741	07_4	
19	B	10	YGR052W	FMP48	protein kinase FMP48	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation	protein phosphorylation	kinase activity, transferase activity	mitochondrion, cytoplasm	4682	BY4741	07_4	
19	B	11	YGR054W	-	-	Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A	translational initiation	RNA binding, translation factor activity, RNA binding, mRNA binding	ribosome, cytoplasm	4684	BY4741	07_4	
19	B	12	YGR055W	MUP1	-	High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake	ion transport, amino acid transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	4685	BY4741	07_4	
19	C	1	YGR056W	RSC1	RSC subunit protein RSC1	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication	DNA repair, chromatin organization, sporulation, cellular response to DNA damage stimulus, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	hydrolase activity, ATPase activity	nucleus	4686	BY4741	07_4	
19	C	2	YGR057C	LST7	-	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface	signaling	enzyme regulator activity	membrane, vacuole, cytoplasm	4687	BY4741	07_4	
19	C	3	YGR058W	PEF1	-	Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly	mitotic cell cycle, cell budding, regulation of organelle organization, cytokinesis, regulation of transport, vesicle organization, protein complex biogenesis, Golgi vesicle transport	ion binding	nucleus, cellular bud, site of polarized growth, cytoplasm	4688	BY4741	07_4	
19	C	4	YGR059W	SPR3	septin SPR3	Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes	meiotic cell cycle, sporulation	structural molecule activity	cell cortex, cytoskeleton, cell wall, membrane, cytoplasm	4689	BY4741	07_4	
19	C	5	YGR061C	ADE6	phosphoribosylformylglycinamidine synthase	Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway	nucleobase-containing small molecule metabolic process	ligase activity	cytoplasm	4691	BY4741	07_4	
19	C	6	YGR062C	COX18	membrane insertase COX18|OXA2	Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p	mitochondrion organization	protein transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4692	BY4741	07_4	
19	C	7	YGR064W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C	other	molecular_function	cellular_component	4694	BY4741	07_4	
19	C	8	YGR066C	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	4696	BY4741	07_4	
19	C	9	YGR067C	-	-	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	biological_process	DNA binding	cellular_component	4697	BY4741	07_4	
19	C	10	YGR068C	ART5	-	Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol	endocytosis	enzyme binding	cytoplasm	4698	BY4741	07_4	
19	C	11	YGR069W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4699	BY4741	07_4	
19	C	12	YGR070W	ROM1	Rho family guanine nucleotide exchange factor ROM1|SKC1	Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication	signaling	guanyl-nucleotide exchange factor activity	other	4700	BY4741	07_4	
19	D	1	YGR071C	ENV11	-	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication	vacuole organization, protein maturation	molecular_function	nucleus	4701	BY4741	07_4	
19	D	2	YGR072W	UPF3	SUP112|SUA6	Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance	RNA catabolic process, protein modification by small protein conjugation or removal, DNA recombination	RNA binding, mRNA binding	nucleus, nucleolus, cytoplasm	4702	BY4741	07_4	
19	D	3	YGR076C	MRPL25	mitochondrial 54S ribosomal protein YmL25|AFO1|YmL25|YMR26	Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4706	BY4741	07_4	
19	D	4	YGR077C	PEX8	PAS6	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p	protein targeting, transmembrane transport, peroxisome organization	protein binding, bridging	peroxisome, membrane, cytoplasm	4707	BY4741	07_4	
19	D	5	YGR078C	PAC10	tubulin-binding prefolding complex subunit PAC10|RKS2|PFD3|GIM2	Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding	protein complex biogenesis	cytoskeletal protein binding	cytoplasm	4708	BY4741	07_4	
19	D	6	YGR079W	-	-	Putative protein of unknown function; YGR079W is not an essential gene	biological_process	molecular_function	cellular_component	4709	BY4741	07_4	
19	D	7	YGR080W	TWF1	-	Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis	cytoskeletal protein binding	cell cortex, site of polarized growth, cytoskeleton, cytoplasm	4710	BY4741	07_4	
19	D	8	YGR081C	SLX9	-	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant	rRNA processing, ribosomal subunit export from nucleus, nuclear transport, ribosomal small subunit biogenesis	molecular_function	nucleus, nucleolus	4711	BY4741	07_4	
19	D	9	YGR084C	MRP13	mitochondrial 37S ribosomal protein YmS-A	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	4714	BY4741	07_4	
19	D	10	YGR085C	RPL11B	uL5|ribosomal 60S subunit protein L11B|rp39B|YL22|L5|L16A|L11B	Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication	cytoplasmic translation, organelle assembly, ribosomal large subunit biogenesis, ribosome assembly	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	4715	BY4741	07_4	
19	D	11	YGR087C	PDC6	indolepyruvate decarboxylase 6	Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation	cellular amino acid metabolic process	lyase activity	cytoplasm	4717	BY4741	07_4	
19	D	12	YGR088W	CTT1	catalase T|SPS101	Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide	response to chemical, response to oxidative stress, response to osmotic stress	oxidoreductase activity	cytoplasm	4718	BY4741	07_4	
19	E	1	YGR096W	TPC1	thiamine transporter TPC1	Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family	ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4726	BY4741	07_4	
19	E	2	YGR097W	ASK10	RGC2	Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme	response to chemical, carbohydrate transport, regulation of transport, response to oxidative stress	other	nucleus, cytoplasm	4727	BY4741	07_4	
19	E	3	YGR100W	MDR1	GYP2|MIC1	Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function	other	enzyme regulator activity	cytoplasm	4730	BY4741	07_4	
19	E	4	YGR101W	PCP1	rhomboid protease PCP1|RBD1|MDM37	Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases	mitochondrion organization, regulation of organelle organization, protein maturation	peptidase activity, hydrolase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	4731	BY4741	07_4	
19	E	5	YGR102C	GTF1	glutamyl-tRNA(Gln) amidotransferase subunit F	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria	cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	4732	BY4741	07_4	
19	E	6	YGR104C	SRB5	MED18	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance	DNA-templated transcription, initiation, transcription from RNA polymerase II promoter, DNA-templated transcription, termination	DNA binding, transcription factor activity, protein binding	nucleus	4734	BY4741	07_4	
19	E	7	YGR105W	VMA21	-	Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive Autophagy); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)	protein complex biogenesis	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4735	BY4741	07_4	
19	E	8	YGR107W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4737	BY4741	07_4	
19	E	9	YGR108W	CLB1	B-type cyclin CLB1|SCB1	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication	mitotic cell cycle, meiotic cell cycle, protein phosphorylation, organelle fission, cytoskeleton organization, regulation of organelle organization, regulation of protein modification process, regulation of cell cycle	enzyme regulator activity	nucleus, cytoplasm	4738	BY4741	07_4	
19	E	10	YGR109C	CLB6	B-type cyclin CLB6	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication	mitotic cell cycle, meiotic cell cycle, regulation of protein modification process, protein phosphorylation, DNA replication, regulation of DNA metabolic process, regulation of cell cycle	enzyme regulator activity	cellular_component	4739	BY4741	07_4	
19	E	11	YGR111W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	other	molecular_function	nucleus, cytoplasm	4741	BY4741	07_4	
19	E	12	YGR112W	SHY1	-	Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase	mitochondrion organization, protein complex biogenesis	unfolded protein binding	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4742	BY4741	07_4	
19	F	1	YGR118W	RPS23A	uS12|ribosomal 40S subunit protein S23A|rp37|YS14|S28A|S23A|S12	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	regulation of translation, rRNA processing, translational elongation, ribosomal small subunit biogenesis	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	4748	BY4741	07_4	
19	F	2	YGR121C	MEP1	ammonium permease MEP1|AMT1	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication	ion transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	4751	BY4741	07_4	
19	F	3	YGR122W	-	-	Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress	RNA catabolic process, transcription from RNA polymerase II promoter	molecular_function	nucleus, membrane, plasma membrane, cytoplasm	4752	BY4741	07_4	
19	F	4	YOR097C	-	-	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene	biological_process	molecular_function	cellular_component	2353	BY4741	15_2	
19	F	5	YOR099W	KTR1	alpha-1,2-mannosyltransferase KTR1	Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	2355	BY4741	15_2	
19	F	6	YOR100C	CRC1	carnitine:acyl carnitine antiporter	Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant	lipid metabolic process, monocarboxylic acid metabolic process	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2356	BY4741	15_2	
19	F	7	YOR101W	RAS1	Ras family GTPase RAS1	GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication	nucleobase-containing small molecule metabolic process, signaling	GTPase activity, hydrolase activity	nucleus, membrane, cytoplasm, plasma membrane	2357	BY4741	15_2	
19	F	8	YOR104W	PIN2	-	Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated	biological_process	molecular_function	vacuole, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	2360	BY4741	15_2	
19	F	9	YOR105W	-	-	Protein of unknown function; expressed at both mRNA and protein levels	biological_process	molecular_function	cellular_component	2361	BY4741	15_2	
19	F	10	YOR106W	VAM3	SNAP receptor VAM3|PTH1	Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region	vacuole organization, organelle fusion, vesicle organization, membrane fusion	other	vacuole, membrane, cytoplasm	2362	BY4741	15_2	
19	F	11	YOR107W	RGS2	GTPase-activating protein RGS2	Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p	signaling	enzyme regulator activity	nucleus, cytoplasm	2363	BY4741	15_2	
19	F	12	YOR108W	LEU9	2-isopropylmalate synthase LEU9	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication	cellular amino acid metabolic process	transferase activity	mitochondrion, cytoplasm	2364	BY4741	15_2	
19	G	1	YOR109W	INP53	phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53|SOP2|SJL3	Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication	lipid metabolic process	phosphatase activity, hydrolase activity	membrane, cell cortex, cytoskeleton, cytoplasm	2365	BY4741	15_2	
19	G	2	YOR111W	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	2367	BY4741	15_2	
19	G	3	YOR112W	CEX1	-	Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex	nucleobase-containing compound transport, nuclear transport	RNA binding	nucleus, endomembrane system, cytoplasm	2368	BY4741	15_2	
19	G	4	YOR113W	AZF1	-	Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia	response to chemical, cell wall organization or biogenesis, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	2369	BY4741	15_2	
19	G	5	YOR114W	-	-	Putative protein of unknown function; null mutant is viable	biological_process	molecular_function	cellular_component	2370	BY4741	15_2	
19	G	6	YOR115C	TRS33	-	Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy	vacuole organization, organelle assembly, protein complex biogenesis, Golgi vesicle transport	molecular_function	cytoplasmic vesicle, endomembrane system, Golgi apparatus, cytoplasm	2371	BY4741	15_2	
19	G	7	YOR118W	RTC5	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity	biological_process	molecular_function	cytoplasm	2374	BY4741	15_2	
19	G	8	YOR120W	GCY1	glycerol 2-dehydrogenase (NADP(+)) GCY1|GCY	Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication	carbohydrate metabolic process, response to chemical, response to oxidative stress	RNA binding, oxidoreductase activity, mRNA binding	nucleus, cytoplasm	2376	BY4741	15_2	
19	G	9	YOR121C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W	biological_process	molecular_function	cellular_component	2377	BY4741	15_2	
19	G	10	YOR123C	LEO1	-	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	transcription from RNA polymerase I promoter, peptidyl-amino acid modification, chromatin organization, DNA-templated transcription, termination, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation, DNA repair, protein alkylation, cellular response to DNA damage stimulus, histone modification, regulation of protein modification process, protein modification by small protein conjugation or removal, regulation of DNA metabolic process	RNA binding, enzyme binding, ion binding, transcription factor activity, protein binding	nucleus	2379	BY4741	15_2	
19	G	11	YOR124C	UBP2	ubiquitin-specific protease UBP2	Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity	protein modification by small protein conjugation or removal, proteolysis involved in cellular protein catabolic process	peptidase activity, hydrolase activity	cytoplasm	2380	BY4741	15_2	
19	G	12	YOR125C	CAT5	putative monooxygenase CAT5|COQ7	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation	cofactor metabolic process	oxidoreductase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2381	BY4741	15_2	
19	H	1	YOR126C	IAH1	isoamyl acetate-hydrolyzing esterase	Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing	monocarboxylic acid metabolic process	hydrolase activity	cellular_component	2382	BY4741	15_2	
19	H	3	YOR127W	RGA1	THE1|DBM1	GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication	response to chemical, invasive growth in response to glucose limitation, cell budding, cytoskeleton organization, conjugation, pseudohyphal growth, signaling	enzyme regulator activity	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	2383	BY4741	15_2	
19	H	4	YOR129C	AFI1	-	Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p	mitotic cell cycle, cytokinesis	molecular_function	nucleus, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	2385	BY4741	15_2	
19	H	5	YOR130C	ORT1	ARG11	Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement	ion transport, cellular amino acid metabolic process, amino acid transport	transmembrane transporter activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	2386	BY4741	15_2	
19	H	6	YOR131C	-	putative haloacid dehalogenase-like hydrolase	Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus, cytoplasm	2387	BY4741	15_2	
19	H	7	YOR132W	VPS17	retromer subunit VPS17|VPT3|PEP21	Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes	endosomal transport	protein transporter activity, lipid binding, ion binding	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	2388	BY4741	15_2	
19	H	8	YOR133W	EFT1	elongation factor 2	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication	regulation of translation, translational elongation	RNA binding, GTPase activity, hydrolase activity, translation factor activity, RNA binding	ribosome, cytoplasm	2389	BY4741	15_2	
19	H	9	YOR134W	BAG7	-	Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication	signaling	enzyme regulator activity	cellular_component	2390	BY4741	15_2	
19	H	10	YOR135C	IRC14	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci	meiotic cell cycle, sporulation, DNA recombination, transcription from RNA polymerase II promoter	molecular_function	cellular_component	2391	BY4741	15_2	
19	H	11	YOR136W	IDH2	isocitrate dehydrogenase (NAD(+)) IDH2	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated	generation of precursor metabolites and energy, cellular respiration, cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	2392	BY4741	15_2	
19	H	12	YOR137C	SIA1	-	Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization	ion transport	molecular_function	cellular_component	2393	BY4741	15_2	
20	A	1	YOR138C	RUP1	-	Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress	regulation of protein modification process, protein modification by small protein conjugation or removal	other	nucleus, cytoplasm	2394	BY4741	15_2	
20	A	2	YOR139C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W	biological_process	molecular_function	cellular_component	2395	BY4741	15_2	
20	A	3	YOR140W	SFL1	-	Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)	invasive growth in response to glucose limitation, pseudohyphal growth, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding, transcription factor binding	nucleus	2396	BY4741	15_2	
20	A	4	YOR141C	ARP8	-	Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity	DNA repair, chromatin organization, cellular response to DNA damage stimulus, DNA recombination	RNA binding, hydrolase activity, ATPase activity, helicase activity, mRNA binding	nucleus, chromosome	2397	BY4741	15_2	
20	A	5	YOR142W	LSC1	succinate--CoA ligase (GDP-forming) subunit alpha	Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated	cofactor metabolic process, generation of precursor metabolites and energy, cellular respiration	ligase activity	mitochondrion, cytoplasm	2398	BY4741	15_2	
20	A	6	YOR144C	ELG1	RTT110	Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication	mitotic cell cycle, DNA repair, telomere organization, organelle fission, DNA replication, cellular response to DNA damage stimulus, transposition, chromosome segregation, DNA recombination, regulation of DNA metabolic process	chromatin binding	nucleus, chromosome, mitochondrion, cytoplasm	2400	BY4741	15_2	
20	A	7	YOR152C	ATG40	-	Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy	other	protein binding, bridging	membrane, cell cortex, endomembrane system, endoplasmic reticulum, cytoplasm	2408	BY4741	15_2	
20	A	8	YOR153W	PDR5	ATP-binding cassette multidrug transporter PDR5|STS1|YDR1|LEM1	Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication	response to chemical, cellular ion homeostasis	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, cytoplasm, plasma membrane	2409	BY4741	15_2	
20	A	9	YOR154W	SLP1	-	Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p	protein folding	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2410	BY4741	15_2	
20	A	10	YOR155C	ISN1	IMP 5'-nucleotidase	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms	nucleobase-containing small molecule metabolic process	phosphatase activity, hydrolase activity	cellular_component	2411	BY4741	15_2	
20	A	11	YOR156C	NFI1	SUMO ligase NFI1|SIZ2	SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance	peptidyl-amino acid modification, chromosome segregation, protein modification by small protein conjugation or removal	transferase activity, DNA binding	nucleus, chromosome, cytoplasm	2412	BY4741	15_2	
20	A	12	YOR161C	PNS1	-	Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport	biological_process	molecular_function	membrane, plasma membrane	2417	BY4741	15_2	
20	B	1	YOR162C	YRR1	PDR2	Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication	response to chemical, transcription from RNA polymerase II promoter, response to oxidative stress	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	2418	BY4741	15_2	
20	B	2	YOR163W	DDP1	polyphosphatase DDP1	Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress	carbohydrate metabolic process, nucleobase-containing small molecule metabolic process	nuclease activity, hydrolase activity	nucleus, cytoplasm	2419	BY4741	15_2	
20	B	3	YOR164C	GET4	ENV8	Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20	protein targeting	molecular_function	cytoplasm	2420	BY4741	15_2	
20	B	4	YOR165W	SEY1	dynamin-like GTPase SEY1	Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3	organelle fusion, membrane fusion, organelle inheritance	GTPase activity, hydrolase activity	cell cortex, endomembrane system, cellular bud, membrane, endoplasmic reticulum, cytoplasm	2421	BY4741	15_2	
20	B	5	YOR166C	SWT1	mRNA-processing endoribonuclease	RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain	RNA catabolic process	nuclease activity, hydrolase activity	nucleus, cytoplasm	2422	BY4741	15_2	
20	B	6	YOR167C	RPS28A	eS28|ribosomal 40S subunit protein S28A|S28e|YS27|S33A|S28A|RPS33A	Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication	cytoplasmic translation, nucleobase-containing compound transport, RNA catabolic process, nuclear transport	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	2423	BY4741	15_2	
20	B	7	YOR170W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4	biological_process	molecular_function	cellular_component	2426	BY4741	15_2	
20	B	9	YOR171C	LCB4	sphinganine kinase LCB4	Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication	lipid metabolic process, signaling	kinase activity, transferase activity	cell cortex, endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm, plasma membrane	2427	BY4741	15_2	
20	B	10	YOR172W	YRM1	-	Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	2428	BY4741	15_2	
20	B	11	YOR173W	DCS2	5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase	m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication	RNA catabolic process, response to starvation	hydrolase activity	cytoplasm	2429	BY4741	15_2	
20	B	12	YOR175C	ALE1	lysophospholipid acyltransferase|LCA1|LPT1|SLC4	Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids	lipid metabolic process	transferase activity	membrane, endomembrane system, ribosome, endoplasmic reticulum, cytoplasm	2431	BY4741	15_2	
20	C	1	YOR177C	MPC54	-	Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate	meiotic cell cycle, sporulation	structural molecule activity	cytoskeleton, microtubule organizing center	2433	BY4741	15_2	
20	C	2	YOR178C	GAC1	protein phosphatase regulator GAC1	Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication	response to heat, mitotic cell cycle, meiotic cell cycle, carbohydrate metabolic process, organelle fission, regulation of organelle organization, generation of precursor metabolites and energy, chromosome segregation, regulation of cell cycle	enzyme regulator activity	cytoplasm	2434	BY4741	15_2	
20	C	3	YOR182C	RPS30B	eS30|ribosomal 40S subunit protein S30B|S30e|S30B	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	2438	BY4741	15_2	
20	C	4	YOR183W	FYV12	-	Protein of unknown function; required for survival upon exposure to K1 killer toxin	biological_process	molecular_function	cellular_component	2439	BY4741	15_2	
20	C	5	YOR184W	SER1	O-phospho-L-serine:2-oxoglutarate transaminase|ADE9	3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress	nucleobase-containing small molecule metabolic process, cellular amino acid metabolic process	transferase activity	cytoplasm	2440	BY4741	15_2	
20	C	6	YOR185C	GSP2	Ran GTPase GSP2|CNR2	GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication	nucleus organization	GTPase activity, hydrolase activity	nucleus, membrane	2441	BY4741	15_2	
20	C	7	YOR186W	-	-	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; mCherry fusion protein localizes to the vacuole; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	2442	BY4741	15_2	
20	C	8	YOR187W	TUF1	translation elongation factor Tu|tufM	Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria	mitochondrial translation, mitochondrion organization, translational elongation	RNA binding, GTPase activity, hydrolase activity, translation factor activity, RNA binding	mitochondrion, cytoplasm	2443	BY4741	15_2	
20	C	9	YOR188W	MSB1	-	Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress	other	molecular_function	cellular bud, membrane, site of polarized growth, mitochondrion, plasma membrane, cytoplasm	2444	BY4741	15_2	
20	C	10	YOR189W	IES4	-	Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses	telomere organization, DNA recombination, cellular response to DNA damage stimulus	molecular_function	nucleus, chromosome	2445	BY4741	15_2	
20	C	11	YOR190W	SPR1	glucan 1,3-beta-glucosidase|SSG1	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication	meiotic cell cycle, sporulation	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cell wall, membrane, vacuole, cytoplasm	2446	BY4741	15_2	
20	C	12	YOR191W	ULS1	translocase ULS1|RIS1|TID4|DIS1	Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress	DNA repair, chromatin organization, cellular response to DNA damage stimulus, regulation of DNA metabolic process	hydrolase activity, ubiquitin-like protein binding, ATPase activity	nucleus, chromosome, mitochondrion, nucleolus, cytoplasm	2447	BY4741	15_2	
20	D	1	YOR192C	THI72	thiamine transporter	Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p	transmembrane transport	other	membrane, vacuole, cytoplasm	2448	BY4741	15_2	
20	D	2	YOR193W	PEX27	-	Peripheral peroxisomal membrane protein; involved in controlling peroxisome size and number, interacts with Pex25p; PEX27 has a paralog, PEX25, that arose from the whole genome duplication	peroxisome organization	molecular_function	peroxisome, membrane, cytoplasm	2449	BY4741	15_3	
20	D	3	YOR195W	SLK19	-	Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate	mitotic cell cycle, meiotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, chromosome segregation, regulation of cell cycle	molecular_function	nucleus, cytoskeleton, chromosome	2451	BY4741	15_3	
20	D	4	YOR196C	LIP5	putative lipoate synthase	Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase	other	transferase activity, ligase activity	mitochondrion, cytoplasm	2452	BY4741	15_3	
20	D	5	YOR197W	MCA1	Ca(2+)-dependent cysteine protease MCA1|YCA1	Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization	proteolysis involved in cellular protein catabolic process	peptidase activity, hydrolase activity	nucleus, cytoplasm	2453	BY4741	15_3	
20	D	6	YOR198C	BFR1	-	Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity	mitotic cell cycle, meiotic cell cycle, organelle fission, regulation of organelle organization, regulation of cell cycle	RNA binding, mRNA binding	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	2454	BY4741	15_3	
20	D	7	YOR199W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2455	BY4741	15_3	
20	D	8	YOR200W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c	biological_process	molecular_function	cellular_component	2456	BY4741	15_3	
20	D	9	YOR201C	MRM1	PET56	Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA	rRNA processing, RNA modification	transferase activity, methyltransferase activity	mitochondrion, cytoplasm	2457	BY4741	15_3	
20	D	10	YOR202W	HIS3	imidazoleglycerol-phosphate dehydratase HIS3|HIS8|HIS10	Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p	cellular amino acid metabolic process	lyase activity	cellular_component	2458	BY4741	15_3	
20	D	11	YOR205C	GEP3	MTG3|AIM40|LRC5|FMP38	Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p)	rRNA processing, ribosomal small subunit biogenesis	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2461	BY4741	15_3	
20	D	12	YOR208W	PTP2	tyrosine protein phosphatase PTP2	Nuclear phosphotyrosine-specific phosphatase involved in osmosensing; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; with Msg5p co-regulates the calcium signaling pathway	protein phosphorylation, sporulation, protein dephosphorylation, regulation of protein modification process, cell wall organization or biogenesis, response to osmotic stress, signaling	phosphatase activity, hydrolase activity	nucleus	2464	BY4741	15_3	
20	E	1	YOR209C	NPT1	nicotinate phosphoribosyltransferase	Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus	cofactor metabolic process, chromatin organization, nucleobase-containing small molecule metabolic process	transferase activity, transferring glycosyl groups, transferase activity	nucleus	2465	BY4741	15_3	
20	E	2	YOR211C	MGM1	dynamin-related GTPase MGM1|MNA1	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy	mitochondrion organization, organelle fusion, membrane fusion	GTPase activity, hydrolase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	2467	BY4741	15_3	
20	E	3	YOR212W	STE4	G protein subunit beta|HMD2	G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays critical role in chemotropism; may recruit Rho1p to polarized growth site during mating; contains WD40 repeats	response to chemical, invasive growth in response to glucose limitation, transposition, conjugation, signaling	signal transducer activity	membrane, plasma membrane	2468	BY4741	15_3	
20	E	4	YOR213C	SAS5	-	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity	chromatin organization	transferase activity	nucleus, chromosome	2469	BY4741	15_3	
20	E	5	YOR214C	SPR2	-	Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication	biological_process	molecular_function	cell wall, vacuole, cytoplasm	2470	BY4741	15_3	
20	E	6	YOR215C	AIM41	-	Protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss	biological_process	molecular_function	mitochondrion, cytoplasm	2471	BY4741	15_3	
20	E	7	YOR216C	RUD3	GRP1	Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1	Golgi vesicle transport	enzyme binding	membrane, endomembrane system, cytoplasm, Golgi apparatus	2472	BY4741	15_3	
20	E	8	YOR219C	STE13	YCI1	Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor	protein maturation	peptidase activity, hydrolase activity	endomembrane system, cytoplasm, Golgi apparatus	2475	BY4741	15_3	
20	E	9	YOR220W	RCN2	WSP1	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm	2476	BY4741	15_3	
20	E	10	YOR221C	MCT1	[acyl-carrier-protein] S-malonyltransferase	Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling	lipid metabolic process, monocarboxylic acid metabolic process	transferase activity	mitochondrion, cytoplasm	2477	BY4741	15_3	
20	E	11	YOR222W	ODC2	mitochondrial 2-oxodicarboxylate carrier	Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication	other	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2478	BY4741	15_3	
20	E	12	YOR223W	DSC3	-	Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3	biological_process	molecular_function	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	2479	BY4741	15_3	
20	F	1	YOR225W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2481	BY4741	15_3	
20	F	2	YOR226C	ISU2	putative iron-binding protein ISU2|NUA2	Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant	cofactor metabolic process, cellular ion homeostasis, tRNA processing, RNA modification	molecular_function	mitochondrion, cytoplasm	2482	BY4741	15_3	
20	F	3	YOR227W	HER1	-	Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication	other	molecular_function	ribosome, mitochondrion, cytoplasm	2483	BY4741	15_3	
20	F	4	YOR228C	MCP1	-	Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2484	BY4741	15_3	
20	F	5	YOR229W	WTM2	transcriptional modulator	Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication	meiotic cell cycle, chromatin organization, cellular response to DNA damage stimulus, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, transcription factor activity, protein binding	nucleus, cytoplasm	2485	BY4741	15_3	
20	F	6	YOR230W	WTM1	transcriptional modulator	Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats	meiotic cell cycle, protein targeting, chromatin organization, transcription from RNA polymerase II promoter, nuclear transport	transcription factor activity, protein binding	nucleus	2486	BY4741	15_3	
20	F	7	YOR231W	MKK1	mitogen-activated protein kinase kinase MKK1|SSP32	MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication	protein phosphorylation, cell wall organization or biogenesis, signaling	kinase activity, transferase activity, signal transducer activity	cellular bud, site of polarized growth, cytoplasm	2487	BY4741	15_3	
20	F	8	YOR233W	KIN4	putative serine/threonine protein kinase KIN4|KIN3|KIN31	Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication	mitotic cell cycle, protein phosphorylation, organelle fission, regulation of organelle organization, chromosome segregation, regulation of cell cycle	kinase activity, transferase activity	cell cortex, cytoskeleton, microtubule organizing center, cellular bud, site of polarized growth, cytoplasm	2489	BY4741	15_3	
20	F	9	YOR234C	RPL33B	eL33|ribosomal 60S subunit protein L33B|L33e|rp47|Yl37|L37B|L33B|RPL37B	Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	2490	BY4741	15_3	
20	F	10	YOR235W	IRC13	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci	biological_process	molecular_function	cellular_component	2491	BY4741	15_3	
20	F	11	YOR237W	HES1	oxysterol-binding protein related protein HES1|OSH5	Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication	lipid transport, exocytosis, endocytosis	lipid binding	vacuole, cellular bud, membrane, site of polarized growth, cytoplasm	2493	BY4741	15_3	
20	F	12	YOR238W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm	2494	BY4741	15_3	
20	G	1	YOR239W	ABP140	TRM140|YOR240W	AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift	cytoskeleton organization, tRNA processing, RNA modification	protein binding, bridging, transferase activity, methyltransferase activity, cytoskeletal protein binding	cell cortex, cytoskeleton, site of polarized growth, cytoplasm	2495	BY4741	15_3	
20	G	2	YOR240W	cell cortex, cytoskeleton, site of polarized growth, cytoplasm	cell cortex, cytoskeleton, site of polarized growth, cytoplasm	cell cortex, cytoskeleton, site of polarized growth, cytoplasm	-	-	-	2496	BY4741	15_3	
20	G	3	YOR241W	MET7	tetrahydrofolate synthase|MET23	Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress	other	ligase activity	endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	2497	BY4741	15_3	
20	G	4	YOR242C	SSP2	-	Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression controlled by a tightly regulated middle-meiotic promoter that is activated by Ndt80p; translation of SSP2 mRNA is delayed, such that the mRNA is present as nuclear divisions are taking place but is not engaged by ribosomes until relatively late in meiotic development	meiotic cell cycle, protein phosphorylation, sporulation, regulation of protein modification process, cell wall organization or biogenesis	molecular_function	nucleus, cell wall, membrane	2498	BY4741	15_3	
20	G	5	YOR243C	PUS7	pseudouridine synthase PUS7	Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria	tRNA processing, rRNA processing, RNA modification	isomerase activity	nucleus, cytoplasm	2499	BY4741	15_3	
20	G	6	YOR245C	DGA1	diacylglycerol O-acyltransferase	Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles	lipid metabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2501	BY4741	15_3	
20	G	7	YOR246C	ENV9	-	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts	vacuole organization, protein maturation	oxidoreductase activity	mitochondrion, cytoplasm	2502	BY4741	15_3	
20	G	8	YOR247W	SRL1	-	Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication	cell wall organization or biogenesis	molecular_function	cellular bud, cell wall, site of polarized growth, vacuole, cytoplasm	2503	BY4741	15_3	
20	G	9	YOR248W	-	TOS11	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2504	BY4741	15_3	
20	G	10	YOR251C	TUM1	thiosulfate sulfurtransferase	Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized	tRNA processing, RNA modification	transferase activity	mitochondrion, cytoplasm	2507	BY4741	15_3	
20	G	11	YOR252W	TMA16	RBF17	Protein of unknown function that associates with ribosomes	biological_process	molecular_function	nucleus, ribosome, cytoplasm	2508	BY4741	15_3	
20	G	12	YOR253W	NAT5	peptide alpha-N-acetyltransferase subunit NAT5|NAA50|ROG2|ARD2	Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing	protein acylation	transferase activity	ribosome, cytoplasm	2509	BY4741	15_3	
20	H	1	YOR255W	OSW1	-	Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	membrane	2511	BY4741	15_3	
20	H	3	YOR258W	HNT3	DNA 5'-adenosine monophosphate hydrolase	DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress	cellular response to DNA damage stimulus	nuclease activity, hydrolase activity	nucleus, cytoplasm	2514	BY4741	15_3	
20	H	4	YOR263C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W	biological_process	molecular_function	cellular_component	2519	BY4741	15_3	
20	H	5	YOR264W	DSE3	-	Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress	biological_process	molecular_function	cellular bud, nucleus, site of polarized growth, cytoplasm	2520	BY4741	15_3	
20	H	6	YOR277C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20	biological_process	molecular_function	cellular_component	2533	BY4741	15_3	
20	H	7	YOR279C	RFM1	-	Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication	DNA replication, regulation of DNA metabolic process, transcription from RNA polymerase II promoter	protein binding, bridging	nucleus	2535	BY4741	15_3	
20	H	8	YOR280C	FSH3	putative serine hydrolase	Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2	biological_process	molecular_function	cellular_component	2536	BY4741	15_3	
20	H	9	YOR283W	-	phosphoglycerate mutase	Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene	other	phosphatase activity, hydrolase activity	nucleus, cytoplasm	2539	BY4741	15_3	
20	H	10	YOR284W	HUA2	-	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly	biological_process	molecular_function	cytoplasm	2540	BY4741	15_3	
20	H	11	YOR285W	RDL1	thiosulfate sulfurtransferase RDL1	Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene	biological_process	transferase activity	membrane, endomembrane system, mitochondrial envelope, mitochondrion, endoplasmic reticulum, cytoplasm	2541	BY4741	15_3	
20	H	12	YOR286W	RDL2	thiosulfate sulfurtransferase RDL2|AIM42|FMP31	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss	biological_process	transferase activity	mitochondrion, cytoplasm	2542	BY4741	15_3	
21	A	1	YOR288C	MPD1	protein disulfide isomerase MPD1	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation	protein folding	isomerase activity, oxidoreductase activity	endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	2544	BY4741	15_3	
21	A	2	YJL218W	-	acetyltransferase	Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene	biological_process	transferase activity	cellular_component	1207	BY4741	10_1	
21	A	3	YJL217W	REE1	-	Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle	biological_process	molecular_function	cytoplasm	1208	BY4741	10_1	
21	A	4	YJL216C	IMA5	oligo-1,6-glucosidase IMA5	Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro	carbohydrate metabolic process, oligosaccharide metabolic process	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cellular_component	1209	BY4741	10_1	
21	A	5	YJL215C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1210	BY4741	10_1	
21	A	6	YJL214W	HXT8	hexose transporter HXT8	Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose	carbohydrate transport	transmembrane transporter activity	membrane, plasma membrane	1211	BY4741	10_1	
21	A	7	YJL212C	OPT1	oligopeptide transporter OPT1|GSH11|HGT1	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family	other	transmembrane transporter activity	membrane, plasma membrane	1213	BY4741	10_1	
21	A	8	YJL210W	PEX2	ubiquitin-protein ligase peroxin 2|PAS5|CRT1	RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import	protein targeting, protein modification by small protein conjugation or removal, transmembrane transport, peroxisome organization	transferase activity	peroxisome, membrane, cytoplasm	1214	BY4741	10_1	
21	A	9	YJL211C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2	biological_process	molecular_function	cellular_component	1215	BY4741	10_1	
21	A	10	YJL209W	CBP1	-	Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress	generation of precursor metabolites and energy, cellular respiration, RNA catabolic process	RNA binding, mRNA binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1216	BY4741	10_1	
21	A	11	YJL208C	NUC1	ribonuclease	Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG	RNA catabolic process, DNA recombination	nuclease activity, hydrolase activity	nucleus, membrane, mitochondrial envelope, mitochondrion, cytoplasm	1217	BY4741	10_1	
21	A	12	YJL207C	LAA1	-	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene	endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, ribosome, membrane, Golgi apparatus, cytoplasm	1218	BY4741	10_1	
21	B	1	YJL206C	-	-	Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment	biological_process	molecular_function	cellular_component	1219	BY4741	10_1	
21	B	2	YJL206C-A	cellular_component	cellular_component	cellular_component	-	-	-	1220	BY4741	10_1	
21	B	3	YJL204C	RCY1	-	F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway	Golgi vesicle transport, endosomal transport, endocytosis	other	cytoplasmic vesicle, endomembrane system, cellular bud, site of polarized growth, Golgi apparatus, cytoplasm	1221	BY4741	10_1	
21	B	4	YJL201W	ECM25	-	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p	biological_process	molecular_function	cytoplasm	1224	BY4741	10_1	
21	B	5	YJL200C	ACO2	aconitate hydratase ACO2	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol	biological_process	lyase activity	mitochondrion, cytoplasm	1225	BY4741	10_1	
21	B	6	YJL199C	MBB1	-	Putative protein of unknown function; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies; YJL199C is not an essential gene	biological_process	molecular_function	cellular_component	1226	BY4741	10_1	
21	B	7	YJL198W	PHO90	SPX domain-containing inorganic phosphate transporter	Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication	transmembrane transport, ion transport, regulation of transport	transmembrane transporter activity	membrane, plasma membrane	1227	BY4741	10_1	
21	B	8	YJL197W	UBP12	putative ubiquitin-specific protease UBP12	Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm	biological_process	peptidase activity, hydrolase activity	nucleus, cytoplasm	1228	BY4741	10_1	
21	B	10	YJL196C	ELO1	fatty acid elongase ELO1	Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication	lipid metabolic process, monocarboxylic acid metabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1229	BY4741	10_1	
21	B	11	YJL193W	-	-	Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect	biological_process	molecular_function	membrane	1232	BY4741	10_1	
21	B	12	YJL192C	SOP4	EMC7	ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER	Golgi vesicle transport	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	1233	BY4741	10_1	
21	C	1	YJL191W	RPS14B	uS11|ribosomal 40S subunit protein S14B|S11|rp59B|S14B|CRY2	Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, organelle assembly, ribosomal small subunit biogenesis, ribosome assembly	RNA binding, structural constituent of ribosome, rRNA binding, structural molecule activity	ribosome, cytoplasm	1234	BY4741	10_1	
21	C	2	YJL190C	RPS22A	uS8|ribosomal 40S subunit protein S22A|S8|rp50|YS22|S24A|S22A|RPS24	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1235	BY4741	10_1	
21	C	3	YJL189W	RPL39	eL39|ribosomal 60S subunit protein L39|L39e|YL40|L46|L39|SPB2|RPL46	Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	1236	BY4741	10_1	
21	C	4	YJL188C	BUD19	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay	mitotic cell cycle, cytokinesis	molecular_function	cellular_component	1237	BY4741	10_1	
21	C	5	YJL187C	SWE1	tyrosine protein kinase SWE1|WEE1	Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate	mitotic cell cycle, meiotic cell cycle, protein phosphorylation, organelle fission, cytoskeleton organization, regulation of organelle organization, regulation of protein modification process, lipid metabolic process, regulation of cell cycle	kinase activity, transferase activity	nucleus, cellular bud, site of polarized growth	1238	BY4741	10_1	
21	C	6	YJL186W	MNN5	alpha-1,2-mannosyltransferase MNN5	Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, cytoplasm, Golgi apparatus	1239	BY4741	10_1	
21	C	7	YJL185C	ATG36	-	Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene	other	molecular_function	peroxisome, cytoplasm	1240	BY4741	10_1	
21	C	8	YJL183W	MNN11	alpha-1,6-mannosyltransferase	Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	1242	BY4741	10_1	
21	C	9	YJL181W	RBH1	RBH1	Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	1243	BY4741	10_1	
21	C	10	YJL182C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W	biological_process	molecular_function	cellular_component	1244	BY4741	10_1	
21	C	11	YJL180C	ATP12	ATP synthase complex assembly protein ATP12	Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency	mitochondrion organization, protein complex biogenesis	other	mitochondrion, cytoplasm	1245	BY4741	10_1	
21	C	12	YJL179W	PFD1	prefolding complex chaperone subunit|GIM6	Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation	protein folding, cytoskeleton organization, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	unfolded protein binding	other	1246	BY4741	10_1	
21	D	1	YJL178C	ATG27	ETF1	Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site	vacuole organization, protein targeting, organelle assembly, vesicle organization	lipid binding, ion binding	endomembrane system, vacuole, mitochondrion, membrane, Golgi apparatus, cytoplasm	1247	BY4741	10_1	
21	D	2	YJL176C	SWI3	HAF2|TYE2	Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions	carbohydrate metabolic process, response to chemical, chromatin organization, transcription from RNA polymerase II promoter, oligosaccharide metabolic process	histone binding, hydrolase activity, DNA binding, ATPase activity	nucleus, cytoplasm	1250	BY4741	10_1	
21	D	3	YJL172W	CPS1	Gly-Xaa carboxypeptidase	Vacuolar carboxypeptidase S; expression is induced under low-nitrogen conditions	proteolysis involved in cellular protein catabolic process	peptidase activity, hydrolase activity	vacuole, cytoplasm	1253	BY4741	10_1	
21	D	4	YJL171C	TOH1	-	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cell wall, membrane, endomembrane system, mitochondrion, endoplasmic reticulum, plasma membrane, cytoplasm	1254	BY4741	10_1	
21	D	5	YJL170C	ASG7	-	Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor	conjugation	molecular_function	membrane, plasma membrane	1255	BY4741	10_1	
21	D	6	YJL169W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2	biological_process	molecular_function	cellular_component	1256	BY4741	10_1	
21	D	7	YJL168C	SET2	histone methyltransferase SET2|KMT3|EZL1	Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia	peptidyl-amino acid modification, meiotic cell cycle, protein acylation, organelle fission, chromatin organization, DNA replication, DNA-templated transcription, termination, DNA recombination, DNA-templated transcription, elongation, protein alkylation, sporulation, regulation of organelle organization, histone modification, regulation of protein modification process, regulation of DNA metabolic process, regulation of cell cycle	methyltransferase activity, transferase activity	nucleus, cytoplasm	1257	BY4741	10_1	
21	D	8	YJL166W	QCR8	ubiquinol--cytochrome-c reductase subunit 8|COR5	Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	1259	BY4741	10_1	
21	D	9	YJL165C	HAL5	protein kinase HAL5	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication	cellular ion homeostasis, protein phosphorylation, protein dephosphorylation	kinase activity, transferase activity	cellular_component	1260	BY4741	10_1	
21	D	10	YJL164C	TPK1	cAMP-dependent protein kinase catalytic subunit TPK1|SRA3|PKA1	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication	protein phosphorylation, signaling	kinase activity, transferase activity	nucleus, chromosome, cytoplasm	1261	BY4741	10_1	
21	D	11	YJL163C	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane, vacuole, cytoplasm	1262	BY4741	10_1	
21	D	12	YJL162C	JJJ2	-	Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein	biological_process	molecular_function	nucleus, cytoplasm	1263	BY4741	10_1	
21	E	1	YJL161W	FMP33	-	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	1264	BY4741	10_1	
21	E	2	YJL159W	HSP150	heat shock protein HSP150|PIR2|ORE1|CCW7	O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication	cell wall organization or biogenesis	structural molecule activity, ATPase activity, hydrolase activity	cell wall, extracellular region, cytoplasm	1266	BY4741	10_1	
21	E	3	YJL158C	CIS3	SCW8|CCW5|PIR4|CCW11	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family	cell wall organization or biogenesis	structural molecule activity	endomembrane system, vacuole, cell wall, cellular bud, extracellular region, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm, plasma membrane	1267	BY4741	10_1	
21	E	4	YJL157C	FAR1	cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1	CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites	mitotic cell cycle, response to chemical, conjugation, signaling, regulation of cell cycle	enzyme regulator activity	nucleus, membrane, site of polarized growth, cytoplasm	1268	BY4741	10_1	
21	E	5	YJL155C	FBP26	fructose-2,6-bisphosphatase	Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress	carbohydrate metabolic process	phosphatase activity, hydrolase activity	cytoplasm	1270	BY4741	10_1	
21	E	6	YJL154C	VPS35	retromer subunit VPS35|VPT7|GRD9	Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant	endosomal transport	protein transporter activity	membrane, cytoplasmic vesicle, endomembrane system, vacuole, cytoplasm	1271	BY4741	10_1	
21	E	7	YJL153C	INO1	inositol-3-phosphate synthase INO1|APR1	Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element	carbohydrate metabolic process	isomerase activity	cytoplasm	1272	BY4741	10_1	
21	E	8	YJL152W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1273	BY4741	10_1	
21	E	9	YJL151C	SNA3	-	Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles	endosomal transport	enzyme binding	membrane, vacuole, cytoplasm	1274	BY4741	10_1	
21	E	10	YJL150W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	1275	BY4741	10_1	
21	E	11	YJL149W	DAS1	DUH1|SCF ubiquitin ligase complex subunit DAS1	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C	proteolysis involved in cellular protein catabolic process	protein binding, bridging, transferase activity	other	1276	BY4741	10_1	
21	E	12	YJL148W	RPA34	DNA-directed RNA polymerase I subunit RPA34|CST21|A34.5	RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p	transcription from RNA polymerase I promoter, DNA-templated transcription, elongation	transferase activity, nucleotidyltransferase activity	nucleus, nucleolus	1277	BY4741	10_1	
21	F	1	YJL147C	MRX5	-	Protein that associates with mitochondrial ribosome; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene	biological_process	molecular_function	mitochondrion, cytoplasm	1278	BY4741	10_1	
21	F	2	YJL146W	IDS2	-	Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation	meiotic cell cycle, organelle fission	molecular_function	nucleus, cytoplasm	1279	BY4741	10_1	
21	F	3	YJL145W	SFH5	-	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress	ion transport, regulation of transport, Golgi vesicle transport, lipid transport, lipid metabolic process, exocytosis	other	nucleus, cell cortex, endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	1280	BY4741	10_1	
21	F	4	YJL144W	-	-	Cytoplasmic hydrophilin essential in desiccation-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress	response to chemical	molecular_function	cytoplasm	1281	BY4741	10_1	
21	F	5	YJL142C	IRC9	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci	DNA recombination	molecular_function	membrane	1283	BY4741	10_1	
21	F	6	YJL140W	RPB4	DNA-directed RNA polymerase II subunit RPB4|B32|CTF15	RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation	response to heat, translational initiation, regulation of translation, nucleobase-containing compound transport, RNA catabolic process, DNA-templated transcription, initiation, mRNA processing, transcription from RNA polymerase II promoter, nuclear transport	RNA binding, transferase activity, nucleotidyltransferase activity, DNA binding	nucleus, cytoplasm	1285	BY4741	10_1	
21	F	7	YJL139C	YUR1	mannosyltransferase YUR1	Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication	protein glycosylation, cell wall organization or biogenesis	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, endoplasmic reticulum, Golgi apparatus, cytoplasm	1286	BY4741	10_1	
21	F	8	YJL138C	TIF2	translation initiation factor eIF4A|eIF4A	Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication	translational initiation, regulation of translation	RNA binding, hydrolase activity, translation factor activity, RNA binding, ATPase activity, helicase activity	ribosome, membrane, cytoplasm, plasma membrane	1287	BY4741	10_1	
21	F	9	YJL135W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3	biological_process	molecular_function	cellular_component	1290	BY4741	10_1	
21	F	10	YJL134W	LCB3	sphinganine kinase LCB3|YSR2|LBP1	Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication	lipid metabolic process, signaling	phosphatase activity, hydrolase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	1291	BY4741	10_1	
21	F	11	YJL133W	MRS3	Fe(2+) transporter	Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication	RNA splicing, ion transport	transmembrane transporter activity	membrane, mitochondrion, cytoplasm	1292	BY4741	10_1	
21	F	12	YJL132W	-	-	Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene	biological_process	molecular_function	membrane, vacuole, cytoplasm	1293	BY4741	10_1	
21	G	1	YJL131C	AIM23	-	Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss	translational initiation, mitochondrial translation, mitochondrion organization	RNA binding, translation factor activity, RNA binding	mitochondrion, cytoplasm	1294	BY4741	10_1	
21	G	2	YJL130C	URA2	bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase	Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP	nucleobase-containing small molecule metabolic process, cellular amino acid metabolic process	transferase activity, ligase activity	membrane, mitochondrion, cytoplasm	1295	BY4741	10_1	
21	G	3	YJL129C	TRK1	-	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication	cellular ion homeostasis	transmembrane transporter activity	membrane, plasma membrane	1296	BY4741	10_1	
21	G	4	YLR324W	PEX30	peroxisome biogenesis protein	ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; partially redundant with Pex31p; may function at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication	peroxisome organization	molecular_function	peroxisome, endomembrane system, cellular bud, membrane, endoplasmic reticulum, cytoplasm	5233	BY4741	12_5	
21	G	5	YLR325C	RPL38	eL38|ribosomal 60S subunit protein L38|L38e|L38	Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5234	BY4741	12_5	
21	G	6	YLR326W	-	-	Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; predicted to be palmitoylated	biological_process	molecular_function	other	5235	BY4741	12_5	
21	G	7	YLR327C	TMA10	RBF9|SFL2	Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, ribosome, cytoplasm	5236	BY4741	12_5	
21	G	8	YLR328W	NMA1	nicotinamide-nucleotide adenylyltransferase NMA1	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process	transferase activity, nucleotidyltransferase activity	nucleus, cytoplasm	5237	BY4741	12_5	
21	G	9	YLR329W	REC102	-	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination	meiotic cell cycle, organelle fission, DNA recombination	molecular_function	nucleus, chromosome	5238	BY4741	12_5	
21	G	10	YLR330W	CHS5	CAL3	Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus	mitotic cell cycle, meiotic cell cycle, carbohydrate metabolic process, sporulation, cytokinesis, Golgi vesicle transport, conjugation, cell wall organization or biogenesis	enzyme binding	cytoplasmic vesicle, endomembrane system, site of polarized growth, Golgi apparatus, cytoplasm	5239	BY4741	12_5	
21	G	11	YLR331C	JIP3	-	Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2	biological_process	molecular_function	cellular_component	5240	BY4741	12_5	
21	G	12	YLR332W	MID2	KAI1	O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; MID2 has a paralog, MTL1, that arose from the whole genome duplication	response to chemical, RNA splicing, cell morphogenesis, conjugation, mRNA processing, cell wall organization or biogenesis, signaling, response to osmotic stress	signal transducer activity	vacuole, membrane, site of polarized growth, cytoplasm, plasma membrane	5241	BY4741	12_5	
21	H	1	YLR333C	RPS25B	eS25|ribosomal 40S subunit protein S25B|S25e|rp45|YS23|S31B|S25B	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5242	BY4741	12_5	
21	H	3	YLR335W	NUP2	nucleoporin NUP2	Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization	response to heat, protein targeting, chromatin organization, nucleobase-containing compound transport, nuclear transport, nucleus organization	enzyme binding	nucleus, endomembrane system, mitochondrion, membrane, cytoplasm	5244	BY4741	12_5	
21	H	4	YLR341W	SPO77	-	Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	other	5250	BY4741	12_5	
21	H	5	YLR342W	FKS1	1,3-beta-D-glucan synthase|PBR1|GSC1|ETG1|CWH53|CND1	Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication	carbohydrate metabolic process, regulation of transport, endocytosis	transferase activity, transferring glycosyl groups, transferase activity	cell cortex, cytoskeleton, mitochondrion, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	5251	BY4741	12_5	
21	H	6	YLR344W	RPL26A	uL24|ribosomal 60S subunit protein L26A|L24|YL33|L33A|L26A	Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication	cytoplasmic translation	RNA binding, structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5253	BY4741	12_5	
21	H	7	YLR345W	-	bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase	Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene	carbohydrate metabolic process, cofactor metabolic process, nucleobase-containing small molecule metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process	kinase activity, transferase activity	cytoplasm	5254	BY4741	12_5	
21	H	8	YLR348C	DIC1	-	Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix	ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5257	BY4741	12_5	
21	H	9	YLR349W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C	biological_process	molecular_function	cellular_component	5258	BY4741	12_5	
21	H	10	YLR350W	ORM2	sphingolipid homeostasis protein ORM2	Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication	response to chemical, lipid metabolic process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	5259	BY4741	12_5	
21	H	11	YLR351C	NIT3	putative hydrolase	Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member	biological_process	hydrolase activity	mitochondrion, cytoplasm	5260	BY4741	12_5	
21	H	12	YLR352W	-	-	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene	biological_process	molecular_function	other	5261	BY4741	12_5	
22	A	1	YLR353W	BUD8	-	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication	mitotic cell cycle, cytokinesis, pseudohyphal growth	molecular_function	cellular bud, membrane, site of polarized growth, plasma membrane	5262	BY4741	12_5	
22	A	2	YLR354C	TAL1	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process	transferase activity	nucleus, cytoplasm	5263	BY4741	12_5	
22	A	3	YLR356W	ATG33	-	Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes; ATG33 has a paralog, SCM4, that arose from the whole genome duplication	mitochondrion organization	molecular_function	membrane, mitochondrion, cytoplasm	5265	BY4741	12_5	
22	A	4	YLR357W	RSC2	-	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication	DNA repair, chromatin organization, cellular response to DNA damage stimulus, chromosome segregation, DNA recombination, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	hydrolase activity, ATPase activity	nucleus	5266	BY4741	12_5	
22	A	5	YLR360W	VPS38	VPL17	Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated	endosomal transport	molecular_function	membrane, vacuole, cytoplasm	5269	BY4741	12_5	
22	A	6	YLR362W	STE11	mitogen-activated protein kinase kinase kinase STE11	Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress	response to heat, response to chemical, protein phosphorylation, invasive growth in response to glucose limitation, transposition, regulation of protein modification process, conjugation, pseudohyphal growth, cell wall organization or biogenesis, signaling, response to osmotic stress	kinase activity, transferase activity, signal transducer activity	cytoplasm	5271	BY4741	12_5	
22	A	7	YLR363C	NMD4	-	Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	RNA catabolic process	molecular_function	nucleus, cytoplasm	5272	BY4741	12_5	
22	A	8	YLR364W	GRX8	glutathione-disulfide reductase GRX8	Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic	biological_process	oxidoreductase activity	cytoplasm	5273	BY4741	12_5	
22	A	9	YLR365W	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YLR365W is not an essential gene	biological_process	molecular_function	cellular_component	5274	BY4741	12_5	
22	A	10	YLR366W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A	biological_process	molecular_function	cellular_component	5275	BY4741	12_5	
22	A	11	YLR367W	RPS22B	uS8|ribosomal 40S subunit protein S22B|S8|rp50|YS22|S24B|S22B	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5276	BY4741	12_5	
22	A	12	YLR368W	MDM30	SCF ubiquitin ligase complex subunit MDM30|DSG1	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains	mitochondrion organization, regulation of transport, organelle fusion, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, membrane fusion, protein modification by small protein conjugation or removal, nuclear transport	transferase activity	nucleus, mitochondrion, cytoplasm	5277	BY4741	12_5	
22	B	1	YLR371W	ROM2	Rho family guanine nucleotide exchange factor ROM2	Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication	regulation of transport, cell wall organization or biogenesis, signaling, endocytosis	guanyl-nucleotide exchange factor activity, lipid binding, ion binding, signal transducer activity	nucleus, cellular bud, site of polarized growth	5280	BY4741	12_5	
22	B	2	YLR372W	ELO3	SUR4|fatty acid elongase ELO3|APA1|VBM1|SRE1	Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7	monocarboxylic acid metabolic process, Golgi vesicle transport, lipid metabolic process, endosomal transport	transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	5281	BY4741	12_5	
22	B	3	YLR373C	VID22	-	Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles; VID22 has a paralog, ENV11, that arose from the whole genome duplication	other	molecular_function	nucleus, membrane, plasma membrane	5282	BY4741	12_5	
22	B	4	YLR374C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W	biological_process	molecular_function	cellular_component	5283	BY4741	12_5	
22	B	5	YLR375W	STP3	-	Zinc-finger protein of unknown function; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication	biological_process	DNA binding	nucleus	5284	BY4741	12_5	
22	B	6	YLR376C	PSY3	-	Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C	DNA repair, DNA recombination, cellular response to DNA damage stimulus	molecular_function	nucleus, chromosome, cytoplasm	5285	BY4741	12_5	
22	B	7	YLR377C	FBP1	fructose 1,6-bisphosphate 1-phosphatase|ACN8	Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p	carbohydrate metabolic process	phosphatase activity, hydrolase activity	cytoplasm	5286	BY4741	12_5	
22	B	8	YLR380W	CSR1	SFH2	Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress	ion transport, monocarboxylic acid metabolic process, Golgi vesicle transport, lipid transport, lipid metabolic process	other	cytoplasmic vesicle, endomembrane system, mitochondrion, membrane, cytoplasm	5289	BY4741	12_5	
22	B	9	YLR381W	CTF3	CHL3	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6	mitotic cell cycle, organelle fission, DNA replication, regulation of organelle organization, chromosome segregation, regulation of cell cycle	molecular_function	nucleus, chromosome	5290	BY4741	12_5	
22	B	11	YLR384C	IKI3	Elongator subunit IKI3|KTI7|TOT1|ELP1	Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)	tRNA processing, transcription from RNA polymerase II promoter, RNA modification	RNA binding	nucleus, cytoplasm	5293	BY4741	12_5	
22	B	12	YLR385C	SWC7	AWS1	Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin	chromatin organization	molecular_function	nucleus, chromosome	5294	BY4741	12_5	
22	C	1	YLR386W	VAC14	-	Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p	lipid metabolic process	protein binding, bridging	membrane, vacuole, cytoplasm	5295	BY4741	12_5	
22	C	2	YLR387C	REH1	-	Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains	ribosomal large subunit biogenesis	molecular_function	ribosome, cytoplasm	5296	BY4741	12_5	
22	C	3	YLR388W	RPS29A	uS14|ribosomal 40S subunit protein S29A|S14|YS29|S36A|S29A|YS29A	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5297	BY4741	12_5	
22	C	4	YLR390W	ECM19	-	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	5299	BY4741	12_5	
22	C	5	YLR392C	ART10	-	Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene	biological_process	molecular_function	cytoplasm	5301	BY4741	12_5	
22	C	6	YLR393W	ATP10	-	Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6	mitochondrion organization, protein complex biogenesis	unfolded protein binding	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5302	BY4741	12_5	
22	C	7	YLR395C	COX8	cytochrome c oxidase subunit VIII	Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	5304	BY4741	12_5	
22	C	8	YLR398C	SKI2	SKI complex RNA helicase subunit SKI2	Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome	RNA catabolic process	RNA binding, mRNA binding, helicase activity, hydrolase activity	cytoplasm	5307	BY4741	12_5	
22	C	9	YLR400W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5309	BY4741	12_5	
22	C	10	YLR401C	DUS3	tRNA dihydrouridine synthase DUS3	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress	tRNA processing, RNA modification	RNA binding, mRNA binding, oxidoreductase activity	nucleus, cytoplasm	5310	BY4741	12_5	
22	C	11	YLR402W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5311	BY4741	12_5	
22	C	12	YLR404W	SEI1	seipin|FLD1	Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the cytosolic side of the membrane; forms a complex with Ldb16p at ER-LD contact sites, stabilizing these sites; null mutants have localized accumulation of phosphatidic acid (PA) marker proteins; BSCL2, human homolog implicated in congenital lipodystrophy, complements yeast null mutant	other	molecular_function	membrane, cell cortex, endomembrane system, endoplasmic reticulum, cytoplasm	5313	BY4741	12_5	
22	D	1	YLR405W	DUS4	tRNA dihydrouridine synthase	Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p	tRNA processing, RNA modification	oxidoreductase activity	cellular_component	5314	BY4741	12_5	
22	D	2	YLR407W	-	-	Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus	biological_process	molecular_function	cellular_component	5316	BY4741	12_5	
22	D	3	YLR408C	BLS1	BLB1	Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene	vesicle organization	molecular_function	cytoplasmic vesicle, endomembrane system, cytoplasm	5317	BY4741	12_5	
22	D	4	YLR410W	VIP1	inositol polyphosphate kinase VIP1	Inositol hexakisphosphate and inositol heptakisphosphate kinase; inositol heptakisphosphate (IP7) production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1; inositol hexakisphosphate is also known as IP6	other	kinase activity, transferase activity	cytoplasm	5319	BY4741	12_5	
22	D	5	YLR412W	BER1	-	Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene	other	molecular_function	cytoplasm	5320	BY4741	12_5	
22	D	6	YLR413W	INA1	-	Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication	biological_process	molecular_function	membrane, vacuole, plasma membrane, cytoplasm	5321	BY4741	12_5	
22	D	7	YLR414C	PUN1	-	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress	protein complex biogenesis, cell wall organization or biogenesis	molecular_function	endomembrane system, cellular bud, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	5322	BY4741	12_5	
22	D	8	YLR415C	-	-	Putative protein of unknown function; YLR415C is not an essential gene	biological_process	molecular_function	cellular_component	5323	BY4741	12_5	
22	D	9	YLR416C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5324	BY4741	12_5	
22	D	10	YLR417W	VPS36	ESCRT-II subunit protein VPS36|VPL11|VAC3|GRD12	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; plays a role in the formation of mutant huntingtin (Htt) aggregates in yeast	response to chemical, protein targeting, ion transport, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, transcription from RNA polymerase II promoter	ubiquitin-like protein binding	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	5325	BY4741	12_5	
22	D	11	YLR418C	CDC73	-	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers	transcription from RNA polymerase I promoter, peptidyl-amino acid modification, chromatin organization, DNA recombination, mRNA processing, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation, DNA repair, protein alkylation, protein phosphorylation, cellular response to DNA damage stimulus, histone modification, regulation of protein modification process, protein modification by small protein conjugation or removal, regulation of DNA metabolic process	chromatin binding, enzyme binding, ion binding, transcription factor activity, protein binding	nucleus, chromosome	5326	BY4741	12_5	
22	D	12	YLR421C	RPN13	proteasome regulatory particle lid subunit RPN13	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress	proteolysis involved in cellular protein catabolic process	ubiquitin-like protein binding	cytoplasm	5328	BY4741	12_5	
22	E	1	YLR228C	ECM22	-	Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication	lipid transport, lipid metabolic process, response to starvation, regulation of transport, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, membrane, cytoplasm	5137	BY4741	12_4	
22	E	2	YLR231C	BNA5	kynureninase	Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	cofactor metabolic process, nucleobase-containing small molecule metabolic process, cellular amino acid metabolic process	hydrolase activity	nucleus, cytoplasm	5140	BY4741	12_4	
22	E	3	YLR232W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5	biological_process	molecular_function	cellular_component	5141	BY4741	12_4	
22	E	4	YLR233C	EST1	-	TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication	telomere organization, regulation of organelle organization, regulation of DNA metabolic process	RNA binding, DNA binding	nucleus, nucleolus	5142	BY4741	12_4	
22	E	5	YLR234W	TOP3	DNA topoisomerase 3|EDR1	DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination	mitotic cell cycle, meiotic cell cycle, telomere organization, organelle fission, chromosome segregation, DNA recombination, regulation of DNA metabolic process	isomerase activity	nucleus, chromosome	5143	BY4741	12_4	
22	E	6	YLR235C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs TOP3/YLR234W and YLR236C	cellular response to DNA damage stimulus	molecular_function	cellular_component	5144	BY4741	12_4	
22	E	7	YLR236C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YLR235C	biological_process	molecular_function	cellular_component	5145	BY4741	12_4	
22	E	8	YLR238W	FAR10	-	Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication	response to chemical, conjugation, signaling	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	5147	BY4741	12_4	
22	E	9	YLR239C	LIP2	lipoyl(octanoyl) transferase LIP2	Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups	other	ligase activity	mitochondrion, cytoplasm	5148	BY4741	12_4	
22	E	10	YLR241W	CSC1	-	Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1	ion transport	transmembrane transporter activity	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	5150	BY4741	12_4	
22	E	11	YLR242C	ARV1	sterol homeostasis protein ARV1	Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null	lipid transport, lipid metabolic process, protein lipidation, endocytosis	molecular_function	cell cortex, endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	5151	BY4741	12_4	
22	E	12	YLR247C	IRC20	E3 ubiquitin-protein ligase IRC20	E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci	DNA repair, cellular response to DNA damage stimulus, DNA recombination	transferase activity, hydrolase activity, helicase activity	nucleus, mitochondrion, cytoplasm	5156	BY4741	12_4	
22	F	1	YLR248W	RCK2	serine/threonine protein kinase RCK2|CMK3|CLK1	Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication	meiotic cell cycle, response to chemical, protein phosphorylation, organelle fission, regulation of organelle organization, response to oxidative stress, signaling, regulation of cell cycle, response to osmotic stress	kinase activity, transferase activity	cytoplasm	5157	BY4741	12_4	
22	F	2	YLR250W	SSP120	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	vacuole, cytoplasm	5159	BY4741	12_4	
22	F	3	YLR251W	SYM1	ethanol metabolism protein	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 is implicated in hepatocerebral mtDNA depletion syndromes (MDDS), and complements yeast null mutant	other	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5160	BY4741	12_4	
22	F	4	YLR252W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism	biological_process	molecular_function	cellular_component	5161	BY4741	12_4	
22	F	5	YLR253W	MCP2	MRX13	Mitochondrial protein of unknown function involved in lipid homeostasis; associates with mitochondrial ribosome; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5162	BY4741	12_4	
22	F	6	YLR254C	NDL1	-	Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends	other	cytoskeletal protein binding	nucleus, cytoskeleton, cytoplasm	5163	BY4741	12_4	
22	F	7	YLR255C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5164	BY4741	12_4	
22	F	8	YLR257W	-	-	Protein of unknown function; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	cytoplasm	5166	BY4741	12_4	
22	F	9	YLR258W	GSY2	glycogen (starch) synthase GSY2	Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress	carbohydrate metabolic process, generation of precursor metabolites and energy	transferase activity, transferring glycosyl groups, transferase activity	nucleus, cytoplasm	5167	BY4741	12_4	
22	F	10	YLR260W	LCB5	sphinganine kinase LCB5	Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication	response to heat, lipid metabolic process, signaling	kinase activity, transferase activity	nucleus, endomembrane system, membrane, Golgi apparatus, cytoplasm	5169	BY4741	12_4	
22	F	11	YLR261C	VPS63	-	Putative protein of unknown function; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect; decreased levels of protein in enolase deficient mutant	protein targeting	molecular_function	cellular_component	5170	BY4741	12_4	
22	F	12	YLR262C	YPT6	Rab family GTPase YPT6	Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6	vacuole organization, protein targeting, organelle assembly, Golgi vesicle transport, endosomal transport	GTPase activity, hydrolase activity	endomembrane system, Golgi apparatus, cytoplasm	5171	BY4741	12_4	
22	G	1	YLR263W	RED1	-	Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p	meiotic cell cycle, organelle fission, regulation of organelle organization, chromosome segregation, regulation of cell cycle	chromatin binding, DNA binding, structural molecule activity	nucleus, chromosome	5172	BY4741	12_4	
22	G	2	YLR264W	RPS28B	eS28|ribosomal 40S subunit protein S28B|S28e|YS27|S33B|S28B|RPS33B	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication	cytoplasmic translation, nucleobase-containing compound transport, RNA catabolic process, nuclear transport	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	5173	BY4741	12_4	
22	G	3	YLR265C	NEJ1	LIF2	Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p	DNA repair, cellular response to DNA damage stimulus	DNA binding	nucleus	5174	BY4741	12_4	
22	G	4	YLR266C	PDR8	-	Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication	transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	5175	BY4741	12_4	
22	G	5	YLR267W	BOP2	-	Protein of unknown function	biological_process	molecular_function	cellular_component	5176	BY4741	12_4	
22	G	6	YLR268W	SEC22	SNAP receptor SEC22|TS26|TSL26|SLY2	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog	organelle fusion, vesicle organization, Golgi vesicle transport, membrane fusion	other	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	5177	BY4741	12_4	
22	G	7	YLR269C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	meiotic cell cycle, sporulation, transcription from RNA polymerase II promoter	molecular_function	cellular_component	5178	BY4741	12_4	
22	G	8	YLR270W	DCS1	5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase|DcpS	Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication	RNA catabolic process, response to starvation	hydrolase activity, enzyme regulator activity	nucleus, mitochondrion, cytoplasm	5179	BY4741	12_4	
22	G	9	YLR271W	CMG1	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus, cytoplasm	5180	BY4741	12_4	
22	G	10	YLR273C	PIG1	protein phosphatase regulator PIG1	Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication	carbohydrate metabolic process, generation of precursor metabolites and energy	enzyme regulator activity	cytoplasm	5182	BY4741	12_4	
22	G	11	YLR278C	-	-	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	biological_process	DNA binding	nucleus	5187	BY4741	12_4	
22	G	12	YLR279W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5188	BY4741	12_4	
22	H	1	YLR280C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5189	BY4741	12_4	
22	H	3	YLR281C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene	biological_process	molecular_function	mitochondrion, cytoplasm	5190	BY4741	12_4	
22	H	4	YLR282C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition	biological_process	molecular_function	cellular_component	5191	BY4741	12_4	
22	H	5	YLR283W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene	biological_process	molecular_function	endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	5192	BY4741	12_4	
22	H	6	YLR284C	ECI1	dodecenoyl-CoA isomerase	Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication	lipid metabolic process, monocarboxylic acid metabolic process	isomerase activity	peroxisome, cytoplasm	5193	BY4741	12_4	
22	H	7	YLR285W	NNT1	EFM7|S-adenosylmethionine-dependent methyltransferase	S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination	peptidyl-amino acid modification, protein alkylation, chromatin organization	transferase activity, methyltransferase activity	cytoplasm	5194	BY4741	12_4	
22	H	8	YLR287C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene	biological_process	molecular_function	cytoplasm	5196	BY4741	12_4	
22	H	9	YLR287-A	cytoplasm	cytoplasm	cytoplasm	-	-	-	5197	BY4741	12_4	
22	H	10	YLR288C	MEC3	PSO9|PIP3	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1	telomere organization, chromatin organization, cellular response to DNA damage stimulus, DNA recombination, regulation of cell cycle	DNA binding	nucleus, chromosome	5198	BY4741	12_4	
22	H	11	YLR289W	GUF1	GTPase GUF1	Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor	regulation of translation	GTPase activity, hydrolase activity	nucleus, ribosome, mitochondrion, cytoplasm	5199	BY4741	12_4	
22	H	12	YLR290C	COQ11	ubiquinone biosynthesis protein COQ11|MRX2	Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain dehydrogenase/reductase (SDR) superfamily; orthologous gene in some other fungi is fused to the COQ10 ortholog	cofactor metabolic process	molecular_function	mitochondrion, cytoplasm	5200	BY4741	12_4	
23	A	1	YLR292C	SEC72	Sec63 complex subunit SEC72|SIM2|SEC67	Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p, Sec62p, and Sec66p	protein targeting, transmembrane transport	protein transporter activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	5202	BY4741	12_4	
23	A	2	YLR294C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14	generation of precursor metabolites and energy, cellular respiration	molecular_function	cellular_component	5204	BY4741	12_4	
23	A	3	YLR295C	ATP14	F1F0 ATP synthase subunit h	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress	mitochondrion organization, transmembrane transport, ion transport, protein complex biogenesis, nucleobase-containing small molecule metabolic process	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	5205	BY4741	12_4	
23	A	4	YLR296W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5206	BY4741	12_4	
23	A	5	YLR297W	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, membrane, vacuole, cytoplasm	5207	BY4741	12_4	
23	A	6	YLR299W	ECM38	gamma-glutamyltransferase|CIS2	Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation	response to chemical	peptidase activity, hydrolase activity	vacuole, cytoplasm	5209	BY4741	12_4	
23	A	7	YLR300W	EXG1	glucan 1,3-beta-glucosidase|SCW6|BGL1	Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication	carbohydrate metabolic process, cell wall organization or biogenesis	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cell wall, extracellular region, vacuole, cytoplasm	5210	BY4741	12_4	
23	A	8	YLR303W	MET17	bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17|MET25|MET15	O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis	cellular amino acid metabolic process	lyase activity, transferase activity	membrane, plasma membrane, cytoplasm	5211	BY4741	12_4	
23	A	9	YLR304C	ACO1	aconitate hydratase ACO1|GLU1	Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; human homolog ACO2 can complement yeast null mutant	mitochondrion organization, generation of precursor metabolites and energy, cellular respiration	lyase activity, DNA binding	mitochondrion, cytoplasm	5212	BY4741	12_4	
23	A	10	YLR306W	UBC12	NEDD8-conjugating protein UBC12	Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes	protein modification by small protein conjugation or removal	transferase activity	cellular_component	5214	BY4741	12_4	
23	A	11	YLR307W	CDA1	chitin deacetylase CDA1	Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	meiotic cell cycle, sporulation, cell wall organization or biogenesis	hydrolase activity	cell wall, membrane	5215	BY4741	12_4	
23	A	12	YLR308W	CDA2	chitin deacetylase CDA2	Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall	meiotic cell cycle, sporulation, cell wall organization or biogenesis	hydrolase activity	cell wall	5216	BY4741	12_4	"mates like alpha, no growth on -met, growth on -lys. Confirmed Alpha -- CORRECT STRAIN CAN BE FOUND IN PLATE 122 D4"	
23	B	1	YLR309C	IMH1	SYS3	Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi	Golgi vesicle transport	molecular_function	endomembrane system, cytoplasm, Golgi apparatus	5217	BY4741	12_4	
23	B	2	YLR311C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	membrane	5219	BY4741	12_4	
23	B	3	YLR312C	ATG39	QNQ1	Autophagy receptor with a role in degradation of the ER and nucleus; involved specifically in autophagy of perinuclear endoplasmic reticulum in response to nitrogen starvation or rapamycin treatment; localizes to the perinuclear ER	other	protein binding, bridging	endomembrane system, endoplasmic reticulum, cytoplasm	5220	BY4741	12_4	
23	B	4	YLR312W-A	MRPL15	mitochondrial 54S ribosomal protein YmL15|YmL15	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	5221	BY4741	12_4	"slow growth, petite"	
23	B	5	YLR313C	SPH1	YLR312C-B	Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication	mitotic cell cycle, response to chemical, cell morphogenesis, cell budding, cytokinesis, conjugation, pseudohyphal growth	molecular_function	cellular bud, site of polarized growth	5222	BY4741	12_4	
23	B	6	YLR315W	NKP2	-	Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2	chromosome segregation	molecular_function	cytoskeleton, microtubule organizing center, chromosome	5224	BY4741	12_4	
23	B	7	YLR318W	EST2	TERT	Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia	telomere organization	transferase activity, DNA binding, nucleotidyltransferase activity	nucleus, nucleolus	5227	BY4741	12_4	slow growth	
23	B	8	YLR319C	BUD6	AIP3	Actin- and formin-interacting protein; participates in actin cable assembly and organization as a nucleation-promoting factor (NPF) for formins Bni1p and Bnr1p; a triple helical coiled-coil domain in the C-terminal region interacts with Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate	mitotic cell cycle, chromatin organization, cytoskeleton organization, cell budding, cytokinesis, regulation of organelle organization, pseudohyphal growth	cytoskeletal protein binding, enzyme regulator activity	cell cortex, cytoskeleton, microtubule organizing center, cellular bud, membrane, site of polarized growth, cytoplasm	5228	BY4741	12_4	
23	B	9	YLR320W	MMS22	SLM2	Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation	meiotic cell cycle, DNA repair, organelle fission, DNA replication, cellular response to DNA damage stimulus, chromosome segregation, DNA recombination	molecular_function	nucleus	5229	BY4741	12_4	
23	B	10	YLR322W	VPS65	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth	protein targeting	molecular_function	cellular_component	5231	BY4741	12_4	
23	B	12	YDR147W	EKI1	bifunctional choline kinase/ethanolamine kinase EKI1	Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication	lipid metabolic process	kinase activity, transferase activity	cytoplasm	3505	BY4741	04_5	
23	C	1	YDR148C	KGD2	alpha-ketoglutarate dehydrogenase KGD2	Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated	mitochondrion organization, generation of precursor metabolites and energy, cellular respiration	transferase activity	mitochondrion, cytoplasm	3506	BY4741	04_5	"slow growth, petite"	
23	C	2	YDR149C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1/YDR150W; null mutation blocks anaerobic growth	biological_process	molecular_function	cellular_component	3507	BY4741	04_5	
23	C	3	YDR150W	NUM1	PAC12	Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and mitochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex	organelle fission, mitochondrion organization, cytoskeleton organization, organelle inheritance	cytoskeletal protein binding	cell cortex, endomembrane system, mitochondrion, cellular bud, site of polarized growth, endoplasmic reticulum, cytoplasm	3508	BY4741	04_5	
23	C	4	YDR151C	CTH1	putative mRNA-binding protein CTH1	Member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; CTH1 has a paralog, TIS11, that arose from the whole genome duplication	RNA catabolic process, cellular ion homeostasis	RNA binding, mRNA binding	nucleus	3509	BY4741	04_5	
23	C	5	YDR152W	GIR2	-	Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p	cytoplasmic translation, response to starvation	other	cytoplasm	3510	BY4741	04_5	
23	C	6	YDR153C	ENT5	-	Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin	Golgi vesicle transport, endosomal transport	lipid binding, ion binding	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	3511	BY4741	04_5	
23	C	7	YDR154C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component	3512	BY4741	04_5	
23	C	8	YDR155C	CPR1	peptidylprolyl isomerase CPR1|CPH1|CYP1	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress	meiotic cell cycle, organelle fission, chromatin organization, sporulation, regulation of organelle organization, histone modification, regulation of cell cycle	RNA binding, isomerase activity, mRNA binding	nucleus, chromosome, mitochondrion, mitochondrial envelope, cytoplasm	3513	BY4741	04_5	
23	C	9	YDR156W	RPA14	DNA-directed RNA polymerase I subunit RPA14|A14	RNA polymerase I subunit A14	transcription from RNA polymerase I promoter	transferase activity, nucleotidyltransferase activity	nucleus, nucleolus	3514	BY4741	04_5	
23	C	10	YDR157W	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains	biological_process	molecular_function	cellular_component	3515	BY4741	04_5	
23	C	11	YDR158W	HOM2	aspartate-semialdehyde dehydrogenase|THR2	Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis	cellular amino acid metabolic process	oxidoreductase activity	nucleus, membrane, plasma membrane, cytoplasm	3516	BY4741	04_5	no growth on drop-in media	
23	C	12	YDR159W	SAC3	LEP1	mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)	mitotic cell cycle, DNA repair, organelle fission, cellular response to DNA damage stimulus, nucleobase-containing compound transport, ribosomal small subunit biogenesis, RNA catabolic process, mRNA processing, nuclear transport	other	nucleus, endomembrane system	3517	BY4741	04_5	slow growth	
23	D	1	YDR161W	ACL4	-	Specific assembly chaperone for ribosomal protein Rpl4p; binds to an evolutionarily conserved surface extension of nascent Rpl4p and chaperones Rpl4p until its assembly into the pre-ribosome; transcriptionally co-regulated with rRNA and ribosome biosynthesis genes	response to chemical, proteolysis involved in cellular protein catabolic process	molecular_function	nucleus, cytoplasm	3519	BY4741	04_5	
23	D	2	YDR162C	NBP2	-	Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)	response to heat, protein phosphorylation, regulation of protein modification process, cell wall organization or biogenesis, signaling, response to osmotic stress	protein binding, bridging	nucleus, cytoplasm	3520	BY4741	04_5	
23	D	3	YDR163W	CWC15	U2-type spliceosomal complex subunit CWC15	Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p	RNA splicing, mRNA processing	molecular_function	nucleus	3521	BY4741	04_5	
23	D	4	YDR165W	TRM82	-	Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism	tRNA processing, RNA modification	transferase activity, methyltransferase activity	nucleus, cytoplasm	3523	BY4741	04_5	
23	D	5	YDR169C	STB3	-	Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress	response to chemical, transcription from RNA polymerase II promoter	DNA binding	nucleus, cytoplasm	3527	BY4741	04_5	
23	D	6	YDR171W	HSP42	heat shock protein HSP42	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress	cytoskeleton organization	unfolded protein binding	cytoskeleton, cytoplasm	3529	BY4741	04_5	
23	D	7	YDR173C	ARG82	inositol polyphosphate multikinase|ARGRIII|IPK2|ARGR3	Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes	lipid metabolic process, transcription from RNA polymerase II promoter, cellular amino acid metabolic process	protein binding, bridging, kinase activity, transferase activity	nucleus	3531	BY4741	04_5	
23	D	8	YDR175C	RSM24	mitochondrial 37S ribosomal protein RSM24	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	3533	BY4741	04_5	"slow growth, petite"	
23	D	9	YDR176W	NGG1	histone acetyltransferase NGG1|SWI7|ADA3	Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex, the SAGA complex, and the SLIK complex; transcriptional regulator involved in glucose repression of Gal4p-regulated genes	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification	transferase activity	nucleus	3534	BY4741	04_5	
23	D	10	YDR178W	SDH4	succinate dehydrogenase membrane anchor subunit SDH4|ACN18	Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3536	BY4741	04_5	
23	D	11	YDR179C	CSN9	-	Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling	response to chemical, protein modification by small protein conjugation or removal, conjugation, signaling	molecular_function	nucleus	3537	BY4741	04_5	
23	D	12	YDR179W-A	NVJ3	-	Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA domain	other	ion binding, lipid binding	other	3538	BY4741	04_5	
23	E	1	YDR181C	SAS4	-	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p	chromatin organization	transferase activity	nucleus, chromosome	3540	BY4741	04_5	
23	E	2	YDR183W	PLP1	-	Protein that interacts with CCT (chaperonin containing TCP-1) complex; has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators	response to chemical, protein folding, transcription from RNA polymerase II promoter	other	cellular_component	3542	BY4741	04_5	
23	E	3	YDR184C	ATC1	LIC4	Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress	mitotic cell cycle, cellular ion homeostasis, cell budding, cytokinesis	molecular_function	nucleus, cytoplasm	3543	BY4741	04_5	
23	E	4	YDR185C	UPS3	GEP2	Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog, UPS2, that arose from the whole genome duplication	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	3544	BY4741	04_5	
23	E	5	YDR186C	SND1	-	Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Env10p/Snd2p and Pho88p/Snd3p; can compensate for loss of SRP; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm	biological_process	molecular_function	ribosome, cytoplasm	3545	BY4741	04_5	
23	E	6	YDR191W	HST4	NAD-dependent histone deacetylase HST4	NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3	chromatin organization, monocarboxylic acid metabolic process, histone modification, lipid metabolic process, response to starvation	hydrolase activity	nucleus, mitochondrion, cytoplasm	3550	BY4741	04_5	
23	E	7	YDR192C	NUP42	FG-nucleoporin NUP42|UIP1|RIP1	FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p	response to heat, protein targeting, nucleobase-containing compound transport, nuclear transport, response to osmotic stress	structural molecule activity	nucleus, membrane, endomembrane system	3551	BY4741	04_5	
23	E	8	YDR193W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	membrane	3552	BY4741	04_5	
23	E	9	YDR194C	MSS116	ATP-dependent RNA helicase	Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate	RNA splicing, DNA-templated transcription, elongation	RNA binding, hydrolase activity, ATPase activity, helicase activity, mRNA binding	mitochondrion, cytoplasm	3553	BY4741	04_5	"slow growth, petite"	
23	E	10	YDR195W	REF2	RNA-processing protein REF2	RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; putative regulatory subunit of type 1 protein phosphatase Glc7p, required for actomyosin ring formation, and for timely dephosphorylation and release of Bnr1p from the division site; relocalizes to the cytosol in response to hypoxia	mitotic cell cycle, snoRNA processing, protein dephosphorylation, cytoskeleton organization, regulation of organelle organization, cytokinesis, DNA-templated transcription, termination, mRNA processing, transcription from RNA polymerase II promoter, regulation of cell cycle	chromatin binding, RNA binding	nucleus, cytoplasm	3554	BY4741	04_5	slow growth	
23	E	11	YDR197W	CBS2	CBP7	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader	mitochondrial translation, regulation of translation, mitochondrion organization, regulation of organelle organization, protein complex biogenesis	other	ribosome, mitochondrion, membrane, mitochondrial envelope, cytoplasm	3556	BY4741	04_5	slow growth	
23	E	12	YDR198C	RKM2	protein-lysine N-methyltransferase	Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp	peptidyl-amino acid modification, protein alkylation	transferase activity, methyltransferase activity	cellular_component	3557	BY4741	04_5	
23	F	1	YDR199W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64/YDR200C; computationally predicted to have thiol-disulfide oxidoreductase activity	biological_process	molecular_function	cellular_component	3558	BY4741	04_5	
23	F	2	YDR200C	VPS64	FAR9	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog, FAR10, that arose from the whole genome duplication	response to chemical, protein targeting, conjugation, signaling	molecular_function	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	3559	BY4741	04_5	
23	F	3	YDR203W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAV2/YDR202C	biological_process	molecular_function	cellular_component	3562	BY4741	04_5	
23	F	4	YDR204W	COQ4	ubiquinone biosynthesis protein COQ4	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on matrix face of mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; human homolog COQ4 can complement yeast coq4 null mutant	cofactor metabolic process	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	3563	BY4741	04_5	"slow growth, petite"	
23	F	5	YDR206W	EBS1	-	Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication	RNA catabolic process, regulation of translation, DNA recombination	molecular_function	cytoplasm	3565	BY4741	04_5	
23	F	6	YDR207C	UME6	DNA-binding transcriptional regulator UME6|RIM16|NIM2|CAR80	Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence, represses transcription by recruiting conserved histone deacetylase Rpd3p (through co-repressor Sin3p) and chromatin-remodeling factor Isw2p; couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms compl	meiotic cell cycle, response to chemical, organelle fission, chromatin organization, lipid metabolic process, transcription from RNA polymerase II promoter, carbohydrate metabolic process, regulation of organelle organization, pseudohyphal growth, regulation of cell cycle	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding, transcription factor binding	nucleus, chromosome	3566	BY4741	04_5	
23	F	7	YDR209C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains; YDR209C is not an essential gene; partially overlaps uncharacterized gene YDR210W	biological_process	molecular_function	cellular_component	3568	BY4741	04_5	
23	F	8	YDR210W	-	-	Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	cellular_component	3569	BY4741	04_5	
23	F	9	YDR213W	UPC2	MOX4	Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication	response to chemical, regulation of transport, lipid metabolic process, lipid transport, response to starvation, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, membrane, cytoplasm	3572	BY4741	04_5	
23	F	10	YDR214W	AHA1	-	Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress	response to heat, protein folding	enzyme regulator activity	cytoplasm	3573	BY4741	04_5	
23	F	11	YDR215C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein	biological_process	molecular_function	cellular_component	3574	BY4741	04_5	
23	F	12	YDR216W	ADR1	DNA-binding transcription factor ADR1	Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization	response to chemical, chromatin organization, regulation of organelle organization, peroxisome organization, monocarboxylic acid metabolic process, lipid metabolic process, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding, transcription factor binding	nucleus, cytoplasm	3575	BY4741	04_5	
23	G	1	YDR217C	RAD9	chromatin-binding protein RAD9	DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p	mitotic cell cycle, DNA repair, cellular response to DNA damage stimulus, transcription from RNA polymerase II promoter, regulation of cell cycle	histone binding, enzyme regulator activity, DNA binding	nucleus, chromosome	3576	BY4741	04_5	
23	G	2	YDR218C	SPR28	septin SPR28	Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes	meiotic cell cycle, sporulation	structural molecule activity	cell cortex, cytoskeleton, cell wall, membrane, cytoplasm	3577	BY4741	04_5	
23	G	3	YDR219C	MFB1	-	Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding	mitochondrion organization, proteolysis involved in cellular protein catabolic process	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	3578	BY4741	04_5	
23	G	4	YDR220C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component	3579	BY4741	04_5	
23	G	5	YDR221W	GTB1	-	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress	protein glycosylation, carbohydrate metabolic process	hydrolase activity, hydrolase activity, acting on glycosyl bonds	endomembrane system, endoplasmic reticulum, cytoplasm	3580	BY4741	04_5	
23	G	6	YDR222W	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication	biological_process	molecular_function	cytoplasm	3581	BY4741	04_5	
23	G	7	YDR223W	CRF1	-	Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication	transcription from RNA polymerase II promoter	transcription factor activity, protein binding	nucleus, chromosome, cytoplasm	3582	BY4741	04_5	
23	G	8	YDR225W	HTA1	histone H2A|SPT11|H2A1	Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo	DNA repair, chromatin organization, cellular response to DNA damage stimulus, transcription from RNA polymerase II promoter	DNA binding	nucleus, chromosome	3584	BY4741	04_5	
23	G	9	YDR226W	ADK1	adenylate kinase ADK1|AKY2|AKY1	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant	DNA replication, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	mitochondrial envelope, mitochondrion, cytoplasm	3585	BY4741	04_5	slow growth	
23	G	10	YDR227W	SIR4	chromatin-silencing protein SIR4|UTH2|STE9|ASD1	SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some alleles of SIR4 prolong lifespan; required for telomere hypercluster formation in quiescent yeast cells	chromatin organization	chromatin binding, DNA binding	nucleus, chromosome	3586	BY4741	04_5	"does not  mate, sterile"	
23	G	11	YDR229W	IVY1	-	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase	vacuole organization, organelle fusion, membrane fusion	lipid binding, ion binding	vacuole, membrane, cytoplasm	3588	BY4741	04_5	
23	G	12	YDR230W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20/YDR231C	biological_process	molecular_function	cellular_component	3589	BY4741	04_5	"slow growth, petite"	
23	H	1	YDR231C	COX20	-	Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase	mitochondrion organization, protein maturation, generation of precursor metabolites and energy, protein complex biogenesis, cellular respiration	unfolded protein binding	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3590	BY4741	04_5	"slow growth, petite"	
23	H	3	YDR233C	RTN1	-	Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily	peroxisome organization, protein complex biogenesis, organelle inheritance, nucleus organization	molecular_function	cell cortex, endomembrane system, mitochondrion, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	3592	BY4741	04_5	
23	H	4	YDR234W	LYS4	homoaconitate hydratase LYS4|LYS3	Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway	cellular amino acid metabolic process	lyase activity	mitochondrion, cytoplasm	3593	BY4741	04_5	"no growth on -lys,  no growth on drop-in media"	
23	H	5	YDR237W	MRPL7	mitochondrial 54S ribosomal protein YmL7/YmL5|YmL7|YmL5	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	3596	BY4741	04_5	"slow growth, petite"	
23	H	6	YDR239C	-	-	Protein of unknown function; may interact with ribosomes, based on co-purification experiments	biological_process	molecular_function	ribosome, cytoplasm	3598	BY4741	04_5	
23	H	7	YDR241W	BUD26	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay	mitotic cell cycle, cytokinesis	molecular_function	cellular_component	3600	BY4741	04_5	
23	H	8	YGL194C	HOS2	histone deacetylase HOS2|RTL1	Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS	meiotic cell cycle, protein phosphorylation, organelle fission, chromatin organization, regulation of organelle organization, histone modification, regulation of protein modification process, signaling, regulation of cell cycle	hydrolase activity	nucleus, chromosome, cytoplasm	4561	BY4741	07_3	
23	H	9	YGL195W	GCN1	AAS103|NDR1	Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA	regulation of translation, translational elongation	enzyme regulator activity	ribosome, mitochondrion, cytoplasm	4562	BY4741	07_3	
23	H	10	YGL196W	DSD1	D-serine ammonia-lyase DSD1	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate	cellular amino acid metabolic process	lyase activity	cellular_component	4563	BY4741	07_3	
23	H	11	YGL197W	MDS3	-	Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication	sporulation, pseudohyphal growth, signaling	molecular_function	mitochondrion, cytoplasm	4564	BY4741	07_3	
23	H	12	YGL198W	YIP4	-	Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport	biological_process	enzyme binding	membrane, endomembrane system, cytoplasm, Golgi apparatus	4565	BY4741	07_3	
24	A	1	YGL199C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W	biological_process	molecular_function	cellular_component	4566	BY4741	07_3	
24	A	2	YGL200C	EMP24	BST2	Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles	vesicle organization, Golgi vesicle transport	molecular_function	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	4567	BY4741	07_3	"Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport"	super slow growth	
24	A	3	YGL202W	ARO8	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis	cellular amino acid metabolic process	transferase activity	cytoplasm	4569	BY4741	07_3	
24	A	4	YGL203C	KEX1	serine-type carboxypeptidase	Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins	other	peptidase activity, hydrolase activity	endomembrane system, vacuole, cytoplasm, Golgi apparatus	4570	BY4741	07_3	
24	A	5	YGL205W	POX1	acyl-CoA oxidase|FOX1	Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix	lipid metabolic process, monocarboxylic acid metabolic process	oxidoreductase activity	peroxisome, cytoplasm	4571	BY4741	07_3	
24	A	6	YGL208W	SIP2	SPM2	One of three beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication	protein phosphorylation, invasive growth in response to glucose limitation, protein complex biogenesis, response to starvation, signaling	kinase activity, transferase activity	membrane, cytoplasm, plasma membrane	4574	BY4741	07_3	
24	A	7	YGL209W	MIG2	MLZ1	Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose	response to chemical, response to starvation, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, mitochondrion, cytoplasm	4575	BY4741	07_3	
24	A	8	YGL210W	YPT32	Rab family GTPase YPT32	Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication	Golgi vesicle transport, exocytosis, endosomal transport	GTPase activity, hydrolase activity	cytoplasmic vesicle, endomembrane system, mitochondrion, cellular bud, membrane, site of polarized growth, mitochondrial envelope, Golgi apparatus, cytoplasm	4576	BY4741	07_3	
24	A	9	YGL211W	NCS6	TUC1|YGL210W-A	Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae	tRNA processing, protein modification by small protein conjugation or removal, RNA modification	RNA binding	mitochondrion, cytoplasm	4577	BY4741	07_3	
24	A	10	YGL212W	VAM7	VPL24|VPS43	Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress	vacuole organization, protein targeting, organelle fusion, vesicle organization, membrane fusion	lipid binding, ion binding	vacuole, membrane, cytoplasm	4578	BY4741	07_3	slow growth	
24	A	11	YGL213C	SKI8	SKI complex subunit WD repeat protein SKI8|REC103	Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype	meiotic cell cycle, organelle fission, protein complex biogenesis, RNA catabolic process, DNA recombination	molecular_function	nucleus, chromosome, cytoplasm	4579	BY4741	07_3	
24	A	12	YGL214W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C	biological_process	molecular_function	cellular_component	4580	BY4741	07_3	
24	B	1	YGL215W	CLG1	-	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2	other	enzyme regulator activity	other	4581	BY4741	07_3	
24	B	2	YGL216W	KIP3	tubulin-dependent ATPase KIP3	Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation, destabilizing late anaphase spindle microtubules that polymerize beyond the midzone	mitotic cell cycle, organelle fission, cytoskeleton organization, regulation of organelle organization, organelle assembly, protein complex biogenesis, chromosome segregation, regulation of cell cycle	hydrolase activity, ATPase activity	nucleus, cytoskeleton, cytoplasm	4582	BY4741	07_3	
24	B	3	YGL217C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W	biological_process	molecular_function	cellular_component	4583	BY4741	07_3	
24	B	4	YGL218W	-	SRF1	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance	biological_process	molecular_function	cellular_component	4584	BY4741	07_3	
24	B	5	YGL220W	BOL2	FRA2|AIM15	Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2	response to chemical, transcription from RNA polymerase II promoter	molecular_function	nucleus, cytoplasm	4586	BY4741	07_3	"slow growth, petite"	
24	B	6	YGL221C	NIF3	hypothetical protein	Protein of unknown function; similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	4587	BY4741	07_3	
24	B	7	YGL222C	EDC1	-	RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication	RNA catabolic process, regulation of translation	RNA binding, mRNA binding	nucleus, cytoplasm	4588	BY4741	07_3	
24	B	8	YGL224C	SDT1	nucleotidase|SSM1	Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication	nucleobase-containing small molecule metabolic process	phosphatase activity, hydrolase activity	cellular_component	4590	BY4741	07_3	
24	B	9	YGL226C-A	OST5	dolichyl-diphosphooligosaccharide--protein glycotransferase subunit	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins	protein glycosylation	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4592	BY4741	07_3	
24	B	10	YGL226W	MTC3	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1	biological_process	molecular_function	mitochondrion, cytoplasm	4593	BY4741	07_3	
24	B	11	YGL227W	VID30	glucose-induced degradation complex subunit VID30|GID1	Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm	carbohydrate metabolic process, proteolysis involved in cellular protein catabolic process	molecular_function	nucleus, cytoplasm	4594	BY4741	07_3	
24	C	1	YGL228W	SHE10	-	Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest;; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; SHE10 has a paralog, OSW7/YFR039C, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly	meiotic cell cycle, sporulation, cell wall organization or biogenesis	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	4595	BY4741	07_3	
24	C	2	YGL229C	SAP4	-	Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication	mitotic cell cycle	phosphatase activity, hydrolase activity	mitochondrion, cytoplasm	4596	BY4741	07_3	
24	C	3	YGL230C	-	-	Putative protein of unknown function; non-essential gene	biological_process	molecular_function	endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	4597	BY4741	07_3	
24	C	4	YGL231C	EMC4	chaperone EMC4	Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4	protein folding	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4598	BY4741	07_3	
24	C	5	YGL232W	TAN1	putative tRNA acetyltransferase	Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress	tRNA processing, RNA modification	RNA binding	nucleus, cytoplasm	4599	BY4741	07_3	
24	C	6	YGL234W	ADE5,7	bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase	Enzyme of the 'de novo' purine nucleotide biosynthetic pathway; contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities	nucleobase-containing small molecule metabolic process	ligase activity	cytoplasm	4601	BY4741	07_3	"slow,  no growth on drop-in media"	
24	C	7	YGL235W	-	-	Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2	biological_process	molecular_function	cellular_component	4602	BY4741	07_3	
24	C	8	YGL236C	MTO1	tRNA modification protein MTO1|IPS1	Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant	tRNA processing, mitochondrion organization, RNA modification	molecular_function	mitochondrion, cytoplasm	4603	BY4741	07_3	
24	C	9	YGL237C	HAP2	-	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; respiratory defect of the null mutant is functionally complemented by human NFYA	response to chemical, transcription from RNA polymerase II promoter, generation of precursor metabolites and energy, cellular respiration	nucleic acid binding transcription factor activity, DNA binding	nucleus	4604	BY4741	07_3	
24	C	10	YGL241W	KAP114	-	Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress	protein targeting, nuclear transport	protein transporter activity	nucleus, membrane, cytoplasm	4608	BY4741	07_3	"slow growth, petite"	
24	C	11	YGL242C	-	-	Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable	biological_process	molecular_function	cellular_component	4609	BY4741	07_3	
24	C	12	YGL243W	TAD1	tRNA-specific adenosine deaminase	tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala	tRNA processing, RNA modification	hydrolase activity	nucleus	4610	BY4741	07_3	
24	D	1	YGL244W	RTF1	CSL3	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay	transcription from RNA polymerase I promoter, peptidyl-amino acid modification, snoRNA processing, chromatin organization, DNA-templated transcription, termination, mRNA processing, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation, DNA repair, protein alkylation, protein phosphorylation, cellular response to DNA damage stimulus, histone modification, regulation of protein modification process, protein modification by small protein conjugation or removal, regulation of DNA metabolic process	RNA binding, enzyme binding, ion binding, transcription factor activity, protein binding	nucleus, chromosome	4611	BY4741	07_3	
24	D	2	YGL246C	RAI1	decapping nuclease	Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z	rRNA processing, ribosomal large subunit biogenesis, DNA-templated transcription, termination, RNA catabolic process, transcription from RNA polymerase II promoter	hydrolase activity, enzyme regulator activity, nuclease activity	nucleus, cytoplasm	4613	BY4741	07_3	"slow growth, petite"	
24	D	3	YGL248W	PDE1	3',5'-cyclic-nucleotide phosphodiesterase PDE1	Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation	signaling	hydrolase activity	cellular_component	4615	BY4741	07_3	
24	D	4	YGL249W	ZIP2	-	Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress	peptidyl-amino acid modification, meiotic cell cycle, organelle fission, chromosome segregation, regulation of protein modification process, protein modification by small protein conjugation or removal, DNA recombination	molecular_function	nucleus, chromosome, mitochondrion, cytoplasm	4616	BY4741	07_3	
24	D	5	YGL250W	RMR1	-	Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus	meiotic cell cycle, organelle fission, DNA recombination	molecular_function	nucleus, cytoplasm	4617	BY4741	07_3	
24	D	6	YGL251C	HFM1	MER3	Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity	meiotic cell cycle, organelle fission, DNA replication, chromosome segregation, DNA recombination	hydrolase activity, helicase activity	nucleus	4618	BY4741	07_3	
24	D	7	YGL252C	RTG2	-	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p	response to chemical, protein targeting, chromatin organization, transcription from RNA polymerase II promoter, nuclear transport, signaling	transcription factor activity, protein binding	nucleus, chromosome, cytoplasm	4619	BY4741	07_3	
24	D	8	YGL253W	HXK2	hexokinase 2|SCI2|HKB|HEX1	Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, carbohydrate transport, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	nucleus, mitochondrion, cytoplasm	4620	BY4741	07_3	
24	D	9	YGL254W	FZF1	SUL1|RSU1|NRC299	Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress	ion transport, regulation of transport, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus	4621	BY4741	07_3	
24	D	10	YGL255W	ZRT1	high-affinity Zn(2+) transporter ZRT1	High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor	transmembrane transport, ion transport	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	4622	BY4741	07_3	
24	D	11	YGL256W	ADH4	alcohol dehydrogenase ADH4|ZRG5|NRC465	Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency	generation of precursor metabolites and energy, cellular amino acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	4623	BY4741	07_3	
24	D	12	YGL257C	MNT2	alpha-1,3-mannosyltransferase MNT2	Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans	protein glycosylation	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm	4624	BY4741	07_3	
24	E	1	YGL258W	VEL1	-	Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplication	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	4625	BY4741	07_3	
24	E	2	YGL259W	YPS5	-	Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole	biological_process	peptidase activity, hydrolase activity	cellular_component	4626	BY4741	07_3	
24	E	3	YGL260W	-	-	Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium	biological_process	molecular_function	cellular_component	4627	BY4741	07_3	
24	E	4	YGL261C	PAU11	seripauperin PAU11	Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2	biological_process	molecular_function	cellular_component	4628	BY4741	07_3	
24	E	5	YGL262W	-	-	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene	biological_process	molecular_function	cellular_component	4629	BY4741	07_3	
24	E	6	YGL263W	COS12	-	Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins	protein targeting, proteolysis involved in cellular protein catabolic process, endosomal transport	molecular_function	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	4630	BY4741	07_3	
24	E	7	YGR001C	EFM5	protein-lysine N-methyltransferase|AML1	S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro	peptidyl-amino acid modification, protein alkylation	transferase activity, methyltransferase activity	cytoplasm	4631	BY4741	07_3	no growth on drop-in media	
24	E	8	YGR003W	CUL3	cullin CUL3|CULLIN B|CULB	Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3	protein modification by small protein conjugation or removal, proteolysis involved in cellular protein catabolic process	transferase activity	nucleus, cytoplasm	4633	BY4741	07_3	
24	E	9	YGR004W	PEX31	peroxisome biogenesis protein	Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication	peroxisome organization	molecular_function	peroxisome, membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4634	BY4741	07_3	
24	E	10	YGR006W	PRP18	mRNA splicing protein PRP18	Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p	RNA catabolic process, RNA splicing, mRNA processing	other	nucleus	4636	BY4741	07_3	slow growth	
24	E	11	YGR007W	ECT1	ethanolamine-phosphate cytidylyltransferase|MUQ1	Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2	lipid metabolic process	transferase activity, nucleotidyltransferase activity	nucleus, cytoplasm	4637	BY4741	07_3	
24	E	12	YGR008C	STF2	ATPase-stabilizing factor family protein	Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication	response to chemical	molecular_function	cytoplasm	4638	BY4741	07_3	
24	F	1	YGR010W	NMA2	nicotinamide-nucleotide adenylyltransferase NMA2	Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication	cofactor metabolic process, nucleobase-containing small molecule metabolic process	transferase activity, nucleotidyltransferase activity	nucleus	4640	BY4741	07_3	
24	F	2	YGR011W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	4641	BY4741	07_3	
24	F	3	YGR012W	MCY1	putative cysteine synthase	Putative cysteine synthase; localized to the mitochondrial outer membrane	biological_process	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	4642	BY4741	07_3	
24	F	4	YGR014W	MSB2	-	Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate	signaling, response to osmotic stress	signal transducer activity	membrane, extracellular region, site of polarized growth, plasma membrane	4644	BY4741	07_3	
24	F	5	YGR015C	-	putative hydrolase	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion	biological_process	molecular_function	mitochondrion, cytoplasm	4645	BY4741	07_3	
24	F	6	YGR016W	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4646	BY4741	07_3	
24	F	7	YGR017W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm	biological_process	molecular_function	nucleus, cytoplasm	4647	BY4741	07_3	
24	F	8	YGR018C	-	-	Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W	biological_process	molecular_function	cellular_component	4648	BY4741	07_3	
24	F	9	YGR019W	UGA1	4-aminobutyrate transaminase	Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress	monocarboxylic acid metabolic process, cellular amino acid metabolic process	transferase activity	cytoplasm	4649	BY4741	07_3	
24	F	10	YGR020C	VMA7	H(+)-transporting V1 sector ATPase subunit F	Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits	cellular ion homeostasis	ATPase activity, hydrolase activity, transmembrane transporter activity	membrane, vacuole, cytoplasm	4650	BY4741	07_3	"slow growth, petite"	
24	F	11	YGR021W	-	HAH1	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	mitochondrion, cytoplasm	4651	BY4741	07_3	
24	F	12	YGR022C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W	biological_process	molecular_function	cellular_component	4652	BY4741	07_3	
24	G	1	YGR023W	MTL1	-	Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication	response to chemical, response to starvation, cell wall organization or biogenesis, response to oxidative stress	molecular_function	membrane, plasma membrane	4653	BY4741	07_3	
24	G	2	YGR025W	-	-	Putative protein of unknown function; conserved across S. cerevisiae strains	biological_process	molecular_function	cellular_component	4655	BY4741	07_3	
24	G	3	YGR026W	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	4656	BY4741	07_3	
24	G	4	YPL091W	GLR1	glutathione-disulfide reductase GLR1|LPG17	Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress	response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, mitochondrion, cytoplasm	2737	BY4741	16_3	
24	G	5	YPL090C	RPS6A	eS6|ribosomal 40S subunit protein S6A|S6e|rp9|YS4|S6A|S10A	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	2738	BY4741	16_3	
24	G	6	YPL089C	RLM1	-	MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication	transcription from RNA polymerase II promoter, signaling	nucleic acid binding transcription factor activity, DNA binding	nucleus	2739	BY4741	16_3	
24	G	7	YPL088W	-	aldo-keto reductase superfamily protein	Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance	other	oxidoreductase activity	cellular_component	2740	BY4741	16_3	
24	G	8	YPL087W	YDC1	alkaline dihydroceramidase	Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication	lipid metabolic process	hydrolase activity, hydrolase activity, acting on glycosyl bonds	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	2741	BY4741	16_3	
24	G	9	YPL086C	ELP3	Elongator subunit ELP3|KAT9|KTI8|TOT3|HPA1	Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant	tRNA processing, transcription from RNA polymerase II promoter, RNA modification	transferase activity	nucleus, cytoplasm	2742	BY4741	16_3	
24	G	10	YPL084W	BRO1	NPI3|ASI6|VPS31|LPF2	Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes	response to chemical, protein targeting, ion transport, vesicle organization, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, endosomal transport, protein modification by small protein conjugation or removal	enzyme regulator activity	cytoplasmic vesicle, endomembrane system, cytoplasm	2744	BY4741	16_3	
24	G	11	YPL081W	RPS9A	uS4|ribosomal 40S subunit protein S9A|rp21|YS11|S9A|S4|S13	Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication	cytoplasmic translation, rRNA processing, ribosomal small subunit biogenesis	RNA binding, structural constituent of ribosome, rRNA binding, structural molecule activity	ribosome, cytoplasm	2747	BY4741	16_3	
24	G	12	YPL080C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2748	BY4741	16_3	
24	H	1	YPL079W	RPL21B	eL21|ribosomal 60S subunit protein L21B|L21e|L21B	Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	2749	BY4741	16_3	
24	H	3	YPL078C	ATP4	F1F0 ATP synthase subunit 4|LPF7	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated	transmembrane transport, ion transport, protein complex biogenesis, nucleobase-containing small molecule metabolic process	hydrolase activity, transmembrane transporter activity, ATPase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	2750	BY4741	16_3	slow growth	
24	H	4	YPL077C	-	-	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	2751	BY4741	16_3	
24	H	5	YPL074W	YTA6	putative AAA family ATPase YTA6	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress	biological_process	ATPase activity, hydrolase activity	cell cortex, cytoplasm	2754	BY4741	16_3	
24	H	6	YPL072W	UBP16	putative ubiquitin-specific protease UBP16	Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria	protein modification by small protein conjugation or removal	peptidase activity, hydrolase activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2755	BY4741	16_3	
24	H	7	YPL073C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments	biological_process	molecular_function	ribosome, cytoplasm	2756	BY4741	16_3	
24	H	8	YPL071C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus, cytoplasm	2757	BY4741	16_3	
24	H	9	YPL070W	MUK1	guanine nucleotide exchange factor MUK1	Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain	Golgi vesicle transport, endosomal transport	guanyl-nucleotide exchange factor activity	cytoplasm	2758	BY4741	16_3	
24	H	10	YPL069C	BTS1	farnesyltranstransferase	Geranylgeranyl diphosphate synthase (GGPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic	lipid metabolic process	transferase activity	mitochondrion, cytoplasm	2759	BY4741	16_3	
24	H	11	YPL068C	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	nucleus	2760	BY4741	16_3	
24	H	12	YPL067C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene	biological_process	molecular_function	cytoplasm	2761	BY4741	16_3	
25	A	1	YPL066W	RGL1	-	Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source	other	molecular_function	cellular bud, site of polarized growth, cytoplasm	2762	BY4741	16_3	
25	A	2	YPL065W	VPS28	ESCRT-I subunit protein VPS28|VPL13|VPT28	Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p	protein targeting, ion transport, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport	other	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	2763	BY4741	16_3	
25	A	3	YPL064C	CWC27	putative peptidylprolyl isomerase CWC27	Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress	biological_process	molecular_function	nucleus	2764	BY4741	16_3	
25	A	4	YPL062W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation	biological_process	molecular_function	cellular_component	2766	BY4741	16_3	
25	A	5	YPL061W	ALD6	aldehyde dehydrogenase (NADP(+)) ALD6|ALD1	Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress	cofactor metabolic process, nucleobase-containing small molecule metabolic process, response to osmotic stress, monocarboxylic acid metabolic process	oxidoreductase activity	mitochondrion, cytoplasm	2767	BY4741	16_3	
25	A	6	YPL060W	MFM1	LPE10	Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p	ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2768	BY4741	16_3	
25	A	7	YPL058C	PDR12	ATP-binding cassette multidrug transporter PDR12	Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity	other	transmembrane transporter activity	membrane, plasma membrane	2770	BY4741	16_3	
25	A	8	YPL057C	SUR1	mannosylinositol phosphorylceramide synthase catalytic subunit SUR1|LPE15|CSG1|BCL21	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication	lipid metabolic process	transferase activity, transferring glycosyl groups, transferase activity	membrane, vacuole, cytoplasm	2771	BY4741	16_3	
25	A	9	YPL056C	LCL1	-	Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan	biological_process	molecular_function	cellular_component	2772	BY4741	16_3	
25	A	10	YPL055C	LGE1	-	Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division	meiotic cell cycle, protein alkylation, chromatin organization, DNA replication, histone modification, protein modification by small protein conjugation or removal	molecular_function	nucleus	2773	BY4741	16_3	
25	A	11	YPL054W	LEE1	-	Zinc-finger protein of unknown function	biological_process	molecular_function	cellular_component	2774	BY4741	16_3	
25	A	12	YPL053C	KTR6	putative mannosyltransferase|MNN6	Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication	protein glycosylation, cell wall organization or biogenesis	transferase activity	membrane, vacuole, cytoplasm	2775	BY4741	16_3	
25	B	1	YPL052W	OAZ1	YPL052W-A	Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p	regulation of translation, translational elongation, proteolysis involved in cellular protein catabolic process	enzyme regulator activity	cytoplasm	2776	BY4741	16_3	
25	B	2	YPL051W	ARL3	Arf family GTPase ARL3	ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1	protein targeting, Golgi vesicle transport	GTPase activity, hydrolase activity	endomembrane system, membrane, Golgi apparatus, cytoplasm	2777	BY4741	16_3	
25	B	3	YPL049C	DIG1	RST1	MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication	response to chemical, invasive growth in response to glucose limitation, pseudohyphal growth, transcription from RNA polymerase II promoter	DNA binding, transcription factor binding	nucleus	2779	BY4741	16_3	
25	B	4	YPL048W	CAM1	translation elongation factor EF1B gamma|CPBP|TEF3	One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids	regulation of translation, translational elongation, transcription from RNA polymerase II promoter	guanyl-nucleotide exchange factor activity, nucleic acid binding transcription factor activity, lipid binding, DNA binding, ion binding	nucleus, cytoplasm	2780	BY4741	16_3	
25	B	5	YPL047W	SGF11	SAGA histone acetyltransferase complex subunit SGF11	Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation	chromatin organization, protein modification by small protein conjugation or removal, transcription from RNA polymerase II promoter, histone modification	enzyme regulator activity	nucleus	2781	BY4741	16_3	
25	B	6	YPL046C	ELC1	elongin C	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair	DNA repair, protein modification by small protein conjugation or removal, cellular response to DNA damage stimulus, proteolysis involved in cellular protein catabolic process	transferase activity	nucleus	2782	BY4741	16_3	
25	B	7	YPL042C	SSN3	cyclin-dependent serine/threonine protein kinase SSN3|URR1|SSX7|CDK8|RYE5|UME5|SRB10|NUT7|GIG2	Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression	RNA catabolic process, response to chemical, protein phosphorylation, transcription from RNA polymerase II promoter	kinase activity, transferase activity	nucleus	2786	BY4741	16_3	
25	B	8	YPL041C	MRX11	-	Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length	biological_process	molecular_function	mitochondrion, cytoplasm	2787	BY4741	16_3	
25	B	9	YPL040C	ISM1	isoleucine--tRNA ligase ISM1	Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant	mitochondrial translation, tRNA aminoacylation for protein translation, mitochondrion organization, cellular amino acid metabolic process	ligase activity	mitochondrion, cytoplasm	2788	BY4741	16_3	
25	B	10	YPL039W	-	-	Putative protein of unknown function; YPL039W is not an essential gene	biological_process	molecular_function	cellular_component	2789	BY4741	16_3	
25	B	11	YPL038W	MET31	-	Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication	transcription from RNA polymerase II promoter, cellular amino acid metabolic process	nucleic acid binding transcription factor activity, DNA binding, transcription factor activity, protein binding	nucleus, cytoplasm	2790	BY4741	16_3	
25	B	12	YPL037C	EGD1	-	Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication	protein targeting, protein folding	unfolded protein binding	cytoplasm	2791	BY4741	16_3	
25	C	2	YPL035C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene	biological_process	molecular_function	cellular_component	2794	BY4741	16_3	
25	C	3	YPL033C	SRL4	-	Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p	nucleobase-containing small molecule metabolic process	molecular_function	mitochondrion, cytoplasm	2795	BY4741	16_3	
25	C	4	YPL032C	SVL3	-	Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication	endocytosis	molecular_function	cellular bud, site of polarized growth, cytoplasm	2796	BY4741	16_3	
25	C	5	YPL030W	TRM44	tRNA (uracil) methyltransferase	tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene	tRNA processing, RNA modification	transferase activity, methyltransferase activity	cytoplasm	2798	BY4741	16_3	
25	C	6	YPL029W	SUV3	ATP-dependent RNA helicase SUV3|LPB2	ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant	RNA catabolic process, RNA splicing, DNA replication, mitochondrion organization	helicase activity, ATPase activity, nuclease activity, hydrolase activity	chromosome, mitochondrion, cytoplasm	2799	BY4741	16_3	
25	C	7	YPL026C	SKS1	putative serine/threonine protein kinase SKS1|SHA3	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication	response to chemical, protein phosphorylation, carbohydrate transport, pseudohyphal growth, transcription from RNA polymerase II promoter	kinase activity, transferase activity	nucleus, cytoplasm	2802	BY4741	16_3	
25	C	8	YPL025C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	2803	BY4741	16_3	
25	C	9	YPL023C	MET12	methylenetetrahydrofolate reductase (NAD(P)H) MET12	Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)	biological_process	oxidoreductase activity	cellular_component	2805	BY4741	16_3	
25	C	10	YPL022W	RAD1	RAD12|ssDNA endodeoxyribonuclease RAD1|LPB9	Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein	meiotic cell cycle, DNA repair, organelle fission, cellular response to DNA damage stimulus, DNA recombination	hydrolase activity, DNA binding, nuclease activity	nucleus	2806	BY4741	16_3	
25	C	11	YPL021W	ECM23	SRD2	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p	pseudohyphal growth	DNA binding	cellular_component	2807	BY4741	16_3	
25	C	12	YPL019C	VTC3	vacuolar transporter chaperone|PHM2	Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog, VTC2, that arose from the whole genome duplication	vacuole organization, organelle fusion, membrane fusion	molecular_function	endomembrane system, vacuole, membrane, endoplasmic reticulum, cytoplasm	2809	BY4741	16_3	
25	D	1	YPL018W	CTF19	MCM18	Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2	mitotic cell cycle, organelle fission, regulation of organelle organization, chromosome segregation, regulation of cell cycle	molecular_function	nucleus, chromosome	2810	BY4741	16_3	
25	D	2	YPL015C	HST2	histone deacetylase HST2	Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export	chromatin organization, DNA recombination, regulation of DNA metabolic process	hydrolase activity	nucleus, cytoplasm	2813	BY4741	16_3	
25	D	3	YPL014W	CIP1	-	Cyclin-dependent kinase inhibitor; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus	mitotic cell cycle, regulation of protein modification process, protein phosphorylation, regulation of cell cycle	enzyme regulator activity	nucleus, cytoplasm	2814	BY4741	16_3	
25	D	4	YPL013C	MRPS16	mitochondrial 37S ribosomal protein MRPS16	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	2815	BY4741	16_3	"slow growth, petite"	
25	D	5	YPL009C	RQC2	TAE2	Component of RQC, which mediates nascent chain degradation; RQC (ribosome quality control complex) is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p	regulation of translation, translational elongation, proteolysis involved in cellular protein catabolic process	RNA binding, mRNA binding	ribosome, cytoplasm	2819	BY4741	16_3	
25	D	6	YPL008W	CHL1	MCM12|LPA9|CTF1	Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome	mitotic cell cycle, DNA repair, organelle fission, cellular response to DNA damage stimulus, chromosome segregation	hydrolase activity, helicase activity	nucleus, chromosome	2820	BY4741	16_3	
25	D	7	YPL006W	NCR1	sphingolipid transporter 	Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p	lipid metabolic process	other	membrane, endomembrane system, vacuole, endoplasmic reticulum, cytoplasm	2822	BY4741	16_3	mates like alpha. Confirmed Alpha -- CORRECT STRAIN CAN BE FOUND IN PLATE 123 H11	
25	D	8	YPL005W	AEP3	-	Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA	translational initiation, mitochondrial translation, mitochondrion organization	molecular_function	mitochondrion, membrane, mitochondrial envelope, cytoplasm	2823	BY4741	16_3	
25	D	9	YPL003W	ULA1	ENR2	Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation	protein modification by small protein conjugation or removal	ligase activity	cellular_component	2825	BY4741	16_3	
25	D	10	YPL002C	SNF8	ESCRT-II subunit protein SNF8|VPL14|VPS22	Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression	response to chemical, protein targeting, ion transport, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, transcription from RNA polymerase II promoter	molecular_function	cytoplasmic vesicle, endomembrane system, membrane, cytoplasm	2826	BY4741	16_3	
25	D	11	YPL001W	HAT1	histone acetyltransferase catalytic subunit HAT1|KAT1	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification	chromatin binding, transferase activity, histone binding	nucleus, cytoplasm	2827	BY4741	16_3	
25	D	12	YPR001W	CIT3	citrate (Si)-synthase CIT3	Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate	lipid metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, cellular respiration	transferase activity	mitochondrion, cytoplasm	2828	BY4741	16_3	"slow growth, bi-mater"	
25	E	1	YPR002W	PDH1	putative 2-methylcitrate dehydratase	Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate	lipid metabolic process, monocarboxylic acid metabolic process	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	2829	BY4741	16_3	
25	E	2	YPR003C	-	-	Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	2830	BY4741	16_3	
25	E	3	YPR004C	AIM45	-	Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit	biological_process	molecular_function	mitochondrion, cytoplasm	2831	BY4741	16_3	
25	E	4	YPR005C	HAL1	-	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p	transcription from RNA polymerase II promoter, response to osmotic stress	molecular_function	cytoplasm	2832	BY4741	16_3	
25	E	5	YPR106W	ISR1	putative protein kinase ISR1	Predicted protein kinase; overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C	biological_process	kinase activity, transferase activity	cellular_component	5522	BY4741	16_5	
25	E	6	YPR109W	-	-	Predicted membrane protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; diploid deletion strain has high budding index	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	5525	BY4741	16_5	
25	E	7	YPR111W	DBF20	serine/threonine-protein kinase DBF20	Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication	mitotic cell cycle, protein phosphorylation, organelle fission, cytokinesis, RNA catabolic process	kinase activity, transferase activity	cytoskeleton, microtubule organizing center, cellular bud, site of polarized growth, cytoplasm	5527	BY4741	16_5	
25	E	8	YPR114W	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	5530	BY4741	16_5	"grows on -met, grows on -lys "	
25	E	9	YPR115W	RGC1	GCA1	Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	carbohydrate transport, regulation of transport	other	cytoplasm	5531	BY4741	16_5	
25	E	10	YPR116W	RRG8	-	Protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport	mitochondrion organization	molecular_function	mitochondrion, cytoplasm	5532	BY4741	16_5	"slow growth, petite"	
25	E	11	YPR117W	-	BSH1	Putative protein of unknown function	biological_process	molecular_function	cellular_component	5533	BY4741	16_5	
25	E	12	YPR119W	CLB2	B-type cyclin CLB2	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication	mitotic cell cycle, protein phosphorylation, organelle fission, protein dephosphorylation, cytoskeleton organization, regulation of organelle organization, chromosome segregation, regulation of protein modification process, regulation of cell cycle	enzyme regulator activity	nucleus, cytoskeleton, microtubule organizing center, cellular bud, site of polarized growth, cytoplasm	5534	BY4741	16_5	
25	F	1	YPR120C	CLB5	B-type cyclin CLB5	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication	mitotic cell cycle, meiotic cell cycle, protein phosphorylation, organelle fission, DNA replication, cytoskeleton organization, regulation of organelle organization, organelle assembly, regulation of protein modification process, regulation of DNA metabolic process, regulation of cell cycle	enzyme regulator activity	nucleus	5535	BY4741	16_5	
25	F	2	YPR121W	THI22	putative phosphomethylpyrimidine kinase	Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively	vitamin metabolic process	molecular_function	cellular_component	5536	BY4741	16_5	
25	F	3	YPR122W	AXL1	STE22|FUS5	Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells	mitotic cell cycle, cell budding, cytokinesis, protein maturation, conjugation	peptidase activity, hydrolase activity	cellular bud, site of polarized growth	5537	BY4741	16_5	
25	F	4	YPR123C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR	biological_process	molecular_function	membrane	5538	BY4741	16_5	petite	
25	F	5	YPR124W	CTR1	high-affinity Cu transporter CTR1	High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion	ion transport	transmembrane transporter activity	nucleus, membrane, plasma membrane, cytoplasm	5539	BY4741	16_5	"slow growth, petite"	
25	F	6	YPR125W	YLH47	MRS7	Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome	mitochondrion organization, ion transport	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5540	BY4741	16_5	
25	F	7	YPR126C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5541	BY4741	16_5	
25	F	8	YPR127W	-	pyridoxine 4-dehydrogenase	Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus	biological_process	molecular_function	nucleus, cytoplasm	5542	BY4741	16_5	
25	F	9	YPR128C	ANT1	-	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation	ion transport, peroxisome organization, nucleobase-containing compound transport, monocarboxylic acid metabolic process, lipid metabolic process	transmembrane transporter activity	peroxisome, membrane, cytoplasm	5543	BY4741	16_5	
25	F	10	YPR129W	SCD6	LSM13	Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress	translational initiation, regulation of translation, organelle assembly	RNA binding, mRNA binding	cytoplasm	5544	BY4741	16_5	
25	F	11	YPR130C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5545	BY4741	16_5	
25	F	12	YOL151W	GRE2	methylglyoxal reductase (NADPH-dependent) GRE2	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase	lipid metabolic process	oxidoreductase activity	nucleus, cytoplasm	7391	BY4741	00_18	
25	G	1	YPR132W	RPS23B	uS12|ribosomal 40S subunit protein S23B|rp37|YS14|S28B|S23B|S12	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal	regulation of translation, rRNA processing, translational elongation, ribosomal small subunit biogenesis	structural constituent of ribosome, structural molecule activity	ribosome, cytoplasm	5547	BY4741	16_5	
25	G	2	YPR134W	MSS18	-	Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions	RNA splicing	molecular_function	mitochondrion, cytoplasm	5549	BY4741	16_5	slow growth	
25	G	3	YPR135W	CTF4	chromatin-binding protein CTF4|POB1|CHL15	Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion	mitotic cell cycle, DNA repair, organelle fission, DNA replication, cellular response to DNA damage stimulus, chromosome segregation, DNA recombination	chromatin binding, DNA binding	nucleus, chromosome	5550	BY4741	16_5	
25	G	4	YPR138C	MEP3	ammonium permease MEP3	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication	ion transport	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	5553	BY4741	16_5	
25	G	5	YPR139C	LOA1	lysophosphatidic acid acyltransferase LOA1|VPS66	Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA	protein targeting	transferase activity	endomembrane system, endoplasmic reticulum, cytoplasm	5554	BY4741	16_5	
25	G	6	YPR140W	TAZ1	lysophosphatidylcholine acyltransferase	Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant	mitochondrion organization, generation of precursor metabolites and energy, protein complex biogenesis, cellular respiration, lipid metabolic process, nucleobase-containing small molecule metabolic process	transferase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	5555	BY4741	16_5	
25	G	7	YPR141C	KAR3	OSR11	Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate	mitotic cell cycle, meiotic cell cycle, organelle fission, cytoskeleton organization, organelle fusion, conjugation, regulation of organelle organization, chromosome segregation, nucleus organization, regulation of cell cycle	hydrolase activity, cytoskeletal protein binding, ATPase activity	nucleus, cytoskeleton, microtubule organizing center, membrane, cytoplasm	5556	BY4741	16_5	
25	G	8	YPR145W	ASN1	asparagine synthase (glutamine-hydrolyzing) 1	Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication	monocarboxylic acid metabolic process, cellular amino acid metabolic process	ligase activity	cytoplasm	5560	BY4741	16_5	
25	G	9	YPR146C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	mitochondrion, cytoplasm	5561	BY4741	16_5	
25	G	10	YPR147C	-	-	Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS	biological_process	molecular_function	cytoplasm	5562	BY4741	16_5	
25	G	11	YPR148C	-	-	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	ribosome, cytoplasm	5563	BY4741	16_5	
25	G	12	YPR149W	NCE102	NCE2	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication	protein phosphorylation, ion transport, regulation of transport, regulation of protein modification process, lipid transport, cell wall organization or biogenesis	molecular_function	endomembrane system, mitochondrion, cellular bud, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	5564	BY4741	16_5	
25	H	1	YPR150W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C	biological_process	molecular_function	membrane	5565	BY4741	16_5	
25	H	3	YPR152C	URN1	-	Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase	biological_process	molecular_function	nucleus	5567	BY4741	16_5	
25	H	4	YPR153W	MAY24	-	Protein of unknown function	biological_process	molecular_function	membrane	5568	BY4741	16_5	bi-mater	
25	H	5	YPR154W	PIN3	LSB2	Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication	cytoskeleton organization, regulation of organelle organization, protein complex biogenesis	molecular_function	nucleus, cell cortex, cytoskeleton, cytoplasm	5569	BY4741	16_5	
25	H	6	YPR155C	NCA2	-	Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p	generation of precursor metabolites and energy, cellular respiration	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5570	BY4741	16_5	
25	H	7	YPR156C	TPO3	spermine transporter	Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication	ion transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	5571	BY4741	16_5	
25	H	8	YPR157W	TDA6	-	Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; TDA6 has a paralog, VPS62, that arose from the whole genome duplication	biological_process	molecular_function	vacuole, cytoplasm	5572	BY4741	16_5	
25	H	9	YPR158W	CUR1	-	Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication	response to heat, protein folding	other	nucleus	5573	BY4741	16_5	
25	H	10	YPR159W	KRE6	beta-glucan synthesis-associated protein KRE6|CWH48	Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication	carbohydrate metabolic process, cell wall organization or biogenesis	hydrolase activity, hydrolase activity, acting on glycosyl bonds	cytoplasmic vesicle, endomembrane system, cellular bud, membrane, site of polarized growth, endoplasmic reticulum, cytoplasm, plasma membrane	5574	BY4741	16_5	
25	H	11	YPR160W	GPH1	glycogen phosphorylase	Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway	carbohydrate metabolic process, generation of precursor metabolites and energy	transferase activity, transferring glycosyl groups, transferase activity	cytoplasm	5575	BY4741	16_5	slow growth	
25	H	12	YPR163C	TIF3	eIF4B|STM1|RBL3	Translation initiation factor eIF-4B; contains an RNA recognition motif and binds to single-stranded RNA; has RNA annealing activity; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel	cytoplasmic translation, translational initiation, protein complex biogenesis	RNA binding, mRNA binding	ribosome, cytoplasm	5578	BY4741	16_5	
26	A	1	YPR164W	MMS1	SLM6|RTT108	Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay	RNA catabolic process, DNA repair, DNA replication, DNA recombination, cellular response to DNA damage stimulus, transposition	molecular_function	other	5579	BY4741	16_5	
26	A	2	YPR166C	MRP2	mitochondrial 37S ribosomal protein MRP2	Mitochondrial ribosomal protein of the small subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	5581	BY4741	16_5	"slow growth, petite"	
26	A	3	YPR167C	MET16	phosphoadenylyl-sulfate reductase (thioredoxin)	3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism	other	oxidoreductase activity	cytoplasm	5582	BY4741	16_5	
26	A	4	YPR170C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORFs YPR169W-A and YPR170W-B	biological_process	molecular_function	cellular_component	5585	BY4741	16_5	
26	A	5	YPR171W	BSP1	-	Adapter that links synaptojanins to the cortical actin cytoskeleton; the synaptojanins are Inp52p and Inp53p 	other	protein binding, bridging	cellular bud, membrane, cell cortex, site of polarized growth, cytoskeleton, cytoplasm	5586	BY4741	16_5	
26	A	6	YPR172W	-	pyridoxal 5'-phosphate synthase	Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoplasm	5587	BY4741	16_5	
26	A	7	YPR173C	VPS4	AAA family ATPase VPS4|DID6|VPT10|VPL4|GRD13|END13|CSC1	AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism	vesicle organization, protein complex biogenesis, lipid metabolic process, endosomal transport	hydrolase activity, ion binding, ATPase activity	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, cytoplasm	5588	BY4741	16_5	
26	A	8	YPR174C	-	-	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication	biological_process	molecular_function	nucleus, cytoskeleton, microtubule organizing center, endomembrane system	5589	BY4741	16_5	
26	A	9	YPR179C	HDA3	PLO1	Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p	chromatin organization, histone modification, chromosome segregation, transcription from RNA polymerase II promoter	chromatin binding, hydrolase activity, DNA binding	nucleus, chromosome, cytoplasm	5594	BY4741	16_5	
26	A	10	YPR184W	GDB1	bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase	Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress	carbohydrate metabolic process, generation of precursor metabolites and energy	transferase activity, transferring glycosyl groups, transferase activity, hydrolase activity, hydrolase activity, acting on glycosyl bonds	mitochondrion, cytoplasm	5599	BY4741	16_5	
26	A	11	YPR185W	ATG13	serine/threonine protein kinase regulatory subunit ATG13|APG13	Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure	vacuole organization, protein targeting, protein phosphorylation, mitochondrion organization, organelle assembly, regulation of protein modification process	enzyme regulator activity	membrane, cytoplasm	5600	BY4741	16_5	
26	A	12	YPR188C	MLC2	-	Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring	cytokinesis	cytoskeletal protein binding	cellular bud, cell cortex, site of polarized growth, cytoskeleton, cytoplasm	5603	BY4741	16_5	
26	B	1	YPR189W	SKI3	SKI complex subunit tetratricopeptide repeat protein SKI3|SKI5	Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome	RNA catabolic process	molecular_function	cytoplasm	5604	BY4741	16_5	
26	B	2	YPR191W	QCR2	ubiquinol--cytochrome-c reductase subunit 2|UCR2|COR2	Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	5606	BY4741	16_5	"slow growth, petite"	
26	B	3	YPR192W	AQY1	-	Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance	meiotic cell cycle, sporulation, transmembrane transport	transmembrane transporter activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm, plasma membrane	5607	BY4741	16_5	
26	B	4	YPR193C	HPA2	histone acetyltransferase|KAT10	Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines	peptidyl-amino acid modification, protein acylation, chromatin organization, protein complex biogenesis, histone modification	transferase activity	cytoplasm	5608	BY4741	16_5	
26	B	5	YPR194C	OPT2	-	Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth	vacuole organization, cell morphogenesis, regulation of organelle organization, ion transport, regulation of transport, organelle fusion, membrane fusion, lipid transport	other	peroxisome, endomembrane system, vacuole, membrane, Golgi apparatus, cytoplasm, plasma membrane	5609	BY4741	16_5	
26	B	6	YPR195C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5610	BY4741	16_5	
26	B	7	YPR196W	-	putative maltose-responsive transcription factor	Putative maltose-responsive transcription factor	other	DNA binding	cellular_component	5611	BY4741	16_5	
26	B	8	YPR197C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SGE1/YPR198W	biological_process	molecular_function	cellular_component	5612	BY4741	16_5	
26	B	9	YPR198W	SGE1	NOR1	Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations	response to chemical	transmembrane transporter activity	membrane, endomembrane system, endoplasmic reticulum, plasma membrane, cytoplasm	5613	BY4741	16_5	
26	B	10	YPR199C	ARR1	ACR1|YAP8	Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8	response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	5614	BY4741	16_5	
26	B	11	YPR200C	ARR2	ACR2	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p	response to chemical	oxidoreductase activity	cellular_component	5615	BY4741	16_5	
26	B	12	YPR201W	ARR3	ACR3	Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite	ion transport	transmembrane transporter activity	membrane, plasma membrane	5616	BY4741	16_5	
26	C	1	YCR090C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene	biological_process	molecular_function	nucleus, cytoplasm	5809	BY4741	00_2	
26	C	3	YCR091W	KIN82	putative serine/threonine protein kinase KIN82|FPK2	Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication	response to chemical, protein phosphorylation, ion transport, lipid transport, conjugation	kinase activity, transferase activity	cellular_component	5810	BY4741	00_2	
26	C	4	YCR092C	MSH3	mismatch repair protein MSH3	Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability	meiotic cell cycle, DNA repair, organelle fission, DNA replication, cellular response to DNA damage stimulus, DNA recombination, regulation of DNA metabolic process	DNA binding	nucleus, cytoplasm	5811	BY4741	00_2	
26	C	5	YCR094W	CDC50	aminophospholipid translocase regulatory protein CDC50	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication	ion transport, lipid transport, endocytosis	hydrolase activity, ATPase activity	cytoplasmic vesicle, endomembrane system, membrane, endoplasmic reticulum, Golgi apparatus, cytoplasm	5813	BY4741	00_2	
26	C	6	YCR098C	GIT1	-	Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability	transmembrane transport, ion transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	5815	BY4741	00_2	
26	C	7	YCR099C	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane	5816	BY4741	00_2	
26	C	8	YCR100C	-	-	Putative protein of unknown function	biological_process	molecular_function	membrane	5817	BY4741	00_2	
26	C	9	YCR101C	-	-	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene	biological_process	molecular_function	membrane, vacuole, cytoplasm	5818	BY4741	00_2	
26	C	10	YCR102C	-	-	Putative protein of unknown function; involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family	response to chemical	molecular_function	cellular_component	5819	BY4741	00_2	
26	C	11	YCR105W	ADH7	NADP-dependent alcohol dehydrogenase|ADHVII	NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance	other	oxidoreductase activity	cellular_component	5821	BY4741	00_2	
26	C	12	YCR106W	RDS1	-	Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide	response to chemical	DNA binding	cellular_component	5822	BY4741	00_2	
26	D	1	YDL130W-A	STF1	ATPase-binding protein|AIS2	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication	other	enzyme binding	mitochondrion, cytoplasm	5823	BY4741	00_2	
26	D	2	YDR363W-A	SEM1	proteasome regulatory particle lid subunit SEM1|HOD1|DSS1	19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress	chromatin organization, proteolysis involved in cellular protein catabolic process, nucleobase-containing compound transport, protein complex biogenesis, histone modification, protein modification by small protein conjugation or removal, exocytosis, nuclear transport, regulation of cell cycle	molecular_function	nucleus, cytoplasm	5828	BY4741	00_2	
26	D	3	YDR525W-A	SNA2	-	Protein of unknown function; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern	biological_process	molecular_function	membrane, vacuole, cytoplasm	5829	BY4741	00_2	
26	D	4	YDR535C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene	biological_process	molecular_function	cellular_component	5830	BY4741	00_2	
26	D	5	YDR536W	STL1	glucose-inactivated glycerol proton symporter STL1	Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock	transmembrane transport, carbohydrate transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	5831	BY4741	00_2	
26	D	6	YDR538W	PAD1	phenylacrylic acid decarboxylase PAD1|POF1	Phenylacrylic acid decarboxylase; confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX; co-overproduction of Pad1p and Fdc1p greatly increases cinnamic acid decarboxylase activity	monocarboxylic acid metabolic process	lyase activity, RNA binding, mRNA binding	mitochondrion, cytoplasm	5833	BY4741	00_2	
26	D	7	YDR539W	FDC1	putative phenylacrylic acid decarboxylase FDC1	Ferulic acid decarboxylase, also active on p-coumaric acid; essential for decarboxylation of aromatic carboxylic acids to corresponding vinyl derivatives; co-overproduction of Pad1p and Fdc1p greatly increases cinnamic acid decarboxylase activity; structure implicates Glu285 as the general base in the nonoxidative decarboxylation reaction catalyzed by Fdc1p; homolog of E. coli UbiD; GFP-fusion protein localizes to cytoplasm	monocarboxylic acid metabolic process	lyase activity	cytoplasm	5834	BY4741	00_2	
26	D	8	YDR540C	IRC4	-	Protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus	DNA recombination	molecular_function	nucleus, cytoplasm	5835	BY4741	00_2	
26	D	9	YDR541C	-	carbonyl reductase (NADPH-dependent)	Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively	response to chemical	oxidoreductase activity	cellular_component	5836	BY4741	00_2	
26	D	10	YER039C-A	-	-	Putative protein of unknown function; YER039C-A is not an essential gene	biological_process	molecular_function	membrane	5838	BY4741	00_2	
26	D	11	YER091C-A	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	5841	BY4741	00_2	
26	D	12	YER144C	UBP5	putative ubiquitin-specific protease UBP5	Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication	protein modification by small protein conjugation or removal	peptidase activity, hydrolase activity	cellular bud, site of polarized growth	5842	BY4741	00_2	
26	E	1	YER188W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p	biological_process	molecular_function	cellular_component	5843	BY4741	00_2	
26	E	2	YFL034C-A	RPL22B	eL22|ribosomal 60S subunit protein L22B|L22e|rp4|l1c|YL31|L22B|YFL035C-B	Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5844	BY4741	00_2	
26	E	3	YFR032C	RRT5	-	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation	biological_process	molecular_function	membrane	5845	BY4741	00_2	
26	E	4	YFR032C-A	RPL29	eL29|ribosomal 60S subunit protein L29|L29e|YL43|L29	Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	5846	BY4741	00_2	
26	E	5	YFR033C	QCR6	ubiquinol--cytochrome-c reductase subunit 6|UCR6|COR3	Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space	generation of precursor metabolites and energy, cellular respiration, nucleobase-containing small molecule metabolic process	transmembrane transporter activity, oxidoreductase activity	nucleus, mitochondrion, membrane, mitochondrial envelope, cytoplasm	5847	BY4741	00_2	
26	E	6	YFR034C	PHO4	phosphate-sensing transcription factor PHO4|phoD	Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability	chromatin organization, response to starvation, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity, DNA binding	nucleus, cytoplasm	5848	BY4741	00_2	
26	E	7	YFR035C	-	-	Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein	biological_process	molecular_function	cellular_component	5849	BY4741	00_2	
26	E	8	YFR036W	CDC26	anaphase promoting complex subunit CDC26|SCD26|HIT3	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia	chromatin organization, protein modification by small protein conjugation or removal, proteolysis involved in cellular protein catabolic process	transferase activity	nucleus, cytoplasm	5850	BY4741	00_2	
26	E	9	YFR038W	IRC5	putative ATPase	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus	DNA recombination	ATPase activity, hydrolase activity	nucleus	5852	BY4741	00_2	Incorrect.	
26	E	10	YFR040W	SAP155	-	Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication	mitotic cell cycle	molecular_function	cytoplasm	5854	BY4741	00_2	
26	E	11	YFR041C	ERJ5	-	Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response	protein folding	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	5855	BY4741	00_2	
26	E	12	YFR043C	IRC6	-	Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci	other	protein binding, bridging	cellular_component	5857	BY4741	00_2	
26	F	1	YFR044C	DUG1	metallodipeptidase	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant	other	peptidase activity, hydrolase activity	ribosome, mitochondrion, cytoplasm	5858	BY4741	00_2	
26	F	2	YFR045W	-	-	Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white	other	other	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5859	BY4741	00_2	
26	F	3	YFR046C	CNN1	centromere-binding protein CNN1	Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T	regulation of organelle organization, organelle assembly, protein complex biogenesis, chromosome segregation	DNA binding	nucleus, chromosome	5860	BY4741	00_2	
26	F	4	YFR047C	BNA6	nicotinate-nucleotide diphosphorylase (carboxylating)|QPT1	Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p	cofactor metabolic process, nucleobase-containing small molecule metabolic process, cellular amino acid metabolic process	transferase activity, transferring glycosyl groups, transferase activity	nucleus, cytoplasm	5861	BY4741	00_2	
26	F	5	YFR048W	RMD8	-	Cytosolic protein required for sporulation	biological_process	molecular_function	endomembrane system, endoplasmic reticulum, cytoplasm	5862	BY4741	00_2	
26	F	6	YFR049W	YMR31	KGD4|mitochondrial 37S ribosomal protein YMR31	Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; has similarity to human mitochondrial ribosomal protein MRP-S36	mitochondrial translation, mitochondrion organization, generation of precursor metabolites and energy, cellular respiration	structural constituent of ribosome, oxidoreductase activity, structural molecule activity	ribosome, mitochondrion, cytoplasm	5863	BY4741	00_2	
26	F	7	YFR053C	HXK1	hexokinase 1	Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication	carbohydrate metabolic process, cofactor metabolic process, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, carbohydrate transport, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	mitochondrion, cytoplasm	5867	BY4741	00_2	
26	F	8	YFR054C	-	-	Putative protein of unknown function; conserved among S. cerevisiae strains	biological_process	molecular_function	cellular_component	5868	BY4741	00_2	
26	F	9	YFR055W	IRC7	cysteine-S-conjugate beta-lyase IRC7	Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner	monocarboxylic acid metabolic process, cellular amino acid metabolic process	lyase activity	cellular_component	5869	BY4741	00_2	
26	F	10	YFR056C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W	biological_process	molecular_function	cellular_component	5870	BY4741	00_2	
26	F	11	YFR057W	-	-	Putative protein of unknown function	biological_process	molecular_function	cellular_component	5871	BY4741	00_2	
26	F	12	YGR220C	MRPL9	mitochondrial 54S ribosomal protein YmL9|YmL9	Mitochondrial ribosomal protein of the large subunit	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	5873	BY4741	00_2	slow growth	
26	G	1	YGR221C	TOS2	-	Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication	cell budding	molecular_function	cellular bud, site of polarized growth	5874	BY4741	00_2	
26	G	2	YGR223C	HSV2	-	Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization	other	lipid binding, ion binding	cytoplasmic vesicle, endomembrane system, vacuole, membrane, cytoplasm	5876	BY4741	00_2	
26	G	3	YGR224W	AZR1	azole transporter	Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole	other	other	membrane, plasma membrane	5877	BY4741	00_2	
26	G	4	YGR225W	AMA1	SPO70	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest	meiotic cell cycle, organelle fission, sporulation, cell wall organization or biogenesis, regulation of cell cycle, chromosome segregation	enzyme regulator activity	nucleus	5878	BY4741	00_2	
26	G	5	YGR226C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W	biological_process	molecular_function	cellular_component	5879	BY4741	00_2	
26	G	6	YGR227W	DIE2	dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase|ALG10	Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant	protein glycosylation, lipid metabolic process	transferase activity, transferring glycosyl groups, transferase activity	endomembrane system, membrane, endoplasmic reticulum, cytoplasm	5880	BY4741	00_2	
26	G	7	YGR228W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C	biological_process	molecular_function	membrane	5881	BY4741	00_2	
26	G	8	YGR230W	BNS1	-	Protein of unknown function; overexpression bypasses need for Spo12p, but not required for meiosis; BNS1 has a paralog, SPO12, that arose from the whole genome duplication	meiotic cell cycle, organelle fission	molecular_function	cellular_component	5883	BY4741	00_2	
26	G	9	YGR231C	PHB2	prohibitin subunit PHB2	Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)	protein folding, organelle inheritance, mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5884	BY4741	00_2	
26	G	10	YGR232W	NAS6	-	Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6	protein complex biogenesis	molecular_function	nucleus, cytoplasm	5885	BY4741	00_2	
26	G	11	YGR233C	PHO81	VAC6|phoS	Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress	other	enzyme regulator activity	nucleus, cytoplasm	5886	BY4741	00_2	
26	G	12	YGR234W	YHB1	flavohemoglobin|YHB4	Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress	response to chemical, response to oxidative stress	oxidoreductase activity	nucleus, mitochondrion, cytoplasm	5887	BY4741	00_2	
26	H	1	YGR235C	MIC26	MOS2|MCS29|MIO27	Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex	mitochondrion organization	molecular_function	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5888	BY4741	00_2	
26	H	3	YGR236C	SPG1	-	Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies	biological_process	molecular_function	endomembrane system, mitochondrion, endoplasmic reticulum, cytoplasm	5889	BY4741	00_2	
26	H	4	YGR237C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm	biological_process	molecular_function	cytoplasm	5890	BY4741	00_2	
26	H	5	YGR240C	PFK1	6-phosphofructokinase subunit alpha	Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes	carbohydrate metabolic process, cofactor metabolic process, ion transport, generation of precursor metabolites and energy, monocarboxylic acid metabolic process, cellular ion homeostasis, nucleobase-containing small molecule metabolic process	kinase activity, transferase activity	vacuole, mitochondrion, membrane, cytoplasm	5893	BY4741	00_2	
26	H	6	YGR241C	YAP1802	-	Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication	endocytosis	other	cell cortex, cytoskeleton, cellular bud, membrane, site of polarized growth, cytoplasm	5894	BY4741	00_2	
26	H	7	YGR242W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C	biological_process	molecular_function	ribosome, cytoplasm	5895	BY4741	00_2	
26	H	8	YGR243W	MPC3	mitochondrial pyruvate carrier|FMP43	Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress	transmembrane transport, ion transport	transmembrane transporter activity	membrane, mitochondrial envelope, mitochondrion, cytoplasm	5896	BY4741	00_2	
26	H	9	YGR244C	LSC2	succinate--CoA ligase (GDP-forming) subunit beta	Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate	cofactor metabolic process, generation of precursor metabolites and energy, cellular respiration	ligase activity	mitochondrion, cytoplasm	5897	BY4741	00_2	
26	H	10	YGR247W	CPD1	2',3'-cyclic-nucleotide 3'-phosphodiesterase	Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress	nucleobase-containing small molecule metabolic process	hydrolase activity	cytoplasmic vesicle, cytoplasm	5900	BY4741	00_2	
26	H	11	YGR249W	MGA1	-	Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	other	nucleic acid binding transcription factor activity, DNA binding	nucleus	5902	BY4741	00_2	
26	H	12	YBL001C	ECM15	-	Non-essential protein of unknown function; likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis	biological_process	molecular_function	nucleus, cytoplasm	3025	BY4741	02_1	
27	A	1	YOL152W	FRE7	putative ferric-chelate reductase	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels	ion transport	oxidoreductase activity	membrane, plasma membrane	7392	BY4741	00_18	
27	A	2	YBL003C	HTA2	histone H2A|H2A2	Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p	DNA repair, chromatin organization, cellular response to DNA damage stimulus	DNA binding	nucleus, chromosome	3027	BY4741	02_1	
27	A	3	YBL005W	PDR3	drug-responsive transcription factor PDR3|TPE2|AMY2	Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate	response to chemical, transcription from RNA polymerase II promoter	nucleic acid binding transcription factor activity	nucleus, cytoplasm	3029	BY4741	02_1	
27	A	4	YBL006C	LDB7	RSC14	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions	chromatin organization, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	ATPase activity, hydrolase activity	nucleus	3032	BY4741	02_1	
27	A	5	YBL007C	SLA1	cytoskeletal protein-binding protein SLA1	Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains	cytoskeleton organization, protein complex biogenesis, endocytosis	protein binding, bridging, ubiquitin-like protein binding	nucleus, cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	3033	BY4741	02_1	
27	A	6	YBL008W	HIR1	-	Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores	chromatin organization, transcription from RNA polymerase II promoter, DNA-templated transcription, elongation	chromatin binding, DNA binding, transcription factor activity, protein binding	nucleus, chromosome	3034	BY4741	02_1	
27	A	7	YBL009W	ALK2	protein kinase ALK2	Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins	mitotic cell cycle, meiotic cell cycle, protein phosphorylation, organelle fission	kinase activity, transferase activity	cellular_component	3035	BY4741	02_1	
27	A	8	YBL010C	-	-	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles	biological_process	molecular_function	cytoplasmic vesicle, cytoplasm	3036	BY4741	02_1	
27	A	9	YBL011W	SCT1	bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1|GAT2	Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed	lipid metabolic process	transferase activity	membrane, endomembrane system, endoplasmic reticulum, cytoplasm	3037	BY4741	02_1	
27	A	10	YBL012C	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	3038	BY4741	02_1	"slow growth, petite"	
27	A	11	YBL013W	FMT1	methionyl-tRNA formyltransferase	Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	tRNA processing, RNA modification	transferase activity	mitochondrion, cytoplasm	3039	BY4741	02_1	
27	A	12	YBL015W	ACH1	acetyl-CoA hydrolase	Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth	monocarboxylic acid metabolic process	transferase activity, hydrolase activity	mitochondrion, cytoplasm	3041	BY4741	02_1	
27	B	1	YBL016W	FUS3	mitogen-activated serine/threonine-protein kinase FUS3|DAC2	Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis	response to chemical, regulation of transport, conjugation, invasive growth in response to glucose limitation, protein phosphorylation, transposition, regulation of protein modification process, nuclear transport, regulation of cell cycle, signaling	signal transducer activity, kinase activity, transferase activity	nucleus, mitochondrion, site of polarized growth, cytoplasm	3042	BY4741	02_1	
27	B	2	YBL017C	PEP1	type I sorting receptor|VPT1|VPS10	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments	protein targeting	other	membrane, endomembrane system, vacuole, cytoplasm, Golgi apparatus	3043	BY4741	02_1	
27	B	3	YBL019W	APN2	DNA-(apurinic or apyrimidinic site) lyase APN2|ETH1	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII	DNA repair, cellular response to DNA damage stimulus	lyase activity, nuclease activity, hydrolase activity	nucleus	3045	BY4741	02_1	
27	B	4	YBL021C	HAP3	-	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding	response to chemical, transcription from RNA polymerase II promoter, generation of precursor metabolites and energy, cellular respiration	nucleic acid binding transcription factor activity, DNA binding	nucleus	3047	BY4741	02_1	"slow growth, petite"	
27	B	5	YBL022C	PIM1	ATP-dependent Lon protease PIM1|LON1	ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria	proteolysis involved in cellular protein catabolic process, protein complex biogenesis	peptidase activity, ATPase activity, hydrolase activity	mitochondrion, cytoplasm	3048	BY4741	02_1	"slow growth, petite"	
27	B	6	YBL024W	NCL1	tRNA (cytosine-C5-)-methyltransferase|TRM4	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120	response to chemical, tRNA processing, response to oxidative stress, RNA modification	RNA binding, transferase activity, methyltransferase activity	nucleus	3050	BY4741	02_1	
27	B	7	YBL027W	RPL19B	eL19|ribosomal 60S subunit protein L19B|L19e|rpl5L|YL14|L23B|L19B	Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication	cytoplasmic translation	structural molecule activity, structural constituent of ribosome	ribosome, cytoplasm	3053	BY4741	02_1	
27	B	8	YBL028C	-	-	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis	biological_process	molecular_function	nucleus, nucleolus, ribosome, cytoplasm	3054	BY4741	02_1	
27	B	9	YBL029W	-	-	Non-essential protein of unknown function	biological_process	molecular_function	nucleus, cytoplasm	3055	BY4741	02_1	
27	B	10	YBL031W	SHE1	-	Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function	mitotic cell cycle, organelle fission, cytoskeleton organization, chromosome segregation	cytoskeletal protein binding	nucleus, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	3057	BY4741	02_1	
27	B	11	YBL032W	HEK2	KHD1	RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K	telomere organization	RNA binding, mRNA binding	nucleus, chromosome, cytoplasm	3058	BY4741	02_1	
27	B	12	YBL036C	-	-	Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS	biological_process	ion binding	cellular_component	3062	BY4741	02_1	
27	C	1	YBL037W	APL3	-	Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport	other	molecular_function	cytoplasmic vesicle, endomembrane system, cellular bud, membrane, site of polarized growth, cytoplasm, plasma membrane	3063	BY4741	02_1	
27	C	2	YBL038W	MRPL16	RML16|mitochondrial 54S ribosomal protein YmL47|YmL47	Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation	mitochondrial translation, mitochondrion organization	structural molecule activity, structural constituent of ribosome	ribosome, mitochondrion, cytoplasm	3064	BY4741	02_1	"slow growth, petite"	
27	C	4	YBL039C	URA7	CTP synthase URA7	Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication	lipid metabolic process, nucleobase-containing small molecule metabolic process	ligase activity	vacuole, cytoplasm	3065	BY4741	02_1	
27	C	5	YBL042C	FUI1	uridine permease	High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress	transmembrane transport, nucleobase-containing compound transport	transmembrane transporter activity	membrane, vacuole, plasma membrane, cytoplasm	3068	BY4741	02_1	
27	C	6	YBL043W	ECM13	-	Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication	biological_process	molecular_function	cellular_component	3069	BY4741	02_1	
27	C	7	YBL044W	-	-	Putative protein of unknown function; YBL044W is not an essential protein	biological_process	molecular_function	cellular_component	3070	BY4741	02_1	"slow growth, petite"	
27	C	8	YBL045C	COR1	ubiquinol--cytochrome-c reductase subunit COR1|QCR1	Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain	generation of precursor metabolites and energy, cellular respiration	transmembrane transporter activity, oxidoreductase activity	mitochondrion, membrane, mitochondrial envelope, cytoplasm	3071	BY4741	02_1	"slow growth, petite"	
27	C	9	YBL046W	PSY4	HSM6	Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2	protein dephosphorylation, cellular response to DNA damage stimulus, regulation of cell cycle	enzyme regulator activity	nucleus, cytoplasm	3072	BY4741	02_1	
27	C	10	YBL047C	EDE1	BUD15	Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15	response to chemical, cytokinesis, signaling, regulation of cell cycle, endocytosis	ubiquitin-like protein binding	cell cortex, cytoskeleton, cellular bud, site of polarized growth, cytoplasm	3073	BY4741	02_1	
27	C	11	YBL048W	RRT1	-	Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data	biological_process	molecular_function	membrane	3074	BY4741	02_1	
27	C	12	YBL049W	MOH1	-	Protein of unknown function, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport	biological_process	molecular_function	cellular_component	3075	BY4741	02_1	
27	D	1	YBL051C	PIN4	MDT1	Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage	mitotic cell cycle, cellular response to DNA damage stimulus, regulation of cell cycle	RNA binding, mRNA binding	cytoplasm	3077	BY4741	02_1	
27	D	2	YBL052C	SAS3	KAT6	Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal	peptidyl-amino acid modification, protein acylation, chromatin organization, histone modification	transferase activity	nucleus	3078	BY4741	02_1	
27	D	3	YBL053W	-	-	Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data	biological_process	molecular_function	cellular_component	3079	BY4741	02_1	
27	D	4	YBL054W	TOD6	PBF1	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization	transcription from RNA polymerase II promoter	DNA binding	nucleus, chromosome, cytoplasm	3080	BY4741	02_1	
27	D	5	YBL055C	-	3'-5'-exodeoxyribonuclease|Tat-D	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases	response to chemical, response to oxidative stress	nuclease activity, hydrolase activity	cytoplasm	3081	BY4741	02_1	
27	D	6	YBL056W	PTC3	type 2C protein phosphatase PTC3	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication	protein phosphorylation, protein dephosphorylation, regulation of protein modification process, signaling, response to osmotic stress, regulation of cell cycle	phosphatase acti